scholarly journals Study the Immunomodulatory effects of Beta - Glucan in broiler chickens

2012 ◽  
Vol 36 (0E) ◽  
pp. 64-71
Author(s):  
Nidhal Raoof Mahdi

This study was carried out to investigate the immunomodulating activity of β-glucanwhich extracted from the cell wall of Saccharomyces cerevisiae.β-glucan of 225µg/ml wassupplemented in drinking water of broiler chicken vaccinated with Newcastle disease virus(NDV) vaccine. The parameters of the immunomodulating activity employed were the bodyweight, Phagocytic activity and determination of antibody titer to NDV vaccine. Chicks oneday old (120), were divided into four equal groups, G1 treated with β-glucan for six weeksand vaccinated with NDV vaccine; G2 treated with β-glucan for three weeks and vaccinatedwith NDV vaccine; G3 not given β-glucan but vaccinated with NDV vaccine (control group);while G4 was not treated with β-glucan and not vaccinated with NDV vaccine (secondcontrol). The results of the body weight indicated that; there were significant differences (P<0.05) between treated groups (G1 and G2) compared to the control groups (G3 and G4) at21,28 and 35 day of age. The results of phagocytic activity showed that treated group hadsignificantly (P< 0.05) higher clearance of carbon particles from blood circulation than did thecontrol groups; and the antibody titer to NDV showed significant differences (P<0.05)between treated and non treated groups at 14d and 28d. The data presented in this studycontribute for the first time in Iraq; that β –glucan given via drinking water to chicks from dayone for 35 days improves the immune responses and body weight.

2012 ◽  
Vol 3 (2) ◽  
pp. 100-104 ◽  
Author(s):  
SM Kamruzzaman ◽  
SML Kabir ◽  
MM Rahman ◽  
MW IslaM ◽  
MA Reza

The study was carried out to know the effects of probiotics (Proetxin® Boost, Novartis Bangladesh Ltd.) and antibiotic (oxytetracycline-Renamycin®, Renata Animal Health) on growth performances and haemato-biochemical parameters of "Shaver Star Bro" broiler chickens during September and October 2003. A total of 20, day old broilers were randomly selected and assigned into four equal groups n = 5) as A, B, C and D. Group A was considered as control group fed with commercial ration while groups B, C and D were fed with commercial ration with the addition of 200 mg probiotics / liter drinking water, 100 mg probiotics and 50 mg antibiotic (oxytetracycline- Renamycin®) / liter drinking water and 100 mg antibiotic (oxytetracycline- Renamycin®) / liter drinking water respectively up to 35 days of age. The results showed that the body weight gains differed significantly (p < 0.05) at the 2nd, 4th and 5th weeks of age in different treatment groups. The meat yield not differed significantly (p > 0.05). The drumstick, wing differed significantly (p < 0.01) and spleen weight differed at p < 0.05 among different groups. The mean haemato-biochemical values of Hb, ESR, PCV, heterophil, eosinophil, basophil, triglyceride, HDL, LDL, SGPT and SGOT were differed significantly (p < 0.01) in different groups. The present findings suggest that supplementation of probiotics has significant effect on growth performance and certain haemato-biochemical parameters of broiler chickens as compared to antibiotic supplementation.


Author(s):  
L. Gamko ◽  
T. Tarinskaya

It is known that necessary to replace the components of organic acids, which are part of acidifiers when drinking water to poultry in order to prevent the adaptation of microbes in the gastrointestinal tract. In the poultry industry organic acids are widely used, which are used as acidifiers to preserve the properties of water consumed. The purpose of this work was to evaluate the efficiency of broiler meat production when using acidifying agents of drinking water Aquasafe and Veleguard. The experimental part of the work has been performed in JSC “Kurinoe Tsarstvo-Bryansk” broiler area “Roshcha” in the Pochepsky district. The object of research was the livestock of broiler chickens cross Cobb 500 at floor housing. The effect of water acidifiers on meat productivity has been studied. Groups of chickens have been formed on the principle of pairs-analogues. Broiler chickens of experimental groups have been separated from the main livestock by a grid in the corner of the room for 100 heads in each group. It has been found by a result of research to be optimal dose usage of acidifying agents water Aquasafe and Veleguard to drink to broiler chickens. The positive effect of these acidifiers on the digestion of crude protein, crude fat, crude fiber, contributing to the effective use of nitrogen, which led to an increase in the intensity of growth, young animals’ livability and improved feed conversion. Slaughter yield in the control group was 55,1 %, and in the experimental group 57,2 and 58,4 %, which was by 2,1 and 3,3 % higher with the same level of metabolic energy and nutrients. In chickens that consumed acidifi ers more intensively used nutrients feed for deposition in the body of the components of the carcass, which affected the production. A positive impact of acidifying agents Aquasafe and Veleguard on meat quality in broiler chickens has been found.


