scholarly journals Proporsi Vanillylmandelic Acid Urin pada Pasien Terduga Tumor Neuroendokrin: Hubungannya dengan Usia dan Jenis Kelamin

2020 ◽  
Vol 9 (1) ◽  
pp. 27-34
Author(s):  
Annada Sofia ◽  
Mohamad Sadikin ◽  
Sri Widia Jusman ◽  
Septelia Inawati Wanandi ◽  
Ani Retno Prijanti ◽  
...  
Keyword(s):  
Neuroendocrine Tumor ◽  
Neuroendocrine Tumors ◽  
Secondary Data ◽  
Spot Test ◽  
Vanillylmandelic Acid ◽  
Tumor Patients ◽  
Cross Sectional ◽  
Examination Result ◽  
Cross Sectional Design ◽  
And Gender

Abstract Cancer prevalence in Indonesia is 1.8 per 1000 population in 2018. Early diagnosis is needed to reduce the mortality rate and one of which is by examining vanillylmandelic acid (VMA) level as tumor markers. VMA is a catecholamine metabolite whose level will increase in several neuroendocrine tumors. This study was conducted to determine the proportion of positive VMA in urine of patients with suspected neuroendocrine tumors in Jakarta and its association with age and gender. This study was a cross-sectional design using secondary data of urinary VMA laboratory examination from 295 patients who suspected neuroendocrine tumors period 2010 to 2019 in Laboratory of Department of Biochemistry and Molecular Biology, Faculty of Medicine Universitas Indonesia. Qualitative examination of urinary VMA used spot test. Positive examination result showed levels of VMA in urine >8mg/24 hours, while negative result showed  8mg/24 hours. Inclusion criteria were subject data with a provisional diagnosis of neuroblastoma, pheochromocytoma, and paraganglioma. The proportion of positive VMA in urine of suspected neuroendocrine tumor patients was 14,2%. There was a significant association between VMA in urine with age (p 0,023), while gender was not significant (p 0,885). In conclusion, there was an association between urinary VMA of suspected neuroendocrine tumor patients with age, however no association with gender.   Keywords: neuroendocrine tumors; urinary vanillylmandelic acid; age; gender     Abstrak Prevalensi kanker di Indonesia pada 2018 adalah 1,8 per 1000 penduduk. Diagnosis dini dibutuhkan untuk mengurangi angka mortalitas, salah satunya melalui pemeriksaan penanda tumor berupa vanillylmandelic acid (VMA). VMA termasuk metabolit katekolamin yang meningkat produksinya pada beberapa tumor neuroendokrin. Penelitian dilakukan untuk mengetahui proporsi VMA positif dalam urin pasien dugaan tumor neuroendokrin di Jakarta serta hubungannya dengan usia dan jenis kelamin. Penelitian ini menggunakan desain cross-sectional yang menggunakan data sekunder hasil pemeriksaan laboratorium VMA urin dari 295 pasien dugaan tumor neuroendokrin periode 2010 hingga 2019 di Laboratorium Departemen Biokimia dan Biologi Molekuler, Fakultas Kedokteran Universitas Indonesia. Data VMA kualitatif yang diperoleh, diperiksa dengan metode spot test. Hasil positif menunjukkan kadarnya > 8 mg/24 jam, sedangkan hasil negatif menunjukkan kadarnya  8 mg/24 jam. Kriteria inklusi berupa diagnosis sementara neuroblastoma, pheochromocytoma, dan paraganglioma. Proporsi VMA positif dalam urin pasien dugaan tumor neuroendokrin adalah 14,2%. Terdapat hubungan bermakna antara kadar VMA dalam urin dengan usia (p 0,023), sedangkan dengan jenis kelamin menunjukkan hasil yang tidak bermakna (p 0,885). Dengan demikian dapat disimpukan bahwa terdapat hubungan antara VMA urin pasien dugaan tumor neuroendokrin dengan usia, namun tidak terdapat hubungan dengan jenis kelamin.   Kata kunci: tumor neuroendokrin; vanillylmandelic acid urin; usia; jenis kelamin  

FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN PERNIKAHAN DINI DI DUSUN I DESA BARU KEC PANCUR BATU DELI SERDANG SUMATERA UTARA TAHUN 2017

