scholarly journals How Micro Current Created by Grounding Stimulates Meridian Points in Acupressure?

2021 ◽  
Vol 3 (2) ◽  
pp. 79-83
Author(s):  
Madiha Khalid ◽  
Jeremy Madvin
Keyword(s):  
Side Effects ◽  
Free Electron ◽  
Therapeutic Efficacy ◽  
Electron Flow ◽  
The Body ◽  
Oriental Medicine ◽  
Therapeutic Method

Acupressure in Oriental medicine is used as a core therapeutic method due to its therapeutic efficacy and minimal side-effects. However, microcurrent stimulation, combined with acupressure and grounding, has not been studied under acupressure conditions in terms of how this combination might affect acupressure therapy's effectiveness. This paper clarifies the new concept of acupressure stimulation combined with a microcurrent that generates electron flow during earthing. In grounding the body, there is free electron movement from and to the body that creates microcurrent. Acupressure uses these currents to activate specific acupoints for therapeutic purposes and activating these acupoints adjust the imbalance between Qi across channels (meridians) and ultimately treat diseases. It is time for proper research and implementation of this technique to increase acupressure efficacy and reduce society's cost.

Biocompatible Polymers and their Potential Biomedical Applications: A Review

2019 ◽  
Vol 25 (34) ◽  
pp. 3608-3619 ◽  
Author(s):  
Uzma Arif ◽  
Sajjad Haider ◽  
Adnan Haider ◽  
Naeem Khan ◽  
Abdulaziz A. Alghyamah ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Biomedical Applications ◽  
Living System ◽  
Health Condition ◽  
The Body ◽  
Biocompatible Polymers ◽  
Nano Technology ◽  
Artificial Grafts ◽  
Immunological Reactions

Background: Biocompatible polymers are gaining great interest in the field of biomedical applications. The term biocompatibility refers to the suitability of a polymer to body and body fluids exposure. Biocompatible polymers are both synthetic (man-made) and natural and aid in the close vicinity of a living system or work in intimacy with living cells. These are used to gauge, treat, boost, or substitute any tissue, organ or function of the body. A biocompatible polymer improves body functions without altering its normal functioning and triggering allergies or other side effects. It encompasses advances in tissue culture, tissue scaffolds, implantation, artificial grafts, wound fabrication, controlled drug delivery, bone filler material, etc. Objectives: This review provides an insight into the remarkable contribution made by some well-known biopolymers such as polylactic-co-glycolic acid, poly(ε-caprolactone) (PCL), polyLactic Acid, poly(3- hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), Chitosan and Cellulose in the therapeutic measure for many biomedical applications. Methods: : Various techniques and methods have made biopolymers more significant in the biomedical fields such as augmentation (replaced petroleum based polymers), film processing, injection modeling, blow molding techniques, controlled / implantable drug delivery devices, biological grafting, nano technology, tissue engineering etc. Results: The fore mentioned techniques and other advanced techniques have resulted in improved biocompatibility, nontoxicity, renewability, mild processing conditions, health condition, reduced immunological reactions and minimized side effects that would occur if synthetic polymers are used in a host cell. Conclusion: Biopolymers have brought effective and attainable targets in pharmaceutics and therapeutics. There are huge numbers of biopolymers reported in the literature that has been used effectively and extensively.

Nanotechnological Innovations Enhancing the Topical Therapeutic Efficacy of Quercetin: A Succinct Review

2020 ◽  
Vol 17 (4) ◽  
pp. 270-278
Author(s):  
Maha Nasr ◽  
Rawan Al-Karaki
Keyword(s):  
Side Effects ◽  
Therapeutic Efficacy ◽  
Skin Permeation ◽  
Skin Penetration ◽  
Topical Delivery ◽  
Natural Compounds ◽  
Therapeutic Activity ◽  
Dermatological Diseases ◽  
Anti Inflammatory ◽  
Topical Applications

Nanotechnology is currently a hot topic in dermatology and nutraceutical/cosmeceutical delivery, owing to the advantages it provides in terms of enhancing the skin permeation of drugs, as well as increasing their therapeutic efficacy in the treatment of different dermatological diseases. There is also a great interest in the topical delivery of nutraceuticals; which are natural compounds with both therapeutic and cosmetic benefits, in order to overcome the side effects of topically applied chemical drugs. Quercetin is a key nutraceutical with topical antioxidant and anti-inflammatory properties which was reported to be effective in the treatment of different dermatological diseases, however, its topical therapeutic activity is hindered by its poor skin penetration. This review highlights the topical applications of quercetin, and summarizes the nanocarrier-based solutions to its percutaneous delivery challenges.

