scholarly journals Genomic and Metabolic Characteristics of the Pathogenicity in Pseudomonas aeruginosa

2021 ◽  
Vol 22 (23) ◽  
pp. 12892
Author(s):  
Telma de Sousa ◽  
Michel Hébraud ◽  
Maria L. N. Enes Dapkevicius ◽  
Luís Maltez ◽  
José Eduardo Pereira ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Metabolic Pathways ◽  
One Health ◽  
High Rate ◽  
Secretion Systems ◽  
Major Health Problem ◽  
Major Health ◽  
Metabolic Characteristics ◽  
Tract Infections ◽  
Immunocompromised Hosts

In recent years, the effectiveness of antimicrobials in the treatment of Pseudomonas aeruginosa infections has gradually decreased. This pathogen can be observed in several clinical cases, such as pneumonia, urinary tract infections, sepsis, in immunocompromised hosts, such as neutropenic cancer, burns, and AIDS patients. Furthermore, Pseudomonas aeruginosa causes diseases in both livestock and pets. The highly flexible and versatile genome of P. aeruginosa allows it to have a high rate of pathogenicity. The numerous secreted virulence factors, resulting from its numerous secretion systems, the multi-resistance to different classes of antibiotics, and the ability to produce biofilms are pathogenicity factors that cause numerous problems in the fight against P. aeruginosa infections and that must be better understood for an effective treatment. Infections by P. aeruginosa represent, therefore, a major health problem and, as resistance genes can be disseminated between the microbiotas associated with humans, animals, and the environment, this issue needs be addressed on the basis of an One Health approach. This review intends to bring together and describe in detail the molecular and metabolic pathways in P. aeruginosa’s pathogenesis, to contribute for the development of a more targeted therapy against this pathogen.

scholarly journals NMR-based metabolomics associated with chronic kidney disease in humans and animals: a one health perspective

2021 ◽  
Author(s):  
Elena Hunter ◽  
Benita Percival ◽  
Zeeshan Ahmad ◽  
Ming-Wei Chang ◽  
John A. Hunt ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
One Health ◽  
Analytical Techniques ◽  
Major Health Problem ◽  
Major Health ◽  
Mortality And Morbidity ◽  
Initial Stage ◽  
New Biomarkers

AbstractChronic kidney disease (CKD) is a renal dysfunction that can lead to high rates of mortality and morbidity, particularly when coupled with late diagnosis. CKD has become a major health problem due to its challenging detection at early stages when clear symptoms are yet to be presented. Thus, CKD is likely to be identified when the substantive conditions of the disease are manifest. In order to address the development of the disease and provide necessary treatments at the initial stage, the investigation of new biomarkers and metabolites associated with early detection of CKD are needed. Identified metabolites could be used to confirm the presence of the disease, obtain information on its mechanism and facilitate the development of novel pharmaceutical treatments. Such metabolites may be detected from biofluids and tissues using a range of analytical techniques. There are a number of metabolites that have been identified by mass spectrometry at high sensitivities, whilst the detection of metabolites directly from biofluids using NMR could present a more rapid way to expand our understanding of this disease. This review is focused on NMR-based metabolomics associated with CKD in humans and animals.

scholarly journals Endothelial Dysfunction and Neutrophil Degranulation as Central Events in Sepsis Physiopathology

2021 ◽  
Vol 22 (12) ◽  
pp. 6272
Author(s):  
Marta Martín-Fernández ◽  
Álvaro Tamayo-Velasco ◽  
Rocío Aller ◽  
Hugo Gonzalo-Benito ◽  
Pedro Martínez-Paz ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Emergency Services ◽  
Progressive Increase ◽  
High Rate ◽  
Diagnostic Tools ◽  
Major Health Problem ◽  
Major Health ◽  
Neutrophil Degranulation ◽  
New Biomarkers

Sepsis is a major health problem worldwide. It is a time-dependent disease, with a high rate of morbidity and mortality. In this sense, an early diagnosis is essential to reduce these rates. The progressive increase of both the incidence and prevalence of sepsis has translated into a significant socioeconomic burden for health systems. Currently, it is the leading cause of noncoronary mortality worldwide and represents one of the most prevalent pathologies both in hospital emergency services and in intensive care units. In this article, we review the role of both endothelial dysfunction and neutrophil dysregulation in the physiopathology of this disease. The lack of a key symptom in sepsis makes it difficult to obtain a quick and accurate diagnosis of this condition. Thus, it is essential to have fast and reliable diagnostic tools. In this sense, the use of biomarkers can be a very important alternative when it comes to achieving these goals. Both new biomarkers and treatments related to endothelial dysfunction and neutrophil dysregulation deserve to be further investigated in order to open new venues for the diagnosis, treatment and prognosis of sepsis.