2019 ◽  
Vol 4 (1) ◽  
pp. 41-49
Author(s):  
Meriati Bunga Arta Purba
Keyword(s):  
Divorce Rate ◽  
Drop Out ◽  
Early Marriage ◽  
P Value ◽  
Cross Sectional ◽  
Birth Complication ◽  
Sexuality And Gender ◽  
Analytical Research ◽  
Cross Sectional Design ◽  
And Gender

Based on the research by the Sexuality and Gender Study Center of University of Indonesia, the rate of early marriage in Indonesia is the second highest in Southeast Asian in which 2 million out of 7.3 million women below 15 years old are married and drop out from school. Early marriage hinders them from going to school, causes pregnancy and birth complication, impedes the achievement of KB (Family Planning) Program and increases divorce rate. Goals : The objective of the research was to discover the correlation of value of virginity, knowledge and trust with early marriage at Dusun I Desa Baru. Methods: This is an observational analytical research with cross sectional design. It was done at Dusun I Desa Baru, Pancur Batu Subdistrict from November, 2017 until February, 2018. The population covered the teenagers below 20 years old which was all taken as the research samples i.e. 139 people. The dependent variable was early marriage, while the independent variables were parent income, trust, knowledge and value of virginity. The data were collected through questionnaires. Multiple logistic regression testing was employed to analyze the data. Result : The research results demonstrated that the variable with the most dominant influence was parent income at p-value = 0.006 (p<0.05) and Exp. β value = 3.675, followed by the variable of trust at p-value = 0.027 (p<0.05) and Exp. β value = 2.368, the variable of knowledge at p-value = 0.003 (p<0.05) and Exp. β value 6.064, and the variable of virginity at p-value = 0.003 (p<0.05) and Exp. Β value = 6.064. Based on these results, it was concluded that f(y) was 97%. It indicated that the probability of the variables of parent income, trust, knowledge and virginity influenced early marriage of 97.7%. Conclusion: It is recommended that the local government cooperate with local Puskesmas, Religious Figures, and Parents to conduct counseling to improve people’s knowledge of the ideal age to get married, so that they can prevent from possible problems due to early marriage and provide their children parent income at early age the importance of protecting their virginity until they get married.

scholarly journals CORRELATION BETWEEN SMOKE-FREE AREAS AND SMOKING BEHAVIOR IN INDONESIA

2020 ◽  
Vol 8 (2) ◽  
pp. 117
Author(s):  
Mohamad Anis Fahmi
Keyword(s):  
Public Awareness ◽  
Smoking Behavior ◽  
Secondary Data ◽  
Computer Application ◽  
P Value ◽  
Cross Sectional ◽  
Positive Correlation ◽  
The Government ◽  
Cross Sectional Design ◽  
The Impact

Background: Low public awareness of the impact of smoking makes the implementation of smoke-free areas (KTR) difficult. Smoke-free areas aim to protect the public from the direct and indirect effects of smoking. Purpose: This study aimed to analyze the correlation between the application of smoke-free areas and the prevalence of active and ex-smokers in Indonesia. Method: This study implemented a cross-sectional design, using secondary data from the Riskesdas 2018 on active and ex-smokers. KTR application data were obtained from the Profile of Non-Communicable Diseases in 2016. A Pearson product-moment test was conducted by a computer application to determine the correlation coefficient (r). This coefficient was used to describe the level of correlation between the two variables; significance was determined as a p value of 5%. Results: This study showed that the average application of KTR throughout Indonesia was 50.83%, active smokers comprised 23.49% of the population, and ex-smokers comprised 4.94%. Most active smokers were in Java and Sumatra, while the majority of ex-smokers were in Java and Sulawesi and the majority of KTR was in Java. This study shows that there is a positive correlation between KTR application and the percentage of ex-smokers (r = 0.46; p value = 0.01). Conclusion: There is a positive correlation between the application of KTR and an increase in ex-smokers. The government needs to increase the application of KTR policies.

