scholarly journals Pharmacologically Induced Ex Copula Ejaculation in Horses and Donkeys

2021 ◽  
Vol 8 ◽  
Author(s):  
Afroza Khanam ◽  
Ayman A. Swelum ◽  
Firdous A. Khan
Keyword(s):  
Smooth Muscle ◽  
Side Effects ◽  
Adrenergic Receptor ◽  
Tricyclic Antidepressants ◽  
The Body ◽  
Clinical Settings ◽  
Health Issues ◽  
Semen Collection ◽  
Effective Option ◽  
Artificial Vagina

Pharmacologically induced ex copula ejaculation is a method used for collection of semen when the traditional methods of semen collection are not feasible. Common indications for this method include health issues that either preclude the physical act of mating or result in impaired erection and ejaculation. The method also offers an alternative when there is a lack of equipment and facilities required for semen collection using the conventional artificial vagina method. A variety of pharmacological protocols for ex copula ejaculation in stallions have been evaluated in both research and clinical settings with no serious side-effects reported. In general, these protocols included tricyclic antidepressants, alpha-2 adrenergic receptor agonists, and smooth muscle stimulators, either individually or in combination. Although there is a lot of variation in the ejaculatory rates among studies, a combination of imipramine and xylazine appears to be an effective option for inducing ejaculation in stallions. In cases where this protocol is not successful, collections should be reattempted using a combination of imipramine, detomidine, and oxytocin. Regardless of the protocol used, a quiet environment with minimal disturbance is associated with a better outcome. In contrast to the body of literature available on pharmacologically induced ex copula ejaculation in horses, only a few studies have been published so far on this topic in donkeys. Further studies are warranted to investigate whether pharmacologically induced ex copula ejaculation is an effective method of semen collection in jacks and to compare different pharmacological protocols for inducing ejaculation in jacks.

scholarly journals Targeted transgenesis identifies Gαs as the bottleneck in β2-adrenergic receptor cell signaling and physiological function in airway smooth muscle

2014 ◽  
Vol 307 (10) ◽  
pp. L775-L780 ◽  
Author(s):  
Wayne C. H. Wang ◽  
Susan H. Pauer ◽  
Dan'elle C. Smith ◽  
Madison A. Dixon ◽  
David J. Disimile ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Transgenic Mice ◽  
G Protein ◽  
Airway Smooth Muscle ◽  
Adrenergic Receptor ◽  
Coupling Efficiency ◽  
The Body ◽  
Limiting Factor ◽  
Camp Production ◽  
Β2 Adrenergic Receptor

G protein-coupled receptors are the most pervasive signaling superfamily in the body and act as receptors to endogenous agonists and drugs. For β-agonist-mediated bronchodilation, the receptor-G protein-effector network consists of the β2-adrenergic receptor (β2AR), Gs, and adenylyl cyclase, expressed on airway smooth muscle (ASM). Using ASM-targeted transgenesis, we previously explored which of these three early signaling elements represents a limiting factor, or bottleneck, in transmission of the signal from agonist binding to ASM relaxation. Here we overexpressed Gαs in transgenic mice and found that agonist-promoted relaxation of airways was enhanced in direct proportion to the level of Gαs expression. Contraction of ASM from acetylcholine was not affected in Gαs transgenic mice, nor was relaxation by bitter taste receptors. Furthermore, agonist-promoted (but not basal) cAMP production in ASM cells from Gαs-transgenic mice was enhanced compared with ASM from nontransgenic littermates. Agonist-promoted inhibition of platelet-derived growth factor-stimulated ASM proliferation was also enhanced in Gαs mouse ASM. The enhanced maximal β-agonist response was of similar magnitude for relaxation, cAMP production, and growth inhibition. Taken together, it appears that a limiting factor in β-agonist responsiveness in ASM is the expression level of Gαs. Gene therapy or pharmacological means of increasing Gαs (or its coupling efficiency to β2AR) thus represent an interface for development of novel therapeutic agents for improvement of β-agonist therapy.

