scholarly journals COMPARISON OF EFFECTS OF MASSAGE THERAPY ALONE AND IN COMBINATION WITH GREEN COCONUT WATER THERAPY ON Β-ENDORPHIN LEVEL IN TEENAGE GIRLS WITH DYSMENORRHEA

2017 ◽  
Vol 3 (4) ◽  
pp. 412-419
Author(s):  
Fitria Hikmatul Ulya ◽  
Agus Suwandono ◽  
Ida Ariyanti ◽  
Ari Suwondo ◽  
Suryati Kumorowulan ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Rating Scale ◽  
Therapy Group ◽  
Massage Therapy ◽  
Coconut Water ◽  
Bivariate Analysis ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Menstrual Pain ◽  
Teenage Girls

Background: Dysmenorrhea is pain during menstruation in lower abdomen, and is not due to other diseases. Effleurage massage and consuming green coconut water are considered able to reduce menstrual pain. However, little is known about the effect of the combination between the two interventions.Objective: To compare the effectiveness of effleurage massage and in combination with green coconut water on pain, anxiety, and ß-endorphin level in teenage girls with menstrual pain (dysmenorrhea).Design: A quasy experiment with pretest-posttest approach design with control group. There were 36 samples recruited in this study by purposive sampling, which were divided into a massage therapy group, the combination therapy group, and a control group. Menstrual pain was measured using Numeric Rating Scale, while anxiety was measured using Zung Self rating Anxiety Scale (ZSAS), and endorphin level using ELISA (Enzyme-Linked Immunosorbent Assay). One way anova test and repeated anova were performed as a bivariate analysis. Mancova and post hoc anova were used for multivariate analysis.Result: The combination of massage and green coconut water was more effective in reducing pain (p 0.013) and anxiety levels (p 0.000), and in increasing β-endorphin  (p 0.029) with significant value of <0.05 compared to the massage therapy alone.Conclusion: The combination of effleurage massage and green coconut water had significant effect in decreasing anxiety and pain levels, and increasing β-endorphin levels in teenage girls with painful periods (dysmenorrhea); and more effective than performing effleurage massage only. It is suggested that this combination therapy could be used as an alternative therapy for women with dysmenrrohea.

scholarly journals The Administration Of Red Fruit Extract (Pandanus Conoideus Lamk.) To Reduce Menstrual Pain Among Adolescent Girls

2021 ◽  
Vol 5 (1) ◽  
pp. 72
Author(s):  
Cory Chorajon Situmorang ◽  
Ni Nyoman Sri Artina Dewi
Keyword(s):  
Rating Scale ◽  
Univariate Analysis ◽  
Intervention Group ◽  
Numeric Rating Scale ◽  
Pain Scale ◽  
Bivariate Analysis ◽  
Control Group ◽  
Menstrual Pain ◽  
Fruit Extract ◽  
Two Samples

Menstrual pain or dysmenorrhea is felt by many young women and this can hinder their activities, including learning tasks at school and at home. Therefore, alternatives to overcome pain are always being developed, one of which in this study is the red fruit extract which is known to contain vitamin E with tocopherol as a substance that can inhibit inflammation. Using a pre- and posttest design, this study was divided into two samples (respondents), namely the intervention group by giving red fruit extract for 3 menstrual cycles and the control group that was without treatment. This study used measuring instrument in form of the observation sheet and a numeric rating scale (NRS) 0-10 for pain scale. Processing and data analysis used the SPSS program through editing, coding, scoring, and tabulating activities. Data were analyzed using univariate analysis and bivariate analysis with independent smaple t-test, Kolmogorov Smirnov and Mann-Whitney. The results obtained were that there was a change in the majority of respondents in the intervention group from the majority of pain in the moderate category to the mild category. These results were significantly different when looking at the results in the control group. Therefore, red fruit extract is recommended to be a useful alternative in reducing menstrual pain.