scholarly journals Gradings of periodontitis in relation with systemic disease

2021 ◽  
Vol 8 (7) ◽  
pp. 3671
Author(s):  
Abdulhameed G. Albeshr ◽  
Yazeed A. Alhabdan ◽  
Raef Mohamad Aljasem ◽  
Maha Assad Munshi ◽  
Ahmed Mohammadhassan Bagasi ◽  
...  
Keyword(s):  
Respiratory Tract Infections ◽  
Systemic Disease ◽  
Systemic Diseases ◽  
Major Health Problem ◽  
Major Health ◽  
Proper Management ◽  
Key Factor ◽  
Artery Disease ◽  
Tract Infections ◽  
Insight Into

With the increasing prevalence rates of periodontitis cases, it has a great impact on human health, especially elderly patients. It constitutes a major health problem that can cause significant burdens. Infections are the main pathology that have been previously reported among studies in the literature because it has a strong correlation. There are common mechanisms that can cause systemic diseases: induction of systemic inflammation, inflammatory markers, the release of toxins, and translocation into other organs through the bloodstream. Proving the correlation between the potential presence of the involved pathogen and systemic diseases might be a significant key factor in predicting these systemic events. In addition, it will assist to have proper management in early intervention. The aim of the study was to provide more insight into the effect of correlation between periodontitis and other systemic diseases according to studies in the literature. Multiple organisms that can cause periodontitis have been significantly correlated with the development of many systemic diseases, such as atherosclerosis, coronary artery disease (CAD), pneumonia, respiratory tract infections, oral and colorectal cancers, diabetes and Alzheimer’s disease. Moreover, Porphyromonas gingivalis has been commonly reported with the variously discussed systemic diseases which should draw more attention towards the proper management and prevent this organism and other microbes within the literature to enhance the outcomes.

scholarly journals Iron Fortification and Supplementation: Fighting Anemia of Chronic Diseases or Fueling Obesity?

2021 ◽  
Vol 5 (4) ◽  
Author(s):  
Carla A El-Mallah ◽  
Yara S Beyh ◽  
Omar A Obeid
Keyword(s):  
Chronic Diseases ◽  
Iron Status ◽  
Health Impact ◽  
High Rate ◽  
Low Grade ◽  
Iron Intake ◽  
Major Health Problem ◽  
Major Health ◽  
Medical Interventions ◽  
Excess Adiposity

ABSTRACT The significant worldwide increase in obesity has become a major health problem. Excess adiposity has been extensively linked to inflammation. Recently, studies have shown that dietary intake and microbiota dysbiosis can affect the health of the gut and lead to low-grade systemic inflammation, worsening the state of obesity and further exacerbating inflammation. The latter is shown to decrease iron status and potentially increase the risk of anemia by inhibiting iron absorption. Hence, anemia of obesity is independent of iron intake and does not properly respond to increased iron ingestion. Therefore, countries with a high rate of obesity should assess the health impact of fortification and supplementation with iron due to their potential drawbacks. This review tries to elucidate the relation between inflammation and iron status to better understand the etiology of anemia of obesity and chronic diseases and wisely design any dietary or medical interventions for the management of anemia and/or obesity.

Detection of Mycobacterium tuberculosis in smear negative sputum by PCR

2012 ◽  
Vol 6 (2) ◽  
pp. 2-6 ◽  
Author(s):  
Mohammad Jobayer ◽  
SM Shamsuzzaman ◽  
Kazi Zulfiquer Mamun
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Pulmonary Tuberculosis ◽  
Accurate Method ◽  
Major Health Problem ◽  
Major Health ◽  
Tuberculosis Patients ◽  
Diagnostic Potential ◽  
Total Death ◽  
Smear Negative ◽  
Negative Sputum

