scholarly journals PENGARUH PEMBERIAN EKSTRAK ETANOL DAUN SAUROPUS ANDROGYNUS (L). MERR (KATUK) TERHADAP KADAR HORMON PROLAKTIN PADA TIKUS PUTIH (WISTAR ALBINO MENYUSUI)

2018 ◽  
Vol 12 (3) ◽  
pp. 202
Author(s):  
Sari Ida Miharti ◽  
Fadil Oenzil ◽  
Iskandar Syarif
Keyword(s):  
Hormone Level ◽  
Ethanol Extract ◽  
Control Group ◽  
Control Group Design ◽  
White Rats ◽  
Significant Difference ◽  
Post Test ◽  
Good Nutrition ◽  
Post Hoc ◽  
Prolactin Hormone

<p align="center"><strong>ABSTRACT</strong></p><p align="center"> </p><p>That katuk leaf (Sauropus androgynus (L). Merr) has good nutrition and is able to increase breastmilk production. The study of the effect of katuk leaf ethanol extract administration on prolactin hormone level in the breastfeeding white rats. The purpose of this study was to analyze the effect of katuk leaf ethanol extract administration on prolactin hormone level and oxytocin hormone level in the breastfeeding white rats.</p><p> </p><p>The type of the research is experimental with Post-Test Only Control Group design. The sample size consisted of 24 breastfeeding white rats which are divided into 4 groups, i.e. one control group and three treated groups (P1, P2 and P3), each given 24 mg, 48 mg and 72 mg katuk leaf ethanol extract. The research was conducted at Pharmacy Laboratory and Biomedical Laboratory of University of Andalas, Padang. The prolactin hormone levels are measured by using the ELISA method, the statistical test used One Way ANOVA test and continued with Multifer Comparisons (post hoc test) Bonferroni-type test.</p><p> </p><p>The results showed a significant difference  of the hormone prolactin levels between the control group (13,679 ± 2.061 ng/L) value (p &lt;0.05) and the P3 group (17.509 ± 2.515 ng/L), as well as P1 group (13.816 ± 1.665 ng/L) and P3 group (17.509 ± 2.515 ng/L) in 24 mg and 72 mg of dose.</p><p> </p><p>In conclusion, there was a significant increase in prolactin levels after the administration of katuk leaves extract (Sauropus androgynus (L). Merr) in white rats.</p><p> </p><p> </p><p><strong>Keywords: </strong>Katuk Leaf, Prolaktin,</p><p> </p><p> </p><p align="center"><strong>ABSTRAK</strong></p><p>Daun katuk (<em>Sauropus androgynus</em> (<em>L</em>) <em>Merr</em>) memiliki gizi yang baik dan dapat memperlancar air susu. Penelitian pengaruh pemberian ekstrak etanol daun katuk terhadap hormon prolaktin pada tikus putih. Tujuan Penelitian ini untuk menganalisis pengaruh pemberian ekstrak etanol daun katuk terhadap hormon prolaktin dan hormon oksitosin pada tikus putih meyusui.</p><p><strong>            </strong></p><p>Jenis penelitian ini adalah eksperimental dengan <em>desain Post-Tes Only Control Group</em>. Jumlah sampel 24 tikus menyusui yang dibagi menjadi 4 kelompok, yaitu kelompok kontrol dan 3 kelompok perlakukan P1, P2 dan P3 yang masing–masing diberi 24 mg, 48 mg dan 72 mg ekstrak etanol daun katuk. Penelitian dilakukan di Labor Farmasi dan Biomedik Universitas Andalas. Hormon prolaktin diukur dengan mengunakan metode ELISA uji statistik mengunakan uji <em>One Way </em>ANOVA dan dilanjutkan dengan uji <em>Multiple Comparisons</em> (<em>post hoc test</em>) jenis <em>Bonferroni</em>.</p><p> </p><p>Hasil penelitian ini menunjukakan terdapat perbedaan kadar hormon prolaktin antara kelompok kontrol (13,679±2,061ng/L) nilai (p&lt;0,05) dengan kelompok P3 (17,509±2,515 ng/L) dan kelompok P1(13,816±1,665 ng/L) dengan kelompok P3 (17,509±2,515 ng/L) dengan dosis 24 mg dan 72 mg.</p><p>            Kesimpulan, terdapat peningkatan signifikan pada kadar hormon prolaktin setelah pemberian ekstrak etanol daun katuk (<em>Sauropus androgynus</em> (<em>L</em>) <em>Merr</em>) pada tikus putih menyusui</p><p> </p><p> </p><p> </p><p> </p><p><strong>Kata kunci     : </strong>Daun Katuk, Prolaktin,</p>

scholarly journals The In Vitro Anti-Diabetic Activity of Lime Peels (Citrus amblycarpa (Hassk.) Ochse)