Antipyretic Plants: An Updated Review

2020 ◽  
Vol 16 (1) ◽  
pp. 4-12
Author(s):  
Vandana Garg ◽  
Rohit Dutt
Keyword(s):  
Side Effects ◽  
Body Temperature ◽  
Medicinal Plants ◽  
Inflammatory Mediators ◽  
Review Paper ◽  
The Body ◽  
Hypothalamic Area ◽  
Antipyretic Activity ◽  
Disease States ◽  
Elevated Body Temperature

Background: Fever, is known as pyrexia, may occur due to infection, inflammation, or any tissue damage and disease states. Normally, the infected or damaged tissue initiates the enhanced formation of pro-inflammatory mediators like cytokines which further increases the synthesis of prostaglandin E2 (PgE2) near the hypothalamic area and thereby trigger the hypothalamus to elevate the body temperature. Objective: Antipyretics are the agents which reduce the elevated body temperature. The most commonly used antipyretic agent, paracetamol, may be fatal due to its side effects. Methods: In this review paper, Chemical Abstracts, Google Scholar, PubMed, and Science Direct were the sources for the published article to collect information regarding antipyretic activity. Results: This review compiles the antipyretic plants that may be useful to treat fever due to various diseases. Conclusion: These medicinal plants could be good alternatives for traditional allopathic antipyretics.

Nanostructured Ketorolac-Tromethamine/MCF: Synthesis, Characterization and Application in Drug Release System

2018 ◽  
Vol 14 (5) ◽  
pp. 432-439 ◽  
Author(s):  
Juliana M. Juarez ◽  
Jorgelina Cussa ◽  
Marcos B. Gomez Costa ◽  
Oscar A. Anunziata
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Therapeutic Efficacy ◽  
Drug Delivery Systems ◽  
Controlled Drug Release ◽  
Delivery Systems ◽  
The Body ◽  
Fickian Diffusion ◽  
Ketorolac Tromethamine

Background: Controlled drug delivery systems can maintain the concentration of drugs in the exact sites of the body within the optimum range and below the toxicity threshold, improving therapeutic efficacy and reducing toxicity. Mesostructured Cellular Foam (MCF) material is a new promising host for drug delivery systems due to high biocompatibility, in vivo biodegradability and low toxicity. Methods: Ketorolac-Tromethamine/MCF composite was synthesized. The material synthesis and loading of ketorolac-tromethamine into MCF pores were successful as shown by XRD, FTIR, TGA, TEM and textural analyses. Results: We obtained promising results for controlled drug release using the novel MCF material. The application of these materials in KETO release is innovative, achieving an initial high release rate and then maintaining a constant rate at high times. This allows keeping drug concentration within the range of therapeutic efficacy, being highly applicable for the treatment of diseases that need a rapid response. The release of KETO/MCF was compared with other containers of KETO (KETO/SBA-15) and commercial tablets. Conclusion: The best model to fit experimental data was Ritger-Peppas equation. Other models used in this work could not properly explain the controlled drug release of this material. The predominant release of KETO from MCF was non-Fickian diffusion.

The Effect of Phase Transition Temperature on Therapeutic Efficacy of Liposomal Bortezomib

2020 ◽  
Vol 20 (6) ◽  
pp. 700-708
Author(s):  
Mitra Korani ◽  
Sara Nikoofal-Sahlabadi ◽  
Amin R. Nikpoor ◽  
Solmaz Ghaffari ◽  
Hossein Attar ◽  
...  
Keyword(s):  
Side Effects ◽  
Cell Line ◽  
Therapeutic Efficacy ◽  
Drug Loading ◽  
Particle Diameter ◽  
In Vitro Cytotoxicity ◽  
Liposomal Formulations ◽  
Cytotoxicity Studies ◽  
Anti Tumor Activity

