scholarly journals Evaluasi Pengendalian Schistosomiasis oleh Lintas Sektor Tahun 2018

2019 ◽  
Vol 47 (4) ◽  
Author(s):  
Hayani Anastasia ◽  
Junus Widjaja ◽  
Anis Nurwidayati
Keyword(s):  
Schistosoma Japonicum ◽  
Interactive Media ◽  
Control Program ◽  
Cross Sectional Study ◽  
Oncomelania Hupensis ◽  
Cross Sectional ◽  
Schistosomiasis Control ◽  
Control Programs ◽  
Significant Difference ◽  
Central Sulawesi

Abstract In Indonesia, schistosomiasis is caused by Schistosoma japonicum with Oncomelania hupensis lindoensis as the intermediate host. Schistosomiasis can infect humans and all species of mammals. In order to achieve schistosomiasis elimination by 2020, schistosomiasis control including environmental management, has been carried out by multi-sectors. A cross-sectional study was conducted in 2018 to evaluate multi-sectoral schistosomiasis control programs. Data were collected by in-depth interviews with stakeholders, stool survey, snail survey, field observation, and document reviews. About 53.6% of control programs targeted in the schistosomiasis control roadmap were not achieved. Moreover, there was no significant difference between the number of foci area prior to the control programs and that of after the control programs completed in 2018. In addition, the prevalence of schistosomiasis in the humans was 0-5.1% and in mammals was in the range of 0 to 10%. In order to overcome the problems, establishment of a policy concerning schistosomiasis as a priority program beyond the Ministry of Health is needed. Innovative health promotion with interactive media is also needed to be applied. Nonetheless, the schistosomiasis work teams need to be more active to collaborate with other sectors and the Agency of Regional Development of Central Sulawesi Province as the leading sector. Keywords: schistosomiasis, control program, multi-sector, evaluation Abstrak Schistosomiasis di Indonesia disebabkan oleh cacing trematoda jenis Schistosoma japonicum dengan hospes perantara keong Oncomelania hupensis lindoensis. Schistosomiasis selain menginfeksi manusia, juga menginfeksi semua jenis mamalia. Untuk mencapai eliminasi schistosomiasis pada tahun 2020 dilakukan pengendalian schistosomiasis oleh lintas sektor termasuk di dalamnya pelaksanaan manajemen lingkungan. Upaya pencapaian eliminasi schistosomiasis dilakukan terutama dengan manajemen lingkungan yang direncanakan bersama oleh lintas sektor. Penelitian cross sectional dilakukan untuk mengevaluasi pelaksanaan program pengendalian schistosomiasis oleh lintas sektor dan implementasi pengendalian schistosomiasis terpadu untuk eliminasi schistosomiasis. Pengumpulan data dilakukan dengan wawancara mendalam stakeholder, review dokumen, survei keong, observasi lapangan, dan survei tinja. Hasil penelitian menunjukkan 53,6% kegiatan yang direncanakan dalam roadmap tidak terlaksana tahun 2018. Perbandingan jumlah fokus yang ditemukan pada akhir tahun 2018 tidak jauh berbeda dengan sebelum kegiatan pengendalian. Prevalensi schistosomiasis pada manusia tahun 2018 berkisar 0-5,1%. Prevalensi schistosomiasis pada hewan berkisar 0-10%. Untuk mengatasi permasalahan yang dihadapi perlu adanya rekomendasi kebijakan schistosomiasis sebagai kegiatan prioritas di kementerian di luar kesehatan sehingga memungkinkan perencanaan kegiatan yang lebih terarah oleh lintas sektor. Selain itu perlu dilakukan promosi kesehatan yang lebih inovatif dengan menggunakan media yang lebih menarik dan interaktif. Peranan aktif kelompok kerja tim pengendalian schistosomiasis perlu ditingkatkan dengan Bappeda sebagai leading sector. Kata kunci: schistosomiasis, pengendalian, lintas sektor, evaluasi

scholarly journals Rencana Aksi Lintas Sektor dan Peran Serta Masyarakat dalam Pengendalian Fokus Keong Perantara Schistosomiasis di Dataran Tinggi Napu Kabupaten Poso Sulawesi Tengah