scholarly journals EFFECT OF CARICA PAPAYA L LEAF ON MENSTRUAL PAIN AND PROSTAGLANDIN LEVEL IN ADOLESCENT WITH PRIMARY DYSMENORRHEA: A TRUE EXPERIMENT

2017 ◽  
Vol 3 (3) ◽  
pp. 198-204
Author(s):  
Siska Nurul Abidah ◽  
Soeharyo Hadisaputro ◽  
Runjati Runjati ◽  
Syarief Thaufik Hidayat ◽  
Ari Suwondo ◽  
...  
Keyword(s):  
Leaf Extract ◽  
Carica Papaya ◽  
Rating Scale ◽  
T Test ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Primary Dysmenorrhea ◽  
Menstrual Pain ◽  
Prostaglandin Level ◽  
Experimental Group

Background: Primary dysmenorrhea occurs because of the excessive amount of prostaglandins in the blood. Papaya leaf extract is considered to be able to reduce prostaglandin and menstrual pain.Objective: This study aims to prove that papaya leaf extract (Carica Papaya L.) can decrease the level of menstrual pain and prostaglandin levels in primary dysmenorrhea.Methods: A true experimental study with randomized pretest posttest control group design. There were 32 samples recruited using simple random sampling, with 16 each assigned to an experiment and control group. Numerical Rating Scale (NRS) was used to measure menstrual pain, and the level of prostaglandin was measured using the enzyme-linked immunosorbent assay (ELISA) method. Independent t-test and paired t-test were performed for data analysis.Results: There was statistically significant differencec of menstrual pain and prostaglandin level before and after intervention with p-value 0.000 (<0.005), which indiciated that papaya leaf extract had a significant effect on reducing menstrual pain. The decrease of menstrual pain in the experimental group was -3.375 and in the control group was -3.438; while the decrease of prostaglandin level in the experimental group was -56.971 and in the control group was -57.557.Conclusion: Provision of papaya leaf extract (Carica Papaya L.) significantly decreased the level of menstrual pain and prostaglandin levels in primary dysmenorrhea. Papaya leaf extract can be used as a safe and effective herbal medicine for primary dysmenorrhoea which has almost the same efficacy as mefenamic acid.

scholarly journals Dominican Children with HIV Not Receiving Antiretrovirals: Massage Therapy Influences their Behavior and Development

2008 ◽  
Vol 5 (3) ◽  
pp. 345-354 ◽  
Author(s):  
Maria Hernandez-Reif ◽  
Gail Shor-Posner ◽  
Jeannette Baez ◽  
Solange Soto ◽  
Rosangela Mendoza ◽  
...  
Keyword(s):  
Therapy Group ◽  
Massage Therapy ◽  
Control Group ◽  
Normal Functioning ◽  
Alternative Interventions ◽  
Self Help ◽  
Play Session ◽  
Negative Thoughts ◽  
Very High ◽  
Hiv Aids

Forty-eight children (Mage = 4.8 years) infected with HIV/AIDS and living in the Dominican Republic were randomly assigned to a massage therapy or a play session control group. The children in the massage therapy group received two weekly 20-min massages for 12 weeks; the children in the control group participated in a play session (coloring, playing with blocks) for the same duration and length as the massage therapy group. Overall, the children in the massage therapy group improved in self-help abilities and communication, suggesting that massage therapy may enhance daily functioning for children with HIV/AIDS. Moreover, the HIV infected children who were six or older also showed a decrease in internalizing behaviors; specifically depressive/anxious behaviors and negative thoughts were reduced. Additionally, baseline assessments revealed IQ equivalence below normal functioning for 70% of the HIV infected children and very high incidences of mood problems (depression, withdrawn) for 40% of the children and anxiety problems for 20% of the children, suggesting the need for better monitoring and alternative interventions in countries with limited resources to improve cognition and the mental health status of children infected with HIV/AIDS.

scholarly journals Spiritual relaxation to reduce dysmenorrhea: a quasy experimental

