Is there a relationship between Lund-Mackay scale, olfactory bulb depth and width, and Keros classification in patients with nasal polyps?

Abstract OBJECTIVE. We investigated the relationship between Lund-Mackay scale, olfactory bulb depth and width, and Keros classification in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). MATERIAL AND METHODS. In this retrospective study, paranasal sinus computed tomography (PNSCT) images of 47 patients with CRSwNP and 47 healthy subjects (control) were evaluated. In the CRSwNP group, PNSCT scans were assessed based on Lund-Mackay scale. In both groups, olfactory fossae (OF) depth and width, and Keros classification were evaluated. RESULTS. The total Lund-Mackay score was 17.1±5.9. There were no significant differences between OF depth and width values of the nasal polyps group and control group. For both groups, Type II Keros was the most detected type; secondly, Keros type I and rarely Keros type III were detected. There was no significant correlation between Lund-Mackay score (All items and total score) and OF depth and width, and Keros type. There were negative correlations between ipsilateral OF depth and width (p<0.05), whereas there were positive correlations between contralateral OF depth and width (p>0.05). Keros type was positively correlated between ipsilateral and contralateral OF depth and Keros type (p<0.05). In older patients, left OF depth and Keros type decreased (p<0.05). CONCLUSION. As a conclusion, there was no correlation between Lund-Mackay score and olfactory fossa dimensions (depth and width). When considering age, one could notice that Keros type decreased in older patients.

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Implications of Aerobic Exercises and Walking Parallel to Diabetes Medications on Diabetic Sportspersons

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2021/v33i33a31786 ◽

2021 ◽

pp. 197-204

Author(s):

Fehmida Ayub ◽

Abida Naseer ◽

Saeed Javed ◽

Adnan Asghar ◽

Abd Rahim Mohd Shariff ◽

...

Keyword(s):

Aerobic Exercise ◽

Blood Glucose Control ◽

Daily Basis ◽

Control Group ◽

Type I ◽

Type Ii ◽

Glucose Levels ◽

Spare Time ◽

And Control ◽

Experimental Group

Objective: Diabetes have a central contribution with type I or type II towards the healthy lifestyles of sportspersons. Aerobic exercise and daily walking stay them fit and control their glucose levels in their bloodstream. The aim of this study was to find out the effects of aerobic exercises and walk on the sportspersons of type I and II diabetes. Methodology: The existing research has experimental design itself wherein pre-tests and post-tests were employed to make sure the novelty of results. The data was collected from the diabetic sportspersons dividing them equally into control group (N-20) and experimental group (N-20). Both groups had type I (N-20) and type II (N-20) diabetic individuals. Aerobic exercise and walk protocol was applied for six weeks on experimental group, whereas, control group continued their routine activities. Afterwards, the data was collected through pre and post treatments and edited into SPSS (v-26). The collected data was analyzed through descriptive statistics using frequencies and percentages, whereas, T-test was applied to make the differences of pre and post treatments. Results: The findings has shown that aerobic exercises and walk decrease the higher levels of glucose in blood and enable to stable glycemic balance, weight loss maintenance, decrease insulin resistance, blood pressure decrease, and blood glucose control. Conclusion: The prominent differences were observed between control and experimental groups either type I or type II. It was concluded that the sportspersons may reduce the excessive glucose engaging in aerobic exercises and walk on daily basis rather than using medications. They should spend their happy lives and get rid of medications and insulin through spending their spare time using light exercises and maintain their glucose levels in blood as well.

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A retrospective study assessing the acceleration effect of type I Helicobacter pylori infection on the progress of atrophic gastritis

Scientific Reports ◽

10.1038/s41598-021-83647-6 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Weidong Liu ◽

Junjie Tian ◽

Wenjia Hui ◽

Wenjie Kong ◽

Yan Feng ◽

...

