scholarly journals Assessing the Impact of Technological Factors on the Stability of Liposomes the Photosensitizer Phthalocyanine Series

2019 ◽  
Vol 8 (2) ◽  
pp. 66-73
Author(s):  
T. A. Timofeeva ◽  
M. V. Dmitrieva ◽  
L. L. Nikolaeva ◽  
O. L. Orlova ◽  
N. A. Oborotova ◽  
...  
Keyword(s):  
Practical Importance ◽  
Biologically Active ◽  
Liposomal Form ◽  
Liposomal Preparation ◽  
Ζ Potential ◽  
Technological Factors ◽  
Stage Of Development ◽  
The Stability ◽  
The Impact ◽  
Liposomal Dispersion

Introduction.Liposomal technologies are widely used in medicine and cosmetology as a delivery system for diagnostic and medicinal products and biologically active substances. The undoubted practical importance at the stage of development of a liposomal preparation is represented by the characteristic and assessment of the sustainability of the obtained product, and special attention is paid to the study of the latter. Essentially, the methods for their preparation affect the stability of liposomes; therefore, the study of the influence of technological factors on the properties of the product at various stages of the preparation of liposomes is very important. This article is devoted to the study of the dependence of the quality of liposomes loaded with a phthalocyanine photosensitizer – thiosens, on the conditions of their production.Aim.Detection of the influence of various technological factors on the stability indicators of the liposomal form of the thiosens photosensitizer.Materials and methods.For this purpose, an analysis of the average size, polydispersity and zeta (ζ) potential of the liposomes of thiosens obtained at the stage of hydration of the lipid film, filtration of the liposomal dispersion, its extrusion, homogenization, ultrasonic treatment, and lyophilization was carried out.Results and discussion.During the preparation of a liposomal preparation, various changes in conditions can be made within the framework of the technological process. At each stage of obtaining a liposomal form, there are many critical points and parameters that must be strictly monitored and controlled. In the course of the work, the influence of technological factors on the stability of liposomal intermediate and finished products was assessed. The conditions of the most effective hydration with the formation of a stable dispersion of multilayer liposomes of thiosens and the optimal method of their grinding have been determined. It was also shown that liposomes formed after rehydration of the lyophilisate are more uniform in size and have the highest ζ-potential value in comparison with non-lyophilized liposomal dispersion.Conclusion.Using the example of a thiosens phthalocyanine photosensitizer liposomes, the influence of various technological factors on the stability of this nanostructure is shown, therefore, the characteristic and assessment of the sustainability of the resulting product according to 3 main indicators – vesicle size, polydispersity index, and ζ-potential are of undoubted practical importance.

scholarly journals THE PROBLEM OF TENSION AND CONFLICT INTER-ETHNIC INTERACTION IN TODAY'S WORLD

2020 ◽  
Vol 3 (4) ◽  
pp. 40-54
Author(s):  
Svetlana V. Murasheva
Keyword(s):  
Social Relations ◽  
Practical Importance ◽  
National Policy ◽  
Practical Significance ◽  
Modern World ◽  
Ethnic Conflicts ◽  
Important Place ◽  
Stage Of Development ◽  
Interethnic Interaction ◽  
The Impact

The urgency of the problem of studying the tension and conflict of interethnic interaction in the modern world is caused by the prevalence of negative opinions and stereotypical attitudes in society about persons belonging to ethnic groups different from Russian, the rapidly growing alienation of nations, the injustice of the administrative and territorial hierarchy of peoples, facts of ethnophobia and xenophobia. The ethnic component is becoming key and decisive in the social and political life of our country and causes inter-ethnic tensions and conflicts. At the current stage of development of social relations, there is an urgent need to develop and further introduce a system of prevention and resolution of inter-ethnic conflicts, which would be based on the Concept of State National Policy. Consolidation of society in order to solve national problems should be identified as a priority in the Concept of State National Policy. Due to these circumstances, research into the tensions and conflicts of inter-ethnic interaction has conceptual and practical significance, attracts the close attention of researchers from various fields of scientific knowledge and encourages them to develop and implement effective ways of preventing and settling conflicts of this type. The aim of the article was to present the results of the study of interethnic tensions and conflicts in the modern world. An important place is given to the impact of interethnic conflicts on the development of social relations. The scientific novelty of the provisions proposed in the article is the study of the peculiarities of interethnic interaction and conflicts. Practical importance lies in the possibility of using the findings of the article to develop programmes for preventing and settling inter-ethnic conflicts.