scholarly journals Perbedaan kadar hemoglobin pada remaja gizi baik yang tinggal di pegunungan dengan yang tinggal di tepi pantai

e-CliniC ◽  
2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Marianne C. Jacobus ◽  
Max F.J Mantik ◽  
Adrian . Umboh
Keyword(s):  
Analytical Study ◽  
Nutrition Status ◽  
P Value ◽  
Cross Sectional ◽  
Significant Difference ◽  
Good Nutrition ◽  
The Difference ◽  
Cross Sectional Design ◽  
And Gender ◽  
Main Component

Abstract: Haemoglobin is the main component of red blood cells that serves as a transporter of oxygen and carbon dioxide in the blood. The normal range of haemoglobin values can be used to determine the degree of anemia according to age and gender. Geographical condition such as altitude influences the haemoglobin value. This study aimed to obtain the difference of haemoglobin levels between teenagers with good nutrition status who live at the highland and those at the seaside. This was an observational analytical study with a cross sectional design. Samples were students with good nutrition status of SMPN 3 Tomohon (living at the highland) and those of SMP Kristen Nazaret Tuminting (living at the seaside). There were 60 students who met the inclusion criteria as follows: adolescent, good nutrition status, healthy, aged 13-15 years, lived at the highland or at the seaside ≥ 6 month, and willing to be performed blood examinations, and had been approved by their parents. The Mann-Whitney test for the difference between haemoglobin levels of the two groups showed a p value < 0,001. Conclusion: There was a very significant difference between haemoglobin levels of good nutrition teenagers who lived at the highland and at the seaside. Keywords: haemoglobin levels, good nutrition, teenagers, highland, seaside  Abstrak: Hemoglobin merupakan komponen utama sel darah merah dan berfungsi sebagai transporter oksigen dan karbon dioksida dalam darah. Batas normal nilai hemoglobin dapat digunakan untuk menetapkan derajat anemia, dengan distribusi usia dan jenis kelamin spesifik didasarkan pada sampel referensi sehat. Kondisi geografis, seperti ketinggian tempat dari permukaan laut menjadi faktor pertimbangan dalam distribusi nilai normal hemoglobin. Penelitian ini bertujuan untuk mendapatkan perbedaan kadar hemoglobin antara remaja gizi baik yang tinggal di pegunungan dengan yang tinggal di tepi pantai. Jenis penelitian ini analitik-observasional dengan desain potong lintang. Sampel penelitian yaitu remaja gizi baik yang tinggal di pegunungan yaitu siswa SMPN 3 Tomohon dan yang di tepi pantai yaitu siswa SMP Kristen Nazaret Tuminting. Subjek penelitian berjumlah 60 remaja yang memenuhi kriteria inklusi yaitu gizi baik, sehat, berumur 13-15 tahun, berdomisili di pegunungan atau tepi pantai ≥6 bulan, bersedia dilakukan pemeriksaan darah, dan telah disetujui oleh orang tua. Data yang diperoleh dianalisis menggunakan uji Mann-Whitney dengan bantuan program SPSS. Hasil uji Mann-Whitney mengenai perbedaan kadar hemoglobin antara kedua kelompok menunjukkan nila p <0,001. Simpulan: Terdapat perbedaan yang sangat bermakna kadar hemoglobin remaja gizi baik yang tinggal di pegunungan dengan di tepi pantai.Kata kunci: kadar hemoglobin, remaja gizi baik, pegunungan, tepi pantai

scholarly journals RISK ASSESSMENT PADA PEKERJAAN MENEBANG KAYU DI HUTAN PRODUKSI (STUDI KASUS PADA PENGOPERASIAN CHAINSAW PERUM PERHUTANI KPH MADIUN)

2017 ◽  
Vol 5 (2) ◽  
pp. 153
Author(s):  
Raditya Angga Pradipta
Keyword(s):  
Risk Assessment ◽  
High Risk ◽  
Descriptive Analysis ◽  
Secondary Data ◽  
Analysis Data ◽  
Observational Research ◽  
Primary Data ◽  
Cross Sectional ◽  
Forest Production ◽  
Cross Sectional Design