2020 ◽  
Vol 17 (35) ◽  
pp. 800-812
Author(s):  
Ilgiz DOLININ ◽  
George BAZEKIN ◽  
Evgeny SKOVORODIN ◽  
Almaz SHARIPOV ◽  
Ivan CHUDOV

Poultry farming holds a special place in ensuring the products that the consumers demand, it provides the population with essential food products,such as eggs and meat,that contain vital micro and macronutrients, proteins, lipids, and vitamins. Therefore, the issues of rational, economically feasible feeding of meat poultry, namely broiler chickens, are an urgent task. It is also essential to find effective methods of their application in order to correct the natural resistance and immune and biological reactivity of birds. The purpose of this research is to study the effect of the biological stimulant-Nucleostim on the growth and development of chickens, hematological, and immunological parameters of the blood of birds.This Biostimulant is a purified bovine spleen extract containing at least 1 mg / ml of low molecular weight peptides (nucleotides and nucleosides) formed as a result of autolysis, using dry whey and diatomite as fillers. Onthe application ofNucleostim, the gain in live weight of chickens was increased by 9.7%. At the end of the experiment, the livability of the chicks of the experimental group treated with Nucleostimcame up to 88%, compared with the 72% of the control group. The use of biostimulant had a stimulating effect on the liver of chickens confirmed by the research results presented in the article, as well as contributed to the development of the thymus in the setting of general dystrophy. Thus, it improved chicklivability and increased body weight gain. The biological stimulant-Nucleostim as an adaptogenic, anabolic, and immunostimulatory agent is promising for finding new drugs that improve the health and productivity of poultry.


2010 ◽  
Vol 10 (2) ◽  
pp. 21-26
Author(s):  
Sugito Sugito ◽  
Erdiansyah Rahmi ◽  
Azhari Azhari ◽  
M. Isa

The gain body weight and Spoilage of meat broiler which giving jaloh extract to combine with chromiumABSTRACT. A study was conducted on broiler chickens under heat stress to evaluate the effect of combined jaloh (Salix tetrasperma Roxb) extract with chromium mineral in the body weight, value of feed ratio conversion, and time to meat to become decomposed. Twenty four of 20-day old Cobb female broiler chickens were randomly assigned and divided to 4 treatment groups. Completely randomized design was used in this study. The treatments were as follows: 1) chickens given no heat stress and jaloh extract nor chromium (tCp); 2) chickens under heat stress without given jaloh extract nor chromium (Cp); 3) chickens under heat stress and given jaloh extract in 1.000 mg/lt drinking water (Cp+Ej); and 4) chickens under heat stress, given jaloh extract in 1.000 mg/lt drinking water, and chromium in 1.000 ug/lt drinking water (Cp+Ej+Cr). Heat stress given was 33 ± 1oC of cage temperature during 4 hours per day within 15 days. Jaloh extract and chromium treatments in drinking water were given at 2 hour before cage temperature reaching 33 ± 1oC and were stopped being given after 1 hour, when cage temperature back to room temperature. On the 16th day of the study chickens were measured before slaughtered. Samples obtained were chicken meat that taken from breast part (musculus pectoralis). The result suggested that either giving jaloh extract per se at the dose of 1.000 mg/lt in drinking water or combine it with chromium that given two hours before cage temperature reaching 33 ± 1oC, can prevent chickens from decreasing their body weight, decreasing value of feed ratio convertion, and extending time to meat to become decomposed.


2020 ◽  
Vol 11 (SPL4) ◽  
pp. 2704-2709
Author(s):  
Ranjana Kohli ◽  
Madan L Kaushik ◽  
Jai Parkash Kadian ◽  
Bhupendra Chauhan

The anti-diabetic effect of ethanolic and aqueous extracts of Imperata cylindrical  rhizomes was investigated in alloxan-induced diabeties in rats. Diabetes was induced by a single 150 mg/kg intraperitoneal dose of alloxan. Rats were divided into five groups with six rats in each group i.e. the normal control group, diabetic control group, standard group (glibenclamide, 10mg/kg, p.o.), Test-I group (200 mg/kg ethanolic extract) and Test-II group (200 mg/kg aqueous extract). The above concerned groups were inoculated on 21st day. On the last day of the experiment, fasted rats were killed by cervical dislocation. The body weight was measured at the initial day and final day. The blood samples were collected for estimation of glucose. The loss of body weight in control group, but recovery was observed in drug treated group. The serum glucose level was significant increased in diabetic rats. However, significant improvement was observed in treated group. The biochemical parameters such as HDL and proteins level were decreased in the control group but maintained in drug treated group. LDL, cholesterol, triglyceride creatinine and urea were significant increase in control group however, reduced level in drug treated group. The present study concluded that ethanolic and aqueous extracts of I. cylindrical  rhizome showed an appreciable effect in reducing the hyperglycemia and the complications associated with diabetes. However, aqueous extract is found more significant in decreasing blood glucose level in comparison to the ethanolic extract. The study results justify the traditional use of the plant as anti-diabetic.


