scholarly journals Analogues of a Cyclic Antimicrobial Peptide with a Flexible Linker Show Promising Activity against Pseudomonas aeruginosa and Staphylococcus aureus

Antibiotics ◽  
2020 ◽  
Vol 9 (7) ◽  
pp. 366 ◽  
Author(s):  
Thomas Thomsen ◽  
Helen Mendel ◽  
Wafaa Al-Mansour ◽  
Alberto Oddo ◽  
Anders Løbner-Olesen ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Health Concern ◽  
Side Chain ◽  
Resistant Bacteria ◽  
Bacterial Strains ◽  
Major Health ◽  
E Coli ◽  
Drug Resistant Bacteria ◽  
Multicellular Organisms

The emergence of multi-drug resistant bacteria is becoming a major health concern. New strategies to combat especially Gram-negative pathogens are urgently needed. Antimicrobial peptides (AMPs) found in all multicellular organisms act as a first line of defense in immunity. In recent years, AMPs have attracted increasing attention as potential antibiotics. Naturally occurring antimicrobial cyclic lipopeptides include colistin and daptomycin, both of which contain a flexible linker. We previously reported a cyclic AMP BSI-9 cyclo(Lys-Nal-Lys-Lys-Bip-O2Oc-Nal-Lys-Asn) containing a flexible linker, with a broad spectrum of activity against bacterial strains and low hemolytic activity. In this study, improvement of the antimicrobial activity of BSI-9, against the European Committee on Antimicrobial Susceptibility Testing (EUCAST) strains of S. aureus, E. coli, A. baumannii, and P. aeruginosa was examined. This led to synthesis of eighteen peptide analogues of BSI-9, produced in four individual stages, with a different focus in each stage; cyclization point, hydrophobicity, cationic side-chain length, and combinations of the last two. Specifically the modified compound 11, exhibited improved activity against Staphylococcus aureus and Pseudomonas aeruginosa with MIC of 4 µg/mL and 8 µg/mL, respectively, compared to the original BSI-9, which had an MIC of 16–32 µg/mL.

scholarly journals Synthesis and Study of New Quinolineaminoethanols as Anti-Bacterial Drugs

2019 ◽  
Vol 12 (2) ◽  
pp. 91
Author(s):  
Laumaillé ◽  
Dassonville-Klimpt ◽  
Peltier ◽  
Mullié ◽  
Andréjak ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Klebsiella Pneumoniae ◽  
Resistant Bacteria ◽  
Drug Resistant ◽  
E Coli ◽  
Gram Positive Bacteria ◽  
Drug Resistant Bacteria ◽  
Escherichia Coli Bacteria

The lack of antibiotics with a novel mode of action associated with the spread of drug resistant bacteria make the fight against infectious diseases particularly challenging. A quinoline core is found in several anti-infectious drugs, such as mefloquine and bedaquiline. Two main objectives were set in this work. Firstly, we evaluated the anti-mycobacterial properties of the previous quinolines 3, which have been identified as good candidates against ESKAPEE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter spp. and Escherichia coli) bacteria. Secondly, a new series 4 was designed and assessed against the same bacteria strains, taking the pair of enantiomers 3m/3n as the lead. More than twenty compounds 4 were prepared through a five-step asymmetric synthesis with good enantiomeric excesses (>90%). Interestingly, all compounds of series 3 were efficient on M. avium with MIC = 2–16 µg/mL, while series 4 was less active. Both series 3 and 4 were generally more active than mefloquine against the ESKAPEE bacteria. The quinolines 4 were either active against Gram-positive bacteria (MIC ≤ 4 µg/mL for 4c–4h and 4k/4l) or E. coli (MIC = 32–64 µg/mL for 4q–4v) according to the global lipophilicity of these compounds.

scholarly journals Polyphenylglyoxamide-Based Amphiphilic Small Molecular Peptidomimetics as Antibacterial Agents with Anti-Biofilm Activity