Aims: Here, three liposomal formulations of DPPC/DPPG/Chol/DSPE-mPEG2000 (F1), DPPC/DPPG/Chol (F2) and HSPC/DPPG/Chol/DSPE-mPEG2000 (F3) encapsulating BTZ were prepared and characterized in terms of their size, surface charge, drug loading, and release profile. Mannitol was used as a trapping agent to entrap the BTZ inside the liposomal core. The cytotoxicity and anti-tumor activity of formulations were investigated in vitro and in vivo in mice bearing tumor. Background: Bortezomib (BTZ) is an FDA approved proteasome inhibitor for the treatment of mantle cell lymphoma and multiple myeloma. The low solubility of BTZ has been responsible for the several side effects and low therapeutic efficacy of the drug. Encapsulating BTZ in a nano drug delivery system; helps overcome such issues. Among NDDSs, liposomes are promising diagnostic and therapeutic delivery vehicles in cancer treatment. Objective: Evaluating anti-tumor activity of bortezomib liposomal formulations. Methods: Data prompted us to design and develop three different liposomal formulations of BTZ based on Tm parameter, which determines liposomal stiffness. DPPC (Tm 41°C) and HSPC (Tm 55°C) lipids were chosen as variables associated with liposome rigidity. In vitro cytotoxicity assay was then carried out for the three designed liposomal formulations on C26 and B16F0, which are the colon and melanoma cancer mouse-cell lines, respectively. NIH 3T3 mouse embryonic fibroblast cell line was also used as a normal cell line. The therapeutic efficacy of these formulations was further assessed in mice tumor models. Result: MBTZ were successfully encapsulated into all the three liposomal formulations with a high entrapment efficacy of 60, 64, and 84% for F1, F2, and F3, respectively. The findings showed that liposomes mean particle diameter ranged from 103.4 to 146.8nm. In vitro cytotoxicity studies showed that liposomal-BTZ formulations had higher IC50 value in comparison to free BTZ. F2-liposomes with DPPC, having lower Tm of 41°C, showed much higher anti-tumor efficacy in mice models of C26 and B16F0 tumors compared to F3-HSPC liposomes with a Tm of 55°C. F2 formulation also enhanced mice survival compared with untreated groups, either in BALB/c or in C57BL/6 mice. Conclusion: Our findings indicated that F2-DPPC-liposomal formulations prepared with Tm close to body temperature seem to be effective in reducing the side effects and increasing the therapeutic efficacy of BTZ and merits further investigation.

Critical Review on Standard Operative Procedure of Yapana Basti Karma

2018 ◽  
Vol 3 (5) ◽  
Author(s):  
Dr. Rishu Sharma ◽  
Dr. Gyanendra Datta Shukla ◽  
Dr. Alok Kumar Srivastava
Keyword(s):  
Side Effects ◽  
Critical Review ◽  
Treatment Modality ◽  
Operative Procedure ◽  
The Body ◽  
Dosage Schedule ◽  
Dual Function ◽  
Time Period ◽  
Curative Action

Panchakarma therapy is one of the vital branch of Ayurveda, which deals mainly with purification of the provoked Doshas from the body. Basti Chikitsa is regarded as the prime treatment modality among the Panchakarma. It is having not only curative action but also preventive and promotive actions. It is considered as best treatment for Vata Dosha. Yapana Basti is a subtype of Asthapana Basti, which is having the property to support life and promote longevity and widely used in various disorders. Rajayapana Basti is superior amongst all the Yapana Bastis described by Acharya Charaka as it is the king of Yapana. This Rasayana Yapana Basti performs dual function of both Anuvasana and Niruha; hence this is Srotoshodhaka and Brimhana at the sametime. That’s why there is no need to administer separate Anuvasana while giving Yapana Basti. There is an urgent need of standardizing the classical Panchakarma procedures in consideration of the need of today. The dosage schedule, exact procedures, medicaments, effects, and side effects are to be standardized so that uniform procedure of practice should be followed all over nation. Standardization is the need of hour for physicians, to prevent Atiyoga (over activity), Ayoga (less or no activity) and to get adequate effects in a systematic and sophisticated manner within desired time period.

scholarly journals COVID-19 and Alcohol Poisoning: A Fatal Competition

2021 ◽  
pp. 1-10
Author(s):  
Mohammad Heidari ◽  
Nasrin Sayfouri
Keyword(s):  
Side Effects ◽  
Alcohol Consumption ◽  
Mass Media ◽  
The Body ◽  
Ministry Of Health ◽  
Alcohol Poisoning ◽  
Methanol Poisoning ◽  
The Public

