scholarly journals Evaluation of the Relationship Between Subcarinal Angle Values and Mortality in COPD Patients

2021 ◽  
Author(s):  
Ayse Sahin Tutak ◽  
Hüseyin Avni Fındıklı ◽  
Ercan Çil
Keyword(s):  
Mortality Rates ◽  
Apache Ii ◽  
Chronic Obstructive ◽  
X Rays ◽  
Obstructive Pulmonary Disease ◽  
Copd Patients ◽  
Study Results ◽  
Picture Archiving And Communication ◽  
The Relationship ◽  
Posterior Anterior

Abstract: Abstract Background: We aimed to investigate whether changes occur in the subcarinal angle (SCA) in chronic obstructive pulmonary disease (COPD) and examine the effects of such changes on mortality rates. Materials and Methods: The study included 108 COPD patients; who were followed up in the intensive care unit (ICU) in the period between January 2018 and December 2018 and who had available posterior-anterior chest X-rays (PA-CXRs), APACHE-II (Acute Physiology and Chronic Health Evaluation-II) scores, and laboratory values in the electronic archiving system. SCA values on PA-CXRs were recorded in the Picture Archiving and Communication System (PACS). Patients were divided into two groups as survivors and nonsurvivors. Results: In our study; congestive heart failure, as one of the comorbid diseases with COPD, was found to be associated with mortality (p: 0.011). Furthermore; APACHE-II scores (p: 0.001), SCA values (p: 0.025), elevated CRP levels (p: 0.01), hypoalbuminemia (p: 0.018), and high creatinine values (p: 0.034) were associated with mortality. Conclusions: Our results are compatible with those of previous studies in the literature demonstrating that advanced age, elevated CRP levels, APACHE-II scores, hypoalbuminemia, and high creatinine values were all associated with mortality in COPD patients. Furthermore, SCA was found to be narrower in nonsurvivors in our study. We think that our study results will contribute to the literature because this is the first study that demonstrated the association between SCA and mortality in COPD patients.

scholarly journals CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)

2016 ◽  
Vol 23 (09) ◽  
pp. 1073-1078
Author(s):  
Atif Sitwat Hayat ◽  
Abdul Haque Khan ◽  
Ghulam Nabi Pathan ◽  
Mohammad Zubair Mushtaque
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Cross Sectional Study ◽  
Chronic Obstructive ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Obstructive Pulmonary Disease ◽  
Reactive Protein ◽  
Copd Patients ◽  
Study Results

Objectives: Chronic obstructive pulmonary disease (COPD) leads to partialreversible obstruction of airways. The objective of our study is to determine frequency ofelevated C-reactive protein (CRP) level in patients of COPD at Liaquat University HospitalJamshoro/Hyderabad. Study Design: Cross-sectional study. Setting: Medical Unit-I of LiaquatUniversity Hospital Jamshoro/Hyderabad. Period: 1st March 2013 to 31st August 2013. Patientsand Methods: Patients of either sex and ages from 40-80 years old and having COPD for atleast two years duration were included. Patients below 40 years of age, having malignanciesor autoimmune disorders were excluded from this study. Results: We enrolled 186 patientswith COPD and their mean age was ± SD 57.63±8.45 years. Majority 182 (97.8%) had habitof smoking while 4(2.2%) were non-smokers. Mean CRP level in COPD patients was ± SD1.26±0.79 (range 0.1- 3.0 mg/d1). Out of 186 COPD patients, 94(50.6%) have raised CRP level(higher than 1.0 mg/dl). Median value of CRP level during this study was 1.10 mg/dl. About92(49.4%) patients have normal level of CRP (less than 1.0 mg/dl). Conclusion: On conclusion,frequency of raised C-reactive protein in our study was much higher (50.6%).

scholarly journals Role of Type2 Inflammatory Biomarkers in Chronic Obstructive Pulmonary Disease

2020 ◽  
Vol 9 (8) ◽  
pp. 2670
Author(s):  
Keiji Oishi ◽  
Kazuto Matsunaga ◽  
Toshihiro Shirai ◽  
Keita Hirai ◽  
Yasuhiro Gon
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Stable State ◽  
Epidemiologic Studies ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Copd Patients ◽  
Blood Eosinophils ◽  
The Relationship