scholarly journals Research on the Side Deflection of the Saw Band of a Joinery Band Saw Influenced by the Selected Technical and Technological Factors

2020 ◽  
Vol 28 (3) ◽  
pp. 148-153
Author(s):  
Jozef Krilek ◽  
Tomáš Kuvik ◽  
Ján Kováč ◽  
Ján Melicherčík
Keyword(s):  
Tensile Stress ◽  
Work Productivity ◽  
Theoretical Assumption ◽  
Technological Factors ◽  
Cutting Rate ◽  
The Stability ◽  
Band Saw ◽  
The Cost ◽  
The Impact

AbstractThe paper focuses on measuring and evaluating the impact of selected technical and technological factors -the height of adjustable guides and stretching force - on the side deflection of the saw band of a joinery band saw. There is a detailed description of the ways the side deflection can be measured. In order to find out the intensity of the stretching force was used portable tension meter SANDVIK 5000, enabling to check the tensile stress in the saw blades of a gang saw or in the saw bands of a band saw. The actual experiment was conducted on a joinery band saw, at the cutting rate vc = 15 m·s-1. The results of the measurements confirmed the theoretical assumption of the impact of the selected technical and technological factors on the stability of the saw band, where the side deflection decreases with increasing stretching force and increases with increasing height of the guides. The stability of the saw band affects the quality of the surface to be treated, thus saving the cost of machining the workpiece and making work productivity more efficient.

scholarly journals The Impact of Structural Factors on the Financial Stability of European Pension Systems

2021 ◽  
Vol 106 (6) ◽  
pp. 120-132
Author(s):  
Irina Bitkina ◽  
Keyword(s):  
Financial Stability ◽  
Negative Impact ◽  
European Countries ◽  
Structural Factors ◽  
Pension Policy ◽  
Pension Systems ◽  
Stage Of Development ◽  
The Stability ◽  
State Pension ◽  
The Impact

The study presents an assessment of the impact of structural factors on the financial stability of pension systems in European countries. The purpose of the study is to determine the internal structural factors that have the most significant impact on the financial stability of pension systems in European countries. A review of the scientific literature dealing with the study of the financial stability of European pension systems is carried out. The correlation between the concepts of "financial stability" and "financial resiliency" is determined, the structural factors of pension models are identified and their grouping is carried out. The ranking of European pension systems by the level of their stability (including periods of financial crises) is carried out. The reasons for the decline in the stability and resiliency of European pension systems at this stage of development are identified. The study shows the internal structural factors that have a positive or negative impact on the degree of financial stability and financial resiliency of European pension systems. The conclusions obtained in the study can be used in the formation of the state pension policy of European countries and the choice of directions for reforming pension systems

scholarly journals The Legal Stability as a Factor of Economic and Financial Market Growth: Russia, USA and China

2020 ◽  
Author(s):  
Roman Chikulaev
Keyword(s):  
Global Economy ◽  
Objective Evaluation ◽  
Impact Factors ◽  
Fixed Costs ◽  
Legal Systems ◽  
Market Growth ◽  
Leading Role ◽  
Stage Of Development ◽  
The Stability ◽  
The Impact

Global economy, financial markets and technology are on the verge of moving to a new stage of development – information society. Three major world countries the US, Russia and China will play a leading role in this process. However, the specific development path will depend on many factors, including the stability of legal systems, security of computer and financial technologies, the effectiveness of legislation. The focus of this article is to assess the current condition of the economy the major countries, to identify trends and methods of stabilization of legal systems on the basis of balance of rights and obligations of the business, suggest some methods of objective evaluation of the impact factors of the total taxes, fixed costs and the legal system dynamics on financial indicators.