Keyword(s):

Helicobacter Pylori ◽

Atrophic Gastritis ◽

Control Group ◽

Type I ◽

Type Ii ◽

Gastric Function ◽

Infection Group ◽

Group Type ◽

H Pylori ◽

And Control

AbstractBased on the antibody typing classification, Helicobacter pylori infection can be divided into type I H. pylori infection and type II H. pylori infection. To observe the effects of different H. pylori infection types on the distribution of histopathological characteristics and the levels of three items of serum gastric function (PG I, PG II, G-17). 1175 cases from October 2018 to February 2020 were collected with ratio 1:2. All patients were performed with 14C-Urea breath test (14C-UBT), H. pylori antibody typing classification, three items of serum gastric function detection, painless gastroscopy, pathological examination, etc. According to H. pylori antibody typing classification, patients were divided into three groups: type I H. pylori infection group, type II H. pylori infection group and control group. Significant difference existed among type I H. pylori infection group, type II H. pylori infection group and control group in inflammation and activity (χ2 = 165.43, 354.88, P all < 0.01). The proportion of three groups in OLGA staging had statistic difference (χ2 = 67.99, P all < 0.01); Compared with type II H. pylori infection group and control group, the level of pepsinogen I, pepsinogen II, gastrin17 in type I H. pylori infection group increased, and PG I/PG II ratio (PG I/PG II ratio, PGR) decreased, which was statistically significant (χ2 = 35.08, 166.24, 134.21, 141.19; P all < 0.01). Type I H. pylori infection worsened the severity of gastric mucosal inflammation and activity. H. pylori infection was prone to induce atrophy of gastric mucosa, while type I H. pylori infection played a key role in promoting the progress of atrophic gastritis and affected the level of serum gastric function. The study indicated that the eradication of H. pylori should be treated individually.

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Effects of SR-BI rs5888 and rs4238001 variations on hypertension

Turkish Journal of Biochemistry ◽

10.1515/tjb-2018-0394 ◽

2019 ◽

Vol 44 (4) ◽

pp. 549-553

Author(s):

Burcu Çaykara ◽

Hani Alsaadoni ◽

Halime Hanım Pençe ◽

Sadrettin Pençe ◽

Hülya Yılmaz Aydoğan ◽

...

Keyword(s):

Vessel Wall ◽

Quantitative Polymerase Chain Reaction ◽

Scavenger Receptor ◽

Control Group ◽

Type I ◽

Significant Difference ◽

Class B ◽

Polymerase Chain ◽

And Control ◽

The Relationship

Abstract Background Scavenger receptor class B, type I (SR-BI), involved in reverse cholesterol pathway, is a multilipoprotein receptor and capable of binding HDL, LDL and VLDL. SR-BI may contribute to the development of hypertension due to accumulation of cholesterol in the vessel wall via transporting lipoproteins. Therefore, it was aimed to investigate the relationship between SR-BI rs5888 and rs4238001 variants in the patient with hypertension. Materials and methods Seventy three subjects diagnosed with hypertension and 76 healthy subjects constituted the patient and control group, respectively. Genomic DNA was isolated from peripheral blood samples and a real-time quantitative polymerase chain reaction protocol was performed to detect variations of rs5888 and rs4238001. The results were analyzed with the SPSS 22 program and p < 0.05 was considered statistically significant. Results and discussion SR-BI rs4238001 variation did not show significant difference between patient and control group (p > 0.05). In the SR-BI rs5888 variation; normal homozygous CC and heterozygous CT carriers had an average 2-fold lower risk of hypertension than those carrying the TT genotype (p < 0.05). Conclusion SR-BI rs5888 TT variant may increase hypertension risk by reducing lipid transport to the liver from the vessel wall.

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Effort and the Forced Expiratory Volume in One Second (FEV1)

Clinical Science ◽

10.1042/cs0390747 ◽

1970 ◽

Vol 39 (6) ◽

pp. 747-755 ◽

Cited By ~ 6

Author(s):

J. R. Kemm ◽

P. L. Kamburoff

Keyword(s):