2019 ◽  
Vol 13 (2) ◽  
pp. 125-132
Author(s):  
Junus Widjaja ◽  
Hayani Anastasia
Keyword(s):  
Paddy Field ◽  
Action Plan ◽  
Animal Health ◽  
Control Program ◽  
Public Works ◽  
Oncomelania Hupensis ◽  
Schistosomiasis Control ◽  
Water Catchment ◽  
Central Sulawesi ◽  
Regional Institute

Abstract Schistosomiasis in Indonesia is endemic only in Napu and Bada highlands in Poso District and Lindu highlands in Sigi District, Central Sulawesi. Schistosomiasis control program has been done since 1982; however, it is not successful yet. The objective of this study was to re-identify the active focus area of O.h. lindoensis and the schistosomiasis control program by multi-sector and community. This study mapped the foci area and designed an action plan for schistosomiasis control by multi-sector in provincial level, Poso District, and Sigi District. The sectors involved are Agency for Regional Development, Regional Institute of Research and Development, Health Services, Agriculture Office, Plantation, and Animal Health Office, Maritime and Fisheries Office, Public Works Office, and Village Empowerment Office. The foci area of O.h. lindoensis were distributed in 16 villages in Napu, with a total of 242 foci area. The schistosomiasis control program by multi-sectors was making water catchment, making new paddy field, irrigation, molluscicide, cleaning foci area, draining, re-use of abandoned paddy field and plantation. There is a need for a regulation about budgeting and environmental management in sub-district and village level to support community participation in cleaning foci area, mass drug treatment, and stool survey. Abstrak Schistosomiasis di Indonesia hanya ditemukan di Dataran Tinggi Napu dan Dataran Tinggi Bada, Kabupaten Poso serta Dataran Tinggi Lindu, Kabupaten Sigi, Sulawesi Tengah. Sejak tahun 1982 telah dilakukan upaya pemberantasan tetapi sampai saat ini belum berhasil. Tujuan penulisan adalah mengidentifikasi kembali fokus keong perantara schistosomiasis yang masih aktif dan menyusun rencana aksi  lintas sektor serta peran serta masyarakat dalam penanganan fokus keong. Kegiatan meliputi pemetaan kembali dan melakukan pertemuan menyusun rencana aksi pengendalian schistosomiasis dengan lintas sektor terkait di tingkat Provinsi Sulawesi Tengah, Kabupaten Poso dan Kab. Sigi. Organisasi Perangkat Daerah (OPD) yang terlibat antara lain Badan Perencanaan Pembangunan Daerah (Bappeda), Badan Penelitian dan Pengembangan Daerah (Balitbangda), Dinas Kesehatan, Dinas Pertanian, Perkebunan dan Kesehatan Hewan, Dinas Kelautan dan Perikanan, Dinas Pekerjaan Umum dan Dinas Pemberdayaan Masyarakat Desa (PMD). Fokus keong Oncomelania hupensis lindoensis tersebar pada 16 desa di Dataran Tinggi Napu. Jumlah fokus keong O. hupensis lindoensis 242 fokus. Rencana aksi lintas sektor dengan pembuatan bak penangkap air, pencetakan sawah, pembuatan saluran air permanen dan penyemprotan moluskisida sedangkan peran serta masyarakat berupa pembersihan, pengeringan, pengaktifan sawah dan kebun. Perlu ada regulasi pembiayaan untuk pengembangan manajeman lingkungan dan regulasi di tingkat kecamatan atau desa untuk peningkatan peran serta masyarakat dalam pelaksanaan pembersihan fokus keong, pengobatan massal dan survei tinja.  

scholarly journals PHARMACISTS' PERCEPTION ABOUT THEIR ROLES IN TUBERCULOSIS CONTROL PROGRAM IN MEDAN, INDONESIA

2017 ◽  
Vol 10 (4) ◽  
pp. 256
Author(s):  
Khairunnisa B ◽  
Azizah Nasution
Keyword(s):  
Control Program ◽  
Cross Sectional Study ◽  
P Value ◽  
Chi Square ◽  
Cross Sectional ◽  
Tb Control ◽  
Control Programs ◽  
Validated Questionnaire ◽  
Directly Observed Treatment ◽  
Tb Control Program