2021 ◽  
Vol 22 (14) ◽  
pp. 7344
Author(s):  
Tsz Tin Yu ◽  
Rajesh Kuppusamy ◽  
Muhammad Yasir ◽  
Md. Musfizur Hassan ◽  
Manjulatha Sara ◽  
...  
Keyword(s):  
Quaternary Ammonium ◽  
Antibacterial Agents ◽  
Health Concern ◽  
Resistant Bacteria ◽  
Ammonium Iodide ◽  
E Coli ◽  
Drug Resistant Bacteria ◽  
Permeability Study ◽  
Cationic Group ◽  
Chain Lengths

The rapid emergence of drug-resistant bacteria is a major global health concern. Antimicrobial peptides (AMPs) and peptidomimetics have arisen as a new class of antibacterial agents in recent years in an attempt to overcome antibiotic resistance. A library of phenylglyoxamide-based small molecular peptidomimetics was synthesised by incorporating an N-alkylsulfonyl hydrophobic group with varying alkyl chain lengths and a hydrophilic cationic group into a glyoxamide core appended to phenyl ring systems. The quaternary ammonium iodide salts 16d and 17c showed excellent minimum inhibitory concentration (MIC) of 4 and 8 μM (2.9 and 5.6 μg/mL) against Staphylococcus aureus, respectively, while the guanidinium hydrochloride salt 34a showed an MIC of 16 μM (8.5 μg/mL) against Escherichia coli. Additionally, the quaternary ammonium iodide salt 17c inhibited 70% S. aureus biofilm formation at 16 μM. It also disrupted 44% of pre-established S. aureus biofilms at 32 μM and 28% of pre-established E. coli biofilms 64 μM, respectively. A cytoplasmic membrane permeability study indicated that the synthesised peptidomimetics acted via disruption and depolarisation of membranes. Moreover, the quaternary ammonium iodide salts 16d and 17c were non-toxic against human cells at their therapeutic dosages against S. aureus.

Nghiên cứu sự kháng kháng sinh của các chủng vi khuẩn gây nhiễm khuẩn đường tiết niệu phân lập được tại Bệnh viện Hữu nghị Đa khoa Nghệ An

2021 ◽  
Author(s):  
Trâm Quế Anh
Keyword(s):  
Urinary Tract ◽  
General Hospital ◽  
Urinary Tract Infections ◽  
Resistant Bacteria ◽  
Antibiotics Resistance ◽  
Bacterial Strains ◽  
E Coli ◽  
Linezolid Resistance ◽  
Drug Resistant Bacteria ◽  
Tract Infections

