scholarly journals Effect of Leaf Syzygium aromaticum on Lymphocytes and Macrophages Mice Balb/c

2018 ◽  
Vol 23 (2) ◽  
pp. 79
Author(s):  
Syahran Wael ◽  
Theopilus Wilhelmus Watuguly ◽  
Didik Wahyudi

Syzygium aromaticum as an immunomodulator contains main active compound eugenol which is able to stimulate lymphocyte proliferation and the production of macrophages. Lymphocytes have a very important role to provide protection in the body against infection. This study aims to prove the effects of extract Syzygium aromaticum leaf against increased proliferation of lymphocytes, lymphoblast and macrophages of mice Balb/c of induced Salmonella typhimurium. The method used in this study was experimental with post test only control group. Mice Balb/c were divided into 4 groups as a control group and treatment induced of Salmonella typhimurium. The first treatment group were administrated extracts of 15mg /kgbw, the second treatment 75mg/kgbw, the third treatment of 150mg/kgbw for 12days. ANOVA test showed a significant difference in lymphocyte proliferation but not lymphoblast and macrophages.

2018 ◽  
Vol 38 (3) ◽  
pp. 143-149
Author(s):  
Ardorisye Fornia ◽  
Suradi Suradi ◽  
Aphridasari Aphridasari

Background: Oxidation stress showed clinical evidence of increased in patients with COPD and contribute functionally to expiratory air flow resistance, so the body requires exogenous antioxidants to inhibit oxidative stress. This study was conducted to assess whether there is influence on levels of MDA plasma ubiquinone, FEV1% and patients with stable COPD CAT score. Methods: This study is a clinical trial experimental with pretest and post-test design which aims to determine the effect of plasma MDA, FEV1% and patients with stable COPD CAT score. Subjects consist of 30 patients with stable COPD who came to Pulmonary outpatient clinic of Moewardi hospital Surakarta during June to August 2016. The sample was taken by consecutive sampling. Subjects were divided into two group, the treatment group (n=15) received additional therapy ubiquinone 1x150mg/day and the control group (n=15) received standard therapy. MDA plasma levels, FEV1% and CAT scores were measured at the time of control pulmonary outpatient clinic. Results: Giving ubiquinone can significantly lower CAT score better in the treatment group compared to the control group. There were no statistically significant difference (p=0.744) in plasma MDA treatment group (1.37 ± 0.11) compared to controls (1,39 ± 0.16). There were no statistically significant difference between (p=0.276) the decline in FEV1% treatment group (43.28 ± 20.59) and the control group (36.01 ± 14.73). Conclusion : The use of Ubiquinone in decreasing CAT score for stable COPD patients. There was lowering effect in MDA plasma but there was no excalation value in FEV1%.


2021 ◽  
Vol 4 (1) ◽  
pp. 27
Author(s):  
Muhammad Aulia U H ◽  
Iswinarno Doso Saputro ◽  
Magda Rosalina Hutagalung

Background: The incidence of burns in Indonesia progressively increases with the increase in its population and industries. From January to September 2000, 158 patients were treated in the burn unit of Dr Soetomo Hospital with a mortality rate reaching 5,8%. Burns have a direct effect in causing both local and systemic changes in the body, not occurring in other injuries. In severe burns, a hypermetabolic state can occur, which increases cardiac workload and causes muscle atrophy and other morbidities. The purpose of this study is to examine the effect of propranolol on the hypermetabolic state in severely burned patients by measuring various clinical & laboratory parameters.Methods : This is an experimental study using pre and post test control group design with the objective of assessing the treatment outcome with oral propranolol given in 15 consecutive days for burn patients involving 25%- 60% TBSA. Measurements were taken three times, on day 0, 7 and 14.Results : Obtained 16 samples divided into 2 groups. In the treatment group, there was a significant decrease in CRP levels on days 0, 7 and 14 (p <0.05). The Mid Arm Circumference variable did not obtain a significant decreasing on days 0, 7 and 14. The albumin level studied showed a significant decreasing on day 0 & 7 days with a value of p = 0.045. From the comparison between the two groups, there were significant differences in CRP levels on days 0 & 14, with the mean value of the treatment group -5.12 + 2.88 and the mean value of the control group 2.86 + 7.37, and the value of p = 0.019.Conclusions: This study successfully proved that the administration of propranolol can overcome the effects of hypermetabolism which is characterized by decreasing in CRP levels.