Objectives: to assess the pharmacists' perception about their roles in tuberculosis (TB) control program in Medan, Indonesia. Methods: A cross-sectional study was conducted to assess the pharmacists' perception about their roles in TB control program in Medan, Indonesia using a validated questionnaire. The pharmacists involved in this study (n=117) were asked to choose answering yes, no or do not know for their perception on their roles in TB control program. The collected data consisted of demographics (gender, age, place of practice, and working experience) and the pharmacists’ perception on their roles in TB control program were organized and analyzed by applying descriptive and Chi-square analyses using Statistical Package for the Social Sciences (SPSS, version 19, Chicago, IL, USA) (p value <0.05 was considered significant). Results: Mean age of the participants was 38.6 (standard deviation=11.7) years. Most of them (76.1%) were female. Distribution of the participants by place of practice:  pharmacy, 78.6%; hospital, 20.5%. Most of them (63.2%) have heard about directly observed treatment short-course (DOTS) program. More than 90% of them realized that they could play their roles as providers, managers of anti-TB drugs, drug informans, ensurers for adherence to the TB treatment, educators for patients and publics on TB and its treatment. Only 26.5% of them knew that they could also play their role as inventors of early suspected TB in the community.Conclusion: The study proved that the pharmacists’ roles could be utilized and enhanced to optimize TB control programs in Indonesia.Keywords: Pharmacists’ role, Tuberculosis, DOTS Program

scholarly journals Cross-Sectoral Engagement in the Eradication of Schistosomiasis in Indonesia

2021 ◽  
Vol 13 (10) ◽  
pp. 82
Author(s):  
Gunawan Gunawan ◽  
Junus Widjaja ◽  
Phetisya Pamela Frederika Sumolang ◽  
Hayani Anastasia
Keyword(s):  
Local Governments ◽  
National Level ◽  
National Development ◽  
Control Program ◽  
Development Planning ◽  
Behavioral Changes ◽  
Schistosomiasis Control ◽  
Control Programs ◽  
Planning Agency ◽  
Central Sulawesi

BACKGROUND: Indonesia has planned a roadmap to eradicate schistosomiasis and achieved the elimination of schistosomiasis by 2025. Through cooperation between the Ministry of Health and the Ministry of National Development Planning or the National Development Planning Agency (Bappenas). The roadmap is a reference to plan the shared action multiple sectors, central-regional and communal coordinated by the National Development Planning Agency (Bappenas) and Development Planning Agency at Sub-national Level (Bappeda). OBJECTIVE: analyzing cross-sectoral involvement in 2019 in efforts to eradicate schistosomiasis. The research method is to analyze data and information regarding the schistosomiasis control program in 2019. MATERIAL AND METHODS: The data and information in the study came from six Regional Apparatus Organizations (OPD) in Poso and seven OPDs in Sigi Central Sulawesi. RESULT: This study reveals that, based on the roadmap to eradicate schistosomiasis, mass treatment regarding schistosomiasis for humans is 70-94%; mass medication for livestock is 50%; surveillance on intermediate snails, humans, and animals is 70-94%; 6,000 animals and 49%; the campaigns for behavioral changes and an increase in community participation in 18 villages and multi-sector coordination and intensive integrated supervision is 50%. Meanwhile, public toilets in the focus areas and livestock management have not proceeded. The prevalence of schistosomiasis in humans showed yields of 0.13%, 0%, and 0.0% in the Napu, Bada, and Lindu Plateaus. In addition, the prevalence of schistosomiasis in animals was 3.4% and 2.3% in buffalo and horses. CONCLUSION: Schistosomiasis control in terms of health can reduce the prevalence of schistosomiasis in humans. And schistosomiasis control is not a priority program in terms of agriculture. Who did not build schistosomiasis control programs in 2019 upon good coordination between the central and local governments?

scholarly journals Fluktuasi Schistosomiasis di Daerah Endemis Provinsi Sulawesi Tengah Tahun 2011-2018

2019 ◽  
Vol 47 (3) ◽  
pp. 199-206
Author(s):  
Anis Nurwidayati ◽  
Phetisya Pamela Frederika ◽  
Mohammad Sudomo
Keyword(s):  
Public Health ◽  
At Risk ◽  
Intermediate Host ◽  
Schistosoma Japonicum ◽  
Infection Rate ◽  
Secondary Data ◽  
Parasitic Diseases ◽  
Oncomelania Hupensis ◽  
Cross Sectional ◽  
Central Sulawesi

