scholarly journals Thiosulfinate-Enriched Allium sativum Extract as an Adjunct to Antibiotic Treatment of Sepsis in a Rat Peritonitis Model

2021 ◽  
Vol 11 (11) ◽  
pp. 4760
Author(s):  
Francisco Javier Redondo-Calvo ◽  
Omar Montenegro ◽  
David Padilla-Valverde ◽  
Pedro Villarejo ◽  
Víctor Baladrón ◽  
...  
Keyword(s):  
Treatment Group ◽  
Antibiotic Treatment ◽  
Allium Sativum ◽  
Activity Level ◽  
Control Group ◽  
Sprague Dawley ◽  
E Coli ◽  
Group I ◽  
Group Ii ◽  
Peritonitis Model

Up to now, there are no studies that have shown a decrease in morbidity and mortality in the context of sepsis and septic shock, except for antibiotic therapy and the objective-guided resuscitation strategy. The goal was to evaluate the use of thiosulfinate-enriched Allium sativum extract (TASE) as an adjuvant in the management of sepsis. An experimental in vivo study was carried out with male Sprague Dawley® rats. Animals were randomized in three treatment groups: the control group (I), antibiotic (ceftriaxone) treatment group (II) and ceftriaxone plus TASE treatment group (III). All animals were housed and inoculated with 1 × 1010 CFU/15 mL of intraperitoneal Escherichia coli ATCC 25922. Subsequently, they received a daily treatment according to each group for 7 days. Clinical, analytical, microbiological, and histopathological parameters were evaluated. Statistically significant clinical improvement was observed in the ceftriaxone plus TASE vs. ceftriaxone group in weight, ocular secretions, whiskers separation and physical activity level (p ≤ 0.05). When comparing interleukins on the third day of treatment between II and III, we found statistically significant differences in IL-1 levels (p < 0.05). Blood and peritoneal liquid cultures of group I were positive for multisensitive E. coli. Group II and III cultures were negative for E. coli, although an overgrowth of Enterococcus faecalis was found. In conclusion, TASE used as an adjuvant to antibiotic treatment in the management of sepsis could improve response profiles with sepsis attenuation, thus reducing overall mortality after an animal peritonitis model.

scholarly journals The Effect of Myrmecodia pendans Ethanol Extract on Inflamed Pulp: Study on Sprague Dawley Rats

2019 ◽  
Vol 3 (2) ◽  
pp. 115
Author(s):  
Janti Sudiono ◽  
Meylisa Hardina
Keyword(s):  
Treatment Group ◽  
Healing Process ◽  
Ethanol Extract ◽  
Flavonoid Compound ◽  
Control Group ◽  
Sprague Dawley ◽  
Treatment Groups ◽  
Group I ◽  
Sprague Dawley Rats ◽  
Group Ii

Background: Inflammation is a body response caused by injury and infection. Pulpitis is a pulp tissue inflammation which is the continuous process of pulp hyperemia by bacteria invasion. Myrmecodia pendans or Sarang semut is known to contain flavonoid compound which has the anti inflammation effect. The purpose of this study is to investigate the effect of Myrmecodia pendans ethanol extract on the healing process of pulp inflammation.Materials and Methods: This experimental study involved pre- and post-in vivo treatment of 27 Sprague Dawley rats in which the inducted pulpitis model was obtained by injecting 0.01 mL Porphyromonas gingivalis into the dental pulp for 48 hours. Subjects were divided randomly into Group I (negative control), Group II (pulpitis treated by Myrmecodia pendans extract ethanol as treatment group), and Group III (pulpitis treated by Ca(OH)2 as positive control group). Group II and III as pulpitis treatment groups were divided into subgroups based on the induction periods of 48 hours (2 days), 168 hours (7 days), and 366 hours (14 days). All specimens were processed into the slides and evaluated microscopically for the healing process.Results: The result of this study showed significant difference (p<0.05) among groups on day 2, 4 and 7. On day 4, the pulpitis treatment group of Myrmecodia pendans extract showed better healing process than Ca(OH)2. On day 7, the pulpitis treatment group of Ca(OH)2 showed better healing process than Myrmecodia pendans extract. On day 14, both of the pulpitis treatment groups showed normal pulp.Conclusion: Myrmecodia pendans ethanol extract is effective for the healing process of inflamed pulp.Keywords: inflamed pulp, Myrmecodia pendans, sarang semut, Ca(OH)2 , healing process

scholarly journals Efektivitas Ekstrak Artemisia vulgaris L. sebagai Hepatoprotektor pada sel-sel Hati Tikus yang Diinduksi Niasin

