scholarly journals Whole-Genome Methylation Study of Congenital Lung Malformations in Children

2021 ◽  
Vol 11 ◽  
Author(s):  
Sara Patrizi ◽  
Federica Pederiva ◽  
Adamo Pio d’Adamo
Keyword(s):  
Human Cancer ◽  
Lung Tumors ◽  
Methylation Pattern ◽  
Pleuropulmonary Blastoma ◽  
P Value ◽  
Differentially Methylated Regions ◽  
Asymptomatic Patients ◽  
Genome Methylation ◽  
Congenital Lung Malformations ◽  
And Control

Background and ObjectivesThe treatment of asymptomatic patients with congenital pulmonary malformations (CPMs) remains controversial, partially because the relationship between congenital lung malformations and malignancy is still undefined. Change in methylation pattern is a crucial event in human cancer, including lung cancer. We therefore studied all differentially methylated regions (DMRs) in a series of CPMs in an attempt to find methylation anomalies in genes already described in association with malignancy.MethodsThe DNA extracted from resected congenital lung malformations and control lung tissue was screened using Illumina MethylationEPIC arrays. Comparisons between the group of malformed samples or the malformed samples of same histology or each malformed sample and the controls and between a pleuropulmonary blastoma (PPB) and controls were performed. Moreover, each malformed sample was pairwise compared with its respective control. All differentially methylated regions (DMRs) with an adjusted p-value <0,05 were studied.ResultsEvery comparison highlighted a number of DMRs closed to genes involved either in cell proliferation or in embryonic development or included in the Cancer Gene Census. Their abnormal methylation had been already described in lung tumors.ConclusionsMethylation anomalies already described in lung tumors and also shared by the PPB were found in congenital lung malformations, regardless the histology. The presence of methylation abnormalities is suggestive of a correlation between congenital lung malformations and some step of malignant transformation.

The Estimation of prostate specific antigen (PSA) concentrations in patients with prostatitis by fully automated ELISA technique.

2020 ◽  
Vol 3 (11) ◽  
pp. 1100-1104
Author(s):  
Hussein Naeem Aldhaheri ◽  
Ihsan Edan AlSaimary ◽  
Murtadha Mohammed ALMusafer
Keyword(s):  
Personal Information ◽  
Receptor Gene ◽  
Specific Antigen ◽  
Gene Clusters ◽  
Control Group ◽  
P Value ◽  
Group Data ◽  
Elisa Technique ◽  
And Control

      The Aim of this study was to determine Immunogenetic expression of  Toll-like receptor gene clusters related to prostatitis, to give acknowledge about Role of TLR in prostatitis immunity in men from Basrah and Maysan provinces. A case–control study included 135 confirmed prostatitis patients And 50 persons as a control group. Data about age, marital status, working, infertility, family history and personal information like (Infection, Allergy, Steroid therapy, Residency, Smoking, Alcohol Drinking, Blood group, Body max index (BMI) and the clinical finding for all patients of Prostatitis were collected. This study shows the effect of PSA level in patients with prostatitis and control group, with P-value <0.0001 therefore the study shows a positive significant between elevated PSA levels and Prostatitis.

PENGGUNAAN SELAPUT AMNION SEGAR PADA INSISI LUKA OPERASI SEKSIO SESAREA

2019 ◽  
Vol 1 (2) ◽  
pp. 47-55
Author(s):  
Syahredi Syaiful Adnani ◽  
Hafni Bachtiar
Keyword(s):  
Wound Healing ◽  
Caesarean Section ◽  
Amniotic Membrane ◽  
Healing Time ◽  
Cost Of Care ◽  
Control Group ◽  
P Value ◽  
Control Groups ◽  
And Control ◽  
Wound Healing Time

In the last few decades, the incidence of caesarean section is increasing in the world, especially in Indonesia. One of the way to treat tissue scar is through biologic and synthetic dressing where nowadays, amnion has been used as biologic dressing frequently. This study was conducted to determine the effect of the use of fresh amniotic membrane on wound incision Caesarean section compared with Caesarean section incision wound covered using regular gauze bandages and fixated with plaster in RS. Dr. Reksodiwiryo Padang. The design of this study is an experimen-tal study with Post test design with control group design. Sampling was done using a formula consecutive sampling two different test samples obtained an average of 72 people for each group. The analysis used include univariate and bivariate analyzes. The average wound healing time the difference was statistically significant (p value <0.05) in the treatment and control groups. There was highly significant difference in the proportion of local infection on day 3 between the treatment and control groups (p value <0.05). There were very significant differences in the proportion of local allergic reactions at day 3, and 5 between the treatment and control group (p <0.05). There are significant differences in terms of the cost of care per day between treatment and control groups (p <0.05). From this study, the average wound healing time has a very significant difference.Keywords: Fresh Amniotic Membrane, Wound Cesarean Section, Wound Healing

scholarly journals Clinical Stratification of Pregnant COVID-19 Patients based on Severity: A Single Academic Center Experience