Adjuvant Drugs in Pain Management

2018 ◽  
Author(s):  
David R. Eidelson ◽  
Larry C. Driver
Keyword(s):  
Neuropathic Pain ◽  
Pain Management ◽  
Side Effects ◽  
Cancer Pain ◽  
Adrenergic Receptor ◽  
Serotonin Reuptake ◽  
Tricyclic Antidepressants ◽  
Psychological Symptoms ◽  
Chronic Cancer Pain ◽  
Key Issues

The etiology of cancer pain is often multifactorial, and management is therefore complex. Cancer pain often has both nociceptive and neuropathic pain features, as well as psychological symptoms modulating the expression of pain. Often, inflammation plays a central role in the pathobiology of chronic cancer pain. Therefore, in addition to use of opioids for the management of chronic moderate to severe cancer pain, it is important to consider adjuvants for effective pain management. This chapter discusses the key issues related to adjuvants such as anti-depressants (e.g., serotonin reuptake receptor antagonists, tricyclic antidepressants), α‎2-adrenergic receptor agonists, anti-epileptic, and anti-inflammatory agents for pain management, including indications and side effects.

scholarly journals Study of the rams’ jumping order

2010 ◽  
pp. 59-62
Author(s):  
János Oláh ◽  
Nóra Vass ◽  
Szilvia Kusza ◽  
János Posta ◽  
Anna Pécsi ◽  
...  
Keyword(s):  
Body Condition ◽  
Coming Out ◽  
The Body ◽  
Semen Collection ◽  
Artificial Vagina ◽  
Medium Correlation

The bevahiour of Babolna Tetra, Ile de France and Suffolk rams was studied at semen collection by artificial vagina. The sequence of rams coming out of the group to the place of semen collection and the number of jumpings needed to ejaculation were observed. It was investigated if there were changes in these characters at different occasions, and did they show connection to the body condition. The number of jumpings before ejaculation was different in the different breeds. Semen was taken at the first jump from 63% of the Suffolk, 56% of the Babolna Tetra and 55% of the Ile de France rams. There was no early ejaculation at the Ile de France, but it was common among the Suffolk rams. The greatest changes in the jumping order between different semen collections were observed in the Babolna Tetra breed. There was a medium correlation in the Suffolk breed between the jumping order and body condition in the autumn and spring, which was tight and significant in winter.

A Study on Work-related Musculoskeletal Disorders among Sewing Machine Operators

2020 ◽  
Vol 11 (01) ◽  
Author(s):  
Ekta . ◽  
Manju Mehta ◽  
Praveen Kumar Sharma
Keyword(s):  
Textile Industry ◽  
Work Organization ◽  
Working Hours ◽  
The Body ◽  
Musculoskeletal Symptoms ◽  
Health Issues ◽  
Workplace Design ◽  
Sewing Machine ◽  
Work Related ◽  
Machine Operators

A musculoskeletal disorder is highly dependent on the workplace design. The workers whose job requires repetitive tasks, are more prone to this disorder. Textile industry is one of the labor intensive industries and most of its jobs require continuous engagement with the work. Sewing machine operators in this sector due to workplace design are facing high risk of health issues due to focused attention and static posture of the body. Understanding the health issues linked with continuous working hours and static posture need to be addressed. Both Government and non- government organizations need to be better involved in designing interventions targeting these people and protecting them from such health risks.The present study was conducted in Hisar district from Haryana state in which respondents were selected randomly. Total number of respondents were 60 in which 28 were males and 32 were females with objectives to assess work organization and work space design and to find out the occupational health problems and musculoskeletal symptoms among sewing machine operators. The results showed that maximum numbers of the respondents (68.4%) were took break of fixed duration and (53.4%) respondents were work along with others. Majority (43.3%) respondents were the first experience of MSK symptoms from 7 days to 12 months followed by (33.3%) respondents in 2-3 years.

Theory-Practice Gap: The Experiences of Nigerian Nursing Students

2018 ◽  
Vol 20 (1) ◽  
Author(s):  
Titilayo Dorothy Odetola ◽  
Olusola Oluwasola ◽  
Christoph Pimmer ◽  
Oluwafemi Dipeolu ◽  
Samson Oluwayemi Akande ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Nursing Students ◽  
Developing Country ◽  
The Body ◽  
Clinical Staff ◽  
Clinical Settings ◽  
Practice Gap ◽  
The Difference ◽  
Analyse Data ◽  
Theory Practice Gap