ABSTRACT In March 2020, concurrently with the outbreak of COVID-19 in Iran, the rate of alcohol poisoning was unexpectedly increased in the country. This study has attempted to make an overall description and analysis of this phenomenon by collecting credible data from the field, news, and reports published by the emergency centers and the Iranian Ministry of Health. The investigations showed that in May 20, 2020, more than 6150 people have been affected by methanol poisoning from whom 804 deaths have been reported. A major cause of the increased rate of alcohol poisoning in this period was actually the illusion that alcohol could eliminate the Coronaviruses having entered the body. It is of utmost importance that all mass media try to dismiss the cultural, religious, and political considerations and prepare convincing programs to openly discuss the side-effects of forged alcohol consumption with the public, especially with the youth. It must be clearly specified that “consuming alcohol cannot help prevent COVID-19.”

Can’t wait to feel better: Facebook Live and the recalibration of downtime in tending to the body

2021 ◽  
pp. 016344372110034
Author(s):  
Dang Nguyen
Keyword(s):  
Everyday Life ◽  
Mobile Technology ◽  
Social Practices ◽  
The Body ◽  
Therapeutic Method ◽  
Temporal Space ◽  
The Everyday ◽  
Temporal Structures

This article explores the temporality of liveness on Facebook Live through the analytical lens of downtime. Downtime is conceptualized here as multiscale: downtime exists in between the micro action and inaction of everyday life, but also in larger episodes of personal and health crises that reorient the body toward technologies for instantaneous replenishment of meaning and activity. Living through downtime with mobile technology enables the experience of oscillation between liveness as simultaneity and liveness as instantaneity. By juxtaposing time-as-algorithmic against time-as-lived through the livestreaming practices of diện chẩn, an emergent unregulated therapeutic method, I show how different enactments of liveness on Facebook Live recalibrate downtime so that the body can reconfigure its being-in-time. The temporal reverberation of downtime and liveness creates an alternative temporal space wherein social practices that are shunned by the temporal structures of institution and society can retune and continue to thrive at the margin of these structures and at the central of the everyday.

Dopamine agonists for parkinson’s disease

1991 ◽  
Vol 29 (2) ◽  
pp. 7-8
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Side Effects ◽  
Therapeutic Efficacy ◽  
Dopamine Agonists ◽  
Dopa Decarboxylase ◽  
Decarboxylase Inhibitor ◽  
Duration Of Action ◽  
Motor Disability ◽  
The Uk

Bromocriptine, lysuride (formerly lisuride, Revanil – Roche) and pergolide (not yet marketed in the UK) are dopamine agonists developed for use in the treatment of patients with Parkinson’s disease. Combination of a dopamine agonist with levodopa plus a dopa-decarboxylase inhibitor (‘co-dieldopa’)* may have advantages at all stages of the disease. The aim of combined co-dieldopa + agonist treatment is to limit some of the problems with prolonged co-dieldopa use alone; especially fluctuations in motor disability.1 It is still not clear how the three agonists compare with each other for therapeutic efficacy, duration of action, and side effects, nor how they are best combined with co-dieldopa.

Application of melatonin for prevention and treatment of circadian rhythm disorders

2021 ◽  
Vol 19 (2) ◽  
pp. 34-38
Author(s):  
A. S. SAMOYLOV ◽  
◽  
N. V. RYLOVA ◽  
A. V. ZHOLINSKIY ◽  
I. V. BOLSHAKOV ◽  
...  
Keyword(s):  
Circadian Rhythm ◽  
Side Effects ◽  
Light Exposure ◽  
The Body ◽  
Optimal Dosage ◽  
Vital Activity ◽  
Time Zone ◽  
Prevention And Treatment ◽  
Time Of Administration ◽  
Circadian Rhythm Disorders

The article presents data from the Russian and foreign literature of the properties of melatonin, its role in the vital activity of the body and the regulation of circadian rhythms. The features of using the drug in desynchronosis, the optimal dosage and time of administration, as well as the possibility of its use in combination with non-pharmacological treatment methods are discussed. These methods include dosed light exposure and exercise. Additionally, new studies are considered, indicating the beneficial effect of melatonin and its agonists on the immune, cardiovascular, endocrine and nervous systems. Based on the collected data, it is asserted that melatonin can significantly accelerate the process of adaptation to a new time zone without the development of side effects. Therefore, this drug is the most effective and safe treatment for desynchronosis. It is also important to note that the study of the multifaceted effects of melatonin on body functions opens up great prospects in the treatment of many diseases.

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