2021 ◽  
Vol 38 (05) ◽  
pp. 515-522
Author(s):  
Marissa Berry ◽  
Amanda Wang ◽  
Shannon M. Clark ◽  
Hassan M. Harirah ◽  
Sangeeta Jain ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Disease Severity ◽  
Gestational Age ◽  
Laboratory Data ◽  
Population Characteristics ◽  
Neonatal Outcomes ◽  
P Value ◽  
Asymptomatic Patients ◽  
Increased Risk ◽  
Maternal And Neonatal Outcomes

Objective This study aimed to describe baseline characteristics of a cohort of pregnant women infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and determine if these correlate with disease severity and perinatal outcomes. Study Design This was a retrospective cohort trial conducted at the University of Texas Medical Branch Galveston, Texas. All pregnant women presented to our medical center, who were screened and tested positive for SARS-CoV-2 virus, were included. We stratified our study population in three groups: asymptomatic, symptomatic not requiring oxygen therapy, and patients requiring oxygen support to maintain oxygen saturation >94%. Relevant population characteristics, laboratory data, and maternal and neonatal outcomes were abstracted. A p-value <0.05 was considered statistically significant. Results Between March and July 2020, 91 women tested positive for SARS-CoV-2 upon admission to our labor and delivery unit. Among these, 61.5% were asymptomatic, 34.1% were symptomatic, and 4.4% required oxygen support. Our population was mainly Hispanic (80.2%), multiparous (76.9%), obese (70.3%), and with a median age of 27 years. Median gestational age at symptom onset or diagnosis was 36 weeks. Significant differences were found between gestational age and disease severity. Maternal characteristics including age, body mass index (BMI), and presence of comorbid conditions did not appear to influence severity of SARS-CoV-2 infection. Significant laboratory findings associated with increasing disease severity included decreasing hemoglobin and white blood cell count, lymphopenia, and increasing levels of inflammatory markers including CRP, ferritin, and procalcitonin. Maternal and neonatal outcomes did not differ among groups. No SARS-CoV-2 was detected by polymerase chain reaction testing in neonates of mothers with COVID-19. Conclusion Pregnant patients with COVID-19 infection are predominantly asymptomatic. Patients appear to be at increased risk for more severe infection requiring oxygen support later in pregnancy. Key Points

PENGARUH EDUKASI PERAWAT TERHADAP KETEPATAN KELUARGA PASIEN MELAKUKAN CUCI TANGAN DALAM PENCEGAHAN PENULARAN COVID-19 DI RSUD ARIFIN ACHMAD PROVINSI RIAU

2021 ◽  
Vol 3 (4) ◽  
pp. 70-74
Author(s):  
Nurul Utami
Keyword(s):  
Quantitative Research ◽  
Public Awareness ◽  
Nurse Education ◽  
Hand Washing ◽  
P Value ◽  
Average Value ◽  
High Incidence ◽  
Quasi Experimental ◽  
And Control ◽  
Source Of Information

Corona virus is a virus that attacks the respiratory system. The high incidence of Covid-19 is due to low public awareness of applying health protocols. So the need for prevention and control efforts by complying with health protocols to wear masks, keep your distance and wash your hands properly. Washing hands is an easy routine and is important in infection control, and is the best method to prevent the transmission of microorganisms. The purpose of this study was to determine the effect of nurse education on the accuracy of the patient's family through hand washing in preventing Covid-19 transmission at Arifin Achmad Hospital, Riau Province. This research uses quantitative research with a quasi experimental design, with a population of 20 people. Data collection tools used observation sheets and data analysis was carried out univariate and bivariate with the Wilcoxson test. The results of this study show that the average value before being given education about hand washing is low compared to the average value after being given education about hand washing. So that hand washing education is effective in increasing hand washing to prevent Covid-19 transmission with a p-value of 0.000. The results of this study are expected to be a source of information and knowledge for the nursing profession regarding the effect of providing nurse education on the accuracy of the patient's family in washing hands.

scholarly journals The Effect of Resistance Training on G6Pase Gene Expression in Liver Hepatocytes, Glucose and Insulin Resistance Levels in Type 2 Diabetic Rats