Healthy Subjects ◽

Forced Expiratory Volume ◽

The Body ◽

Type I ◽

Type Ii ◽

Type Iii ◽

Significant Difference ◽

Maximum Effort ◽

The Mean ◽

The Relationship

1. The relationship between volumes expired and the maximum intrathoracic pressures developed within the first second of expiration was examined in a group of healthy subjects and patients with airways obstruction who exhaled with varying degrees of effort. 2. The body plethysmographic method was used to ensure that expirations started from total lung capacity. 3. Three different types of volume-effort curves could be distinguished: Type I; in this the volume expired increased with greater effort. Type II; after a phase in which the volume expired increased with effort, a plateau was reached after which increasing effort made no difference to the volume expired. Type III; this resembles Type II except that instead of a plateau being established at maximum expired volume, increasing effort resulted in diminishing expired volume. Correction for the degree of compression of the intrathoracic gas failed to account for this phenomenon. Type III curves were found in healthy subjects as well as in patients. 4. In most cases the maximum Forced Expiratory Volume in 1 s (FEV1) was not found to coincide with the maximum oesophageal pressure (Poes), nor was there a significant difference between the mean and the maximum FEV1 produced with an effort greater than 75% of maximum. 5. Blowing ‘half as hard’ is an unnatural procedure; all subjects tend to blow nearly as hard as possible or very gently. In the latter case, the resulting FEV1 tracing is easily recognizable as technically unsatisfactory. 6. We conclude that for practical purposes, measurements of FEV1 depend for their reliability upon ensuring that they are started from full inspiration; insistence upon maximum effort is less important because FEV1 is independent of effort for the greater part of the effort range.

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The relationship between BMI, leptin, leptin receptors (LepR) and Foxp3+ Tregs cells in women with asthma

Diagnostyka Laboratoryjna ◽

10.5604/01.3001.0008.2513 ◽

2016 ◽

Vol 51 (4) ◽

pp. 277-284

Author(s):

Łukasz Kraszula ◽

Makandjou-Ola Eusebio ◽

Anna Jasińska ◽

Maciej Kupczyk ◽

Piotr Kuna ◽

...

Keyword(s):

Severe Asthma ◽

Leptin Receptor ◽

Control Group ◽

Soluble Receptor ◽

Leptin Receptors ◽

Global Initiative For Asthma ◽

Moderate Disease ◽

Global Initiative ◽

And Control ◽

The Relationship

The aim of this study was evaluation whether there is an association between BMI, leptin and its soluble receptor, the expression of FoxP3 in CD4+ pTreg in women with severe asthma. Materials and methods. The study included thirty women with asthma: 17 patients with severe and 13 with mild-moderate disease. The control group comprised of 25 healthy women. Asthma was diagnosed in accordance with the Global Initiative For Asthma guidelines (GINA 2014). The phenotype of CD4+CD25highCD127lowFoxp3+CD152+ cells was evaluated by multicolor flow cytometry. The concentration of leptin and its soluble receptor were determined using an immunoenzymatic method (ELISA). Results. It has been shown significantly increased leptin concentration in the group of women with severe asthma compared with mild-moderate asthma and control group (p <0.05). The concentration of the leptin receptor significantly increased (p <0.05) in women with severe asthma compared with control group. There were no differences in percentage of CD4+FoxP3+ and CD4+CD25highCD127low- FoxP3+CD152+ subsets after leptin stimulation in all tested groups. Conclusions. Our results don’t confirm the direct effect of leptin on the CD4+ pTreg cells and the expression of FoxP3 in these cells, in tested groups.

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Echocardiographic evaluation of ventricular septal defect haemodynamics

Srpski arhiv za celokupno lekarstvo ◽

10.2298/sarh0710541m ◽

2007 ◽

Vol 135 (9-10) ◽

pp. 541-546

Author(s):

Vesna Miranovic

Keyword(s):

Ventricular Septal Defect ◽

Pulmonary Artery ◽

Body Surface ◽

Septal Defect ◽

Left Ventricular ◽

The Body ◽

Control Group ◽

Healthy Children ◽

And Control ◽

The Relationship

Introduction Ventricular septal defect (VSD) is an opening in the interventricular septum. 30-50% of patients with congenital heart disease have VSD. Objective The aim of the study was to determine the dependence of the left ventricular diastolic dimension (LVD), left ventricular systolic dimension (LVS), shortening fraction (SF), left atrium (LA), pulmonary artery truncus (TPA) on the body surface and compare their values among experimental, control and a group of healthy children. Values of maximal systolic gradient pressure (Pvsd) of VSD were compared with children from one experimental and control group. Method Children were divided into three groups: experimental (32 children with VSD that were to go to surgery), control (20 children with VSD who did not require surgery) and 40 healthy children. Measurements of LVD, LVS, SF, LA, TPA were performed in accordance to recommendations of the American Echocardiographic Association. The value of Pvsd was calculated from the maximal flow velocity (V) in VSD using the following formula: Pvsd=4xV? (mm Hg). Results For children from the experimental group, the relationship between the body surface and the variability of the LVD was explained with 56.85%, LVS with 66.15%, SF with 4.9%, TPA with 58.92%. For children from the control group, the relationship between the body surface and the variability of LVD was explained with 88.8%, LVS with 72.5%, SF with 0.42%, PA with 58.92%. For healthy children, the relationship between the body surface and the variabilitiy of the LVD was explained with 88.8%, LVS with 88.78%, SF with 5.25% and PA with 84.75%. There was a significant statistical difference between average values of Pvsd in the experimental and control group (p<0.02). Conclusion The presence of the large VSD has an influence on the enlargement of LVD, LVS, SF, TPA. The enlargement of the size of the pulmonary artery depends on the presence of VSD and there is a direct variation in the magnitude of the shunt. There is a relationship and significant dependence of the LVS and LVD on the body surface. There is no statistically significant dependence between SF and body surface.