Airway inflammation in chronic obstructive pulmonary disease (COPD) is typically thought to be driven by Type1 immune responses, while Type2 inflammation appears to be present in definite proportions in the stable state and during exacerbations. In fact, some COPD patients showed gene expression of Type2 inflammation in the airway, and this subset was associated with the inhaled corticosteroid (ICS) response. Interestingly enough, the relationship between COPD and diseases associated with Type2 inflammation from the perspective of impaired lung development is increasingly highlighted by recent epidemiologic studies on the origin of COPD. Therefore, many researchers have shown an interest in the prevalence and the role of existent Type2 biomarkers such as sputum and blood eosinophils, exhaled nitric oxide fraction, and atopy, not only in asthma but also in COPD. Although the evidence about Type2 biomarkers in COPD is inconsistent and less robust, Type2 biomarkers have shown some potential when analyzing various clinical outcomes or therapeutic response to ICS. In this article, we review the existent and emerging Type2 biomarkers with clinically higher applicability in the management of COPD.

Effect of Perceived Dyspnea on Attitude Toward Death From the Perspective of COPD Patients

2021 ◽  
pp. 003022282199362
Author(s):  
Semra Bülbüloğlu ◽  
Emine Kaplan Serin
Keyword(s):  
Public Hospital ◽  
Personal Information ◽  
Fear Of Death ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Life After Death ◽  
Descriptive Research ◽  
Copd Patients ◽  
Comorbid Diseases ◽  
The Relationship

In this study, it was aimed to examine attitudes toward dyspnea and death from the perspective of Chronic Obstructive Pulmonary Disease (COPD) patients and to determine the relationship between them. This descriptive research was carried out in the chest diseases clinic of a public hospital and with the participation of COPD patients (n = 124). The data were obtained from the Personal Information Form, Death Attitude Profile-Revised, and Medical Research Council Scale. The neutral acceptance and approach acceptance subscale is explained as believing that death is an inevitable part of life and a transition to life after death. The escape acceptance subscale is explained as believing that life will save from physical or psychological harms. It was determined that the Neutral Acceptance and Approach Acceptance sub-dimension of the predictors of dyspnea, comorbid diseases, and COPD had a significant effect at a rate of 33% (p = 0.000). Dyspnea, Comorbid diseases, and the predictors of the severity of COPD affect the Escape Acceptance sub-dimension by 57% (p = 0.000). This research has shown that fear of death is high in COPD patients with high perceived dyspnea. The psychological support provided to patients with COPD should be considered to relieve the fear of death. New studies are needed in which these should be reevaluated in the same context.

scholarly journals High resolution computed tomography in chronic obstructive pulmonary disease

2018 ◽  
Vol 5 (5) ◽  
pp. 1222
Author(s):  
Pragati Rao D. ◽  
Aruna Talatam ◽  
Chakradhar B. ◽  
Bhargavi K. ◽  
Bhagyaraj A.
Keyword(s):  
Computed Tomography ◽  
Chronic Obstructive Pulmonary Disease ◽  
High Resolution ◽  
Pulmonary Disease ◽  
Morbidity And Mortality ◽  
Chronic Obstructive ◽  
X Rays ◽  
High Resolution Computed Tomography ◽  
Obstructive Pulmonary Disease ◽  
Copd Patients

Background: Chronic obstructive pulmonary disease (COPD) is a common preventable and treatable disease characterised by persistent respiratory symptoms and airflow limitation with varied presentations (bronchitis and emphysema). High resolution computed tomography (HRCT) plays an important role in identifying the various morphologies thereby reducing morbidity and mortality. The aim of the present study was to evaluate the role of high resolution computed tomography in COPD patients. The Objectives of the present study was to differentiate emphysema predominant, airway predominant and mixed phenotypes and to identify other disease processes and complications.Methods: 50 COPD patients attending Respiratory medicine Department, NRI general hospital were advised for chest x-rays and pulmonary function tests. All the patients selected were smokers with no other co-morbid illnesses. Those patients whose chest x-rays showed no other changes except for COPD changes were selected for HRCT chest.Results: Out of 50 COPD patients emphysema predominance was present in 28 patients (56%), bronchitis predominance in 19 patients (38%) and 3(6%) patients had mixed pattern. In emphysema centriacinar pattern was commonly seen (42.9%), paraseptal in 35.71%, panacinar in 3.57% and bullae in 17.8% cases. All the patients were chronic smokers with pack years >20. All are males with average age above 45 years. Emphysema was common in elderly patients with age above 50 years. Chronic bronchitis is predominantly seen in the age group 40-50 years. Additional diagnoses like bronchiectasis, mass, ILD were identified in 28% cases.Conclusions: HRCT plays a significant role in COPD patients in differentiating phenotypes which have different modes of therapy. Other subtle changes in lungs which cannot be identified on chest x ray are discernible on HRCT. Early identification of complications reduces morbidity and mortality.