MEDISAINS ◽  
2020 ◽  
Vol 17 (3) ◽  
pp. 57
Author(s):  
Qurota A'yun ◽  
Mukhoirotin Mukhoirotin
Keyword(s):  
Rating Scale ◽  
Early Mobilization ◽  
Sampling Technique ◽  
Numeric Rating Scale ◽  
Control Group ◽  
Relaxation Techniques ◽  
Menstrual Pain ◽  
Control Group Design ◽  
And Control ◽  
Numeric Rating

Background: The dysmenorrhea prevalence is still reported high in the world. Several previous studies discovered that deep breathing relaxation effectively reduced dysmenorrhea. Other studies presented the combination of early mobilization and spiritual relaxation could reduce the level of client pain postoperative appendectomy, however the effectiveness of spiritual relaxation techniques to reduce dysmenorrhea is not yet tested.Objective: to determine the effect of spiritual relaxation to reduce dysmenorrhea.Method: The research design used was Quasi Experiment with the pretest-posttest Control Group Design approach. The populations were female students who experienced menstrual pain (dysmenorrhea) and met the inclusion and exclusion criteria. The variable in this study was dysmenorrhea. The sampling technique was simple ramdom sampling consisted of 44 respondents. The calculation instrument was NRS (Numeric Rating Scale) and data were analyzed through statistical test of Paired T-Test and Independent T-Test.Results: After spiritual relaxation treatment, the intensity of menstrual pain reduced significantly from 6.05 - 1.77, it proved that there was an effect of spiritual relaxation on dysmenorrhea with a significant value (ρ) of 0.000 (p ≤ 0.05). There were significant differences in the intensity of menstrual pain in the intervention and control groups (1.77 ± 1,109 vs 5.63 ± 0.445; p> 0.05).Conclusion: Spiritual relaxation effectively reduces dysmenorrhea

scholarly journals Adjunctive Subantimicrobial Dose Doxycycline in the Treatment of Chronic Periodontitis in Type 2 Diabetic Patients: A Unique Combination Therapy

2018 ◽  
Vol 22 (1) ◽  
pp. 32-37
Author(s):  
Marwa Abdelhakim Gomaa ◽  
Hoda Mohamed El Guindy ◽  
Enas Arafa El-Zamrany
Keyword(s):  
Combination Therapy ◽  
Chronic Periodontitis ◽  
Gingival Crevicular Fluid ◽  
Test Group ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Clinical Benefits

Summary Background/Aim: To evaluate the effectiveness of combination therapy including subantimicrobial dose doxycycline (SDD) and locally delivered doxycycline (LD) as adjuncts to scaling and root planing (SRP) in the treatment of chronic periodontitis in patients with type 2 diabetes mellitus (T2DM). Material and Methods: Forty patients with controlled T2DM (HbA1c ≤7%) and chronic periodontitis were selected. They were randomly divided into two groups, twenty patients each: Test group (TG, n=20) patients was treated with combination therapy of full mouth SRP, LD gel 10% and SDD 20 mg twice daily for 6 months. Control group (CG, n=20) patients was treated with full mouth SRP only. The periodontal parameters were recorded at baseline, 3, 6 and 9 months and included periodontal probing depth (PD), clinical attachment level (CAL), and bleeding on probing (BOP). Gingival crevicular fluid (GCF) samples were collected and a quantitative measurement of matrix metalloproteinase-8 (MMP-8) was carried out by using Enzyme-Linked Immunosorbent Assay (ELIZA) at baseline, 3, 6 and 9 months. Results: Statistically significant reduction in all clinical parameters (PPD, CAL, and BOP) was observed at TG over CG at 3, 6, and 9 months (p<0.05). Moreover, combination therapy provided significant reductions in the amount of GCF MMP-8 for the TG compared to CG at 3, 6, and 9 months evaluation period (p<0.05). Conclusions: Combination therapy including SRP, SDD, and LD, provided significantly greater clinical benefits than SRP alone in the treatment of chronic periodontitis in patients with controlled T2DM.

