The Impact of the Circadian Genes CLOCK and ARNTL on Myocardial Infarction

The circadian rhythm regulates various physiological mechanisms, and its disruption can promote many disorders. Disturbance of endogenous circadian rhythms enhances the chance of myocardial infarction (MI), showing that circadian clock genes could have a crucial function in the onset of the disease. This case-control study was performed on 1057 participants. It was hypothesized that the polymorphisms of one nucleotide (SNP) in three circadian clock genes (CLOCK, ARNTL, and PER2) could be associated with MI. Statistically significant differences, estimated by the Chi-square test, were found in the distribution of alleles and genotypes between MI and no-MI groups of the CLOCK (rs6811520 and rs13124436) and ARNTL (rs3789327 and rs12363415) genes. According to the results of the present study, the polymorphisms in the CLOCK and ARNTL genes could be related to MI.

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HUBUNGAN ANTARA USIA, PARITAS, PEKERJAAN DAN INDEK MASSA TUBUH DENGAN KEJADIAN PROLAP ORGAN PANGGUL BERDASARKAN SKOR PELVIC ORGAN PROLAPSE QUANTIFICATION

JOURNAL OBGIN EMAS ◽

10.25077/aogj.2.1.39-44.2018 ◽

2019 ◽

Vol 2 (1) ◽

pp. 39-44

Author(s):

Ermawati Ermawati ◽

Hafni Bachtiar

Keyword(s):

Pelvic Organ Prolapse ◽

Case Control Study ◽

Pelvic Organ ◽

Case Control ◽

T Test ◽

Pelvic Organ Prolapse Quantification ◽

Chi Square ◽

Chi Square Test ◽

Control Study

Prolap organ panggul merupakan kondisi yang mempengaruhi kualitas hidup wanita. Prolaps organ panggul ini dapat disebabkan oleh perlukaan sewaktu proses persalinan, proses penuaan, komposisi jaringan pada seorang wanita, batuk- batuk kronis, atau sering melakukan pekerjaan berat. Pengenalan dini prolaps terkait dengan prognosis pemulihan anatomik dan fungsional organ panggul. Hingga kini, penerapannya dalam dunia klinis belum banyak sehingga pelatihan dan pembelajaran lebih lanjut tentang pelvic organ prolapse quantification (POPQ) jelas diperlukan. Penelitian ini dilakukan dengan metode case control study di polikilinik Obgin RSUP. Dr. M. Djamil Padang mulai bulan September 2013 sampai jumlah sampel terpenuhi sebanyak 98 orang. Dengan 49 orang kelompok kontrol dan 49 orang kelompok kasus .Analisis dilakukan untuk menilai hubungan usia, paritas, pekerjaan dan indek massa tubuh dengan kejadian prolap organ panggul berdasarkan skor POPQ. Data disajikan dalam bentuk tabel. Data diuji dengan t test dan chi square test. Jika p<0,05 menunjukan hasil yang bermakna. Terdapat hubungan yang bermakna antara usia dengan kejadian prolap organ panggul dengan (p<0,05) dan OR 27,871.terdapat hubungan yang bermakna antara paritas dengan kejadian prolap organ panggul dengan (p<0,05) dan OR 52,970.Dari analisa statistik pekerjaan tidak bisa di uji secara statistik.indek massa tubuh tidak terdapat hubungan yang bermakna terhadap kejadian prolap organ panggul.(p>0,05)

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FAKTOR RISIKO KESEGARAN JASMANI SISWI SMA MUHAMMADIYAH 1 PONOROGO Risk Factors of Physical Fitness among Female Student in Muhammadiyah 1 Ponorogo High School

Media Gizi Indonesia ◽

10.20473/mgi.v15i2.73-78 ◽

2020 ◽

Vol 15 (2) ◽

pp. 73

Author(s):

Ikanov Safitri ◽

R. Bambang Wirjatmadi

Keyword(s):

Physical Activity ◽

Risk Factors ◽

High School ◽

Haemoglobin Level ◽

Case Control Study ◽

Female Students ◽

Chi Square ◽

Low Protein ◽

Chi Square Test ◽

Control Study

Physical fi tness is the ability of each individual to carry out various daily activities without feeling fatigue. Physical fi tness is useful as a supporting capacity for the physical activity of children therefore it is expected to improve their health and achievement. Factors that infl uence physical fi tness include genetics, age, gender, physical activity, nutritional status, food intake, haemoglobin level, resting time and smoking habits. The purpose of this study was to analyze the risk factors of physical fi tness among female students in Muhammadiyah 1 Ponorogo High School. This case control study included 50 female students and divided into 25 cases and 25 controls. Chi-Square test was used to analyze the relationships between variables. The results showed that there was an association between protein adequacy (p=0.023) OR = 11.3 and haemoglobin levels (p=0.049) OR = 9.3 with physical fi tness. While the adequacy of iron (p=0.345) did not associated with physical fi tness. Student with low protein adequacy and haemoglobin level have respectively 11.3 and 9.3 times higher risk of having low physical fi tness than student with good protein adequacy and haemoglobin level.

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Circadian clock genes and myocardial infarction in patients with type 2 diabetes mellitus

Gene ◽

10.1016/j.gene.2019.03.038 ◽

2019 ◽

Vol 701 ◽

pp. 98-103 ◽

Cited By ~ 3

Author(s):

Ivana Škrlec ◽

Jakov Milić ◽

Ines Cilenšek ◽

Daniel Petrovič ◽

Jasenka Wagner ◽

...