Logging the forest production is a high risk work. The condition of the forest acreage is difficult, the imbalance between the tools used by condition of the field and the skills of workers can lead to accidents. One of supporting job in the process of logging the forest production is the operation of the chainsaw that has hazards and risks which must be controlled. The main objective of this research was to risk assessment in the operational of the chainsaw in the work to cutting down trees in Perhutani KPH Madiun. This research was an observational research that conducted using cross sectional design and descriptive analysis. Data were used primary data based on interviews, observations and secondary data collected from the company. This research performed based on work activities of operating chainsaw. The result showed that based on idetification of hazards in activities of operating chainsaw in cutting trees, there were18 hazards Risk assessment showed that from 18 pure risks, there were 4 low risks,7 medium risks and 7 high risks. The conclusion from this research is the risk most dominant obtained from the risk assessment is high risk and risks while each one had the amount of 7 danger or 39 % of all the potential here hazards, to at a job should not be continued, work that needs to be set repeated or attempts to control at work to reduce the risk. Control must be reviewed for conformity before work began.Keywords: cut timber, identification hazards, risk assessment

scholarly journals Relationship Host Behavior and The Environment of DHF Incidence in Wonokusumo Surabaya

2018 ◽  
Vol 5 (3) ◽  
pp. 383
Author(s):  
Sofa Nutrima Rismawati
Keyword(s):  
Data Collection ◽  
Dengue Hemorrhagic Fever ◽  
Secondary Data ◽  
Hemorrhagic Fever ◽  
Primary Data ◽  
Environment Interaction ◽  
Cross Sectional ◽  
Host Behavior ◽  
Cross Sectional Design ◽  
Data Collection Technique

ABSTRACTFree Number of larvae (ABJ) in RW 15, Wonokusumo Village is 85%. However, the incidence of Dengue Hemorrhagic Fever (DHF) is still high, ie 17 cases. The high incidence rate of DHF is due to the interaction between host, agent and environment. Host in terms of behavior, dengue virus as an agent and environment derived from the surrounding conditions that can cause and trigger the spread of DHF. The purpose of this research is to analyze the relationship of host and environment behavior to the occurrence of DHF in RW 15. This research using cross sectional design. Random sampling using the guy method. How to calculate the method guy is 10% of the population so that obtained a sample of 78 respondents. Primary data collection technique is done through indepth interview and filling questionnaire. Secondary data collection was obtained from Wonokusumo Puskemas report and report from Surabaya City Health Office. The research was conducted in RW 15. The result of bivariate statistic test showed significant relation between knowledge, attitude, action and environment against DHF incidence with p> α, 0,00> 0,05. The conclusion of this research is that there is host and environment interaction to DHF incidence. Suggestion of this research is procurement of work program every month, independent larvae monitoring movement by society and 3M movement plus every week on Thursday and procurement of training of cadre jumantik about how and regulation of dosage of abate powder according to dose.Keywords: host behavior, environment, disease Dengue Hemorrhagic Fever

scholarly journals Determinants of Injury Incidents in the Productive Aged Groups in Central Sulawesi

2020 ◽  
Author(s):  
Sea Septiana ◽  
◽  
Ira Marti Ayu ◽  
Keyword(s):  
Nutritional Status ◽  
Employment Status ◽  
Secondary Data ◽  
Bivariate Analysis ◽  
Chi Square ◽  
Cross Sectional ◽  
Level Of Education ◽  
Cross Sectional Design ◽  
Central Sulawesi ◽  
Keywords Injury

ABSTRACT Background: Based on RISKESDAS data from 2007, 2013, and 2018, the prevalence of injuries in Indonesia had increased from 7.5%, 8.2%, and 9.2% respectively. In 2018, the proportion of injuries ranked 12th place in morbidity in Indonesia with the highest cases in Central Sulawesi Province (13.8%). This study aimed to determine of injury inci­dents in the productive aged groups in Central Sulawesi. Subjects and Method: This was a cross-sectional design conducted in Central Sulawesi from October 2019 to January 2020. A total of 1,323 reproductive-aged household mem­bers was selected by random sampling method. The dependent variable was the incident of injury. The independent variables were age, gender, level of education, employment status, and nutritional status. The data were collected from secondary data of basic health research data in 2018 with household dan individual questionnaires. Bivariate analysis was performed by chi-square method. Results: The bivariate analysis showed that the incidence of injury among the productive aged groups increased with age (OR= 1.50; 95% CI= 1.10 to 2.05; p= 0.021), gender (OR= 1.29; 95% CI= 1.03 to 1.62; p=0.030), level of education (OR= 2.01; 95% CI= 1.14 to 3.56; p= 0.010), employment status (OR= 1.86; 95% CI= 1.19 to 2.90; p= 0.005), and nutritional status (OR= 0.77; 95% CI= 0.55 to 1.07; p= 0.033). Conclusion: The incidence of injury among the productive aged groups increases with age, gender, level of education, employment status, and nutritional status. Keywords: injury, incidents, determinants, productive age Correspondence: Sea Septiana. Universitas Esa Unggul. Jl. Arjuna Utara No. 9, Kebon Jeruk, West Jakarta, 11510. Email: [email protected]. Mobile: +628978233316 DOI: https://doi.org/10.26911/the7thicph.04.30