scholarly journals Relationship between Vitamin D Level and Serum TNF-α Concentration on the Severity of Chronic Obstructive Pulmonary Disease

2019 ◽  
Vol 7 (14) ◽  
pp. 2298-2304
Author(s):  
Muhammad Ilyas ◽  
Agussalim Agussalim ◽  
Megawati Megawati ◽  
Nasrum Massi ◽  
Irawaty Djaharuddin ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Vitamin D ◽  
Airway Obstruction ◽  
Pulmonary Disease ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Copd Patients ◽  
Vitamin D Levels ◽  
Tnf Α ◽  
The Relationship

Background: Chronic Obstructive Pulmonary Disease (COPD) is a chronic inflammatory disease and disturbed bacterial clearance. Vitamin D deficiency is sometimes observed in COPD patients and as significant roles in increasing inflammation of airway obstruction and systemic obstruction, increasing proinflammatory cytokine including TNF-α, reduction of bacterial clearance and increase exacerbation risk due to infection. Also, vitamin D plays significant roles in the metabolism of calcium and mineralization of bones and regulation system of immune. TNF-α also has essential roles in pathogenesis and inflammation of COPD.  Several studies that investigate the relationship between vitamin D level and serum TNF-α concentration in COPD patients are relatively uncommon, including in Indonesia. For that reason, this study aimed to assess the relationship between vitamin D level and TNF-α concentration in patients on the severity of the chronic obstructive pulmonary disease. Methods This study was a hospital-based descriptive cross-sectional study. Total samples were 50 COPD patients with the average age of older than 60 years during their enrollments at the Department of Pulmonology and Respiratory Medicine of the Dr.Wahidin Sudirohusodo General hospital  Makassar in September 2018-January 2019. All procedures of the present study were reviewed and approved by the Research Ethics Committee of Medicine Faculty of Hasanuddin University. The severity of COPD was assessed according to the combination of COPD assessment stages that referred to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) Guideline 2015 that consisted of the combination of scoring COPD Assessment Test (CAT), the modified Medical Research Council (mMRC) questionnaire and results of the spirometric measurement. Assessment of airway obstruction levels referred to the GOLD spirometric criteria. Determination of thoracic photographs was conducted to verify the COPD diagnosis of the severity of COPD. Determination of serum TNF-α concentration and vitamin D3 [1,25(OH)2D3] level used the ELISA method. Results  The majority of COPD patients were observed in the category of older than 60 years old accounted for 34 COPD patients (68%), and the majority of COPD patients were males accounted for 47 males with COPD (94%). The majority of COPD patients were observed in the group of D (38%). All the study subjects observed in this study were smokers, and 82% of them were in the category of heavy smokers. 21 study subjects had higher concentration of serum TNF-α  (tertile 3 = 0.21-1.83 pg/dl), 20 study subjects  and lower level of vitamin D (tertile 1 = 182.1-364.5 pg/dl). The majority of the study subjects (38%) were in the category of severe COPD (category D of the severity of COPD at the tertile 3) according to the GOLD Combine Assessment. In view of the relationship between vitamin D level and serum TNF-α concentration on the airway obstruction, there were significant positive correlations between the increase of vitamin D levels and the increase of serum TNF-α concentrations on airway obstruction. In view of the relationship between vitamin D level and serum TNF-α concentration on the severity of COPD, there were significant positive correlations between the increase of vitamin D levels (tertiles 1, 2 and 3) and the increase of serum TNF-α concentrations on the severity of COPD at p-value<0.05. Overall, there were non-linear relationships between vitamin D level and serum TNF-α concentration on the severity of COPD. Conclusions: Serum TNF-α concentration was positively associated with airway obstruction level and severity of COPD. Low level of vitamin D was negatively associated with airway obstruction level and severity of COPD. Vitamin D3 level (1,25(OH)2D) was negatively associated with serum TNF-α concentration and airway obstruction level and severity of COPD.

