scholarly journals The Hygiene Hypothesis – Learning From but Not Living in the Past

2021 ◽  
Vol 12 ◽  
Author(s):  
Petra I. Pfefferle ◽  
Corinna U. Keber ◽  
Robert M. Cohen ◽  
Holger Garn
Keyword(s):  
Hygiene Hypothesis ◽  
Modern Life ◽  
Holistic Model ◽  
The Past ◽  
Close Proximity ◽  
The Many ◽  
Immunological Homeostasis ◽  
The Impact ◽  
Evolutionary Aspects ◽  
Initial Focus

Postulated by Strachan more than 30 years ago, the Hygiene Hypothesis has undergone many revisions and adaptations. This review journeys back to the beginnings of the Hygiene Hypothesis and describes the most important landmarks in its development considering the many aspects that have refined and generalized the Hygiene Hypothesis over time. From an epidemiological perspective, the Hygiene Hypothesis advanced to a comprehensive concept expanding beyond the initial focus on allergies. The Hygiene Hypothesis comprise immunological, microbiological and evolutionary aspects. Thus, the original postulate developed into a holistic model that explains the impact of post-modern life-style on humans, who initially evolved in close proximity to a more natural environment. Focusing on diet and the microbiome as the most prominent exogenous influences we describe these discrepancies and the resulting health outcomes and point to potential solutions to reestablish the immunological homeostasis that frequently have been lost in people living in developed societies.

PERLINDUNGAN HUKUM BAGI ANAK AKIBAT KONTEN KEKERASAN YANG TERDAPAT DALAM SITUS YOUTUBE

2020 ◽  
Vol 4 (1) ◽  
Author(s):  
Nabila Nabila
Keyword(s):  
Child Development ◽  
Child Protection ◽  
Legal Protection ◽  
Violence Against Children ◽  
The Past ◽  
Library Research ◽  
Negative Impacts ◽  
The Many ◽  
The Impact ◽  
Protection Commission

The purpose of this study is to determine the impact of negative content that has an element of violence on the YouTube site on child development, determine the form of legal protection of children against negative content that has an element of violence on the YouTube site. This type of research used in this study is normative juridical. The approach used in this study is the statutory approach and the analytic approach, the method of gathering legal material through library research. While the method of analyzing the legal material is done qualitatively. The many negative impacts of the shows or content being watched are supported by data from the Indonesian Child Protection Commission (KPAI) which has recorded that in the past 4 years the number of violence against children has continued to increase. Forms of legal protection for children against negative content that has an element of violence on the YouTube site consists of legal protection that is preventive and repressive legal protection. Keywords: Legal Protection, Negative Content, Youtube

scholarly journals The Human Cost of IIRIRA —Stories from Individuals Impacted by the Immigration Detention System

2017 ◽  
Vol 5 (1) ◽  
pp. 194-216 ◽  
Author(s):  
Saba Ahmed ◽  
Adina Appelbaum ◽  
Rachel Jordan
Keyword(s):  
Public Knowledge ◽  
Legal Services ◽  
Immigration Reform ◽  
Immigration Detention ◽  
Central Function ◽  
Criminal Convictions ◽  
The Past ◽  
Human Cost ◽  
The Many ◽  
The Impact

The 1996 passage of the Illegal Immigration Reform and Immigrant Responsibility Act (IIRIRA) has had a devastating impact on immigrants who are detained, indigent, and forced to face deportation proceedings without representation (pro se). In the past 20 years, immigration detention has grown exponentially and a criminal–immigration detention–deportation pipeline has developed as a central function of the immigration system. Despite the growing specter of the “criminal alien” in the American psyche, there is little public knowledge or scrutiny of the vast immigration detention and deportation machine. Enforcement of IIRIRA has effectively erased human stories and narrowed immigration debates to numbers and statistics. The five vignettes below tell the stories of individuals who have personally experienced the impact of IIRIRA. Part 1 describes the on-the-ground reality of a state public defender's obligations and struggles to defend immigrants from harsh consequences of criminal convictions. Part 2 provides the perspective of an indigent immigrant fighting his deportation pro se. Part 3 describes a nonprofit immigration attorney's challenges in providing legal services to detained immigrants. Part 4 is a glimpse into the brisk pace of an immigration judge's detained docket. Part 5 tells the story of a detained immigrant's family member and the many hoops she must jump through to ensure he has a fighting chance in immigration court. Collectively, these vignettes provide a realistic picture of the immigration detention experience, revealing the human cost of IIRIRA.