TÓM TẮT Đặt vấn đề: Xác định đúng căn nguyên gây NKĐTN và mức độ kháng kháng sinh của các vi khuẩn sẽ giúp cho việc điều trị có hiệu quả, giảm được chi phí điều trị, hạn chế sự gia tăng vi khuẩn đề kháng kháng sinh. Đối tượng và phương pháp nghiên cứu: Các chủng VK gây nhiễm khuẩn đương tiết niệu phân lập được tại bệnh viện Hữu nghị Đa khoa Nghệ An từ 1/2020 đến 12/2020. Thiết kế nghiên cứu: Cắt ngang mô tả. Kết quả: Phân lập được 473 chủng vi khuẩn gây NKĐTN, trong đó, E. coli 38,48%; P. aeruginosa 14,15; Enterococcus sp 10,57; K. pneumoniae 13,32%. E. coli: kháng các kháng sinh Cephalosporine, Quinolones từ 56,7 - 63,8%, Carbapenem 4,5 - 6,2%, sinh ESBL 49,4%. P. aeruginosa: đã kháng các kháng sinh thử nghiệm từ 59,1 - 69,2%. Enterococcus sp: kháng với các kháng sinh nhóm Quinolone 73,5%, kháng Vancomycin 8,3%; Chưa ghi nhận đề kháng Linezolid. K. pneumoniae: kháng nhóm Cephalosporin, Quinolone từ 66,7 - 74,6%, đề kháng với Carbapenem từ 46,0 - 50,8%. Kết luận: Các vi khuẩn gây nhiễm khuẩn tiết niệu thường gặp là: E. coli, P. aeruginosa, Enterococcus sp. K. pneumoniae. Các vi khuẩn phân lập được đã đề kháng với nhiều kháng sinh thường dùng với các mức độ khác nhau. Xuất hiện các chủng vi khuẩn Gram âm kháng Carbapenem, Gram dương kháng Vancomycin. Từ khóa: Nhiễm khuẩn tiết niệu, E.coli, Klebsiella, P.aeruginosa, Enterococcus sp ABSTRACT RESEARCH OF ANTIBIOTICS RESISTANCE OF BACTERIA STRAINS CAUSING URINARY TRACT INFECTIONS ISOLATED AT NGHEAN FRIENDSHIP GENERAL HOSPITAL Background: The good identification of UTI microorganism and their antimicrobial susceptibility would promote the effective treatment, reduce the cost as well as the emergence of drug resistant bacteria. Methods: Bacterial strains causing urinary tract infections were isolated at Nghe An Friendship General Hospital from 1/2020 to 12/2020. Study design: Descriptive cross section. Results: 473 bacterial strains causing UTIs were isolated, in which, E. coli 38.48%; P. aeruginosa 14.15; Enterococcus sp 10.57; K. pneumoniae 13.32%. E. coli: resistant to Cephalosporin antibiotics, Quinolones from 56.7 - 63.8%, Carbapenem 4.5 - 6.2%, producing ESBL 49.4%. P. aeruginosa: was resistant to the tested antibiotics from 59.1 - 69.2%. Enterococcus sp: resistant to Quinolone antibiotics 73.5%, resistant to Vancomycin 8.3%; Linezolid resistance has not been recorded. K. pneumoniae: resistant to Cephalosporin, Quinolone from 66.7 - 74.6%, resistant to Carbapenem from 46.0 - 50.8%. Conclusion: Common bacteria causing urinary tract infections are: E. coli, P. aeruginosa, Enterococcus sp. K. pneumoniae. The isolates were resistant to many commonly used antibiotics to varying degrees. Occurrence of strains of Gram - negative bacteria resistant to Carbapenem, Gram - positive resistant to Vancomycin. Keywords: Urinary Tract infections, E. coli, Klebsiella, P. aeruginosa, Enterococcus sp.

scholarly journals Antibacterial Activity of Polygonum pulchrum Blume Ethanol Extract on Staphylococcus aureus and Escherichia coli

2018 ◽  
Vol 3 (2) ◽  
pp. 26
Author(s):  
Asman Sadino ◽  
Idin Sahidin ◽  
Wahyuni Wahyuni
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Ethanol Extract ◽  
Inhibition Zone ◽  
Health Concern ◽  
Diffusion Method ◽  
Resistant Bacteria ◽  
E Coli ◽  
Weak Antibacterial Activity

The emergence of resistant bacteria strain has become a global health concern. It encourages the exploration of potential antibacterial agents, particularly from natural sources. The aim of this study was to investigate the antibacterial activity of ethanol extract of root, stems, leaves, and flowers of Polygonum pulchrum Blume against Staphylococcus aureus and Escherichia coli, through disc diffusion method using cup-plate method. Inhibition zone against S. aureus from roots, stems, leaves, and flowers ethanol extract were 3.5 mm, 2.5 mm, 2.25 mm, and 2.62 mm, respectively, while the inhibition zone against E. coli were 2.25 mm, 2.12 mm, 1.62 mm, and 1.75 mm, respectively. In conclusion, ethanol extract of root, stem, leaves, and flower of P. pulchrum Bl possessed weak antibacterial activity against S. aureus and E. coli.Keywords: P. pulchrum Bl, antibacterial, E. coli, S. aureus, cup-plate technique

scholarly journals Cationic Anthraquinone Analogs as Selective Antimicrobials

2019 ◽  
Vol 12 ◽  
pp. 117863611984780
Author(s):  
Yagya Prasad Subedi ◽  
Cheng-Wei Tom Chang
Keyword(s):  
Staphylococcus Aureus ◽  
Broad Spectrum ◽  
Mammalian Cells ◽  
Resistant Bacteria ◽  
Multiple Drug ◽  
E Coli ◽  
Broad Spectrum Antibiotics ◽  
Drug Resistant Bacteria ◽  
New Antibiotics ◽  
Low Cytotoxicity