scholarly journals PENGARUH WILLIAM FLEXION EXERCISE TERHADAP PENURUNAN INTENSITAS NYERI HAID (DYSMENORRHEA) PADA SISWI SMAN 7 KOTA MALANG

2019 ◽  
Vol 9 (1) ◽  
pp. 39
Author(s):  
Jaenal Abidin ◽  
Supriyadi Supriyadi ◽  
Mulyani Surendra
Keyword(s):  
Rating Scale ◽  
Sampling Technique ◽  
Control Group ◽  
Pain Rating ◽  
Menstrual Pain ◽  
Control Group Design ◽  
Group Design ◽  
Equivalent Control ◽  
Numeric Pain Rating Scale ◽  
Pain Rating Scale

AbstrakTujuan penelitian ini untuk mengetahui pengaruh William Flexion Exerciseterhadap penurunan intensitas nyeri haid. Penelitian ini menggunakan rancanganeksperimen semu dengan desain non equivalent control group design. Populasi dalampenelitian ini adalah seluruh siswi kelas XI SMAN 7 Kota Malang yang mengalaminyeri haid yang berjumlah 143 orang. Sampel yang diambil 20 orang untuk masingmasingkelompok. Teknik pengambilan sampel menggunakan purposive sampling.Instrumen yang digunakan yaitu Numeric Pain Rating Scale (NPRS). Hasil ujiANOVA diperoleh nilai p = 0,006. Berdasarkan hasil analisis data dapat disimpulkanbahwa terdapat pengaruh William Flexion Exercise terhadap penurunan intensitasnyeri haid (Dysmenorrhea) antara kelompok eksperimen dan kelompok kontrol padasiswi SMAN 7 Kota Malang.Kata Kunci: nyeri haid, william flexion exerciseAbstractThe purpose of this study was to determine the effect of william flexion exerciseon decreasing the intensity of menstrual pain. This study used quasy experimentaldesign with a non equivalent control group design. The population in this study wereall XI of SMAN 7 Malang City who experienced 143 people. Samples were taken by 20people for each group. The sampling technique used purposive sampling instrument.Used is the Numeric Pain Rating Scale (NPRS). ANOVA test results obtained values p= 0,006. Based on the reluts of data analysis it can be concluded that there are in theinfluence of william flexion exercise on the decrease in menstrual pain intensity(Dysmenorrhea) between control group on female students of SMAN 7 Malang City.Keywords: dysmenorrhea, william flexion exercise

scholarly journals Mengurangi Nyeri Persalinan dengan Teknik Birthing Ball

2019 ◽  
Vol 2 (3) ◽  
pp. 129
Author(s):  
Ayu Irawati ◽  
Susanti Susanti ◽  
Iranita Haryono
Keyword(s):  
Rating Scale ◽  
Sampling Technique ◽  
Active Phase ◽  
Pain Scale ◽  
Labor Pain ◽  
Wilcoxon Test ◽  
Bivariate Analysis ◽  
Control Group ◽  
Control Group Design ◽  
First Stage Of Labor

Childbirth and birth is a physiological process that must be experienced by a mother. Pain during labor is caused by the first stage of labor in which contractions cause dilation and thinning of the cervix and uterine ischemia due to contraction of the myometrial arteries. These contractions cause the opening of the cervix to begin labor. Various attempts are made to reduce labor pain, both pharmacologically and non-pharmacological. The non-pharmacological method applied is a distraction with birth balls. The research aims to prove the effectiveness of the use of birthing ball on the reduction of labor pain in the first stage of labor in the active phase. This study used an experimental research design with a pretest-posttest control group design. The research sample was 20 maternity mothers at the Lompoe Health Center, who received treatment and 20 people as control samples. It applied the purposive sampling technique. The instrument of observation was the pain scale using the Faces Pain Rating Scale. Data processing using the Wilcoxon-test to determine the effect of the treatment given. Based on the results of the bivariate analysis showed that the value of Asymp. Sig. (2-tailed) is <0,001. Therefore,  the value of Sig<0,001 <value of α=0.05 which means that Ha was accepted. In conclusion, there is an influence of using the birthing ball to reduce the level of pain in the first stage of labor in the active mother.