2018 ◽  
Vol 6 (2) ◽  
pp. 251
Author(s):  
Laily Rahmawati ◽  
Erma Sulistyaningsih ◽  
Rosita Dewi
Keyword(s):  
Treatment Group ◽  
Liver Damage ◽  
Negative Control Group ◽  
Positive Control ◽  
Negative Control ◽  
Positive Control Group ◽  
Control Group ◽  
Artemisia Vulgaris ◽  
Group I ◽  
Group Ii

  The niacin in energy drinks has metabolic product that cause oxidative stress and liver damage, while the liver damage can be prevented by hepatoprotective agents. Scoparone in Artemisia vulgaris L. can act as a hepatoprotector by its antioxidant effect. This study aimed to investigate the effectivity of Artemisia vulgaris L. extract as a hepatoprotector in wistar hepatocytes induced by niacin. This study used 25 male rats which were divided into 5 groups: normal, the negative control, the positive control, the treatment group I, and II. Treatment was conducted for 28 days. The samples were terminated and the hepatocyte were prepared for histological examination. Histological appearance was catagorized as mild, moderate, and severe damage with or without inflamatory cells activity. The data analysis by Kruskal Wallis showed significant difference (p<0,001). Further analysis by Mann Whitney revealed significantly difference (p<0,05) between normal group and all groups, negative control group and positive control group, and positive control group and treatment group I, but not significantly difference between negative control group and treatment group I, negative control group and treatment group II, positive control group and treatment group II, and between treatment groups. The study concluded that the effectivity of Artemisia vulgaris L. extract has not been proven as a hepatoprotector but further study is needed to draw a definite conclusion.   Keywords: energy drink, niacin, Artemisia vulgaris L., hepatoprotector  

scholarly journals Changes in the number of macrophage and lymphocyte cells in chronic periodontitis due to dental X-ray exposure

2018 ◽  
Vol 51 (2) ◽  
pp. 99 ◽  
Author(s):  
Alhidayati Asymal ◽  
Eha Renwi Astuti ◽  
Rini Devijanti
Keyword(s):  
Treatment Group ◽  
Chronic Periodontitis ◽  
Radiographic Examination ◽  
Control Group ◽  
X Ray ◽  
The Third ◽  
Macrophage Cells ◽  
Group I ◽  
Significant Difference ◽  
Group Ii

Background: Periodontitis is an inflammatory disease caused by specific microorganisms that attacks tooth-supporting tissues, P. gingivalis bacteria are mostly found in patients suffering from chronic periodontitis which is usually diagnosed by means of clinical and radiographic examination. The latter play important roles in the management of periodontitis, including: establishing diagnosis, determining treatment plans and evaluating the results of treatment. Unfortunately, the use of X-rays to perform such radiographic examination has negative effects since the body’s various parts, especially the head, are not well protected from the effects of X-ray radiation. Purpose: This research aimed to analyze the effects of dental X-ray exposure on the number of macrophages and lymphocytes in experimental subjects suffering from periodontitis. Methods: 36 rats that had been diagnosed with chronic periodontitis were divided into three groups, namely: a control group, treatment group I (exposed to a 0.16 mSv dose of radiation) and treatment group II (exposed to a 0.32 mSv dose of radiation). These subjects were subsequently sacrificed on the third and fifth days after treatment. Thereafter, histopathological examination was performed to identify any changes in the number of macrophages and lymphocytes. Results: The results of an HSD test confirmed that, on the third day, there were significant differences in the number of lymphocytes between the control group and treatment group I, as well as between the control group and treatment group II. On the fifth day, there were also significant differences in the number of lymphocytes between the control group and treatment group I, as well as between treatment group I and treatment group II. Similarly, there was a significant difference in the number of macrophage cells on the third day between the control group and treatment group I. On the fifth day, there were also significant differences in the number of macrophage cells between the control group and treatment group I, as well as between treatment group I and treatment group II. Conclusion: Dental x-ray exposure at a dose of 0.16 mSv can elevate the number of macrophages and lymphocytes on the third and fifth days. On the other hand, dental x-ray radiation at a dose of 0.32 mSv can reduce the number of macrophages on day 3 as well as the number of lymphocytes on the third and fifth days.