Dietary Vitamin and Stability of Oral Anticoagulation: Proposal of a Diet with Constant Vitamin K1 Content

1997 ◽  
Vol 77 (03) ◽  
pp. 504-509 ◽  
Author(s):  
Sarah L Booth ◽  
Jacqueline M Charnley ◽  
James A Sadowski ◽  
Edward Saltzman ◽  
Edwin G Bovill ◽  
...  
Keyword(s):  
Dietary Intake ◽  
Vitamin K ◽  
High Performance ◽  
Case Reports ◽  
Food Composition ◽  
Dietary Guidelines ◽  
Dietary Vitamin ◽  
Vitamin K1 ◽  
The Stability ◽  
The Impact

SummaryCase reports cited in Medline or Biological Abstracts (1966-1996) were reviewed to evaluate the impact of vitamin K1 dietary intake on the stability of anticoagulant control in patients using coumarin derivatives. Reported nutrient-drug interactions cannot always be explained by the vitamin K1 content of the food items. However, metabolic data indicate that a consistent dietary intake of vitamin K is important to attain a daily equilibrium in vitamin K status. We report a diet that provides a stable intake of vitamin K1, equivalent to the current U.S. Recommended Dietary Allowance, using food composition data derived from high-performance liquid chromatography. Inconsistencies in the published literature indicate that prospective clinical studies should be undertaken to clarify the putative dietary vitamin K1-coumarin interaction. The dietary guidelines reported here may be used in such studies.

Experimental Study of the Impact of Alisma plantago-aquatica Secretions on Pathogenic Bacteria

2014 ◽  
Vol 1 (3) ◽  
pp. 3-7
Author(s):  
O. Zhukorskyy ◽  
O. Hulay
Keyword(s):  
Pathogenic Bacteria ◽  
Initial Density ◽  
Biologically Active ◽  
Erysipelothrix Rhusiopathiae ◽  
Natural Focus ◽  
Test Species ◽  
Popula Tions ◽  
And Control ◽  
The Impact

Aim. To estimate the impact of in vivo secretions of water plantain (Alisma plantago-aquatica) on the popula- tions of pathogenic bacteria Erysipelothrix rhusiopathiae. Methods. The plants were isolated from their natural conditions, the roots were washed from the substrate residues and cultivated in laboratory conditions for 10 days to heal the damage. Then the water was changed; seven days later the selected samples were sterilized using fi lters with 0.2 μm pore diameter. The dilution of water plantain root diffusates in the experimental samples was 1:10–1:10,000. The initial density of E. rhusiopathiae bacteria populations was the same for both experimental and control samples. The estimation of the results was conducted 48 hours later. Results. When the dilution of root diffusates was 1:10, the density of erysipelothrixes in the experimental samples was 11.26 times higher than that of the control, on average, the dilution of 1:100 − 6.16 times higher, 1:1000 – 3.22 times higher, 1:10,000 – 1.81 times higher, respectively. Conclusions. The plants of A. plantago-aquatica species are capable of affecting the populations of E. rhusiopathiae pathogenic bacteria via the secretion of biologically active substances into the environment. The consequences of this interaction are positive for the abovementioned bacteria, which is demon- strated by the increase in the density of their populations in the experiment compared to the control. The intensity of the stimulating effect on the populations of E. rhusiopathiae in the root diffusates of A. plantago-aquatica is re- ciprocally dependent on the degree of their dilution. The investigated impact of water plantain on erysipelothrixes should be related to the topical type of biocenotic connections, the formation of which between the test species in the ecosystems might promote maintaining the potential of natural focus of rabies. Keywords: Alisma plantago-aquatica, in vivo secretions, Erysipelothrix rhusiopathiae, population density, topical type of connections.

Innovative approaches to the correction of chronotrope status of pregnant and lactating women

2016 ◽  
pp. 37-40
Author(s):  
S.I. Zhuk ◽  
◽  
K.K. Bondarenko ◽  
Keyword(s):  
Folic Acid ◽  
Neural Tube ◽  
Active Form ◽  
Biologically Active ◽  
Lactating Women ◽  
Pathological Conditions ◽  
Prevention And Treatment ◽  
The Impact ◽  
High Bioavailability ◽  
Key Words Mthfr

Most recent studies show the impact of violations in the metabolism of folate and metin period in the pathogenesis of neural tube defects (NTD) of the fetus. Metafolin has a number of advantages, which primarily includes direct intake of substances in biologically active form and the optimum effect, even in the case when the patient homozygote and/or heterozygote genotype 677С T polymorphism in MTHFR. With the aim of prevention and treatment of various pathological conditions related to folate deficiency during pregnancy, it is advisable to apply vitamin-mineral complexes, containing metafolin - active form of folate with high bioavailability. Key words: MTHFR, metafolin, folic acid, pregnancy.