2020 ◽  
Vol 20 (1) ◽  
pp. 247
Author(s):  
Nur Insani ◽  
H.M.T Kamaluddin ◽  
Swanny Swanny

Glutathione (GSH) transferase deficiency due to paracetamol exposure causes further oxidative stress to liver necrosis. To reduce oxidative stress that can cause damage to the liver of the body requires antioxidants. One plant to treat liver disease is the kelor leaf (because it has an active flavonoid material also has antioxidant activity). This study was conducted to determine the difference of glutathione hepar levels of male white rat induced paracetamol toxic dose by giving kelor leaf extract. The type of research is experimental laboratory in vivo with rancagan randomized post test only control group design. With the stages as follows 1.Leaf Extract Kelor with Ethanol 96%, 2.Perpeteration of experimental animals, 3.Treatment of experimental animals by giving extract of 3-dose of kelor leaf that is KP I 250 mg / 200 gr BB rat, KP II 500 mg / 200 gr BB rat, KP III 1000 mg / 200 gr BB rat  for 14 days combined with paracetamol dose 2 gr / 200 gr BB rat compared with the negative control group (group given only paracetamol dose 2 gr / 200 gr BB rat) and control group positif only fed regular feed for 14 days). The result showed that there was a significant difference mean of GSH levels between all treatment groups obtained p = 0,000 (p <α) p values smaller than 0.05. There was the highest increase of GSH in treatment group II (142,7525 μmol / mg) and lowest dose of GSH in positive control group (57,1812 μmol / mg), dose paracetamol toxic dosage and kelor leaf extract 500 mg / gr BB rat can increase GSH hepar p = 0,000 (p <α) p less than 0 , 05. The conclusion of the test results showed that giving of kelor leaf extract at dose of treatment group II can increase GSH hepar level significantly


2021 ◽  
Vol 19 (3) ◽  
pp. 279-288
Author(s):  
Mohammad Hani Mansori ◽  
◽  
Yousef Moghadas Tabrizi ◽  
Kamal Mohammadkhani ◽  
◽  
...  

Objectives: Walking and balance control are determining factors in the independence of the elderly because they are the main components of daily physical activity. This study evaluated the effectiveness of Dynamic Neuromuscular Stability (DNS) training on balance and gait function in the elderly. Methods: This study had a pre-test/post-test design. It was a quasi-experimental study performed on 30 older men aged 60-70 years in Qom Province, Iran, in 2021. The elderly was randomly divided into experimental (n=15) and control (n=15) groups. The Experimental Group (EG) participated in three 45-min sessions of dynamic neuromuscular stability training every week for 6 weeks, and the Control Group (CG) continued their normal daily routine. Berg balance scale (dynamic balance), modified stork stand (static balance), and temporal and spatial gait parameters were used to collect information before and after applying the training protocol. The obtained data were analyzed using ANCOVA statistical method and the paired t test. Results: There were significant differences between pre-test and post-test in EG regarding the variables of dynamic balance, static balance (P=0.001), and gait function, but in the CG, no significant difference was observed for these variables (P>0.05). Also, there was a significant difference between the mean scores obtained in the balance and gait tests between the two groups (P<0.05), and EG performed better in the post-test. Discussion: DNS training due to the great variety of movement in different parts of the body and the effect on improving strength, flexibility, range of motion, and physical fitness can also improve balance and gait function in the elderly. According to the present study results, one of the best ways to reduce the costs and physical, psychological, and social problems caused by aging is to use DNS training for the elderly.