scholarly journals EVALUATION OF CHONDROPROTECTIVE EFFECTS OF INTRA ARTICULAR PIROXICAM IN POST-TRAUMATIC OSTEOARTHRITIS MODEL OF RAT

2021 ◽  
Vol 71 (2) ◽  
pp. 593-97
Author(s):  
Noaman Ishaq ◽  
Shabana Ali ◽  
Qurra Tul Ain Haider ◽  
Muhammad Abdul Basit Qaisrani ◽  
Komal Mumtaz Malik ◽  
...  
Keyword(s):  
Treatment Group ◽  
Cruciate Ligament ◽  
Positive Control ◽  
Control Group ◽  
P Value ◽  
Surgical Removal ◽  
Histopathological Analysis ◽  
Sprague Dawley ◽  
Group I ◽  
Post Traumatic

Objective: To evaluate the chondroprotective effect of piroxicam in post-traumatic osteoarthritis model of rat. Study Design: Laboratory based experimental study. Place and Duration of Study: Pharmacology department, Army Medical College, Rawalpindi, from Apr to Jun 2019. Methodology: Project included sixteen rats of Sprague Dawley breed. Osteoarthritis was induced in anesthetized rats by surgical removal of medial meniscus and anterior cruciate ligament resection. After that rats were randomly allocated in two groups with eight rats in each group. Rats of group I were positive control that received 0.2 ml saline intra articularly once weekly for four weeks. Meanwhile rats of group II (treatment group) received 50 µl piroxicam intra articularly once weekly for four weeks. One week after the drug intervention, radiograph of the right knee joint of all rats were taken. Animals were then sacrificed with inhaled chloroform and part of proximal tibia was obtained for histopathological analysis. Results: Comparison of radiographs of both groups depicted a significant p-value of <0.01. Meanwhile mean histopathological score of control group and treatment group were 11.50 ± 1.195 and 6.50 ± 1.195 respectively with a p-value of <0.01. Conclusion: Intra articular administration of piroxicam in post-traumatic Osteoarthritis model of rats resulted in improvement in radiographic grades and histopathology scores.

scholarly journals Gambaran histologik hati tikus Wistar yang diberi jus tomat setelah diinduksi monosodium gluatamat

2017 ◽  
Vol 5 (1) ◽  
Author(s):  
Christantio Legoh ◽  
Martha M. Kaseke ◽  
Taufiq F. Pasiak
Keyword(s):  
Treatment Group ◽  
Wistar Rats ◽  
Inflammatory Cells ◽  
Fatty Degeneration ◽  
Negative Control Group ◽  
Negative Control ◽  
Tomato Juice ◽  
Control Group ◽  
Group I ◽  
Group Ii

Abstract: Monosodium glutamate (MSG) is one of the ingredients used as flavour additive. However, excessive consumption of MSG could damage the liver. This study was aimed to obtain the impact of MSG exposure on histopathological findings of the liver of Wistar rats administered with tomato juice. This was an experimental study with the post-test only control group design. Subjects were Wistar rats divided into three groups, as follows: the negative control group, treatment group I, and treatment group II. The negative control group was given AD2 pellets; the treatment group I was given AD2 pellets and MSG, while the treated group II was given MSG and tomato juice. This study was conducted for 14 days. The histopathological examination of the treatment group I showed fatty degeneration of hepatocytes and infiltration of inflammatory cells meanwhile of the treatment group II, there was less fatty degeneration of hepatocytes compared to the treatment group I and no inflammatory cells. Moreover, there was no fatty degeneration and inflammatory cells in the negative control group. Conclusion: Wistar rats treated with MSG showed fatty degeneration of hepatocytes and infiltration of inflammatory cells which could be reduced by administration of tomato juice along with MSG.Keywords: tomato juice, MSG Abstrak: Monosodium glutamat (MSG) merupakan salah satu bahan makanan yang sering digunakan sebagai penyedap rasa namun konsumsi MSG berlebihan dapat merusak hati. Penelitian ini bertujuan untuk mengetahui pengaruh pajanan MSG terhadap gambaran histologik hati tikus Wistar dengan dan tanpa disertai pemberian jus tomat. Jenis penelitian ialah eksperimental dengan post-test only control group design. Tikus dibagi menjadi 3 kelompok, yaitu kelompok kontrol negatif, kelompok perlakuan I, dan kelompok perlakuan II. Kelompok kontrol negatif hanya diberikan pelet AD2; kelompok perlakuan 1 diberikan pelet AD2 dan MSG; kelompok perlakuan 2 diberikan MSG dan jus tomat. Penelitian ini dilakukan selama 14 hari. Hasil pengamatan gambaran histologik hati tikus Wistar pada kelompok perlakuan I mendapatkan adanya degenerasi lemak pada hepatosit dan sel-sel radang PMN. Pada kelompok perlakuan 2 masih ditemukan adanya degenerasi lemak pad hepatosit tetapi dengan jumlah yang lebih kurang daripada kelompok perlakuan I, serta tidak ditemukan sel-sel radang PMN. Pada kelompok kontrol negatif tidak ditemukan adanya degenerasi lemak pada hepatosit dan sel radang. Simpulan: Pada tikus wistar dengan pemberian MSG terdapat degenerasi lemak pada hepatosit dan adanya sel-sel radang. Pemberian jus tomat bersamaan dengan pemberian MSG berefek menurunkan terjadinya degenerasi lemak pada hepatosit dan tidak disertai sel-sel radang.Kata kunci: jus tomat, MSG