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Mingle Model for Increasing Productive Language Skills and Relationship with Student’s Personality Based on Jung Theory

Ta'lim al-'Arabiyyah: Jurnal Pendidikan Bahasa Arab & Kebahasaaraban ◽

10.15575/jpba.v5i1.12184 ◽

2021 ◽

Vol 5 (1) ◽

pp. 35-51

Author(s):

Suci Ramadhanti Febriani ◽

Wildana Wargadinata ◽

Syuhadak Syuhadak

Keyword(s):

Data Collection ◽

Research Methods ◽

Significant Relationship ◽

Language Skills ◽

Correlation Method ◽

Quantitative Approach ◽

Control Group ◽

Carl Gustav Jung ◽

And Control ◽

The Relationship

This study aims to find the effect of the implemetation of the Mingle Model on productive language skills and the relationship to the personality based on Carl Gustav Jung Theory in Arabic learning at MTsN Batu City, East Java. This research used a quantitative approach by combining the experimental and correlation methods, it was applying the Mingle Model to improve students' productive skills (speaking and writing) which have been divided into two groups; the Experiment and Control group and connected using the correlation method to extroverted and introverted students based on the theory of Carl Gustav Jung. Data collection through questionnaires, tests, and documentation. The results showed that there was a significant relationship to students' productive skills after applying the Mingle Model and there were no significant differences between extroverted and introverted students. This research recommend that the Mingle Model can be applied to improve students' productive skills. This study recommends further research to utilise more varied research methods with more diverse variables.

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Urine CA-2 as a biomarker for diagnosis urinary stone and prediction of its complications

10.21203/rs.3.rs-59394/v1 ◽

2020 ◽

Author(s):

Yuan-jing Leng ◽

Hai-bin Zhou ◽

Jiang-ling Fu ◽

Wen-juan Wang

Keyword(s):

Healthy Subjects ◽

Characteristic Curve ◽

Urinary Stone ◽

Urinary Stones ◽

Enzyme Linked Immunosorbent Assay ◽

Control Group ◽

Healthy Control ◽

The Mean ◽

The Difference ◽

The Relationship

Abstract PURPOSECarbonic anhydrase-2 (CA-2) plays a role in mineralization and calcification in organism. Strong evidence suggests that CA-2 is associated with urolithiasis. However, the relationship between CA-2 and urinary stone remains unclear. The study aimed to assess the association of urine CA-2 (uCA-2) level and the potential risk of urinary stone.METHODSFrom March 2017 to November 2019, a prospective cohort study was conducted on patients with urinary stones and healthy subjects to determine the pretreatment uCA-2 level detection by Enzyme linked immunosorbent assay (ELISA). The difference of uCA-2 level between patients with urinary stones and healthy subjects was compared. Then comparison between stone patients with complications and without complications was carried out as well as correlation analysis to detect factors associated with biomarker expression.RESULTS118 patients with urinary stones were into urinary stones group and 42 healthy subjects were into healthy control group. The mean pretreatment uCA-2 level was significantly higher in patients with urinary stones group than healthy controls group (P=0.028). Furthermore, The uCA-2 level was positive correlation with urinary stones complications (R=0.379, P=0.000), especially pain complications (R=0.524, P=0.000) and hematuria complications (R=0.374, P=0.000). Receiver operating characteristic curve (ROC) analysis that a uCA-2 level threshold of 10.94 ng/mL had 83.67% sensitivity and 68.12% specificity for predicting urinary stones complications. CONCLUSIONSExcessive uCA-2 excretion is a major risk factor for urinary stone. Our findings suggested that uCA-2 may be used as an unappreciated biomarker for the diagnosis urinary stone in patients and to predict its complications.