scholarly journals The Present State of the Study of Politics

2021 ◽  
Vol 100 (1) ◽  
pp. 183-192
Author(s):  
Ch. E. Merriam
Keyword(s):  
Industrial Development ◽  
Political Process ◽  
Law School ◽  
The Political ◽  
Common Goal ◽  
The Past ◽  
Different Types ◽  
The Subject ◽  
The Many ◽  
The Impact

The original outline of this article included a general overview and critique of the leading trends in the study of politics over the past 30 to 40 years. It was intended to compare the methods and results of different types of political thought-to consider in turn the historical school, the law school, researchers in the field of comparative analysis of forms of government, philosophers themselves, the approach of economists, the contribution of geographers and ethnologists, the work of statisticians, and finally to turn to psychological, sociological and biological interpretations of the political process. It would be an interesting and perhaps useful task to compare the subject and method of such thinkers as Jellinek, Gierke, Dugi, Dicey and Pound, the philosophies of Sorel and Dewey, Ritchie and Russell, Nietzsche and Tolstoy, to look at the methods of Durkheim and Simmel, Ward, Giddings and Small, Cooley and Ross, and to discuss the innovations found in the works of Wallace and Cole. It might be useful to expand the analysis to include important features of the environment in which these ideas flourished, and the many close connections between them. One could also discuss the impact of social and industrial development, class movements and class struggle or group conflicts in a broader sense, consider the impact of urbanism and industrialism, capitalism, socialism and syndicalism, militarism, pacifism, feminism, nationalism. It would be useful, perhaps, to present a critique of the methods and results described and to specifically assess the significance of logical, psychological, sociological, legal, philosophical and historical methodologies and the contribution of each of them to the study of the political. This task, however, was dropped and postponed for the next time, as it became apparent that no such review could be compressed to reasonable volumes. In order to achieve our common goal, it would seem that a different type of analysis would be more productive, aimed at reconstructing the methods of political research and obtaining more extensive results in both the theoretical and practical fields.

Axial Spondyloarthritis

2016 ◽  
Keyword(s):  
Healthcare Professionals ◽  
Axial Spondyloarthritis ◽  
Clinical Expertise ◽  
Sacroiliac Joints ◽  
The Past ◽  
Current State ◽  
Research Programmes ◽  
Active Research ◽  
The Many ◽  
The Impact

Ankylosing spondylitis (AS) is a chronic inflammatory arthritis affecting mainly the sacroiliac joints and spine, resulting in pain, stiffness, and reduced movement. Over the past decade there have been major advances in many aspects of the disease, including a broadening of the disease description to axial spondyloarthritis (axSpA). While the many advances have transformed the lives of patients with axSpA, they have also increased complexity for non-specialists in this area. This handbook contains a timely update of the key developments and current state of play in axSpA. It is intended primarily for the many healthcare professionals who encounter patients with this condition, in both primary and secondary care settings. It will also be of interest to the wider medical and research community.The handbook is written by rheumatologists with active research programmes and clinical expertise in these conditions. The topics covered include: • the clinical features • extra-articular manifestations and complications • the impact on patients’ lives • the major advances in genetics and pathogenesis • imaging advances • classification criteria and diagnosis (and the important differences between these) • treatment advances (particularly TNF inhibitors and upcoming biologics)

Human Exploration of the Deep Seas: Fifty Years and the Inspiration Continues

2009 ◽  
Vol 43 (5) ◽  
pp. 42-62 ◽  
Author(s):  
William Kohnen
Keyword(s):  
Central Element ◽  
Underwater Vehicles ◽  
Deep Dive ◽  
The Past ◽  
The World ◽  
New Ideas ◽  
The Many ◽  
Human Desire ◽  
Human Exploration ◽  
The Impact