scholarly journals Gambaran Histologi Ginjal Tikus Wistar Yang Terpapar MSG Setelah Perlakuan Diberikan Jus Tomat Dan Diberhentikan Perlakuan Saja

2018 ◽  
Vol 1 (2) ◽  
pp. 62
Author(s):  
Yeti Eka Sispitasari
Keyword(s):  
Treatment Group ◽  
The Body ◽  
Proximal Tubules ◽  
Tomato Juice ◽  
Control Group ◽  
Renal Tubules ◽  
Apparent Difference ◽  
Group I ◽  
Significant Difference ◽  
Group Ii

MSG causes many side effects on the body, but MSG has long been used as a food flavor that can bring tastes (umami) and play a role in strengthening the taste. The chemical structure of MSG is no different from Glutamic Acid (glutamate), it is one of the 20 amino acids that make up proteins in the body. So the use of MSG needs to be discontinued to prevent kidney damage due to continued consumption of MSG, two research were conducted to determine the effect of discharging of MSG consumption by being given tomato juice (1) and discharged without treatment (2), the second study was seen from the histology picture of rats wistar mouse.Methods were experimental with post test only control group design. The research (1) used 15 wistar rats divided into three groups: group I without treatment (pellet AD II and drinking water), group II was given MSG for 14 days and group III was given tomato juice and MSG for 14 days. The study (2) used 27 rats divided by 9 groups. The sample is selected by simple random sampling method. The mice were then gradually turned off on the 29th, 43rd and 57th days. There was no significant difference in mean number of normal and damaged proximal tubules in all treatment groups. The renal histologic features in the treatment group I (MSG) and the treatment group II (MSG and tomato juice) showed normal glomeruli, tubular epithelial tubules, and lumen tubular narrowing whereas in mice discharged without treatment there was no apparent difference between the two MSG Giving groups damage to proximal tubules and renal corpusculum and regeneration after 14 days of discontinuation of MSG. Conclusions from these two experiments occurred damage to the renal tubules Keywords: MSG, Kidney, Wistar Rat

scholarly journals Efektivitas Ekstrak Etanol Daun Sirsak (Annona muricata Linn) dalam Mencegah Displasia Dorsum Lingue Tikus Galur Sprague Dawley yang Diinduksi 7,12 Dimetilbenz(Α)Antrasena

e-GIGI ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 174
Author(s):  
Tyas Prihatiningsih ◽  
Tetiana Haniastuti ◽  
Dewi Agustina
Keyword(s):  
Body Weight ◽  
Ethanolic Extract ◽  
Control Group ◽  
Sprague Dawley ◽  
Group Vi ◽  
Control Group Design ◽  
Group Design ◽  
Group I ◽  
Post Test ◽  
Group Ii