Schistosomiasis is one of the most important parasitic diseases in public health . Schistosomiasis infected 230 million people in 77 countries and 600 million people are at risk. Schistosomiasis in Indonesia is caused by a trematode (blood fluke) Schistosoma japonicum. The intermediate host is an amphibious snail, Oncomelania hupensis lindoensis. The disease occured only in Central Sulawesi, i.e in Napu and Bada Highlands, Poso District, and in Lindu Highland, Sigi District.Control activities have been implemented in the last 20 years . This paper aimed to describe the fluctuations of schistosomiasis infection rate among human in 2011-2018, snails, and rat in 2011-2017 in three endemic areas based on secondary data from the Central Sulawesi Provincial Health Office. The results showed that schistosomiasis infection rate among human fluctuated from year 2011-2018, as well as in snail and rat in 2011-2017, and there was a trend of increasing prevalence. The control efforts undertaken include surveying the feces of the population, detection of cercariae in snails and rat examination. It also carried out treatment of the population with praziquantel and eradication of the snail mechanically, chemically and biologically. Cross sectional activities to control schistosomiasis have also been conducted but still need to be strengthen to achieve schistosomiasis elimination in 2020. Keywords: Schistosomiasis, prevalence, Schistosoma japonicum, Indonesia Abstrak Schistosomiasis merupakan salah satu penyakit parasit terpenting dalam kesehatan masyarakat. Schistosomiasis telah menginfeksi 230 juta orang di 77 negara dan 600 juta orang berisiko terinfeksi. Schistosomiasis di Indonesia disebabkan oleh cacing trematoda jenis Schistosoma japonicum dengan hospes perantara keong Oncomelania hupensis lindoensis. Penyakit ini hanya ditemukan di Provinsi Sulawesi Tengah yaitu di Dataran Tinggi Napu dan Dataran Tinggi Bada, Kabupaten Poso serta Dataran Tinggi Lindu, Kabupaten Sigi. Berbagai upaya pengendalian sudah dilakukan selama lebih dari 20 tahun terakhir. Tulisan ini bertujuan untuk memaparkan fluktuasi kasus schistosomiasis pada manusia tahun 2011-2018, data schistosomiasis pada keong dan tikus tahun 2011-2017 di tiga daerah endemis tersebut dengan menganalisis data sekunder dari Dinas Kesehatan Provinsi Sulawesi Tengah. Hasil survei menunjukkan bahwa schistosomiasis masih berfluktuasi dari tahun 2011-2018 pada manusia, pada keong dan tikus tahun 2011-2017, serta terlihat adanya kecenderungan kenaikan prevalensi. Upaya pengendalian yang dilakukan meliputi survei tinja penduduk, deteksi serkaria pada keong dan pemeriksaan tikus. Selain itu juga dilakukan pengobatan penduduk dengan praziquantel dan pemberantasan keong secara mekanik, kimia dan biologi. Pengendalian terpadu oleh lintas sektor juga sudah dilaksanakan, akan tetapi masih perlu penguatan kembali peran lintas sektor untuk dapat mencapai target eliminasi schistosomiasis tahun 2020. Kata kunci: Schistosomiasis, prevalensi, Schistosoma japonicum

Personal Audio System: Hearing Symptoms, Habits, and Sound Pressure Levels Measured in Real Ear and a Manikin

2020 ◽  
Vol 63 (6) ◽  
pp. 2016-2026
Author(s):  
Tamara R. Almeida ◽  
Clayton H. Rocha ◽  
Camila M. Rabelo ◽  
Raquel F. Gomes ◽  
Ivone F. Neves-Lobo ◽  
...  
Keyword(s):  
Sound Pressure ◽  
Daily Basis ◽  
Cross Sectional Study ◽  
Normal Hearing ◽  
Chi Square ◽  
Cross Sectional ◽  
The Real ◽  
Significant Difference ◽  
Sound Pressure Levels ◽  
Audio System