Activity of Sunitinib in Patients With Advanced Neuroendocrine Tumors

2008 ◽  
Vol 26 (20) ◽  
pp. 3403-3410 ◽  
Author(s):  
Matthew H. Kulke ◽  
Heinz-Josef Lenz ◽  
Neal J. Meropol ◽  
James Posey ◽  
David P. Ryan ◽  
...  
Keyword(s):  
Growth Factor ◽  
Tyrosine Kinase ◽  
Neuroendocrine Tumor ◽  
Neuroendocrine Tumors ◽  
Objective Response ◽  
Pancreatic Neuroendocrine Tumor ◽  
Endocrine Tumor ◽  
Pancreatic Endocrine Tumor ◽  
Tumor Patients ◽  
Patient Reported

Purpose Standard cytotoxic chemotherapy has limited efficacy in metastatic neuroendocrine tumor patients. Neuroendocrine tumors express vascular endothelial growth factor (VEGF) and its receptor (VEGFR). Sunitinib malate, an oral tyrosine kinase inhibitor, has activity against VEGFRs as well as platelet-derived growth factor receptors, stem-cell factor receptor, glial cell line–derived neurotrophic factor, and FMS-like tyrosine kinase-3. We evaluated the efficacy of sunitinib in a two-cohort, phase II study of advanced carcinoid and pancreatic neuroendocrine tumor patients. Patients and Methods Patients were treated with repeated 6-week cycles of oral sunitinib (50 mg/d for 4 weeks, followed by 2 weeks off treatment). Patients were observed for response, survival, and adverse events. Patient-reported outcomes were assessed. Results Among 109 enrolled patients, 107 received sunitinib (carcinoid, n = 41; pancreatic endocrine tumor, n = 66). Overall objective response rate (ORR) in pancreatic endocrine tumor patients was 16.7% (11 of 66 patients), and 68% (45 of 66 patients) had stable disease (SD). Among carcinoid patients, ORR was 2.4% (one of 41 patients), and 83% (34 of 41 patients) had SD. Median time to tumor progression was 7.7 months in pancreatic neuroendocrine tumor patients and 10.2 months in carcinoid patients. One-year survival rate was 81.1% in pancreatic neuroendocrine tumor patients and 83.4% in carcinoid patients. No significant differences from baseline in patient-reported quality of life or fatigue were observed during treatment. Conclusion Sunitinib has antitumor activity in pancreatic neuroendocrine tumors; its activity against carcinoid tumors could not be definitively determined in this nonrandomized study. Randomized trials of sunitinib in patients with neuroendocrine tumors are warranted.

Compliance of Personal Protective Equipment (PPE) N-Series Mask Type 8211 and the Description of Lung Function of the Coal Mining Workers, PT. X, Kutai Kartanegara, East Borneo

2018 ◽  
Vol 24 (8) ◽  
pp. 6068-6072
Author(s):  
Felicia Setiawan ◽  
Imron Khazim ◽  
Zarni Amri
Keyword(s):  
Lung Function ◽  
Data Collection ◽  
Coal Mining ◽  
Work Motivation ◽  
Secondary Data ◽  
Primary Data ◽  
Cross Sectional ◽  
Cross Sectional Design ◽  
Series Type ◽  
Field Workers