Abstract: Polycyclic aromatic hydrocarbons (PAH) is one of the largest group of carcinogen in the environment.  An agent that has antigenotoxic and anticarcinogen potency is needed to prevent DNA damage and carcinogenesis. Soursop leaves have a chemopreventive action. This study was aimed to assess the effectiveness of ethanolic extract of soursop leaves in prevention of dysplasia of upper surface of tongue in rats. This was a true laboratory experimental study with the post test-only control group design, using 24 male Sprague Dawley rats divided into six groups. The upper surfaces of tongues of group I-III were induced by DMBA topically three times a week for 16 weeks; group II and III were induced by DMBA added soursop leaves ethanolic extract of 100 and 200 mg/kg body weight daily for 18 weeks; group IV was given soursop leaves ethanolic extract 200 mg/kg body weight; group V was given DMSO 1%; and group VI was untreated. After 18th week, rats were terminated and tongue necropsies in longitudinal anteroposterior direction were conducted. The clinical changes of the upper surfaces of the tongues were observed and the histological changes were observed by using HE staining to confirm signs of dysplasia. The Kruskal Wallis test showed differences between groups, and the Mann-Withney test showed not significantly decrease of mild dysplasia of group II and group III compared to group I (p>0.05). In conclusion, ethanolic extract of soursop leaves was not effective in prevention of dysplasia of the upper surface of rat’s tongue.Keywords: dysplasia; soursop leave extract; dorsal part of tongue; DMBA  Abstrak: Senyawa golongan PAH merupakan salah satu kelompok karsinogen terbesar di lingkungan. Sebagai upaya untuk mencegah kerusakan DNA serta karsinogenesis, diperlukan suatu agen yang berpotensi antigenotoksik sekaligus antikarsinogenik. Daun sirsak terbukti mempunyai aksi kemopreventif. Penelitian ini bertujuan untuk mengkaji efektivitas ekstrak etanol daun sirsak dalam mencegah displasia pada dorsum lingue tikus. Jenis penelitian ialah true experimental laboratory dengan the post test-only control group design yang menggunakan 24 ekor tikus galur Sprague Dawley jantan, dibagi dalam enam kelompok. Dorsum lingue tikus kelompok I - III diinduksi DMBA secara topikal tiga kali seminggu selama 16 minggu; kelompok II dan III selain diinduksi DMBA, juga diberi ekstrak etanol daun sirsak 100 dan 200 mg/kg berat badan setiap hari selama 18 minggu; kelompok IV diberi ekstrak etanol 200 mg/kg BB; kelompok V diberi DMSO 1%; dan kelompok VI tidak diberi perlakuan. Terminasi dan nekropsi lidah tikus longitudinal anteroposterior dilaksanakan setelah minggu ke 18. Perubahan pada dorsum lingue diamati secara klinis dan perubahan histologik dilihat dengan pewarnaan HE untuk mengonfirmasi tanda displasia. Uji Kruskal Wallis menunjukkan perbedaan antar kelompok, sedangkan uji Mann Whitney menunjukkan penurunan tidak bermakna displasia ringan pada kelompok II dan III dibanding kelompok I. Simpulan penelitian ini ialah ekstrak etanol daun sirsak tidak efektif dalam mencegah displasia epitel dorsum lingue tikus.Kata kunci: displasia; ekstrak daun sirsak; dorsum lingue; DMBA

scholarly journals EVALUATION OF CHONDROPROTECTIVE EFFICACY OF TRIAMCINOLONE IN OSTEOARTHRITIS INDUCED RAT MODEL

2021 ◽  
Vol 12 (2) ◽  
Author(s):  
Noaman Ishaq ◽  
Quratulain Mehdi ◽  
Novera Sohail Bajwa ◽  
Shabana Ali ◽  
Bushra Shaheen ◽  
...  
Keyword(s):  
Treatment Group ◽  
Rat Model ◽  
Cruciate Ligament ◽  
Gait Pattern ◽  
Control Group ◽  
P Value ◽  
Surgical Removal ◽  
Sprague Dawley ◽  
Medical College ◽  
Group I

ABSTRACT BACKGROUND AND OBJECTIVE: Osteoarthritis is one of the most common joint diseases afflicting human, characterized by progressive degeneration of articular cartilage in which chondrocytes fails to adequately repair. Objective of this study is to evaluate the chondroprotection offered by triamcinolone in osteoarthritis induced rat model METHODOLOGY: This Laboratory based experimental study was conducted in Department of Pharmacology, Army Medical College, Rawalpindi, in collaboration with National Institute of health, Islamabad from April-June2019. Osteoarthritis was induced by surgical removal of medial meniscus and anterior cruciate ligament resection in right knee joint of Sixteen (16) anesthetized rats of Sprague Dawley breed. They were divided in two (02) groups with eight (08) rats in each group. Group I was disease control in which 0.2 ml Intra articular saline was administered for three weeks. While group II was treatment group that was treated by 70 µl intra articular triamcinolone once weekly for three weeks. After that gait pattern of rats was scored. Animals were euthanized with over dosage of inhaled chloroform and sample of proximal tibia was taken for histopathological analysis.RESULTS: Mean gait score of control group and treatment group was 3.25±.707 and 2.25±.463 with a p value of .028 that is statistically significant. While mean histopathological modified Mankin score of control and treatment group was 11.5±1.195 and 8.5±1.195 respectively with a significant P-value of <0.01. CONCLUSION: Intra articular administration of triamcinolone in Osteoarthritis induced rats resulted in improvement in gait pattern and histopathology. Keywords: Chondroprotective efficacy, Osteoarthritis, Triamcinolone.