Purpose The aims of this study were to characterize hearing symptoms, habits, and sound pressure levels (SPLs) of personal audio system (PAS) used by young adults; estimate the risk of developing hearing loss and assess whether instructions given to users led to behavioral changes; and propose recommendations for PAS users. Method A cross-sectional study was performed in 50 subjects with normal hearing. Procedures included questionnaire and measurement of PAS SPLs (real ear and manikin) through the users' own headphones and devices while they listened to four songs. After 1 year, 30 subjects answered questions about their usage habits. For the statistical analysis, one-way analysis of variance, Tukey's post hoc test, Lin and Spearman coefficients, the chi-square test, and logistic regression were used. Results Most subjects listened to music every day, usually in noisy environments. Sixty percent of the subjects reported hearing symptoms after using a PAS. Substantial variability in the equivalent music listening level (Leq) was noted ( M = 84.7 dBA; min = 65.1 dBA, max = 97.5 dBA). A significant difference was found only in the 4-kHz band when comparing the real-ear and manikin techniques. Based on the Leq, 38% of the individuals exceeded the maximum daily time allowance. Comparison of the subjects according to the maximum allowed daily exposure time revealed a higher number of hearing complaints from people with greater exposure. After 1 year, 43% of the subjects reduced their usage time, and 70% reduced the volume. A volume not exceeding 80% was recommended, and at this volume, the maximum usage time should be 160 min. Conclusions The habit of listening to music at high intensities on a daily basis seems to cause hearing symptoms, even in individuals with normal hearing. The real-ear and manikin techniques produced similar results. Providing instructions on this topic combined with measuring PAS SPLs may be an appropriate strategy for raising the awareness of people who are at risk. Supplemental Material https://doi.org/10.23641/asha.12431435

Estimation of Trace Elements in Gingival Crevicular Fluid and Serum-Comparative Study in Healthy and Periodontitis

2017 ◽  
Vol 9 (5) ◽  
Author(s):  
Bhagavathami Meenaksh ◽  
Chitraa R. Chandran ◽  
Aravindhan Thathchari Ranganathan ◽  
Kavindapadi Venkateswaran Rama ◽  
Valarmathy Srinivasan
Keyword(s):  
Trace Elements ◽  
Inductively Coupled Plasma ◽  
Gingival Crevicular Fluid ◽  
Serum Zinc ◽  
Cross Sectional Study ◽  
Serum Copper ◽  
Cross Sectional ◽  
Inductively Coupled ◽  
Significant Difference ◽  
Copper Zinc

Background: This study aims to determine and compare the levels of trace elements copper, zinc, selenium and chromium in GCF and serum of patients with periodontitis and healthy individuals. Methods: This cross sectional study includes 24 study subjects recruited from the patients reporting to the Department of Periodontics , Tagore Dental College Chennai. All the selected patients were subjected to a clinical examination done by a single examiner. The estimation of trace elements Copper, Zinc, Selenium and Chromium in GCF and serum is performed using Perkin Elmer optima 5300 Inductively Coupled Plasma Emission Spectrometer (ICPOES). Results: GCF and serum copper levels showed no significant difference in both periodontitis and healthy groups . Selenium levels tend to be the same in both groups. Serum zinc levels are more in periodontitis patients than healthy subjects (p less than 0.01). GCF chromium levels are found to be more in patients with periodontitis than healthy. Conclusions : More research is therefore needed to monitor the role of these trace elements C with an increased sample size to ascertain whether they are associated with a reduced risk of periodontitis.

Postpartum Depression and Its Associated Factors among Women in Bandar Abbas City

2018 ◽  
Vol 7 ◽  
Author(s):  
Arefeh Shahi
Keyword(s):  
Postpartum Depression ◽  
Associated Factors ◽  
Parental Education ◽  
Unwanted Pregnancy ◽  
Routine Care ◽  
Cross Sectional Study ◽  
Vulnerable Groups ◽  
Cross Sectional ◽  
Significant Difference ◽  
Bandar Abbas

Background: Postpartum depression with a different incidence of 40- 45% in different societies, which it has adverse effects on the health of mothers and their child, given the negative effects of maternal depression and its harmful effects on the baby and the quality of family life. So, this study was performed with the aim to determine postpartum depression and its associated factors in Bandar Abbas city. Materials and Methods: A descriptive cross-sectional study was conducted in 2015 after obtaining consent from mothers by the census. A total of 343 mothers was examined for depression who referred to Bandar Abbas health centers in the 2nd and 4th months after childbirth. The data collection tools included demographic information and Postpartum Depression Edinburgh questionnaires. Finally, the statistical analyses were performed using SPSS (version 22.0) software and data were analyzed using the Independent t-test, Mann Whitney, Chi-square, and Fisher exact tests.Result: Totally, 68 (19.8%) of samples were in the second month and 54 (15.7%) in the fourth month after delivery had postpartum depression. The incidence of depression in the four months was 6.6%. There was a significant difference between depression and income, parental education, father’s use of cigarette and abnormalities of the infant (P <0.001). There was no significant difference between other factors such as gestational age, infant sex, birth weight, unwanted pregnancy, and type of delivery. Conclusion: Regarding the prevalence of this disorder, it seems that postpartum depression screening planning should be considered during child routine care as an essential component, especially for vulnerable groups.