2020 ◽  
Vol 13 (01) ◽  
pp. 26-33
Author(s):  
Gempita Cahya aulia tambunan ◽  
Aparna Dutt ◽  
Sayra Nadhifa ◽  
Firdha Amelia ◽  
Ermi Girsang
Keyword(s):  
Control Group ◽  
Control Group Design ◽  
Phytochemical Content ◽  
Ic50 Value ◽  
Significant Difference ◽  
Post Test ◽  
Lime Peel ◽  
Post Hoc ◽  
One Way Anova

There are various potential natural anti-diabetic drugs; one of them is lime peel or Citrus amblycarpa. This study was aimed to explore the anti-diabetic activity and phytochemical content of lime peels. This study was an experimental study that used the post-test only control group design. The lime peels that were collected from the Berastagi fruit market in Medan, North Sumatera were extracted using 70% ethanol by maceration methods. The phytochemical screening identified the presence of phenolic, steroid/triterpenoid, terpenoid, saponin, flavonoid, tannin, and alkaloid. Meanwhile, the anti-diabetic activity of lime peels was evaluate using the α-glucosidase enzyme that was gotten from Saccharomyces cerevisiae by α-glucosidase enzyme inhibition methods. Percent of inhibition was express as Mean ± SD and analyzed by One Way ANOVA, Tukey HSD Post Hoc Test, and followed by linear regression. The result of this study showed that there is a significant difference in percentage inhibition α-glucosidase enzyme in each concentration, and it had an IC50 Value amount of 125.93 ± 9.14 µg/mL. The phytochemical content of the lime peels was flavonoid, phenol, steroid/triterpenoid, and alkaloid. Hence, the lime peel has anti-diabetic activity by inhibition of the α-glucosidase enzyme.

scholarly journals SHORT-TERM TOXICITY TEST OF SINGALAWANG EXTRACT ON MALE WHITE RATS KIDNEY NECROSIS

2017 ◽  
Vol 52 (1) ◽  
pp. 62
Author(s):  
Ardy Hamonangan Naibaho ◽  
Arifa Mustika ◽  
Anny Setijo Rahaju
Keyword(s):  
Treatment Group ◽  
Ethanol Extract ◽  
Simple Random Sampling ◽  
Control Group ◽  
Control Group Design ◽  
White Rats ◽  
Post Test ◽  
Experimental Laboratory ◽  
Group 2 ◽  
High Doses

Singawalang leaf is used as a traditional medicine by the communities suffering from pneumonia due to TB disease. However, experiments to explain it’s toxicity are few. Therefore, this study was conducted to disclose it’s toxicity. This was an experimental laboratory study using post–test only control group design. The sampling method was simple random sampling. The animals were randomly divided into 4 (four) groups, each group consisted of 8 (eight) mice, the control group (P0) received distilled water as a solvent material. Treatment group 1 (P1) obtained ethanol extract of singawalang (Petiveria alliaceae) in low doses of 90 mg/kgbw. Treatment group 2 (P2) obtained ethanol extract of singawalang (Petiveria alliaceae) in medium doses of 180 mg/kgbw. Treatment group 3 (P3) obtained ethanol extract of singawalang (Petiveria alliaceae) in high doses of 360 mg/kgbw. Th extracts were given with sonde once a day for 30 days. Results showed that the leaf ethanol extract singawalang (Petiveria alliaceae) does not induce sub-acute necrosis effects on kidney of male white mice (Mus musculus) in doses 90 mg/kgbw, 180 mg/kgbw, and 360 mg/kgbw.

scholarly journals The Comparison Effect Of Energy Drinks And Coffee On Creatinin Level In Rats

2019 ◽  
Vol 3 (4) ◽  
pp. 231 ◽  
Author(s):  
Mohamad Riza ◽  
Andina Putri A
Keyword(s):  
Creatinine Level ◽  
Energy Drinks ◽  
Laboratory Research ◽  
Control Group ◽  
Sprague Dawley ◽  
Control Group Design ◽  
Significant Difference ◽  
Post Test ◽  
Experimental Laboratory ◽  
Post Hoc

