scholarly journals Encapsulation of Calcium Phosphates on Electrospun Nanofibers for Tissue Engineering Applications

Crystals ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 199
Author(s):  
Arputharaj Joseph Nathanael ◽  
Tae Hwan Oh
Keyword(s):  
Tissue Engineering ◽  
Biomedical Applications ◽  
Calcium Phosphates ◽  
Inorganic Ions ◽  
Electrospun Nanofibers ◽  
Future Perspectives ◽  
Versatile Technique ◽  
Nanocomposite Fibers ◽  
Good Biocompatibility ◽  
Broad Overview

In the field of tissue engineering, electrospinning is a versatile technique that provides nanofibers with structure similar to that of the extracellular matrix owing to their flexible functionalization. Considerable developments in electrospinning have been made to produce engineered electrospun nanofibers for different biomedical applications. Various biopolymers possess good biocompatibility and biodegradability and are nontoxic in nature. Modification of these biopolymers can enhance or elicit certain properties. One technique of modification is the incorporation of certain inorganic ions or components that can enhance its specific functional characteristics such as mineralization, osseointegration, and bioactivity. Incidentally, calcium phosphate (CaP) materials have proven to be suitable and versatile for biopolymer incorporation and exploration because of their inherent bioactivity and being key mineral constituents of bone and teeth. The addition of CaP materials to polymers enhances cell infiltration, differentiation, and biomineralization. We aim to provide a broad overview of CaP material (particularly hydroxyapatite (HA))-incorporated electrospun nanocomposite fibers and their possible applications in tissue engineering. Some key polymer/HA composites were discussed in detail, and a brief discussion on other polymer/HA composites was also provided. Finally, we discussed the future perspectives of this interesting and emerging composite material fabricated via electrospinning.

scholarly journals Biopolymer Coatings for Biomedical Applications

Polymers ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3061
Author(s):  
A. Joseph Nathanael ◽  
Tae Hwan Oh
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Cell Proliferation ◽  
Biomedical Applications ◽  
Antimicrobial Agents ◽  
Inorganic Ions ◽  
Polymer Coatings ◽  
Tissue Growth ◽  
Modify Surface ◽  
Broad Overview

Biopolymer coatings exhibit outstanding potential in various biomedical applications, due to their flexible functionalization. In this review, we have discussed the latest developments in biopolymer coatings on various substrates and nanoparticles for improved tissue engineering and drug delivery applications, and summarized the latest research advancements. Polymer coatings are used to modify surface properties to satisfy certain requirements or include additional functionalities for different biomedical applications. Additionally, polymer coatings with different inorganic ions may facilitate different functionalities, such as cell proliferation, tissue growth, repair, and delivery of biomolecules, such as growth factors, active molecules, antimicrobial agents, and drugs. This review primarily focuses on specific polymers for coating applications and different polymer coatings for increased functionalization. We aim to provide broad overview of latest developments in the various kind of biopolymer coatings for biomedical applications, in order to highlight the most important results in the literatures, and to offer a potential outline for impending progress and perspective. Some key polymer coatings were discussed in detail. Further, the use of polymer coatings on nanomaterials for biomedical applications has also been discussed, and the latest research results have been reported.

scholarly journals Electrospun Nanofibers Containing Strontium for Bone Tissue Engineering

2020 ◽  
Vol 2020 ◽  
pp. 1-14
Author(s):  
Qi Zhang ◽  
Yanjing Ji ◽  
Weiping Zheng ◽  
Mingzhe Yan ◽  
Danyang Wang ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Bone Repair ◽  
Composite Nanofibers ◽  
Electrospun Nanofibers ◽  
Biological Properties ◽  
Metal Composite ◽  
Future Perspectives ◽  
Polymer Metal

Electrospun polymer/metal composite nanofibers have received much attention in the field of bone tissue engineering and regenerative medicine (BTERM) owing to their extracellular matrix- (ECM-) like structure, sufficient mechanical strength, favorable biological properties, and bone induction. In particular, electrospun nanofibers containing strontium (Sr) can significantly promote bone repair and regeneration by mediating osteolysis and osteogenesis, which offers a promising bioactive material for BTERM. In this review, we summarized the effects of electrospun nanofibers containing Sr on stem cells, osteoblasts, and osteoclasts in BTERM. Also, current challenges and future perspectives for electrospun nanofibers containing Sr in BTERM are briefly outlined. It is hoped that the systematic overview will inspire the readers to further study Sr-containing nanofibers for BTERM and accelerate their translation from the bench to the clinic.