scholarly journals Pretreatment Hepatoprotective Effect of the Marine Fungus Derived from Sponge on Hepatic Toxicity Induced by Heavy Metals in Rats

2013 ◽  
Vol 2013 ◽  
pp. 1-15 ◽  
Author(s):  
Nehad M. Abdel-Monem ◽  
Ahmed M. Abdel-Azeem ◽  
El-Sayed H. El-Ashry ◽  
Doaa A. Ghareeb ◽  
Asmaa Nabil-adam
Keyword(s):  
Heavy Metal ◽  
Radical Scavenging ◽  
Marine Fungus ◽  
Hepatoprotective Effect ◽  
Control Group ◽  
Sprague Dawley ◽  
Metal Mixtures ◽  
Group I ◽  
Group Ii ◽  
Radical Scavenging Properties

The aim of this study was to evaluate the pretreatment hepatoprotective effect of the extract of marine-derived fungusTrichurus spiralisHasselbr (TS) isolated fromHippospongia communissponge on hepatotoxicity. Twenty-eight male Sprague-Dawley rats were divided into four groups (n=7). Group I served as −ve control, group II served as the induced group receiving subcutaneously for seven days 0.25 mg heavy metal mixtures, group III received (i.p.) TS extract of dose 40 mg for seven days, and group IV served as the protected group pretreated with TS extract for seven days as a protection dose, and then treated with the heavy metal-mixture. The main pathological changes within the liver after heavy-metal mixtures administrations marked hepatic damage evidenced by foci of lobular necrosis with neutrophilic infiltration, adjacent to dysplastic hepatocytes. ALT and AST measurements show a significant increase in group II by 46.20% and 45.12%, respectively. Total protein, elevated by about 38.9% in induction group compared to the −ve control group, in contrast to albumin, decreased as a consequence of metal administration with significant elevation on bilirubin level. The results prove that TS extract possesses a hepatoprotective property due to its proven antioxidant and free-radical scavenging properties.

scholarly journals The Effects of Armillarisin A on Serum IL-1β and IL-4 and in Treating Ulcerative Colitis

2014 ◽  
Vol 72 (1) ◽  
pp. 103-106 ◽  
Author(s):  
Ping Wu ◽  
Yonggao Guo ◽  
Fangyuan Jia ◽  
Xiuli Wang
Keyword(s):  
Ulcerative Colitis ◽  
Treatment Group ◽  
Therapeutic Efficacy ◽  
Therapy Group ◽  
Serum Levels ◽  
Control Group ◽  
Group Iii ◽  
Group I ◽  
Group Ii ◽  
Control Group Group

Abstract To study the therapeutic effect of Armillarisin A on patients with ulcerative colitis (UC) and on serum IL-1β and IL-4, sixty patients with UC were randomly divided into three groups: Armillarisin A treatment group (Group I), Armillarisin-combined hormone therapy group (Group II), and hormones treatment as the control group (Group III). Patients in Group I received Armillarisin A 10 mg enema in 100 ml saline. Patients in Group II received Armillarisin A 10 mg and dexamethasone 5 mg enema in 100 ml saline. Patients in Group III received only dexamethasone 5 mg enema in 100 ml saline. The therapeutic efficacy and serum levels of IL-4 and IL-1β were observed. After 4 week treatment, the total effective rates were 90.0 % in Group I and 95.0 % in Group II. Both are higher than it in control group, which was 70.0 %. The serum levels of IL-4 in Groups I and II were significantly higher than it in control group. Compared to IL-4 levels before treatment, the levels of IL-4 after treatment were significantly higher in both Groups I and II. The serum levels of IL-11β were significantly decreased in Groups I and II in comparison to it in control group. Compared to the levels of IL-1β before treatment, the levels of IL-1β were significantly decreased. Armillarisin A shows a significant effect in treating UC. It helps increase IL-4 and lower IL-1β and the mechanism may be related to the body’s immunity regulation.

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