2020 ◽  
Author(s):  
Ahmad Shokrolahi Ardakani ◽  
Hossein Abednatanzi ◽  
Mandana Gholami ◽  
Nader Shakeri
Keyword(s):  
Resistance Training ◽  
Training Group ◽  
Liver Cells ◽  
Diabetic Rats ◽  
Exercise Session ◽  
P Value ◽  
Insulin Levels ◽  
And Control ◽  
Type 2 Diabetic

Objective: The aim of this study was to determine the effect of 12 weeks resistance training on G6Pase expression in liver cells, as well as glucose and insulin levels in type 2 diabetic rats. Materials and Methods: In this experimental study, 16 wistar rats were selected as the research sample. After injection of nicotinamide and streptozocin to induce diabetes, the rats were randomly divided into two groups of resistance training and control. The resistance group participated in a course of resistance training for up to 12 week in five sessions per week, with intensity of 75% and a time of 30 to 45 minutes. Finally, 48 hours after the last exercise session, G6Pase expression in liver cells, as well as glucose and insulin levels were measured in both groups. Results: Comparison of resistance and control training groups showed a decrease in glucose levels (P-value= 0.001) and increased insulin levels (P-value= 0.001). Exercise also reduced the expression of G6Pase in liver cells in the resistance training group (P-value= 0.001). Conclusion: Based on the results of the study, it is recommended that diabetics use resistance training under the supervision of a specialist to reduce the negative effects of diabetes.  

scholarly journals Simulations of the spread of COVID-19 and control policies in Tunisia

2020 ◽  
Author(s):  
Slimane BenMiled ◽  
Amira Kebir
Keyword(s):  
Epidemiological Model ◽  
Tunisian Population ◽  
Control Policies ◽  
Asymptomatic Patients ◽  
Asymptomatic Individuals ◽  
And Control

AbstractWe develop and analyze in this work an epidemiological model for COVID-19 using Tunisian data. Our aims are first to evaluate Tunisian control policies for COVID-19 and secondly to understand the effect of different screening, quarantine and containment strategies and the rule of the asymptomatic patients on the spread of the virus in the Tunisian population. With this work, we show that Tunisian control policies are efficient in screening infected and asymptomatic individuals and that if containment and curfew are maintained the epidemic will be quickly contained.

scholarly journals E MUSCULOSKELETAL DISORDERS (MS PENGARUH WORKPLACE STRETCHING EXERCISE TERHADAP PENURUNAN KELUHAN MUSCULOSKELETAL DISORDERS(MSDs) PADA PEKERJA BATIK TULIS DI KECAMATAN SOKARAJA

2017 ◽  
Vol 9 (02) ◽  
pp. 49
Author(s):  
Siti Harwanti ◽  
Nur Ulfah ◽  
Budi Aji
Keyword(s):  
Musculoskeletal Disorders ◽  
Wilcoxon Test ◽  
Control Group ◽  
P Value ◽  
Control Group Design ◽  
Test Analysis ◽  
Result Show ◽  
Post Test ◽  
Equivalent Control ◽  
And Control

Batik maked process especially �mbironi�, is done in sit position. If this position maintained for a long period, that could be cause muscle strain which may lead into musculoskeletal disorders. The research was aim to know the effect of Workplace Stretching Exercise (WSE) to reduced MSDs in hand-made batik workers. The research was quasy experimental by non-equivalent control group design. Subjects were 37 female handmade batik workers used purposive sampling. Data analysis used Friedman test and Wilcoxon test, then for two independent sample used Independent t Test and Mann Whitney test with significancy level at 5% or a = 0,05. Analysis result show that there is no difference in MSDs on experiment and control group after pre-test which had p-value = 0,371 (>0,05). The result of middle-test and post-test p value = 0,000 (<0,05) that there is significant mean difference of MSDs between experiment and control group. Based on the middle-test and post-test analysis result, it could be conclude that there is an effect of WSE to reduce MSDs of handmade batik workers.

scholarly journals Android-Based Education toward the Role of Postpartum Primipara Mothers in Fulfilling the Independent Perinium Care

2021 ◽  
Vol 1 (2) ◽  
pp. 55-67
Author(s):  
Werna Nontji ◽  
Dwi Kartika Sari ◽  
Sitti Maria Ulfa ◽  
Syafruddin Syarif ◽  
Inez Vravty Lestari ◽  
...  
Keyword(s):  
Treatment Group ◽  
Intervention Group ◽  
Wilcoxon Test ◽  
Control Group ◽  
P Value ◽  
Control Groups ◽  
Post Test ◽  
Android App ◽  
And Control ◽  
Perineal Care