AbstractThe deep seas have facinated the world for centuries. The flow of new ideas has traveled through the centuries and inspired people to dive below the surface and explore the forms of life that exist in the abyss. Many early ideas led primarily to military developments, with scientific research emerging much later. Only in the past 100 years has the technological capability matched the human desire to deep dive into the oceans and discover its true mysteries. This article looks back at the history and flow of such ideas that involved submersible vehicles, how this led to the development of the Trieste bathyscaph, concurrent activities around the world, the efforts involved in completing the dives, and the impact this deep dive has had on the evolution of submersibles. It presents the successes, the challenges, as well as the grit and luck it sometimes took to make it happen. After fifty years, it is clear that the sea still holds many mysteries. Human-occupied underwater vehicles will remain a central element among the modern tools at the service of knowledge acquisition. The future calls us to see and discover this underwater world—not simply to be awed by its power and beauty but to learn; to comprehend the complex web of inter-relations between our life on land and its impact on the seas. We stand on the shoulders of many dedicated engineers and explorers as we continue to inspire the next generation to study the many alien creatures that will teach us anew.

scholarly journals Marketing the Surveying and Geospatial Profession

2014 ◽  
Vol XL-6 ◽  
pp. 99-101
Author(s):  
J. Trinder
Keyword(s):  
General Population ◽  
Education Programs ◽  
Engineering Programs ◽  
The Past ◽  
Career Opportunities ◽  
The World ◽  
The Future ◽  
The Status ◽  
The Many ◽  
The Impact

Many universities around the world are experiencing a decline in the number of students entering programs in surveying and geospatial engineering, including some institutions with prestigious pasts. For Australia, this raises the question of whether there will be adequate graduates in the future to replace the current cohort of surveying and geospatial professionals when they retire. It is not clear why it has not been possible to attract more school leavers into the surveying and geospatial programs, but it may be because the community at large is unaware of the many career opportunities. Several surveys have been carried out in Australia to determine the status of graduates entering the profession and the impact that shortages of graduates in the surveying and geospatial professions in the future. These shortages could seriously limit the development of infrastructure and housing if they are not overcome. Another issue is whether the demand for graduates is changing due to developments in technology that allow surveying and mapping to be undertaken more quickly and efficiently than in the past. Marketing of education programs into schools and the general population is essential. A solution maybe for a concerted global effort to encourage more school leavers to enrol in surveying and geospatial engineering programs and hence improve the viability of the profession for the future. The paper will review the impacts of shortages in graduates entering the profession and approaches to improve the marketing of the surveying and geospatial professions.

scholarly journals Demystifying Collapse: Climate, environment, and social agency in pre-modern societies

Millennium ◽  
2020 ◽  
Vol 17 (1) ◽  
pp. 1-33
Author(s):  
John Haldon ◽  
Arlen F. Chase ◽  
Warren Eastwood ◽  
Martin Medina-Elizalde ◽  
Adam Izdebski ◽  
...  
Keyword(s):  
Social Groups ◽  
Science Literature ◽  
The Past ◽  
Social Science Literature ◽  
Nuanced Understanding ◽  
Social And Environmental Change ◽  
The Many ◽  
Human Actors ◽  
The Impact ◽  
Different Levels

AbstractCollapse is a term that has attracted much attention in social science literature in recent years, but there remain substantial areas of disagreement about how it should be understood in historical contexts. More specifically, the use of the term collapse often merely serves to dramatize long-past events, to push human actors into the background, and to mystify the past intellectually. At the same time, since human societies are complex systems, the alternative involves grasping the challenges that a holistic analysis presents, taking account of the many different levels and paces at which societies function, and developing appropriate methods that help to integrate science and history. Often neglected elements in considerations of collapse are the perceptions and beliefs of a historical society and how a given society deals with change; an important facet of this, almost entirely ignored in the discussion, is the understanding of time held by the individuals and social groups affected by change; and from this perspective ‘collapse’ depends very much on perception, including the perceptions of the modern commentator. With this in mind, this article challenges simplistic notions of ‘collapse’ in an effort to encourage a more nuanced understanding of the impact and process of both social and environmental change on past human societies.