scholarly journals Validation of the modified nutric score on critically ill patients with acute exacerbations of chronic obstructive pulmonary disease: A retrospective study

2021 ◽  
Vol 8 (9) ◽  
pp. 546-550
Author(s):  
Guler Doganay ◽  
Mustafa Ozgur Cirik ◽  
Gulsah Yurtseven ◽  
Ali Alagoz
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Critically Ill ◽  
Apache Ii ◽  
Nutritional Risk ◽  
Apache Ii Score ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Icu Admission ◽  
Copd Patients

Objective: In critical care patients, the nutritional status is related to many factors such as existing co-morbidities, nutritional history, and the current disease. It is crucial to apply a comprehensive nutritional assessment and to start nutritional support as soon as possible in intensive care unit(ICU) where malnutrition is common. There are many studies on the association between modified Nutritional Risk in Critical Patients (mNUTRIC) score and outcome in ICU patients but the effectiveness of tools for risk assessment is still remains unclear. We aimed to define the correlation between the mNUTRIC score and 28-day mortality in patients with chronic obstructive pulmonary disease (COPD) in ICU. Materials and Methods: The admission of COPD patients to the respiratory ICU in 2018 were determined retrospectively. Demographic data of all patients, body mass index (BMI), mNUTRIC scores, Acute Physiology and Chronic Health Assessment II (APACHE II), Sequential Organ Failure Assessment (SOFA) scores, Charlson Comorbidity Index (CCI), time from patient ward to ICU admission, sepsis parameters including C-reactive protein (CRP) and procalcitonin,  ICU length of stay (LOS ICU), vasopressor use, and 28-day mortality were recorded. Results: 159 COPD patients were involved in the study. Age, CCI, day from patient ward to ICU admission, SOFA score, APACHE II score and 28-day mortality were detected to be statistically higher in patients with mNUTRIC ≥ 5 (p < 0.05). Conclusion: The mNUTRIC score could be an proper method for nutritional risk to predict prognosis in critically ill COPD patients.

scholarly journals Hubungan derajat penyakit paru obstruktif kronik dengan malnutrisi pada pasien penyakit paru obstruktif kronik di poli Rumah Sakit Umum Meuraxa

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Husnah Husnah
Keyword(s):  
Public Health Problem ◽  
Chronic Obstructive ◽  
Cross Sectional ◽  
Obstructive Pulmonary Disease ◽  
Relationship Strength ◽  
Copd Patients ◽  
Cross Sectional Design ◽  
Relationship Of ◽  
Spearman Test ◽  
The Relationship

Abstrak. Latar Belakang: Penyakit paru obstruksi kronik (PPOK) merupakan masalah kesehatan masyarakat yang menjadi peringkat keempat kematian di dunia. Pasien PPOK sering mengalami kehilangan berat badan sekitar 15-50% pada PPOK ringan sampai parah. Tujuan penelitian ini untuk mengetahui hubungan derajat PPOK dengan resiko malnutrisi pada pasien PPOK di poli paru RSU Meuraxa. Metode: Jenis penelitian analitik observasional dengan desain cross-sectional, teknik sampel secara accidental sampling. Penilaian derajat PPOK dengan spirometri dan resiko malnutrisi menggunakan Mini Nutrition Assesment (MNA), dengan waktu penelitian tanggal 1 maret sampai 7 april 2014 didapatkan sejumlah 60 responden. Hasil: Jenis kelamin laki-laki 40 orang (66.7%), usia terbanyak antara 51-60 tahun 25 orang (41.7%), malnutrisi sebanyak 45 orang (75%), PPOK dengan derajat sedang 28 (47.7%), dan pola makan salah 43 orang (71.7%). Analisis secara uji spearman terdapat hubungan antara derajat PPOK dengan malnutrisi nilai p = 00,1 (α0,05). r = -0,665 dengan kekuatan hubungan sedang dimana semakin berat derajat PPOK maka risiko malnutrisi semakin besar.Kata kunci: Derajat PPOK, Malnutrisi, MNA                                             Abstract. Background: Chronic Obstructive Pulmonary Disease (COPD) is a public health problem being ranked 4th death in the world. COPD patients often experience weight loss of approximately 15-50% in mild to severe COPD. The purpose of this study was to determine the relationship of the degree of COPD at risk of malnutrition in patients with COPD. Methods: observational analytic study with cross-sectional design, engineering samples of accidental sampling. Assessment of the degree of COPD with spirometry and risk of malnutrition using Mini Nutrition Assesment (MNA), the research time on 1 March to 7 April 2014 there were 60 respondents. Results: Male gender is 40 people (66.7%), most of them are between 51-60 years of age, 25 people (41.7%), 45 people with malnutrition (75%), 28 people with moderate COPD (47.7%), and 43 people with wrong diet (71.7%). Analysis by means of the spearman test, there was a relationship between the degree of COPD and malnutrition, the value of p = 00.1 (α 0.05). r = -0.665 with moderate relationship strength where the heavier the degree of COPD, the greater the risk of malnutrition.Keywords: Degree of COPD, Malnutrition, MNA