2017 ◽  
Vol 12 (2) ◽  
pp. 212-217
Author(s):  
Roy Januardi Irawan

Pencak Silat is a martial art that has a risk of causing micro-trauma due to physical impact. This trauma will stimulate the secretion of prostaglandin, a compound in the body which is a mediator of pain and inflammatory response that promote pain in bruised trauma. Passion fruit contains high level of anti-inflammatory and antioxidant substances. The objective of this study was to understand the effectiveness of passion fruit juice consumption in reducing bruised trauma pain in Pencak Silat athletes of PSHT Belotan Magetan. The research design is a quantitative descriptive with quasi-experimental. The pretest and posttest group of 20 people PSHT Belotan Magetan Pencak Silat athletes with an average age of 13.4 0.94 years were divided into treatment group (K1) and control group (K0) with 10 subjects respectively. Each treatment group (K1) subject was given the juice twice a day for 10 consecutive days. We used paired sample T-test to assess the mean variance of the group. The result showed that there was a decrease of pain intensity in both the treatment group and the control group. The pain intensity difference assessed by a Bourbonnais Rating Scale in the treatment group showed a significant difference with the t value of 7,216 and a probability value of 0,000, while the control group showed t value of 3,000 and probability value of 0,015. There was a decrease in the athletes muscle soreness who were given passion fruit juice twice a day for 10 days. The athletes pain intensity was in middle category.


2018 ◽  
Vol 14 (4) ◽  
pp. 131
Author(s):  
Putri Nur Fatimah ◽  
Fillah Fithra Dieny ◽  
Etisa Adi Murbawani ◽  
Ahmed Fahmy Arif Tsani

Background: Obesity caused diabetes and cardiovascular disease. Yoga considered three aspects, physic, emotion and mental that helped in obesity therapy.Objective: This research aimed to explain the influence of yoga excercise on body weight, percent of body fat, waist circumference and waist to hip ratio (WHR) in overweight women.Method: This research applied quasi experiment design by using pre-post test with control group design. The subjects of research were 31 women aged 19-25 years old and divided into 2 groups, treatment group and control group. Treatment group was prepared to do yoga in 60 minutes for 10 times during 20 days and given nutrition education, whereas control group was given nutrition education only. Data body weight and percentage of body fat were measured by bioimpedance analysis; waist circumference and WHR were measured by tape measures; food intake were assessed by food recall and food frequency questionnaire. Data were analyzed using paired t-test and independent t-test.Results: There was a significant difference of body weight before and after intervention in both groups. The body weight on treatment group decreased by 0.81 ± 1.29 kg (p<0.05), while the body weight on the control group increased. Percentage of body fat and waist circumference decreased on both of groups, however treatment group decreased more than the control group. WHR no significant on both of groups. Yoga excercise resulted no significant influences on body weight, percentage of body fat, waist circumference and WHR in overweight women (p>0.05). Conclusion: Obesity women with 10 times yoga had no significant influences on body weight, percentage of body fat, waist circumference and WHR.


2012 ◽  
Vol 1 (1) ◽  
pp. 107-114 ◽  
Author(s):  
Putri Sukma Pertiwi ◽  
Hesti Murwani Rahayuningsih

Background: Prediabetes is a condition which pioneers of DM. Diet management is the effective method to decrease fasting blood glucose (FBG) level. One of plant that correlates decreasing FBG level is Aloe vera. The purpose of  the study was to prove the effects of Aloe vera on FBG level in prediabetes women. Method: This study was quasi experiment with pre test-post test design. The subjects were people in Tlogosari Kulon Semarang who taken by consecutive sampling. Total subjects were 26 people which was divided in 2 groups. The treatment group was given juice Aloe vera 150 gram per day during 14 days and control group was not given juice Aloe vera. FBG level was measured before and after intervention using spectrofotometri method. During intervention, both of group recorded food intake using food record and food recall. Data was analyzed by Independent sample t-test, Mann Whitney test, and Wilcoxon test. Result : The decreasing of FBG level in treatment group was 20.38±14.7 (18.92%) mg/dl and control group was 0.38±11.12 mg /dl. Statistic analysis showed that there was significant difference at decreasing of FBG level in treatment group and control group. Conclusion : There was significant decreasing FBG level 20.38 mg/dl after given juice Aloe vera 150 gram per day during 14 days.