scholarly journals Investigation of the Relation Between Epithelial Barrier Function and Autism Symptom Severity in Children with Autism Spectrum Disorder

2021 ◽  
Author(s):  
Kevser Nalbant ◽  
Semih Erden ◽  
Abdullah Yazar ◽  
İbrahim Kılınç
Keyword(s):  
Autism Spectrum Disorder ◽  
Barrier Function ◽  
Rating Scale ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Enzyme Linked Immunosorbent Assay ◽  
Epithelial Barrier ◽  
Control Group ◽  
Epithelial Barrier Function ◽  
Children With Asd

Abstract Autism spectrum disorder (ASD) is a common neurodevelopmental disorder characterized by limitations in mutual communication and social interaction as well as restricted, repetitive patterns of behaviors, interests, or activities. A number of biological abnormalities have been reported in ASD. Therefore the possible role of biological abnormalities in etiopathogenesis arouses research interest in this area. This is a case-control design study evaluating epithelial barrier function by comparing serum concentrations of occludin and zonulin in children with ASD (n = 60) and controls (n = 30). The Childhood Autism Rating Scale (CARS) was used to evaluate autistic symptom levels of all children. Serum occludin and zonulin levels were analyzed using an enzyme-linked immunosorbent assay. Serum occludin was significantly lower in children with ASD than in control subjects. In children with ASD, a decrease in occludin level was significantly associated with the disorder symptom levels item mean score (CARS total scores). Our findings showed that children with ASD had alterations in epithelial barrier function compared to the control group. The investigation of the mechanism underlying the different levels of occludin between ASD and controls may be of importance in clarifying the etiopathogenesis of ASD, as well as its follow-up and treatment.

IFN-α, IFN-γ, IL-2 combined with TNF-α for predicting efficacy of PD-1 inhibitors combination therapy in patients with solid cancers.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. 2584-2584
Author(s):  
Penghui Xing ◽  
Jinyan Zhang ◽  
Rongfeng Liu ◽  
Junyan Wang ◽  
Ming Ma ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Therapy Group ◽  
Control Group ◽  
Coincidence Rate ◽  
Advanced Malignancies ◽  
Tnf Α ◽  
Significant Difference ◽  
Group A ◽  
Ifn Γ ◽  
Group B