Pulmonary tuberculosis is a major health problem in Bangladesh that is responsible for about 7% of total death in a year. This study was conducted to isolate and identify Mycobacterium tuberculosis from sputum and to evaluate the efficacy of PCR as a modern diagnostic tool, for diagnosis of pulmonary tuberculosis, especially in the smear negative cases. One hundred and fifty suspected pulmonary TB patients (male/ female: 97/53) were included in this study. Single morning sputum was collected from each patient and diagnostic potential of PCR was compared with staining and culture. Twenty five (16.7%) sputum were positive by ZN stained smear. Among 125 smear negative samples, 13 (10.4%) yielded growth in culture in LJ media and 21 (16.8%) samples were positive by PCR. The sensitivity and specificity of PCR in smear negative cases was 100% and 92.9% respectively. Mean detection time in PCR was 24 hours. PCR detected M. tuberculosis in 21 smear negative and 9 culture negative samples. For diagnosis of tuberculosis in smear negative cases, PCR directly from sputum was a very sensitive and accurate method. In conclusion, PCR may be done, especially in clinically suspected pulmonary tuberculosis patients who remain negative by conventional methods.DOI: http://dx.doi.org/10.3329/bjmm.v6i2.19368 Bangladesh J Med Microbiol 2012; 06(02): 2-6

Prevention and Treatment of Early Childhood Caries (ECC)

2016 ◽  
Vol 1 (3) ◽  
Author(s):  
Jeffrey .
Keyword(s):  
Early Childhood ◽  
Health Problem ◽  
Early Childhood Caries ◽  
Health Providers ◽  
Missing Teeth ◽  
Optimal Basis ◽  
Major Health Problem ◽  
Major Health ◽  
Childhood Caries

Early Childhood Caries (ECC) is a chronic disease that can be prevented. It commonlyaffects children involving in one or more decayed (with lesions or not) teeth, missing teeth (dueto caries), or teeth with fillings in children aged under 71 months. The disease is sometimesoverlooked, but this condition usually affects the general health of children. Early detection ofEarly Childhood Caries (ECC) can prevent problems which are harmful to children. Therefore,the ECC must be prevented and for teeth that have had dental caries they should be givenproper treatment so as not to worsen and affect the quality of life in children. Prevention of thisdisease is a significant component in any health program to prepare for the optimal basis forthe oral health of children. This condition will become a serious health problem if not handledproperly, and it is a major health problem for health providers throughout the world.Primarypreventive must be initiated since a woman getting pregnant.Keywords: Early Childhood Caries (ECC), prevention, treatment

Detection of tox A gene in Pseudomonas aeruginosa that isolates from different clinical cases by using PCR.

2018 ◽  
pp. 26
Author(s):  
Rana M. Abdullah Al-Shwaikh ◽  
Abbas Falih Alornaaouti
Keyword(s):  
Molecular Weight ◽  
Pseudomonas Aeruginosa ◽  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Otitis Media ◽  
Urinary Tract Infections ◽  
Gel Electrophoresis ◽  
Wound Infections ◽  
Tract Infections

       Current study obtained (75) isolate of Pseudomonas aeruginosa collected from different cases included : 28 isolates from otitis media, 23 isolates from burn infections, 10 isolates from wound infections, 8 isolates from urinary tract infections and 6 isolates from blood, during the period between 1/9/2014 to 1/11/2014        The result revealed that the tox A gene was present in 54 isolates (72%) of Pseudomonas aeruginosa. The gel electrophoresis showed that the molecular weight of tox A gene was 352 bp. The result shows 17 isolates (60.71%) from otitis media has tox A gene, 18 isolates (78.26%) from burn followed by 8 isolate (80%) from wound infection and 5 isolates (62.5%) from urinary tract infection , finally 6 isolates (100%) from blood have this gene.

Salivary and Serum Biochemical Alterations in Patients with Acute Viral Hepatitis

2018 ◽  
Vol 69 (3) ◽  
pp. 747-751 ◽  
Author(s):  
Daniela Gabriela Badita ◽  
Iulia Ioana Stanescu ◽  
Andra Balcangiu Stroescu ◽  
Dan Piperea Sianu ◽  
Daniela Miricescu ◽  
...  
Keyword(s):  
Viral Hepatitis ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
World Population ◽  
Major Health Problem ◽  
Major Health ◽  
Biochemical Alterations ◽  
B Virus ◽  
Serum Biochemical ◽  
Viral Hepatitis A

Viral hepatitis represents a major health problem worldwide. Approximately 1.4 million people are infected with hepatitis A virus every year, although given that most of the cases evolve asymptomatically the real number could be even higher. At the same time, hepatitis B virus affects up to 30% of the world population and represents one of the main causes of cirrhosis and hepatocellular carcinoma. Thus, it is very important to understand the physiopathology of viral hepatitis A and B not only for the diagnosis, but also for the therapeutic protocol. The present research aimed to determine if HAV and HBV can alter serum and salivary levels of total protein and of 2 important electrolytes: calcium and potassium.

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