Development of new antibiotics is always needed in the fight against growing threat from multiple drug–resistant bacteria, such as resistant Gram-negative (G−) Escherichia coli and Klebsiella pneumoniae. While the development of broad-spectrum antibiotics has attracted great attention, careful administration of these antibiotics is important to avoid adverse effects, like Clostridium difficile infection (CDI). The use of broad-spectrum antibiotics, for example, quinolones, can increase the risk of CDI by eradicating the protective bacteria in intestine and encouraging C difficile spore germination. Many common intestine bacteria are G− or anaerobic, including Enterococcus faecalis, Bacteroides fragilis, and E coli. Hence, it may be advantageous in certain therapeutic practices to employ selective antimicrobials. For instance, Gram-positive (G+) methicillin-resistant Staphylococcus aureus (MRSA) that can cause life-threatening sepsis can be controlled with the use of selective antibiotic, vancomycin. Nevertheless, its effectiveness has been limited with the emerging of vancomycin-resistant Staphylococcus aureus (VRSA). A recent report on antimicrobial cationic anthraquinone analogs (CAAs) that show tunable activity and selectivity may provide new hope in the search for selective antimicrobials. In particular, the lead CAA displays prominent activity against MRSA while manifesting low activity against E coli and low cytotoxicity toward normal mammalian cells.

scholarly journals Efficacy of Thai Plant Extracts for Antibacterial and Anti-Biofilm Activities against Pathogenic Bacteria

Antibiotics ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 1470
Author(s):  
Dennapa Saeloh ◽  
Monton Visutthi
Keyword(s):  
Pathogenic Bacteria ◽  
Ethanolic Extract ◽  
Antibacterial Activities ◽  
Resistant Bacteria ◽  
Dilution Method ◽  
Minimal Bactericidal Concentration ◽  
Piper Betle ◽  
Bacterial Strains ◽  
E Coli ◽  
Drug Resistant Bacteria

The emergence of drug-resistant bacteria has impacted the outcome of current therapeutics as a threat to global healthcare; novel medicines are urgently needed. Thirteen medicinal plants were collected in Northeastern Thailand, and their crude ethanolic extracts were evaluated for antibacterial activities against Staphylococcus aureus ATCC25923 and Escherichia coli ATCC25922 using the broth micro-dilution method. Piper betle leaf ethanolic extract showed optimal activity against both representative bacterial strains. Activity was also observed against clinical isolates of methicillin-resistant S. aureus (MRSA) and E. coli, with minimal inhibitory concentration (MIC) ranging from 0.31 mg/mL to 2.5 mg/mL and minimal bactericidal concentration (MBC) ranging from 0.62 mg/mL to 2.5 mg/mL. A time-kill study revealed that the extract activity was time- and dose-dependent, and also bactericidal on the tested bacteria. P. betle extract inhibited biofilm formation and promoted biofilm eradication in both S. aureus and E. coli. 4-Allyl-1,2-diacetoxybenzene and eugenol were identified as the most abundant compounds in the extract and may play major roles in the anti-bacterial and anti-biofilm activity. Results suggest that ethanolic P. betle leaf extract shows promise as an alternative method for the prevention of bacterial diseases.

scholarly journals Bacterial behavior in human blood reveals complement evaders with persister-like features

2020 ◽  
Author(s):  
Stéphane Pont ◽  
Nathan Fraikin ◽  
Yvan Caspar ◽  
Laurence Van Melderen ◽  
Ina Attrée ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Human Blood ◽  
Immune Cells ◽  
Bacterial Load ◽  
Phenotypic Heterogeneity ◽  
Health Concern ◽  
Resistant Bacteria ◽  
Bacterial Cells ◽  
Human Pathogens ◽  
Bacterial Strains