2584 Background: PD-1 inhibitors have transformed the treatment landscape for patients (pts) with many advanced malignancies. Combination therapy with PD-1 inhibitors for cancer is a trend. However, Biomarkers for the efficacy of combination therapy remains unknown. In order for the benefited population to be screened out, biomarkers need to be established. we will conduct the following study, to explore the IFN-α, IFN-γ, IL-2 combined with TNF-α for predicting efficacy of PD-1 inhibitors combination therapy. Methods: Using postoperative without lesions as control group (n=7). Pts with lesions as the experimental group (n=66). 27 of 66 pts received chemoradiotherapy (group A), 39 of 66 pts received PD-1 inhibitors combined with therapy (group B). IFN-α, IFN-γ, IL-2, TNF-α in peripheral blood of all pts were measured using flow cytometry. Results: 1) There was significant difference in proportion above normal concentrations (ANCs) of IFN-α between two groups (57.1% vs 43.5%, P<0.05), but there was no significant difference in IFN-γ, IL-2 and TNF-α between two groups (IFN-γ 57.1% vs 52.2%, IL-2 14.3% vs 5.8%, TNF-α 42.9% vs 43.5%, P>0.05). 2) The normal ratios of IFN-α, IFN-γ and TNF-α in group B was significantly higher than that in group A (IFN-α 64.1% vs 51.9%, IFN-γ 59% vs 37%, TNF-α 69.2% vs 44.4%, P<0.05). The proportion ANCs of IFN-α, IFN-γ, and TNF-α were lower in group A (IFN-α 35.9% vs 63%, P>0.05; IFN-γ 41% vs 63%, P<0.05; TNF-α 30.8% vs 55.6%, P<0.05). However, the proportion ANCs of IL-2 detection was lower (7.4% vs 5.1%). 3) In group B, 21 of 39 pts were evaluable. ORR was 52.4% (11/21) and DCR was 85.7% (18/21). The proportion ANCs of IFN-α, IFN-γ and TNF-α in the pts with PR was higher than that with SD (IFN-α 37.5% vs 28.6%, IFN-γ 37.5% vs 28.6%, TNF-α 50% vs 38.8%, P<0.05). 4) We found that the coincidence rate of IFN-α+ IFN-γ and IFN-α+ IFN-γ+TNF-α was higher in group B (Table). Conclusions: Our results suggest that the proportion ANCs of IFN-α, IFN-γ, and TNF-α in the pts with lesions were lower than that without lesions, it may be the decrease of immune function with lesions. There was positive correlation between proportion ANCs of IFN-α, IFN-γ and TNF-α and efficacy in these pts. IL-2 was not used as a routine detection indicator. The coincidence rate of IFN-α, IFN-γ combined with TNF-α was higher, it may help predict the outcome of PD-1 inhibitors combination therapy in pts with solid cancers, and helpful to screen the benefit population. Further study is needed.[Table: see text]

Effectiveness and safety of Chinese massage therapy (Tui Na) on post-stroke spasticity: a prospective multicenter randomized controlled trial

2016 ◽  
Vol 31 (7) ◽  
pp. 904-912 ◽  
Author(s):  
Yu-jie Yang ◽  
Jun Zhang ◽  
Ying Hou ◽  
Bao-yin Jiang ◽  
Hua-fei Pan ◽  
...  
Keyword(s):  
Barthel Index ◽  
Therapy Group ◽  
Massage Therapy ◽  
Control Group ◽  
Post Stroke ◽  
Modified Ashworth Scale ◽  
Significant Difference ◽  
Multicenter Randomized Controlled Trial ◽  
Muscle Groups ◽  
Ashworth Scale

Objective: To evaluate the effectiveness and safety of Chinese massage therapy (Tui Na) for patients with post-stroke spasticity. Design: A prospective, multicenter, blinded, randomized, placebo-controlled intervention trial. Subject: A total of 90 patients with post-stroke spasticity were randomly assigned to the experimental (Tui Na therapy) group ( n = 45) or control (placebo Tui Na therapy) group ( n = 45). Intervention: Participants in the experimental group received Tui Na therapy, while those in the control group received placebo-Tai Na (gentle rubbing) for 20–25 minutes per limb, once per day, five days per week for a total of four weeks. All participants in both groups received conventional rehabilitation. Main measure: The Modified Ashworth Scale, the Fugl-Meyer Assessment and the Modified Barthel Index were used to assess the severity of spasticity, motor function of limbs and activities of daily living, respectively. Assessments were performed at baseline, at four weeks and at three months. Results: Tui Na group had a significantly greater reduction in Modified Ashworth Scale in only four muscle groups than the control did (elbow flexors, P = 0.026; wrist flexors, P = 0.005; knee flexors, P = 0.023; knee extensors, P = 0.017). Improvements were sustained at three months follow-up. There was no significant difference between the two groups in Fugl-Meyer Assessment ( P = 0.503) and Modified Barthel Index ( P = 0.544). No adverse reaction was recorded in any of the cases mentioned at all study sites. Conclusions: Tui Na might be a safe and effective treatment to reduce post-stroke spasticity of several muscle groups.

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