Objective: to compare the effect of administration of energy drinks and coffee on creatinine levels in rats.Methods: an experimental laboratory research using the post test only control group design. The study used 18 male white Sprague Dawley divided into three groups to receive one of the following treatments: 2 cc distilled water,0.072 g /2cc energy drinks and 0.9 g/cc of coffee for 14 days. The creatinine level was evaluated. Data were analyzed by One Way ANOVA test.Results: The mean creatinine level in the aquades group, energy drinks, coffee group was 0.708 mg/dl, 2.05 mg/dl 1.861 mg/dl, respectively. Post Hoc test the LSD test showed a significant difference among these groups (p <0.05).Conclusion: There was a significant different effect between 0.072 g / 2cc energy drinks and 0.9 g/cc coffee on creatinine levels in rat.International Journal of Human and Health Sciences Vol. 03 No. 04 October’19 Page : 231-234

scholarly journals Efektifitas Debridemen Mekanik Pada Luka Bakar Derajat III Terhadap Kecepatan Penyembuhan Luka

JKEP ◽  
2019 ◽  
Vol 4 (2) ◽  
pp. 93-103
Author(s):  
Nurma Afiani ◽  
Sanarto Santoso ◽  
Tina Handayani N ◽  
M. Fendi Nur Yahya
Keyword(s):  
Simple Random Sampling ◽  
Control Group ◽  
Control Group Design ◽  
Degree Burn ◽  
Significant Difference ◽  
Post Test ◽  
Long Time ◽  
The One ◽  
Post Hoc ◽  
One Way Anova

Third degree burn is a special wound cause consist of eschar for a long time. Kept eschar in third degree burn will delay healing procces. That is why eschar should be disapper by debridement process. Mechanical debridement used in this research. The aim of this research is to know the differences between mechanical debridement 24 hour and 48 hour in healing acceleration. This research is a true experimental by using  post test only control group design. The samples was selected by simple random sampling and was divided into three groups, each group consist of six rats, they are 24 hour group, 48 hour group and control group. The data was analyzed by one-way ANOVA then followed by Post Hoc LSD. The one way ANOVA result  p = 0,018 (p < 0,05) so there was a significant difference between control group and experimental groups. But the Post Hoc LSD results p = 0,123 ( p > 0,05)  so there was no significant difference between 24 hour group and 48 hour group in healing acceleration. For further researchers, it is suggested to use microscopic technique to know the effect of mechanical debridement in healing acceleration.

scholarly journals PHYLLANTHUS NIRURI L TERHADAP IMUNITAS SELULER TIKUS

2016 ◽  
Vol 18 (1) ◽  
pp. 35
Author(s):  
Ima Arum L ◽  
Purwanto AP ◽  
Henna Rya
Keyword(s):  
Typhoid Fever ◽  
Cellular Immunity ◽  
Control Group ◽  
Phyllanthus Niruri ◽  
Control Group Design ◽  
Treatment Groups ◽  
Significant Difference ◽  
Post Test ◽  
The Difference ◽  
Post Hoc

Typhoid fever is a problem in the developing country. Phyllanthus niruri L (meniran) is a traditional plant that can be used as an immunomodulator on cellular or humeral immunity. By giving Phyllanthus niruri L extract to patient who suffers typhoid fever can increase cellular immunity responses in intracellular bacteria infection (S.typhimurium).This research was an experimental study using the post test-only control group design to proof of the effects of Phyllanthus niruri L on cellular immunity balb/c infected by salmonella typhimurium. The samples were taken from thirty male Balb/c mice which were divided into five groups including P1 (infected by S.typhimurium and PnL extract 125 g), P2 (infected by S.typhimurium and PnL extract 250 g), P3 (infected by S.typhimurium and PnL extract 500 g), K1 (infected by S.typhimurium) and K2 (healthy mice). In this study was applied parametric test of one way ANOVA and post hoc test Bonfferoni. It was known that phyllanthus niruri L increased the number of activated lymphocytes and phagocyte ability of macrophage (p=0.003 and p=0.001, respectively). By Bonfferoni post hoc test resulted that no significantly difference between the treated groups (increased of dose). There were no significant difference between the number of leukocyte, the difference count of lymphocyte and the nitrite oxide produced among the treatment groups and controls. Phyllanthus niruri L dose 250 μg increased the activated lymphocyte and index phagocytes. To find out the effects of Phyllanthus niruri L compare to antibiotic and Phyllanthus niruri L combination, continuing/advancing studies are needed

scholarly journals COMPARISON OF LEAVES AND BARK MANGKOKAN (Nothopanax scutellarium) EXTRACTS AGAINST THE DEATH OF HOUSE FLIES (Musca domestica)