The “disconnect” between the body of knowledge acquired in classroom settings and the application of this knowledge in clinical practice is one of the main reasons for professional fear, anxiety and feelings of incompetence among freshly graduated nurses. While the phenomenon of the theory-to-practice gap has been researched quite extensively in high-income country settings much less is known about nursing students’ experiences in a developing country context. To rectify this shortcoming, the qualitative study investigated the experiences of nursing students in their attempt to apply what they learn in classrooms in clinical learning contexts in seven sites in Nigeria. Thematic content analysis was used to analyse data gained from eight focus group discussions (n = 80) with the students. The findings reveal a multifaceted theory-practice gap which plays out along four tensions: (1) procedural, i.e. the difference between practices from education institutions and the ones enacted in clinical wards – and contradictions that emerge even within one clinical setting; (2) political, i.e. conflicts that arise between students and clinical staff, especially personnel with a lower qualification profile than the degree that students pursue; (3) material, i.e. the disconnect between contemporary instruments and equipment available in schools and the lack thereof in clinical settings; and (4) temporal, i.e. restricted opportunities for supervised practice owing to time constraints in clinical settings in which education tends to be undervalued. Many of these aspects are linked to and aggravated by infrastructural limitations, which are typical for the setting of a developing country. Nursing students need to be prepared regarding how to deal with the identified procedural, political, material and temporal tensions before and while being immersed in clinical practice, and, in so doing, they need to be supported by educationally better qualified clinical staff.

Conducting a Virtual Study with Special Considerations for Working with Persons with Aphasia

2020 ◽  
Author(s):  
Ashleigh Doub ◽  
Anne Hittson ◽  
Brielle C Stark
Keyword(s):  
Data Storage ◽  
Study Data ◽  
The Body ◽  
Retention Rates ◽  
Clinical Settings ◽  
Use Of Technology ◽  
Quality Check ◽  
Assessment Procedures ◽  
Post Assessment ◽  
Larger Sample

Purpose: The use of technology (e.g., telehealth) in clinical settings has rapidly increased and its use in research settings continues to grow. The aim of this report is to provide detailed methods for conducting a multi-timepoint (test-retest) virtual paradigm, assessing lifestyle, physiological, cognitive, and linguistic factors in persons with and without aphasia. Methods: Procedures for virtual assessment are detailed in a sample of non-brain damaged adults (NB; N=24) and persons with aphasia (PWA; N=9) on a test-retest paradigm (data collection approximately 10 +/- 3 days apart). This report provides practical information about pre-assessment (e.g. recruitment, scheduling), assessment (e.g. aphasia-friendly consent presentation, investigator fidelity), and post-assessment (e.g. data storage, quality check) procedures for human behavior research using a virtual platform.Results: Preliminary study data is provided, demonstrating high retention rates and feasibility. Common technological troubles and solutions are discussed, and solutions offered. The results suggest that our pre-assessment, assessment, and post-assessment procedures were core to the success of our study. Conclusion: We provide practical methodology for conducting a multi-timepoint study, with considerations for persons with aphasia, adding to the body of research on telehealth in clinical populations. Future studies should continue to evaluate tele-methodology, which may be core for diversifying studies, improving study retention, and enrolling larger sample sizes.

Biocompatible Polymers and their Potential Biomedical Applications: A Review

2019 ◽  
Vol 25 (34) ◽  
pp. 3608-3619 ◽  
Author(s):  
Uzma Arif ◽  
Sajjad Haider ◽  
Adnan Haider ◽  
Naeem Khan ◽  
Abdulaziz A. Alghyamah ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Biomedical Applications ◽  
Living System ◽  
Health Condition ◽  
The Body ◽  
Biocompatible Polymers ◽  
Nano Technology ◽  
Artificial Grafts ◽  
Immunological Reactions

Background: Biocompatible polymers are gaining great interest in the field of biomedical applications. The term biocompatibility refers to the suitability of a polymer to body and body fluids exposure. Biocompatible polymers are both synthetic (man-made) and natural and aid in the close vicinity of a living system or work in intimacy with living cells. These are used to gauge, treat, boost, or substitute any tissue, organ or function of the body. A biocompatible polymer improves body functions without altering its normal functioning and triggering allergies or other side effects. It encompasses advances in tissue culture, tissue scaffolds, implantation, artificial grafts, wound fabrication, controlled drug delivery, bone filler material, etc. Objectives: This review provides an insight into the remarkable contribution made by some well-known biopolymers such as polylactic-co-glycolic acid, poly(ε-caprolactone) (PCL), polyLactic Acid, poly(3- hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), Chitosan and Cellulose in the therapeutic measure for many biomedical applications. Methods: : Various techniques and methods have made biopolymers more significant in the biomedical fields such as augmentation (replaced petroleum based polymers), film processing, injection modeling, blow molding techniques, controlled / implantable drug delivery devices, biological grafting, nano technology, tissue engineering etc. Results: The fore mentioned techniques and other advanced techniques have resulted in improved biocompatibility, nontoxicity, renewability, mild processing conditions, health condition, reduced immunological reactions and minimized side effects that would occur if synthetic polymers are used in a host cell. Conclusion: Biopolymers have brought effective and attainable targets in pharmaceutics and therapeutics. There are huge numbers of biopolymers reported in the literature that has been used effectively and extensively.