Author(s):  
E. B. Umoren ◽  
J. F. Ekpenyong ◽  
O. E. Oyama ◽  
A. O. Obembe

Aim of the Study: This study was undertaken to ascertain if Hibiscus sabdariffa extract can affect the lipid profile (Total cholesterol (TC), triglycerides (TG), high density lipoprotein (HDL), very low density lipoprotein (VLDL), and low density lipoprotein (LDL)) levels in a paracetamol- induced hepatotoxicity using albino Wistar rat as a model. Materials and Methods: Thirty (30) rats used for this study were divided into three groups. Group A (n=10) served as control. Group B (n=10) was administered paracetamol only at a dose of 750 mg/kg body weight. Group C (n=10) was administered paracetamol (dose 750 mg/kg body weight) and aqueous extract of H. sabdariffa (dose 10 ml/kg body weight) of the animal for 3 weeks. All animals were allowed free access to clean drinking water and normal rat chow. Results: Results of the study revealed that TC was significantly lower (p<0.05) in the paracetamol + H. sabdariffa-treated group as compared to paracetamol-treated group and control respectively. Similar trend was observed with TG, VLDL-c, LDL-c and HDL-c. However, the decrease in HDL-c was not statistically significant when compared to control. Conclusion: The presence of bioactive constituents vis; anthocyanins, flavonoids, polyvenols and free radical scavenging properties in H. sabdariffa enabled a hypolipidemic effect on the animals by lowering the levels of serum TG, VLDL-c, LDL-c despite challenge on the liver. However, it was unable to produce significant effect on HDL concentration -very important cholesterol required in high level to maintain homeostasis inside the body. This may be due to the challenge on the liver as a result of the paracetamol abuse.


Author(s):  
Sarah Ibrahim Al Othman, Faten khalif Alanazi, Ghada Jaber S

Monosodium glutamate (MSG) is widely used as a food additive. Excessive consumption of monosodium glutamate has also been shown to affect the liver and kidneys, causing damage to these tissues because of oxidative stress leading to increased production of reactive oxygen species (ROS). The purpose of the study described in this paper was to find out how the liver and kidney toxicity caused by monosodium glutamate can be mitigated using pectin. To this end, 30 albino mice females were divided into four groups. The animals were distributed in special cages. 12-15 weeks with an average body weight of 60 grams. The animals were divided into four groups: the experimental control group (1) comprising 5 female mice were given normal drinking water and the treated group (2) comprising 10 female mice were given monosodium glutamate at a dose of 3 g/kg body weight in drinking water. For three weeks, the treatment group (3) comprising 10 female mice was given pectin at a dose of 300 mg/70 kg body weight in drinking water immediately after the monosodium glutamate dose for three weeks and the pectin group (4) comprising 5 female mice were given Pectin at a dose of 300 mg/70 kg body weight in drinking water for three weeks. The mice were then anesthetized, dissected, and liver and kidney samples were taken from female mice and kept in a 10% neutral formalin solution to make tissue segments. The results showed many histological changes in the liver, such as congestion of the central vein, widening of the sinuses, and the appearance of signs of the death of most hepatocytes, infiltration of the central vein and an invasion of inflammatory cells around the central vein with the emergence of several gaps within the cells. Many of them cavity with the death of most of the tubule cells, the closure of some of them and the expansion and infiltration in others and bleeding inside the tissue. Pectin therapy has led to the disappearance of most of these changes and the emergence of a clear improvement in hepatic and renal tissue.