Fluoropolymers in biomedical applications: state-of-the-art and future perspectives

2021 ◽  
Author(s):  
Jia Lv ◽  
Yiyun Cheng
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Cell Culture ◽  
Gene Delivery ◽  
Bacterial Cell ◽  
Protein Delivery ◽  
Biomedical Applications ◽  
State Of The Art ◽  
Future Perspectives

Biomedical applications of fluoropolymers in gene delivery, protein delivery, drug delivery, 19F MRI, PDT, anti-fouling, anti-bacterial, cell culture, and tissue engineering.

scholarly journals A Mini-Review: Needleless Electrospinning of Nanofibers for Pharmaceutical and Biomedical Applications

Processes ◽  
2020 ◽  
Vol 8 (6) ◽  
pp. 673 ◽  
Author(s):  
Ioannis Partheniadis ◽  
Ioannis Nikolakakis ◽  
Ivo Laidmäe ◽  
Jyrki Heinämäki
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Biomedical Applications ◽  
Research Work ◽  
Production Capacity ◽  
Electrospun Nanofibers ◽  
Review Article ◽  
Full Potential ◽  
Needleless Electrospinning ◽  
Polymeric Nanofibers

Electrospinning (ES) is a convenient and versatile method for the fabrication of nanofibers and has been utilized in many fields including pharmaceutical and biomedical applications. Conventional ES uses a needle spinneret for the generation of nanofibers and is associated with many limitations and drawbacks (i.e., needle clogging, limited production capacity, and low yield). Needleless electrospinning (NLES) has been proposed to overcome these problems. Within the last two decades (2004–2020), many research articles have been published reporting the use of NLES for the fabrication of polymeric nanofibers intended for drug delivery and biomedical tissue engineering applications. The objective of the present mini-review article is to elucidate the potential of NLES for designing such novel nanofibrous drug delivery systems and tissue engineering constructs. This paper also gives an overview of the key NLES approaches, including the most recently introduced NLES method: ultrasound-enhanced electrospinning (USES). The technologies underlying NLES systems and an evaluation of electrospun nanofibers are presented. Even though NLES is a promising approach for the industrial production of nanofibers, it is a multivariate process, and more research work is needed to elucidate its full potential and limitations.

Advances in Electrospun Thermo-sensitive Hydrogels Nanofibrous Materials for Biomedical Applications

2019 ◽  
Vol 12 ◽  
Author(s):  
Lulu Lin ◽  
Minyue Cheng ◽  
Rong Chen ◽  
Weiyang Shen
Keyword(s):  
Tissue Engineering ◽  
Drug Release ◽  
Biomedical Applications ◽  
Antibacterial Effect ◽  
Rapid Development ◽  
Electrospun Nanofibers ◽  
Vital Role ◽  
Temperature Sensitive ◽  
Electrospinning Technique ◽  
Preparation Methods

Aims: To introduce the advance in thermo-sensitive hydrogels based nanofibrous materials for biomedical applications. Background: With the rapid development of nanotechnology, stimulus responsive nanofibers have aroused interest of many researchers in recent years. Objective: To review the temperature-sensitive mechanism, classification & preparation and application of thermo-sensitive hydrogels based on nanofibers. Method: In this work, an introduction of thermo-sensitive hydrogels and electrospinning technique was given firstly. Next, the mechanism of thermo-sensitive hydrogels was explained. Then, detailed classification and preparation methods of thermo-sensitive hydrogels were presented. Finally, the applications of thermo-sensitive hydrogels in nanofibers were stated. Result: The thermo-sensitive hydrogels based nanofibrous materials have played a vital role in biomedical areas including drug release, separation, antibacterial effect, tissue engineering and biosensor. Conclusion: Good biocompatibility and operational simplicity have made thermo-sensitive nanofibers be applied successfully in drug release, separation, antibacterial effect, tissue engineering and biosensor areas. However, they still have some deficiencies, such as low mechanical strength, slow response and initial abrupt release. Besides, what effects the properties of thermo-sensitive hydrogels and process parameters of electrospinning have on sensitivity of thermo-sensitive nanofibers are needed to be thoroughly studied. Other: More efforts are needed to overcome the shortcoming of thermo-sensitive hydrogels and extend the application of thermo-sensitive electrospun nanofibers to other fields.