Hydrogen Cyanide Polymers from the Impact of Comet P/Shoemaker-Levy 9 on Jupiter

1997 ◽  
Vol 161 ◽  
pp. 179-187
Author(s):  
Clifford N. Matthews ◽  
Rose A. Pesce-Rodriguez ◽  
Shirley A. Liebman
Keyword(s):  
Amino Acids ◽  
Solar System ◽  
Hydrogen Cyanide ◽  
Nitrogen Heterocycles ◽  
Laboratory Studies ◽  
Heterogeneous Solids ◽  
The Many ◽  
Comet Halley ◽  
The Impact ◽  
By Products

AbstractHydrogen cyanide polymers – heterogeneous solids ranging in color from yellow to orange to brown to black – may be among the organic macromolecules most readily formed within the Solar System. The non-volatile black crust of comet Halley, for example, as well as the extensive orangebrown streaks in the atmosphere of Jupiter, might consist largely of such polymers synthesized from HCN formed by photolysis of methane and ammonia, the color observed depending on the concentration of HCN involved. Laboratory studies of these ubiquitous compounds point to the presence of polyamidine structures synthesized directly from hydrogen cyanide. These would be converted by water to polypeptides which can be further hydrolyzed to α-amino acids. Black polymers and multimers with conjugated ladder structures derived from HCN could also be formed and might well be the source of the many nitrogen heterocycles, adenine included, observed after pyrolysis. The dark brown color arising from the impacts of comet P/Shoemaker-Levy 9 on Jupiter might therefore be mainly caused by the presence of HCN polymers, whether originally present, deposited by the impactor or synthesized directly from HCN. Spectroscopic detection of these predicted macromolecules and their hydrolytic and pyrolytic by-products would strengthen significantly the hypothesis that cyanide polymerization is a preferred pathway for prebiotic and extraterrestrial chemistry.

On Future Directions in Pathology

1982 ◽  
Vol 40 ◽  
pp. 274-277
Author(s):  
Benjamin F. Trump ◽  
Irene K. Berezesky ◽  
Raymond T. Jones
Keyword(s):  
Electron Microscopy ◽  
Transmission Electron Microscopy ◽  
Clinical Pathology ◽  
Future Directions ◽  
Diagnostic Pathology ◽  
The Past ◽  
Transmission Electron ◽  
Organ Systems ◽  
The Many

The role of electron microscopy and associated techniques is assured in diagnostic pathology. At the present time, most of the progress has been made on tissues examined by transmission electron microscopy (TEM) and correlated with light microscopy (LM) and by cytochemistry using both plastic and paraffin-embedded materials. As mentioned elsewhere in this symposium, this has revolutionized many fields of pathology including diagnostic, anatomic and clinical pathology. It began with the kidney; however, it has now been extended to most other organ systems and to tumor diagnosis in general. The results of the past few years tend to indicate the future directions and needs of this expanding field. Now, in addition to routine EM, pathologists have access to the many newly developed methods and instruments mentioned below which should aid considerably not only in diagnostic pathology but in investigative pathology as well.

Fluorescent potentiometric dyes for membrane-potential imaging

1994 ◽  
Vol 52 ◽  
pp. 166-167
Author(s):  
Leslie M. Loew
Keyword(s):  
Membrane Potential ◽  
Single Cells ◽  
Quantitative Imaging ◽  
Optical Recording ◽  
Biological Processes ◽  
Major Focus ◽  
The Past ◽  
Excitable Systems ◽  
Major Application ◽  
The Impact

A major application of potentiometric dyes has been the multisite optical recording of electrical activity in excitable systems. After being championed by L.B. Cohen and his colleagues for the past 20 years, the impact of this technology is rapidly being felt and is spreading to an increasing number of neuroscience laboratories. A second class of experiments involves using dyes to image membrane potential distributions in single cells by digital imaging microscopy - a major focus of this lab. These studies usually do not require the temporal resolution of multisite optical recording, being primarily focussed on slow cell biological processes, and therefore can achieve much higher spatial resolution. We have developed 2 methods for quantitative imaging of membrane potential. One method uses dual wavelength imaging of membrane-staining dyes and the other uses quantitative 3D imaging of a fluorescent lipophilic cation; the dyes used in each case were synthesized for this purpose in this laboratory.

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