Main hazard for the coal mining workers is chemical dust that will cause declining of lung function with chronic exposure. PT. X experienced elevated trend of decline lung function of its worker within the past three years (2013–2015 i.e., 15.8%, 18.3%, and 21.9%). November 2015, PT. X stipulated new policy to its field workers that oblige them to use PPE mask of N series type 8211. Using cross sectional design with 300 people chosen by convinient sampling; primary data collection was conducted via interview and filling questionnaire, and secondary data collection was compiled from PT. X’s MCU reports of 2015 and 2016 and HRD-HSE monthly reports. As much as 82% of workers are comply to use PPE. There are statistically significant relation between work motivation (p 0.02, ORa 4.80, 95% CI 1.22; 18.86), PPE knowledge (p < 0.01, ORa 353.77, 95% CI 59.93; 2088.25), PPE comfortability (p < 0.01, ORa 61.64, 95% CI 5.99; 634.13), reward/punishment (p < 0.01), and supervision (p < 0.01, ORa 0.08, 95% CI 0.01; 0.43) with workers’ compliance of PPE mask of N series type 8211. There are three people experienced declining of lung function within a year. PT. X was advised to continue its policy.

scholarly journals Perhitungan Konsumsi Obat Untuk Logistik Medik di Rumah Sakit Islam Jemursari Surabaya

2018 ◽  
Vol 5 (2) ◽  
pp. 155
Author(s):  
Nur Azizah Fairuz ◽  
Tito Yustiawan
Keyword(s):  
Secondary Data ◽  
Descriptive Study ◽  
Primary Data ◽  
Cross Sectional ◽  
Consumption Data ◽  
Cross Sectional Design

Inaccurate drugs planning may cause excessive budget, stagnant, and stockout. This research aims to analyze drugs planning in medical logistics of Rumah Sakit Islam Jemursari Surabaya. This research is a descriptive study using cross sectional design. Primary data were obtained through observations and interviews. Secondary data were obtained through drugs planning and drugs consumption data from November to December 2016. Afterward, data were processed and found that 40% drugs item on November 2016 have greater amount of consumption than their planning and 65% drugs item on December 2016 have greater amount of consumption than their planning. The method of drugs planning that used in medical logistics of Rumah Sakit Islam Jemursari Surabaya was consumption method, but it was not calculate the average of drugs consumption. After the calculation based on Keputusan Menteri Kesehatan Nomor 1121 Tahun 2008, there is only 20% drugs item on November 2016 which have greater amount of consumption than their planning and 20% drugs item on December 2016 which have greater amount of consumption than their planning. This research showed that the calculation of drugs consumption for medical logistics in Rumah Sakit Islam Jemursari Surabaya need repairement.Keywords: consumption method, drugs planning, hospital

scholarly journals Relationship Between Postpartum Health Care With Contraceptive After Childbirth In Indonesia

2019 ◽  
Vol 6 (3) ◽  
pp. 13
Author(s):  
Arantika Meidya Pratiwi
Keyword(s):  
Health Care ◽  
Maternal Mortality ◽  
Health Research ◽  
Secondary Data ◽  
Postpartum Health ◽  
Chi Square ◽  
Cross Sectional ◽  
Result Show ◽  
Chi Square Test ◽  
Cross Sectional Design

<p>Result of SDKI 2012 show that MMR in Indonesia is 359 deaths per 100,000 live births. This result show that Indonesia still far from the target SDGs (Suitable Development Goals), who reducing the Maternal Mortality Rate (MMR) to 70 per 100,000 live birth. One of the breakthrough programs of the Ministry of Health in an effort to accelerate the reduction in maternal mortality is to increase contraceptive after childbirth. The coverage of contraceptive after childbirth in Indonesia is still far from what is expected, from the 2013 Riskesdas data the coverage of contraceptive after childbirth in Indonesia was only 59.6%. Papua became a province with the lowest coverage of only 26%. The purpose of this study was to determine the relationship between postpartum health care and contraceptive after childbirth in Indonesia. This study using  secondary data from "2013 Basic Health Research" conducted by the Health Research and Development Institute. The 2013 Riskesdas survey uses a cross sectional design. The results of the Chi-Square test showed that there were 0,0001, which meant that there was a relationship between postpartum health care and contraceptive after childbirth in Indonesia. While the results of the analysis of OR values were 1.595, which means that mothers who received health care during the postpartum were 1.6 times more likely to use contraceptive after childbirth.</p>

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