2020 ◽  
Vol 2 (2) ◽  
pp. 68-75
Author(s):  
Darmadi ◽  
Harni Sepriyani
Keyword(s):  
Musca Domestica ◽  
Methanol Extract ◽  
Ethanol Extract ◽  
Stem Bark ◽  
Control Group ◽  
P Value ◽  
Control Group Design ◽  
House Flies ◽  
Significant Difference ◽  
Post Test

Flies (Musca domestica) are vectors of disease that can transmit to humans. Generally, these flies controlled by using chemical insecticides. Excessive use of insecticide causes resistance and environmental pollution. The alternative way in fly control is to use natural ingredients from the extract of mangkokan stem bark and leaves (Nothopanax scutellaria). This study aims to determine the ratio of fly mortality after administration of ethanol extract of bark and methanol extract of mangkokan leaves (N. scutellarium). The method used in this study is a post-test only control group design. The average mortality rate of house flies using ethanol extract of mangkokan stem bark (N. scutellarium) was 5 for 55 minutes while methanol extract of mangkokan leaves (N. scutellarium) was 5 for 135 minutes with a p-value of 0.374 (p>0.05). It concludes that there is no significant difference in fly mortality with the ethanol extract of stem bark and methanol extract of mangkokan leaves (N. scutellarium). Result of this study shows that the ethanol extract of stem bark and mangkokan leaf extract (N. scutellarium) are equally potential natural insecticides.

PERBANDINGAN KEMAMPUAN KOMUNIKASI MATEMATIS SISWA YANG MENGGUNAKAN METODE SILIH TANYA BERBANTUAN KARTU MODEL DAN METODE MAKE A MATCH

2020 ◽  
Vol 2 (1) ◽  
pp. 32
Author(s):  
Ahmad Farham Majid ◽  
Ismail Ismail ◽  
Mardhiah Mardhiah ◽  
Fitriani Nur
Keyword(s):  
Total Sample ◽  
Control Group ◽  
Match Method ◽  
Mathematical Communication ◽  
Control Group Design ◽  
Purposive Sampling ◽  
Group Design ◽  
Significant Difference ◽  
Post Test ◽  
Quasi Experimental

AbstrakPenelitian ini bertujuan untuk mengetahui kemampuan komunikasi matematis siswa yang menggunakan metode silih tanya berbantuan kartu model dan metode make a match. Jenis penelitian ini adalah quasi eksperimen dengan desain penelitian non equivalent pretest-posttest control group design. Populasi dalam penelitian ini adalah seluruh siswa kelas VII SMPN 4 Sungguminasa Kab. Gowa berjumlah 351 siswa dan total sampel berjumlah 64 siswa dengan teknik pengambilan sampel purposive sampling. Instrumen yang digunakan dalam penelitian ini adalah tes yang terdiri dari pretest dan posttest dan non tes berupa lembar observasi. Berdasarkan hasil analisis data nilai siswa menggunakan statistik deskriptif rata-rata nilai kemampuan komunikasi matematis siswa yang diajar menggunakan metode silih tanya berbantuan kartu model adalah 86,84 dengan kategori sedang dan yang diajar menggunakan metode make a match adalah 77,78 dengan kategori sedang. Berdasarkan analisis statistik inferensial bahwa terdapat perbedaan yang signifikan antara kemampuan komunikasi matematis siswa yang menggunakan metode silih tanya berbantuan kartu model dengan yang menggunakan metode make a match pada kelas VII SMPN 4 Sungguminasa Kab. Gowa. AbstractThis study aims to determine the mathematical communication ability of students who use card-assisted questions method and make a match method. This type of research is a quasi-experimental research with nonequivalent pretest-posttest control group design. The population in this study were all VII grade students of SMPN 4 Sungguminasa, Gowa Regency with 351 students and a total sample of 64 students with purposive sampling techniques. The instrument used in this study was a test consisting of pre-test and post-test and non-test that is observation sheet. Based on the data analysis results that average the value of students’ mathematical communication skills who were taught using the card-assisted questions was 86.84 in the medium category and those who taught using make a match method were 77.78 in the medium category. The results of inferential statistical analysis that there is a significant difference between the mathematical communication abilities of students who use card-assisted questions and using the make a match method in class VII of SMPN 4 Sungguminasa, Gowa Regency.