Background: Educating mothers during their postpartum period could potentially help them to overcome some important phases after giving birth. The process of education is evaluated based on the mothers’ knowledge about their independent self-care. Independency is an activity that is started individually and is done based on self-capability. The independency in the postpartum care is not only important to decrease the mother’s mortality and morbidity rate, but it is also crucial to strengthen and improve the post-partum mother’s healthy behavior during the perineal care. Providing education using Android-based application called BUBI Care could be potential to facilitate a more dynamic transfer of knowledge to the postpartum mothers.Aims: To analyze the knowledge, skills, and independence of primipara postpartum mothers in independent perineal care before and after accessing BUBI Care app. Research Method: employing quasi experimental research with pre-test and post-test design with control group design. The sample for this research were 19 pregnant mothers TM III (pregnancy age of ? 38 weeks) on each group. The treatment group was educated using BUBI Care Android app that was conducted at one of Public Health Center. The control group was educated without BUBI Care that was conducted at a Midwife Practice Clinic. The research was conducted on September to October 2020. Study Result: According to the Wilcoxon test, there was a difference in the pre-test knowledge of the treatment and control groups with the similar median of 53 and p-value of 0.666, the treatment group showed their scores improved to 80 on the post-test while the control group stayed at 53 with the p-value of 0.000. It means that BUBI Care app education influences the post-test. On the other hand, the perineal care skill saw a difference between the intervention and control groups. The intervention group had a mean of 70.05 and 56.68 for the control group with the p-value of 0.002 which means that there was an influence from the BUBI Care app education. Additionally, Mann Whitney test showed that the intervention group had a mean score of 78.95, but the control group only had 49.26, the total difference between the two are 29.69 with the p-value of 0.000. It can be concluded that there is a significance in difference in the independency rate from the provision of BUBI Care Android app education.Conclusion:  there is a significance effect on the intervention group in terms of Android based usage.

scholarly journals Knowledge Enhancement about COVID-19 Prevention on Community with Webinar Program

2021 ◽  
Vol 5 (1) ◽  
pp. 103
Author(s):  
Ratih Damayanti
Keyword(s):  
Community Participation ◽  
Prevention And Control ◽  
P Value ◽  
Public Knowledge ◽  
Age Group ◽  
Community Groups ◽  
Public Facilities ◽  
Knowledge Enhancement ◽  
And Control ◽  
At Home

COVID-19 is increasingly difficult to control. There is evidence of an increase in cases during the beginning of December. There needs to be community participation in prevention and control efforts anywhere (including at home, public facilities and workplaces). Webinars are a method that can be used during a pandemic to increase public knowledge. In this activity, the results showed that some of the participants were female in the age group less than 30 years old with status as students. There was a significant increase in knowledge (p-value = 0.000) of community groups who were provided with counseling through webinars of 9.17 points. It is necessary to expand the reach of people who get counseling through webinars so that information or knowledge about the prevention and handling of COVID-19 can be widely spread throughout Indonesia. 

scholarly journals EFFECT OF AUDIO THERAPY USING AL-QUR'AN MURROTAL ON BEHAVIOR DEVELOPMENT IN CHILDREN WITH AUTISM

2017 ◽  
Vol 3 (5) ◽  
pp. 470-477
Author(s):  
Anjar Astuti ◽  
Suryono Suryono ◽  
Melyana Nurul Widyawati ◽  
Ari Suwondo ◽  
Mardiyono Mardiyono
Keyword(s):  
Neurodevelopmental Disorder ◽  
Alternative Therapy ◽  
Children With Autism ◽  
Simple Random Sampling ◽  
Behavioral Development ◽  
Control Group ◽  
P Value ◽  
Significant Difference ◽  
The Mean ◽  
And Control

Background: Autism is a neurodevelopmental disorder. Audio therapy is considered as one of the complementary therapies to improve the behavior of children with autism.Objective: This study was to analysis the effectiveness of the Al-Qur'an murrotal audio therapy on behavioral development in children with autism.Methods: This study was a true-experimental research using pretest and posttest approach with control group. This research was conducted on November 2016 in the Autism Foundation of Semarang City. There were 30 samples were selected using simple random sampling, with 15 samples assigned in the experiment and control group. Mann Whitney and Wilcoxon tests were used for data analysis in this study.Results: Results showed that there was a significant difference in the mean of behavioral development after given intervention between the experiment group and control group with p-value 0.034 (<0.05). The mean of behavioral development in the experiment group (4.53) was higher than the mean in the control group (3.47).Conclusion: The Al-Qur'an murrotal audio therapy is effective to develop behavior of children with autism. Therefore, it is expected that this audio therapy can be applied an alternative therapy for children with autism.

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