AbstractsBacterial bloodstream infections (BSI) are a major health concern and can cause up to 40% mortality. Pseudomonas aeruginosa BSI is often of nosocomial origin and is associated with a particularly poor prognosis. The mechanism of bacterial persistence in blood is still largely unknown. Here, we analyzed the behavior of a cohort of clinical and laboratory Pseudomonas aeruginosa strains in human blood. In this specific environment, complement was the main defensive mechanism, acting either by direct bacterial lysis or by opsonophagocytosis, which required recognition by immune cells. We found highly variable survival rates for different strains in blood, whatever their origin, serotype, or the nature of their secreted toxins and despite their detection by immune cells. We identified and characterized a complement-tolerant subpopulation of bacterial cells that we named “evaders”. Evaders represented 0.1-0.001% of the initial bacterial load and displayed transient tolerance. Although evaders shared some features with bacterial persisters, which tolerate antibiotic treatment, they appear to have evolved distinct strategies to escape complement. We detected the evaders for five other major human pathogens: Acinetobacter baumannii, Burkholderia multivorans, enteroaggregative Escherichia coli, Klebsiella pneumoniae, and Yersinia enterocolitica. Thus, the evaders could allow the pathogen to persist within the bloodstream, and may be the cause of fatal bacteremia or dissemination, notably in the absence of effective antibiotic treatments.Author summary for “Complement evaders”Blood infections by antibiotic resistant bacteria, notably Pseudomonas aeruginosa, are major concerns in hospital settings. The complex interplay between P. aeruginosa and the innate immune system in the context of human blood is still poorly understood. By studying the behavior of various P. aeruginosa strains in human whole blood and plasma, we showed that bacterial strains display different rate of tolerance to the complement system. Despite the complement microbicide activity, most bacteria withstand elimination through phenotypic heterogeneity creating a tiny (<0.1%) subpopulation of transiently tolerant evaders. While genetically identical to the rest of the complement-sensitive population, evaders allow the bacteria to persist in plasma. This phenotypic heterogeneity thus prevents total elimination of the pathogen from the circulation, and represent a new strategy to disseminate within the organism.

scholarly journals Multi-drug Resistant Bacteria Isolated from Pus and Phenotypic Detection of Metallo β-lactamase Activity of Pseudomonas Aeruginosa

2021 ◽  
Vol 1 (1) ◽  
pp. 8-15
Author(s):  
Pratiksha Paudel ◽  
Sunita Shrestha ◽  
Sushmita Poudel ◽  
Bishnu Raj Tiwari
Keyword(s):  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Cross Sectional Study ◽  
The Body ◽  
Resistant Bacteria ◽  
Drug Resistant ◽  
Cross Sectional ◽  
Gram Negative ◽  
Drug Resistant Bacteria ◽  
Acinetobacter Spp

Introduction: Pus is an exudate, present at the site of inflammation occurring during bacterial, viral or fungal infection and is formed by pyogenic bacteria. Objective: To study the multi-drug resistant bacteria including phenotypic detection of MβL activity of Pseudomonas aeruginosa in pus isolates. Methods: This was hospital based cross-sectional study in which 179 samples of pus was collected from any site of the body either by using swab or aspirated by using syringe and cultured in respective hospitals. Thus, obtained isolates were preserved and were transported to the laboratory for further processing. Results: Out of 162 pus isolated, 67(42.0%) were Methecillin resistant Staphylococcus aureus (MRSA), 14(8%) were Methicillin sensitive Staphylococcus aureus (MSSA), 21(13.0%) were Klebsiella spp, 19(11.7%) were Escherichia coli, 14 (8.6%) were Pseudomonas aeruginosa, 10(6.2%) were Acinetobacter spp, 5(3.1%) were Streptococcus spp, 4(2.5%) were Enterococci ,3(1.9%) were Enterobacter spp, 2(1.2%) were Coagulase negative S. aureus, 1(0.6%) were Proteus vulgaris, and1(0.6%) were Citrobacter spp. Antibiogram of Gram positive cocci revealed that they showed susceptibility towards vancomycin, clindamycin, gentamycin, amikacin. Similarly, Gram negative bacilli showed good response towards gentamycin, amikacin, nitrofurantoin, colistin. Out of 162 isolates, 102(62.96%) were Multi-Drug Resistant (MDR) and 60 (37.04%) were Non-MDR. Out of 14 (8.6%) Pseudomonas aeruginosa isolates, 8(57.1%) were Imepenem resistant and among imepenem resistant, only 3(37.5%) of them showed MβL production activity. Conclusion: This study showed that Gram negative bacteria were highly resistant to antibiotics. Staphylococcus aureus was found to be more predominant bacteria in forming pus. Antibiotics used in the infections related to pus are being more resistant.