Author(s):  
Hanisah Abdullah ◽  
Jeffrey Low Fook Lee

The purpose of this study was to examine the effects of analogy and explicit instructions on 50-m sprint performance and their running kinematics. Forty-five male Physical Education undergraduates participated in this study and were randomly divided into three groups, (i.e. analogy, explicit and control). Their sprint performances were assessed using wireless timing gate while the kinematic data was assessed by Kinovea software. The analogy group received three analogies which were “run tall”, “chin to pocket” and “claw the track” throughout the intervention sessions whereas the explicit group received “keep the body posture in an upright position and aligned, head and butt not tilting outward”, “arms should maintain a 90-degree angle at the elbow throughout the upswing as well as backswing” and “the foot landing should always be on the balls of the feet”. The control group did not receive any instruction throughout the intervention period. All participants were tested again after three weeks for the post test and retention test a week after. A 3 group x 3 tests mixed design ANOVA was used to analyze the sprinting performance whereas the kinematic data was analyzed by using one way MANOVA test. Results displayed that there was no significant difference in sprint performance among the groups. However, the post hoc test showed that the analogy group improved significantly in the post test. The kinematic data showed that both intervention groups were significantly better than the control group. This study concluded that both analogy and explicit instructions resulted in better running mechanics but only the analogy group elicited better in performance. Thus, analogy instructions are suggested to be an effective method to coach sprinters.


2018 ◽  
Vol 2 (1) ◽  
pp. 24-40
Author(s):  
Adi Wijayanto

Triglycerides are source of energy in the body, but triglyceride deposits that exceed the threshold will cause health problems, so triglycerides should be lowered to normal. The reduction of triglycerides can be done through physical activity, therefore this study aims to reveal the effect of regular swimming exercises and irregular exercises against triglyceride levels. This research is an experimental research using The Post Test Only Control Group Design design. Subjects of the study were male of Rattus Norvegicus Wistar, 39 subjects was divided into 3 groups with Matched Subject Design technique, which consisted of 2 groups of treatment that is regular and irregular group, and control group. The exercise program was given a swimming with a 3% weight of body weight and was tied 5 cm from the tip of the tail which was performed 3 times per week consistently for regular exercise and 0 to 5 times per week inconsistently for irregular exercise for 12 weeks, While the control group was not given training. In the last week before the blood was taken, the first three groups were given swimming treatment exercises. Based on the results of the anava test, there was a significant difference in the reduction of triglyceride levels among white mice who were given regular exercise with irregular exercise. These results suggest that regular exercise has a better impact on triglyceride reduction than irregular exercise, due to the higher adaptation process of regular exercise.


2018 ◽  
Vol 6 (2) ◽  
pp. 319
Author(s):  
Rommiyatun Zainiyah ◽  
Erti Ikhtiarini Dewi ◽  
Wantiyah Wantiyah

One of stressor in college students is taking a final project as a graduation requirement. The body'sresponse toward stress includes a rise of heart rate, diarrhea and insomnia. One of stressmanagement is affirmation relaxation (AR) technique. This research aimed to analyze the influenceof AR technique towards stress on students who take a final project in Faculty of Nursing, UniversityOf Jember. This research used a quasi experiment with Pretest-Post test approach and controlgroup design. Sampling technique that used is purposive sampling with respondent divided into twogroups, the treatment group and control group with 15 respondents for each group. Data wasanalyzed by using Dependent t test and Independent t test with 95% CI. The result showed thatthere was a significant difference stress before and after given AR technique within average 19,2 to10,87 (p = 0,001). Mean while, there was no significant difference of stress between pretest and posttest in control group within average 18,73 to 18,4 (p = 0,841). Overall, there was a difference ofstress between treatment group and control group (p =0,02, α = 0,05). The AR techniques reducestress because it can influence the sympathetic and parasympathetic nerves to produce endorphinehormone. The conclusion of this research is there was an influence of AR technique towards stresson students who Taking a Final Project in Faculty of Nursing University of Jember.Keywords: affirmation relaxation technique, stress, final project.


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