Assessment of COVID-19 Related Misinformation among the Community in Basrah, Iraq

2020 ◽  
Vol 2 (CSI) ◽  
pp. 12-18
Author(s):  
Ali Al-Rubaye ◽  
Dhurgham Abdulwahid ◽  
Aymen Albadran ◽  
Abbas Ejbary ◽  
Laith Alrubaiy
Keyword(s):  
Cross Sectional Study ◽  
Bachelor's Degree ◽  
Public Knowledge ◽  
Age Group ◽  
Cross Sectional ◽  
Educational Levels ◽  
The Public ◽  
First Case ◽  
Significant Difference ◽  
Central District

Background: There has been a rapid rise in cases of COVID-19 infection and its mortality rate since the first case reported in February 2020. This led to the rampant dissemination of misinformation and rumors about the disease among the public. Objectives: To investigate the scale of public misinformation about COVID-19 in Basrah, Iraq. Methods: A cross-sectional study based on a 22-item questionnaire to assess public knowledge and understanding of information related to the COVID-19 infection. Results: A total of 483 individuals completed the questionnaire. The most frequent age group was 26–35 years (28.2%); there were 280 (58%) males and 203 (42%) females. Of the participants, 282 (58.4%) were with an education level below the Bachelor’s degree, 342 (70.8%) were married, and 311 (64%) were living in districts in Basra other than the central district. Overall, 50.8% (11.8/ 22 * 100%) of individuals had the correct information regarding COVID-19. There was a significant association between the level of COVID-19 related misinformation and participants’ educational levels and occupation (p <0.05). However, there was no significant difference found across sex, age group, marital state, and area of residence. Conclusions: Misinformation related to COVID-19 is widely spread and has to be addressed in order to control the pandemic. Keywords: COVID-19, misinformation, knowledge, Iraq

Association of CYP2D6*10 (c. 100 C>T) Genotype with Z-END Concentration in Patients with Breast Cancer Receiving Tamoxifen Therapy in Indonesian Population

2019 ◽  
Vol 19 (8) ◽  
pp. 1198-1206 ◽  
Author(s):  
Yenny ◽  
Sonar S. Panigoro ◽  
Denni J. Purwanto ◽  
Adi Hidayat ◽  
Melva Louisa ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Steady State ◽  
Ultra Performance Liquid Chromatography ◽  
Cross Sectional Study ◽  
Threshold Concentration ◽  
Breast Cancer Patients ◽  
Cross Sectional ◽  
Significant Difference ◽  
Pcr Rflp ◽  
Liquid Chromatography Tandem Mass

Background: Tamoxifen (TAM) is a frequently used hormonal prodrug for patients with breast cancer that needs to be activated by cytochrome P450 2D6 (CYP2D6) into Zusammen-endoxifen (Z-END). Objective: The purpose of the study was to determine the association between CYP2D6*10 (c.100C>T) genotype and attainment of the plasma steady-state Z-END minimal threshold concentration (MTC) in Indonesian women with breast cancer. Methods: A cross-sectional study was performed in 125 ambulatory patients with breast cancer consuming TAM at 20 mg/day for at least 4 months. The frequency distribution of CYP2D6*10 (c.100C>T) genotypes (C/C: wild type; C/T: heterozygous mutant; T/T: homozygous mutant) was detected using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), the results of which were subsequently confirmed by sequencing. The genotypes were categorized into plasma Z- END concentrations of <5.9 ng/mL and ≥5.9 ng/mL, which were measured using ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS). Results: Percentages of C/C, CT, and T/T genotypes were 22.4%, 29.6%, and 48.8%, respectively. Median (25-75%) Z-END concentrations in C/C, C/T, and T/T genotypes were 9.58 (0.7-6.0), 9.86 (0.7-26.6), and 3.76 (0.9-26.6) ng/mL, respectively. Statistical analysis showed a significant difference in median Z-END concentration between patients with T/T genotype and those with C/C or C/T genotypes (p<0.001). There was a significant association between CYP2D6*10 (c.100C>T) genotypes and attainment of plasma steady-state Z-END MTC (p<0.001). Conclusion: There was a significant association between CYP2D6*10 (c.100C>T) and attainment of plasma steady-state Z-END MTC in Indonesian breast cancer patients receiving TAM at a dose of 20 mg/day.