IMPACT OF GOVERNMENT DEBT ON FINANCIAL SECURITY OF UKRAINE

2017 ◽  
Author(s):  
Olena Pikaliuk ◽  
◽  
Dmitry Kovalenko ◽  
Keyword(s):  
Economic Development ◽  
Public Debt ◽  
Positive Impact ◽  
The State ◽  
Financial Security ◽  
State Budget ◽  
The Public ◽  
Debt Security ◽  
The Stability ◽  
The Impact

One of the main criteria for economic development is the size of the public debt and its dynamics. The article considers the impact of public debt on the financial security of Ukraine. The views of scientists on the essence of public debt and financial security of the state are substantiated. An analysis of the dynamics and structure of public debt of Ukraine for 2014-2019. It is proved that one of the main criteria for economic development is the size of public debt and its dynamics. State budget deficit, attracting and using loans to cover it have led to the formation and significant growth of public debt in Ukraine. The volume of public debt indicates an increase in the debt security of the state, which is a component of financial security. Therefore, the issue of the impact of public debt on the financial security of Ukraine is becoming increasingly relevant. The constant growth and large amounts of debt make it necessary to study it, which will have a positive impact on economic processes that will ensure the stability of the financial system and enhance its security.

Problems of Implementation of an Import Substitution Policy in the Oil Industry

2019 ◽  
pp. 50-57
Author(s):  
Yu. V. Vertakova ◽  
A. S. Evtyukhin
Keyword(s):  
Import Substitution ◽  
Oil Industry ◽  
Investment Climate ◽  
Scientific Publications ◽  
Stage Of Development ◽  
Current Economic Situation ◽  
Negative Effect ◽  
Substitution Policy ◽  
Investment Process ◽  
The Impact

The presented study addresses the issues of implementation of an import substitution policy in the Russian oil industry. Support of domestic production is a key objective specified in the message of the President of the Russian Federation in 2019. In light of the current economic situation and considering the importance of the oil industry for the Russian economy, an import substitution policy could help achieve the objective set by the President.Aim. The study aims to identify the problems and ways of implementation of an import substitution policy in the Russian oil industry.Tasks. The authors analyze scientific publications on import substitution and the state of the Russian oil industry at the current stage of development; determine the directions and fundamental trends in the development of the oil industry; identify obstacles that hinder the implementation of an import substitution policy in the oil industry; describe conditions that facilitate the development of the  investment process in the oil industry; propose comprehensive methods and ways to intensify investments and optimize costs for enterprises in the oil industry.Methods. This study uses general scientific methods of cognition, comparative and statistical analysis to identify problems in the implementation of an import substitution policy in the oil industry.Results. Examination of the current state and development prospects of the oil industry allows the authors to identify obstacles to the development of import substitution. The study shows their impact on the potential of import substitution, which has a negative effect on the prospects of intensification of investment processes, and proposes comprehensive methods and mechanisms that could neutralize the impact of the identified obstacles, thus facilitating the formation of a positive investment climate. Conclusions. Investment climate is shown to have a decisive impact on the potential of import substitution in the Russian oil industry, and ways of overcoming negative trends in the development of the oil industry are proposed.

Influence of internal and external risks on sustainability of financial system of Аltai krai

2018 ◽  
Vol 35 (4) ◽  
pp. 133-136
Author(s):  
R. N. Ibragimov
Keyword(s):  
Sustainable Development ◽  
Financial Stability ◽  
Management Strategy ◽  
Financial System ◽  
Risk Management Strategy ◽  
The Sustainable Development ◽  
The Stability ◽  
The Impact

The article examines the impact of internal and external risks on the stability of the financial system of the Altai Territory. Classification of internal and external risks of decline, affecting the sustainable development of the financial system, is presented. A risk management strategy is proposed that will allow monitoring of risks, thereby these measures will help reduce the loss of financial stability and ensure the long-term development of the economy of the region.

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