Antipyretic Plants: An Updated Review

2020 ◽  
Vol 16 (1) ◽  
pp. 4-12
Author(s):  
Vandana Garg ◽  
Rohit Dutt
Keyword(s):  
Side Effects ◽  
Body Temperature ◽  
Medicinal Plants ◽  
Inflammatory Mediators ◽  
Review Paper ◽  
The Body ◽  
Hypothalamic Area ◽  
Antipyretic Activity ◽  
Disease States ◽  
Elevated Body Temperature

Background: Fever, is known as pyrexia, may occur due to infection, inflammation, or any tissue damage and disease states. Normally, the infected or damaged tissue initiates the enhanced formation of pro-inflammatory mediators like cytokines which further increases the synthesis of prostaglandin E2 (PgE2) near the hypothalamic area and thereby trigger the hypothalamus to elevate the body temperature. Objective: Antipyretics are the agents which reduce the elevated body temperature. The most commonly used antipyretic agent, paracetamol, may be fatal due to its side effects. Methods: In this review paper, Chemical Abstracts, Google Scholar, PubMed, and Science Direct were the sources for the published article to collect information regarding antipyretic activity. Results: This review compiles the antipyretic plants that may be useful to treat fever due to various diseases. Conclusion: These medicinal plants could be good alternatives for traditional allopathic antipyretics.

Critical Review on Standard Operative Procedure of Yapana Basti Karma

2018 ◽  
Vol 3 (5) ◽  
Author(s):  
Dr. Rishu Sharma ◽  
Dr. Gyanendra Datta Shukla ◽  
Dr. Alok Kumar Srivastava
Keyword(s):  
Side Effects ◽  
Critical Review ◽  
Treatment Modality ◽  
Operative Procedure ◽  
The Body ◽  
Dosage Schedule ◽  
Dual Function ◽  
Time Period ◽  
Curative Action

Panchakarma therapy is one of the vital branch of Ayurveda, which deals mainly with purification of the provoked Doshas from the body. Basti Chikitsa is regarded as the prime treatment modality among the Panchakarma. It is having not only curative action but also preventive and promotive actions. It is considered as best treatment for Vata Dosha. Yapana Basti is a subtype of Asthapana Basti, which is having the property to support life and promote longevity and widely used in various disorders. Rajayapana Basti is superior amongst all the Yapana Bastis described by Acharya Charaka as it is the king of Yapana. This Rasayana Yapana Basti performs dual function of both Anuvasana and Niruha; hence this is Srotoshodhaka and Brimhana at the sametime. That’s why there is no need to administer separate Anuvasana while giving Yapana Basti. There is an urgent need of standardizing the classical Panchakarma procedures in consideration of the need of today. The dosage schedule, exact procedures, medicaments, effects, and side effects are to be standardized so that uniform procedure of practice should be followed all over nation. Standardization is the need of hour for physicians, to prevent Atiyoga (over activity), Ayoga (less or no activity) and to get adequate effects in a systematic and sophisticated manner within desired time period.

scholarly journals COVID-19 and Alcohol Poisoning: A Fatal Competition

2021 ◽  
pp. 1-10
Author(s):  
Mohammad Heidari ◽  
Nasrin Sayfouri
Keyword(s):  
Side Effects ◽  
Alcohol Consumption ◽  
Mass Media ◽  
The Body ◽  
Ministry Of Health ◽  
Alcohol Poisoning ◽  
Methanol Poisoning ◽  
The Public

ABSTRACT In March 2020, concurrently with the outbreak of COVID-19 in Iran, the rate of alcohol poisoning was unexpectedly increased in the country. This study has attempted to make an overall description and analysis of this phenomenon by collecting credible data from the field, news, and reports published by the emergency centers and the Iranian Ministry of Health. The investigations showed that in May 20, 2020, more than 6150 people have been affected by methanol poisoning from whom 804 deaths have been reported. A major cause of the increased rate of alcohol poisoning in this period was actually the illusion that alcohol could eliminate the Coronaviruses having entered the body. It is of utmost importance that all mass media try to dismiss the cultural, religious, and political considerations and prepare convincing programs to openly discuss the side-effects of forged alcohol consumption with the public, especially with the youth. It must be clearly specified that “consuming alcohol cannot help prevent COVID-19.”

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