Perfil Epidemiológico de Pacientes Renais Crônicos em Tratamento Conservador em um Hospital Escola do Sul de Minas/ Epidemiological Profile of Chronic Renal Failure Patients on Conservative Treatment in a Hospital in Southern School of Minas

1970 ◽  
Vol 4 (4) ◽  
pp. 49-60
Author(s):  
Camila Dorilêo Negretti ◽  
Pablo Girardeli Mendonça Mesquita ◽  
Nilo César do Vale Baracho
Keyword(s):  
Diabetes Mellitus ◽  
Conservative Treatment ◽  
Cross Sectional Study ◽  
Age Group ◽  
Sectional Study ◽  
Cross Sectional ◽  
Control Programs ◽  
Keywords Epidemiology ◽  
Epidemiological Profile ◽  
Grade Iii

Objetivo: Determinar o perfil epidemiológico dos pacientes com Doença Renal Crônica em tratamento conservador no ambulatório do Hospital Escola de Itajubá. Materiais e Métodos: Estudo descritivo, de corte transversal, de abordagem quantitativa. Realizado com 171 pacientes atendidos em tratamento conservador no ambulatório de nefrologia no período de janeiro de 2012 a dezembro de 2013. A coleta objetivou caracterizar idade, sexo, raça, estado civil e procedência. Também foram avaliados dados do primeiro atendimento como: valores de ureia e creatinina, o grau de DRC, a etiologia e o número de retorno. Resultados: Dos doentes renais crônicos avaliados, 50,3% eram do sexo masculino, 88% da raça branca, 54,4% casados e a maioria (70,8%) possuía faixa etária prevalente >60 anos. A maioria dos atendidos, 98,5% pertence a microrregião de referência. Quanto a dados de primeira consulta, o diabetes mellitus foi a principal etiologia (38%). Os valores de ureia e creatinina acima da referência preconizada foi observado na maioria dos pacientes e o grau III de DRC em 31% dos casos. O número médio de retornos após a primeira consulta foi de três retornos em 25,13% dos pacientes. Conclusão: A pesquisa permitiu o conhecimento do perfil epidemiológico dos portadores de DRC em tratamento conservador. Os achados reforçam a necessidade de implementação de políticas voltadas para promoção e prevenção à saúde com divulgação de mais programas de controle para minimizar o surgimento de novos casos da DRC. Palavras-chave: Epidemiologia. Doença Renal Crônica. Tratamento. ABSTRACT.Objective: Determine the epidemiological profile of patients with Chronic Kidney Disease (CKD) on conservative treatment at the Hospital Escola de Itajubá. Materials and Methods: A retrospective, descriptive, cross-sectional study of quantitative approach. It was conducted with 171 patients who were treated in conservative treatment at the nephrology clinic from January 2012 to December 2013. The collection aimed to characterize age, sex, race, marital status and origin. We also evaluated data from the first service as: urea and creatinine values, the degree of CKD the etiology and the number of return. Results: Among the chronic renal patients evaluated, 50.3% were male, 88% Caucasian, 54.4% were married and the majority (70.8%) was the most prevalent age group> 60 years. Most of the patients 98.5% belong to micro region of reference. As the first appointment data, diabetes mellitus was the major cause (38%). The urea and creatinine values above the recommended reference was observed in the majority of patients and the DRC grade III in 31% of cases. The average number of returns after the fisrt visit was three return in 25.13% of patients. Conclusion: The research gave us the knowledge of the epidemiological profile of patients with CKD on dialysis. The findings reinforce the need to implement policies for health promotion and prevention with more disclosure of control programs to minimize the appearance of new cases of CKD. Keywords: Epidemiology. Chronic Kidney Disease.Treatment.

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