2004 ◽  
Vol 18 (2) ◽  
pp. 105-109 ◽  
Author(s):  
Lara Cristina Picoli ◽  
Ii-Sei Watanabe ◽  
Ruberval Armando Lopes ◽  
Miguel Angel Sala ◽  
Fábio Picoli

Cadmium (Cd) present in the air, drinking water and food has the potential to affect the health of people, mainly those who live in highly industrialized regions. Cd affects placental function, may cross the placental barrier and directly modify fetal development. It is also excreted into milk. The body is particularly susceptible to Cd exposure during perinatal period. The effect on rat oral epithelium (floor of the mouth) after continuous exposure to drinking water containing low levels of Cd during lactation was studied. Female rats were supplied with ad libitum drinking water containing 300 mg/l of CdCl2 throughout the whole lactation period. Control animals received a similar volume of water without Cd. Lactating rats (21 day-old) were killed by lethal dose of anesthetic. The heads were retrieved, fixed in "alfac" solution (alcohol, acetic acid and formaldehyde) for 24 h, serially sectioned in frontal plane, at the level of the first molars. The 6 µm sections were then stained with hematoxylin and eosin. Nuclear epithelium parameters were estimated, as well as cytoplasm and cell volume, nucleus/cytoplasm ratio, numeric and surface densities, and epithelial thickness. Mean body weight was 34.86 g for the control group and 18.56 g for the Cd-treated group. Histologically, the floor of the mouth epithelium was thinner in the treated group, with smaller and more numerous cells. In this experiment, Cd induced epithelial hypotrophy, indicating a direct action in oral mucosa cells, besides retarded development of the pups.


2018 ◽  
Vol 25 (01) ◽  
pp. 50-57
Author(s):  
Sadia Sundus ◽  
Nazia Qamar ◽  
Raheela Adil ◽  
Muhammad Faisal Fahim

Objective: To observe the absolute, relative weight of kidney and body weightof albino rats on celecoxib induced kidney with protection by lycopene. Study Design:Experimental study. Place and Duration of study: This study was conducted in BMSI (Anatomydepartment), JPMC, Karachi, from 4th May 2015 to 3rd June 2015. Materials and Methods: Fortyhealthy adult, male Albino rats, 90-120 days old, weighing 200-220gm was taken for the study.The rats were divided into 4 groups, Group A was control group, Group B receive Celecoxib 50mg/kg body weight orally, Group C receive Celecoxib 50 mg/kg body weight orally along withlycopene50 mg/kg body weight orally and Group D receive lycopene 50 mg/kg body weightorally for 30 days. At the end of study rats were sacrificed and renal tissue sections were stainedwith hematoxylin and eosin. Results: Markedly decreased weight was observed in rats takingcelecoxib. Slides which were stained with hematoxylin and eosinshowed general architecture ofrenal parenchyma, shape and arrangement of epithelial cells. Apoptosis, hemorrhage, necrosisand vacuolation seen in Celecoxib group, whereas renal architecture were ameliorated andreverted back in celecoxib along with lycopene receiving group. Conclusion: This studyconcludes that lycopene restored the body weight, absolute and relative kidney weight incelecoxib treated group.


2021 ◽  
Author(s):  
Nilce Maria Soares ◽  
Edna Clara Tucci ◽  
Gustavo Perdoncini ◽  
Ricardo Della Matta Junior

Abstract BackgroundMite infestations in laying hens can cause losses to producers due to stress, reduced egg production and even death of birds. A new species of mite, Allopsoroptoides galli (A. galli), Analgoidea: Psoroptoididae, was recently identified in commercial laying farms in Brazil, causing damage due to its highly aggressive infestation that results in a sharp drop in egg production and culling. The present study evaluated the acaricidal action of a formulation containing fluralaner (Exzolt®) against A. galli.Methods The study was carried out from November 2019 to January 2020. Thirty-four laying hens naturally infested with A. galli were equally divided into a fluralaner-treated group and an untreated control group. The fluralaner-treated group received Exzolt® in drinking water at a dose of 0.05 mL/kg body weight (equivalent to 0.5 mg fluralaner/kg body weight), twice, seven days apart. Both groups were followed for 70 days evaluating the level of infestation by counting mites in skin scrapings and assessment of skin lesions.Results The average mite count of the treated group decreased significantly, dropping from 61.6 to 3.8 mites (D+7 to D+70). The efficacy progressively increased on subsequent days, reaching 98.8% on day +56 post-treatment and 96.9% on day +70. Recovery of skin lesions was observed after administration of Exzolt®, showing a marked remission in the degree of lesions (2.5 on day -14 to 0.2 on day +70). The mean number of mites in the untreated control group ranged from 79.3 to 124.1 and the lesion score from 2.6 to 2.9, thus remaining stable throughout the study.Conclusion The results obtained in the present study demonstrated that Exzolt® administered at a dose of 0.05 mL of product/kg body weight (equivalent to 0.5 mg of fluralaner/kg body weight), twice at a seven-day interval, in drinking water was effective in the treatment of the mite Allopsoroptoides galli in naturally infested laying hens.


Sign in / Sign up

Export Citation Format

Share Document