scholarly journals Effect of Relative Humidity on the Electrospinning Performance of Regenerated Silk Solution

Polymers ◽  
2021 ◽  
Vol 13 (15) ◽  
pp. 2479
Author(s):  
Bo Kyung Park ◽  
In Chul Um
Keyword(s):  
Tissue Engineering ◽  
Fourier Transform ◽  
Relative Humidity ◽  
Biomedical Applications ◽  
Molecular Conformation ◽  
Fiber Diameter ◽  
Tissue Engineering Scaffolds ◽  
Formic Acid Solution ◽  
Good Biocompatibility ◽  
Β Sheet

Recently, the electrospun silk web has been intensively studied in terms of its biomedical applications, including tissue engineering scaffolds, due to its good biocompatibility, cytocompatibility, and biodegradability. In this study, the effect of relative humidity (RH) conditions on the morphology of electrospun silk fiber and the electrospinning production rate of silk solution was examined. In addition, the effect of RH on the molecular conformation of electrospun silk web was examined using Fourier transform infrared (FTIR) spectroscopy. As RH was increased, the maximum electrospinning rate of silk solution and fiber diameter of the resultant electrospun silk web were decreased. When RH was increased to 60%, some beads were observed, which showed that the electrospinnability of silk formic acid solution deteriorated with an increase in RH. The FTIR results showed that electrospun silk web was partially β-sheet crystallized and RH did not affect the molecular conformation of silk.

scholarly journals Poly(3-hydroxybutyrate): Promising biomaterial for bone tissue engineering

2020 ◽  
Vol 70 (1) ◽  
pp. 1-15 ◽  
Author(s):  
Barbara Dariš ◽  
Željko Knez
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Biomedical Applications ◽  
Bone Cells ◽  
Drug Carriers ◽  
Physico Chemical ◽  
Good Biocompatibility

AbstractPoly(3-hydroxybutyrate) is a natural polymer, produced by different bacteria, with good biocompatibility and biodegradability. Cardiovascular patches, scaffolds in tissue engineering and drug carriers are some of the possible biomedical applications of poly(3-hydroxybutyrate). In the past decade, many researchers examined the different physico-chemical modifications of poly(3-hydroxybutyrate) in order to improve its properties for use in the field of bone tissue engineering. Poly(3-hydroxybutyrate) composites with hydroxyapatite and bioglass are intensively tested with animal and human osteoblasts in vitro to provide information about their biocompatibility, biodegradability and osteoinductivity. Good bone regeneration was proven when poly(3-hydroxy-butyrate) patches were implanted in vivo in bone tissue of cats, minipigs and rats. This review summarizes the recent reports of in vitro and in vivo studies of pure poly(3-hydroxy-butyrate) and poly(3-hydroxybutyrate) composites with the emphasis on their bioactivity and biocompatibility with bone cells.

Medical Applications of Functional Electrospun Nanofibers - A Review

2017 ◽  
Vol 752 ◽  
pp. 132-138 ◽  
Author(s):  
Liliana Rozemarie Manea ◽  
Alexandru Popa ◽  
Andrei Petru Bertea
Keyword(s):  
Tissue Engineering ◽  
Biomedical Applications ◽  
Review Paper ◽  
Electrospun Nanofibers ◽  
Electrospinning Process ◽  
Polymer Materials ◽  
Medical Applications ◽  
Medical Field ◽  
Future Directions ◽  
Early 21St Century

Electrospinning is one of the most extensively used technique in the early 21st century, due to its adaptability and potential for applications in various domains. Electrospun nanofibers are used in many fields, for example nanoelectronics, optical devices, protective clothing, sound absorption, nano membranes and many biomedical applications. This review paper provides a summary of the electrospinning process, polymer solution and work parameters that influence the nanofibers manufacture, focusing on subjects related to electrospun nanofibers that are used for medical applications such as: wound healing, artificial skin, selective separation, immobilization of active agents and molecules, scaffold for tissue engineering, nervous system and bone tissue engineering, drug delivery. New groups of polymer materials and new generations of composite and nanostructural materials and their new applicability in the medical field are reviewed. The paper ends with perspectives and future directions for design, manufacture and utilization electrospun nanofibers for medical applications.