scholarly journals Effects of Diabetes on pulmonary function tests in COPD Patient

2021 ◽  
pp. 48-51
Author(s):  
Bantupalli Suranjan ◽  
Atluri Deekshit ◽  
Bala Yaswanth Kumar S ◽  
Mano Ranjitha Pulivarthi
Keyword(s):  
Inflammatory Responses ◽  
Pulmonary Function Tests ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Copd Patients ◽  
Increased Risk ◽  
Study Results ◽  
Lung Dysfunction ◽  
Patients With Diabetes ◽  
Group 2

COPD (chronic obstructive pulmonary disease) is a condition caused by abnormalities in the inflammatory responses of the lungs to irritable particles or gases. This is an irreversible condition that progresses in later years.Diabetes patients have an increased risk of developing abnormal lung functioning and also in conditions of COPD it even worsens the condition, up to 1.6-16% of the COPD population were affected due to diabetes mellitus.Many studies also suggest that the lungs are a target organ in diabetes and glycemic exposure may be a causation factor for reduced lung function. Systemic inflammation, hypoxemia, oxidative stress, altered gas exchange, and changes in lung tissues were the major impacts on the respiratory system which were induced by hypoglycemia. In this study, we aimed to assess the lung functioning in COPD patients with diabetes by performing the pulmonary functions test like spirometry by obtaining the values of FVC, FEV1, FEV/FVC, and PEF thereby analyzing the level of lung dysfunction that has been done. Patients were includes of both genders and were divided into two groups depending on their disease group 1 includes COPD and group 2 includes COPD with DM considering twenty members in each group. Our study results show that diabetes worsens the lung functioning in COPD than it already is, it may also cause respiratory collapse if untreated.

scholarly journals Chronic obstructive pulmonary disease and cardiovascular comorbidity

Kardiologiia ◽  
2019 ◽  
Vol 59 (8S) ◽  
pp. 24-36 ◽  
Author(s):  
Z. R. Aisanov ◽  
A. G. Chuchalin ◽  
E. N. Kalmanova
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
General Population ◽  
Pulmonary Disease ◽  
Point Of View ◽  
Chronic Obstructive ◽  
Bronchial Obstruction ◽  
Obstructive Pulmonary Disease ◽  
Cardiovascular Comorbidity ◽  
Copd Patients ◽  
The Relationship

In recent years, a greater understanding of the heterogeneity and complexity of chronic obstructive pulmonary disease (COPD) has come from the point of view of an integrated clinical assessment of severity, pathophysiology, and the relationship with other pathologies. A typical COPD patient suffers on average 4 or more concomitant diseases and every day about a third of patients take from 5 to 10 different drugs. The mechanisms of the interaction of COPD and cardiovascular disease (CVD) include the effects of systemic inflammation, hyperinflation (hyperinflation) of the lungs and bronchial obstruction. The risk of developing CVD in patients with COPD is on average 2–3 times higher than in people of a comparable age in the general population, even taking into account the risk of smoking. The prevalence of coronary heart disease, heart failure, and rhythm disturbances among COPD patients is significantly higher than in the general population. The article discusses in detail the safety of prescribing various groups of drugs for the treatment of CVD in patients with COPD. Achieving success in understanding and managing patients with COPD and CVD is possible using an integrated multidisciplinary approach.

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