The effect of patience training on university students’ patience and life satisfaction levels

2021 ◽  
Vol 9 (3) ◽  
pp. 712-719
Author(s):  
Ayşe Eliüşük Bülbül ◽  
Keyword(s):  
Life Satisfaction ◽  
University Students ◽  
Wilcoxon Test ◽  
Control Group ◽  
Control Group Design ◽  
Satisfaction Scale ◽  
Significant Difference ◽  
Post Test ◽  
And Control ◽  
Experimental Group

The purpose of this study is to determine the effect of the "patience training program" on the patience and life satisfaction levels of university students. The study was organized as a pre-test, post-test experiment and control group design. For a total of 30 students from which were 17 in the control group and 17 in the experimental group, patience training was given for 5 weeks. The "Patient Scale" developed by Schnitker (2010) and adapted to Turkish by Eliüşük and Arslan (2016) and the "Life Satisfaction Scale" developed by Diener, Emmons, Larsen and Griffin (1985) and adapted to Turkish by Dağlı and Baysal (2016) were used as a data collection tool in the study. The "Wilcoxon" test was used for the comparison of in-group differences in the analysis of obtained data and the "Mann-Whitney U" test was used in examining the differences between the two groups. As a result of the study, it was observed that the patience and life satisfaction average scores of students in the experimental group receiving "patience training" increased significantly, while there was no significant difference in the patience and life satisfaction averages scores of the control group students.

scholarly journals USING SOCIOGRAM TO IMPROVE THE WRITING AND SPEAKING ACHIEVEMENTS OF THE EIGHT GRADE STUDENTS OF SMPN 1 JARAI

2019 ◽  
Vol 2 (2) ◽  
pp. 269
Author(s):  
Yoga Pratama
Keyword(s):  
Eighth Grade ◽  
Control Group ◽  
Control Groups ◽  
Control Group Design ◽  
Significant Difference ◽  
Eighth Grade Students ◽  
Post Test ◽  
And Control ◽  
Experimental Group ◽  
Test Control

The objectives of this study were to find out whether or not there was significant improvement in writing and speaking achievements of the eighth grade students of SMPN1 Jarai after they were taught by using Sociogram, to find out whether or not there was significant improvement in each aspect of writing and speaking achievements of the eighth grade students of SMPN1 Jarai after they were taught by using Sociogram, to find out whether or not there was significant difference in writing and speaking achievements between the eighth grade students of SMP 1 Jarai who were taught by using Sociogram and those who were not, and to find out the perception of the eighth grade students of SMPN 1 Jarai after they were taught by using Socoiogram. In this paper, an experimental research method with pre and post test control group design was used with 70 students as the sample divided into two groups, experimental and control group. However, only the students of the experimental group were taught by using Sociogram. The obtained data were analyzed by using t-test. The students were given questionnaire to know their perceptions. The result showed that there was a significant difference in both students? writing and speaking achievements after they were tought by using Sociogram. Furthermore, it was found that there was a significant difference in students? writing and speaking achievement between the experimental and control groups. In conclusion, Sociogram improves the students? writing and speaking achievements.

scholarly journals PENGARUH GELATIN IKAN PATIN (PANGASIUS DJAMBAL) TERHADAP JUMLAH FIBROBLAS PADA LUKA PASCA PENCABUTAN GIGI TIKUS PUTIH (RATTUS NORVEGICUS)

2019 ◽  
Vol 6 (1) ◽  
pp. 1
Author(s):  
Fredy Mardiyantoro ◽  
Fidya Fidya ◽  
Dena Savira Andriani
Keyword(s):  
Rattus Norvegicus ◽  
Tooth Extraction ◽  
Control Group ◽  
Fish Gelatin ◽  
Tukey Test ◽  
White Rats ◽  
Significant Difference ◽  
Post Hoc ◽  
Hematoxylin Eosin ◽  
Test Result

Background: Gelatin has been used as a hemostatic agent to stop bleeding and it can be absorbed by human body within 6 hours. The patin fish (Pangasius djambal) gelatin has a high amount of amino acid, especially glutamine which has an important role in increasing the proliferation of fibroblast in wounds. The purpose of this study was to determine the effect of patin fish gelatin to the number of fibroblast in wound after tooth extraction.Method: Rat’s tooth extraction is done on the lower left incisive tooth. Thirty white rats were divided into two groups randomly with 3 time series. Control group was the rats without given of patin fish gelatin and treatment group was the rats given 1cc of patin fish gelatin with pipette. Socket taken for histologically processed by Hematoxylin Eosin staining.Result: It showed there were significant differences in the number of fibroblasts between groups. The Post Hoc Tukey test result showed there was a significant difference between the control group and the treatment group.Conclusion: Patin fish gelatin has effect increasing the number of fibroblast inwound after white rat’s (Rattus norvegicus) tooth extraction

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