scholarly journals Phenotypic Study and Sensitivity to Anti-Infective Chemotherapy of Bacterial Strains Isolated from Cutaneous-Mucosal Infections

2018 ◽  
Vol 55 (3) ◽  
pp. 372-375
Author(s):  
Delia Mira Berceanu Vaduva ◽  
Dana Emilia Velimirovici ◽  
Marcel Mihai Berceanu Vaduva ◽  
Livia Stanga ◽  
Horatiu Petrescu ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Streptococcus Pyogenes ◽  
Correct Diagnosis ◽  
Clinical Signs ◽  
Cross Resistance ◽  
Bacterial Strains ◽  
Sensitivity Testing ◽  
E Coli ◽  
The Right

Skin- and mucosal infections, especially purulent, can often cause diagnostic and treatment problems. Therefore, we intend to conduct a microbiological study of isolated bacterial strains from ambulatory patients with various cutaneous-mucosal infections. In isolated strains we determined the sensitivity to antibiotics and we established the phenotypes of resistance in which they fall. We took in account 98 strains isolated by a private laboratory in Timisoara between January 2016 and December 2017. After bacterial identification, sensitivity testing to antibiotics was realized using Kirby-Bauer disc diffusion according to the CLSI standard. Antibiogram was performed for all strains except for Streptococcus pyogenes. By interpreting the antibiograms, the phenotypes of resistance were determined. Most infections were caused by Staphylococcus aureus. In order of frequency following strains were isolated: Staphylococcus aureus (75.52%), Streptococcus pyogenes (11.22%), Pseudomonas aeruginosa (7.14%), E. coli (4.08%) �i Enterobacter spp. (2.04%). S. aureus strains were resistant to penicillin in 94.60% of cases. We observed a higher sensitivity to oxacillin (87.84%), tobramycin (86.49%), gentamycin (87.84%), ciprofloxacin (83.78%) and clindamycin (89.20%). Most strains of S. aureus were of phenotype Peni-R Meti-S (82.44%). 12.16% were of phenotype Peni-R Meti-R (MRSA) and only 5.40% were sensitive to betalactams (Peni-S Meti-S). Gram-negative bacilli strains (Pseudomonas aeruginosa, E. coli, Enterobacter spp.) were less resistant, all being wild strains. Determining antibiotic resistance phenotypes is necessary in order to be able to make the right decision when choosing anti-infectious treatment, but also to prevent the selection of multi-resistant bacterial strains. The presence of MRSA at a rate of 12.16% is an alarm signal because the MRSA strains are multi-resistant to antibiotics with cross-resistance to the betalactams. Resistance usualy extends also to other classes of antibiotics. For a correct diagnosis and treatment, the results of the bacteriological testing need to be corroborated with the clinical signs.

scholarly journals Photodynamic effect of lanthanide derivatives of meso-tetra(N-methyl-4-pyridyl)porphine against Staphylococcus aureus.

2008 ◽  
Vol 55 (3) ◽  
pp. 581-585 ◽  
Author(s):  
Agata Jurczak ◽  
Bozena Szramka ◽  
Mariusz Grinholc ◽  
Janina Legendziewicz ◽  
Krzysztof P Bielawski
Keyword(s):  
Staphylococcus Aureus ◽  
Bactericidal Effect ◽  
Lanthanide Ions ◽  
Resistant Bacteria ◽  
Bacterial Strains ◽  
Drug Resistant Bacteria ◽  
Bacterial Cell Death ◽  
Antistaphylococcal Activity ◽  
Significant Difference ◽  
Derivatives Of

Photodynamic therapy (PDT), used for cancer treatment, is also an alternative method for eradication of drug-resistant bacteria. This method utilizes a nontoxic light-activated dye, called a photosensitizer, and visible light to produce reactive oxygen species that lead to bacterial cell death. The purpose of this study was to investigate the bactericidal effect of PDT using lanthanide derivatives of meso-tetra(N-methyl-4-pyridyl)porphine against Staphylococcus aureus strains. The new photosensitizers appeared to be photodynamically ineffective. No enhancement of antistaphylococcal activity of TMPyP was observed after the conjugation of the porphyrin with lanthanide ions. Additionally, a significant difference in the susceptibility of two bacterial strains to unmodified TMPyP was observed.

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