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Roles of gene transcription and PKA subtype activation in maturation of murine oocytes

Reproduction ◽

10.1530/rep.0.1230799 ◽

2002 ◽

pp. 799-806 ◽

Cited By ~ 13

Author(s):

KF Rodriguez ◽

RM Petters ◽

AE Crosier ◽

CE Farin

Keyword(s):

Gene Transcription ◽

Cumulus Cell ◽

Cumulus Cells ◽

Type I ◽

Type Ii ◽

Germinal Vesicle Breakdown ◽

Series Of Experiments ◽

And Control ◽

Alpha Amanitin

The aims of this study were to examine the role of transcription and the coincident involvement of type I and type II protein kinase A (PKA) in the resumption of meiosis in murine cumulus-oocyte complexes (COCs) using the transcriptional inhibitors 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB) and alpha-amanitin. The first series of experiments was designed to: (i) characterize the role of transcription in gonadotrophin-mediated and spontaneous maturation of murine oocytes; (ii) examine the roles of specific gonadotrophins (FSH versus hCG) and cumulus cells in transcriptionally mediated oocyte maturation; and (iii) determine the reversibility of the transcriptional arrest of meiosis. In the presence of FSH, transcriptional inhibitors arrested germinal vesicle breakdown (GVBD) (DRB: 2 +/- 2% and control: 76 +/- 2%; alpha-amanitin: 4 +/- 4% and control: 70 +/- 4%). Furthermore, cumulus cells were required for transcriptional inhibitors to arrest GVBD (DRB with cumulus cells: 0 +/- 15%; DRB without cumulus cells: 94 +/- 13%; alpha-amanitin with cumulus cells: 15 +/- 2%; alpha-amanitin without cumulus cells: 99 +/- 2%). Thus, in mice, FSH-mediated GVBD uses a transcriptional mechanism, which probably occurs within the cumulus cell compartment. In a second series of experiments, the role of transcription in mediating the resumption of meiosis after activation of either type I or type II PKA was examined. Activation of type I PKA in murine COCs resulted in an arrest of GVBD that was independent of a transcriptional event (with DRB: 7 +/- 9% GVBD; without DRB: 11 +/- 9% GVBD). In contrast, activation of type II PKA resulted in a resumption of meiosis, which required the occurrence of gene transcription (with DRB: 12 +/- 9% GVBD; without DRB: 80 +/- 9% GVBD). As FSH binding to cumulus cells activates the PKA second messenger system, our results indicate that, in cultured murine COCs, FSH binding to cumulus cells results in the activation of type II PKA, which, in turn, mediates a downstream transcriptional event required for the initiation of GVBD.

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Relationship between neutrophil/lymphocyte ratio and epicardial fat tissue thickness in patients with newly diagnosed hypertension

Journal of International Medical Research ◽

10.1177/0300060517749130 ◽

2018 ◽

Vol 46 (3) ◽

pp. 940-950 ◽

Cited By ~ 6

Author(s):

Mehmet Ali Derya ◽

Vahit Demir ◽

Huseyin Ede

Keyword(s):

Blood Pressure ◽

Healthy Subjects ◽

Control Group ◽

Newly Diagnosed ◽

Fat Tissue ◽

Tissue Thickness ◽

Neutrophil Lymphocyte Ratio ◽

Lymphocyte Ratio ◽

Epicardial Fat Tissue ◽

The Relationship

Objective Epicardial fat tissue thickness (EFT) and the neutrophil/lymphocyte ratio (NLR) are associated with atherosclerosis. Few studies have focused on the relationship between these parameters in patients with newly diagnosed hypertension. In this study, we examined the relationship between EFT and the NLR in patients with newly diagnosed hypertension detected by 24-hour ambulatory blood pressure monitoring (ABPM). Methods Eighty consecutive patients without chronic illness who were diagnosed with hypertension according to ABPM results and 80 otherwise healthy subjects were enrolled in the study. EFT of each participant was measured echocardiographically. The C-reactive protein (CRP) concentration and NLR were measured from venous blood samples. Results The 24-hour average systolic blood pressure was significantly higher in the hypertension group than in the control group (143±17 vs. 117±7 mmHg, respectively). There were no significant differences in age, sex, or body mass index between the two groups. EFT, the NLR, and the CRP concentration were significantly higher in the hypertension group than control group. Additionally, a significantly positive correlation between EFT and the NLR was found in both the control group and hypertension group. Conclusion A higher EFT and NLR were detected in patients with newly diagnosed hypertension than in healthy subjects.

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