Recent Insights on Biomedical Applications of Bacterial Cellulose based Composite Hydrogels

2021 ◽  
Vol 28 ◽  
Author(s):  
Wei Liu ◽  
Haishun Du ◽  
Ting Zheng ◽  
Chuanling Si
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Bacterial Cellulose ◽  
High Purity ◽  
Biomedical Applications ◽  
3D Structure ◽  
Wound Dressings ◽  
Tissue Engineering Scaffolds ◽  
Composite Hydrogels ◽  
Good Biocompatibility

Background: Bacterial cellulose (BC) and its derivatives are a rich source of renewable natural ingredients, which are of great significance for biomedical and medical applications but have not yet been fully exploited. BC is a high-purity, biocompatible, and versatile biomaterial that can be used alone or in combination with other ingredients such as polymers and nanoparticles to provide different structural organization and function. This review briefly introduces the research status of BC hydrogels, focusing on the preparation of BC based composite hydrogels and their applications in the field of biomedicine, particularly the wound dressings, tissue engineering scaffolds, and drug delivery. Methods: By reviewing the most recent literature on this subject, we summarized recent advances in the preparation of BC based composite hydrogels and their advances in biomedical applications, including wound dressings, tissue engineering, and drug delivery. Results: BC composite hydrogels have broadened the field of application of BC and developed a variety of BC-based biomaterials with excellent properties. BC-based hydrogels have good biocompatibility and broad application prospects in the biomedical field. Conclusion: BC based composite hydrogels with the advantages of 3D structure, non-toxicity, high purity, and good biocompatibility, have great prospects in the development of sustainable and multifunctional biomaterials for biomedical applications.

Bacterial Cellulose Produced by Gluconacetobacter xylinus Culture Using Complex Carbon Sources for Biomedical Applications

MRS Advances ◽  
2016 ◽  
Vol 1 (36) ◽  
pp. 2563-2567
Author(s):  
Mayra Elizabeth Garcia-Sanchez ◽  
Ines Jimenez Palomar ◽  
Yolanda Gonzalez-Garcia ◽  
Jorge R. Robledo-Ortiz
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Additive Manufacturing ◽  
Bacterial Cellulose ◽  
Tissue Regeneration ◽  
Biomedical Applications ◽  
Cell Attachment ◽  
Calcium Phosphates ◽  
Complex Structures ◽  
Complex Carbon

ABSTRACTTissue engineering scaffolding is the external media or structure in which cell growth, migration and reproduction is enabled in order to stimulate tissue regeneration. In order to promote tissue regeneration, scaffolding materials are required to have certain properties such as biocompatibility, adequate mechanical properties and surface topographical features in order to provide specific biological signals to promote cell attachment and proliferation [1].Cellulose is the most abundant, inexpensive and readily available carbohydrate polymer in the world and it is traditionally extracted from plants or their wastes [2]. Although the plant itself is the major contributor of cellulose, various types of bacteria are able to produce cellulose and it is termed bacterial cellulose [3]. Bacterial cellulose is a well suited scaffold for tissue regeneration due to its biocompatibility, mechanical properties and its ability to be combined with other structures such calcium phosphates [4], which can create composites with intrinsic properties that meet the requirements of the different tissues of the human body [5].Through additive manufacturing, highly complex structures can be created which are similar to those found in nature. This work will explore the different ways to produce biomimetic structures for tissue engineering applications through the combination of bacterial cellulose and additive manufacturing producing complex structures of a highly a biocompatible material for a range of different biomedical applications [6]. In addition to the manufacturing and processing techniques, the use of mango (juice/peel) as a complex carbon source for the production of bacterial cellulose was investigated.

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