Keyword(s):

Diabetes Mellitus ◽

Myocardial Infarction ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Circadian Clock ◽

Clock Genes ◽

Circadian Clock Genes

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A CASE CONTROL STUDY ON DETERMINANTS OF CHILDHOOD ASTHMA IN SCHOOL CHIL-DREN OF CHITRADURGA CITY

International Journal of Current Pharmaceutical Research ◽

10.22159/ijcpr.2018v10i3.27335 ◽

2018 ◽

Vol 10 (3) ◽

pp. 39

Author(s):

Prakruthi G. M. ◽

Bharathi D. R. ◽

Yogananda R.

Keyword(s):

Childhood Asthma ◽

Case Control Study ◽

Case Control ◽

Age Group ◽

Community Based ◽

Chi Square ◽

Asthmatic Children ◽

Chi Square Test ◽

Strength Of Association ◽

Control Study

Objective: Asthma is a chronic airway inflammatory disease in which many cells and cellular elements play a role often arising from allergies, subsequently cause shortness of breath, wheezing and coughing it affects children in different ways. To study the sociodemographic characteristics of asthmatic children and compare the predisposing factors of asthma in children.Methods: A Community based Case control study in selected schools in chitradurga for a period of 6 mo. A total of 90 children, among which 30 asthma children and 60 non asthma children were participated. Odds ratio will be calculated to know the strength of association. chi square test will be calculated to the significance.Results: A total of 90 children aged<14 y data. Female children are more exposed to asthma than male. In childhood asthma age group between 10-14years the age group of 10 y(26.7%) and 12 y (26.7%) were more exposed to the asthma.Conclusion: In Chitradurga city, the study area, is of no exception with regard to case control. From the total of 90 children selected for the study majority were found risk factors affected. It was due to their family history, exposure to pet animals, allergy, age group, BMI and sex.

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Predictors of Death in Severe COVID-19 Patients at Millennium COVID-19 Care Center in Ethiopia: A Case-Control Study

10.1101/2020.10.07.20205575 ◽

2020 ◽

Cited By ~ 2

Author(s):

Endalkachew H. Maru ◽

Tigist W. Leulseged ◽

Ishmael S. Hassen ◽

Wuletaw C. Zewde ◽

Nigat W. Chamesew ◽

...

Keyword(s):

Case Control Study ◽

Care Center ◽

Binary Logistic Regression ◽

Case Control ◽

P Value ◽

Chi Square ◽

P Values ◽

Significant Difference ◽

Chi Square Test ◽

Control Study

ABSTRACTBackgroundAs the number of new cases and death due to COVID-19 is increasing, understanding the characteristics of severe COVID-19 patients and identifying characteristics that lead to death is a key to make an informed decision. In Ethiopia, as of September 27, 2020, a total of 72,700 cases and 1165 deaths were reported.ObjectiveThe study aimed to assess the determinants of death in Severe COVID-19 patients admitted to Millennium COVID-19 Care Center in Ethiopia.MethodsA case-control study of 147 Severe COVID-19 patients (49 deaths and 98 discharged alive cases) was conducted from August to September 2020. A comparison of underlying characteristics between cases (death) and controls (alive) was assessed using a chi-square test and an independent t-test with a p-value of <0.05 considered as having a statistically significant difference. Multivariable binary logistic regression was used to assess a statistically significant association between the predictor variables and outcome of Severe COVID-19 (Alive Vs Death) where Adjusted Odds ratio (AOR), 95% CIs for AOR, and P-values were used for testing significance and interpretation of results.ResultsHaving diabetes mellitus (AOR= 3.257, 95% CI= 1.348, 7.867, p-value=0.00), fever (AOR=0.328, 95% CI: 0.123, 0.878, p-value= 0.027) and Shortness of breath (AOR= 4.034, 95% CI= 1.481, 10.988, p-value=0.006) were found to be significant predictors of death in Severe COVID-19 patients.ConclusionsThe outcome of death in Severe COVID-19 patients is found to be associated with exposures to being diabetic and having SOB at admission. On the other hand, having a fever at admission was associated with a favorable outcome of being discharged alive.

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Circadian clock genes and circadian phenotypes in patients with myocardial infarction

Advances in Medical Sciences ◽

10.1016/j.advms.2018.12.003 ◽

2019 ◽

Vol 64 (2) ◽

pp. 224-229 ◽

Cited By ~ 6

Author(s):

Ivana Škrlec ◽

Jakov Milić ◽

Marija Heffer ◽

Jasenka Wagner ◽

Borut Peterlin

Keyword(s):

Myocardial Infarction ◽

Circadian Clock ◽

Clock Genes ◽

Circadian Clock Genes

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The Vascular Circadian Clock in Chronic Kidney Disease

Cells ◽

10.3390/cells10071769 ◽

2021 ◽

Vol 10 (7) ◽

pp. 1769

Author(s):

Søren Egstrand ◽

Maria L. Mace ◽

Klaus Olgaard ◽

Ewa Lewin

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Circadian Clock ◽

Vascular Function ◽

Clock Genes ◽

Peripheral Tissues ◽

Circadian Clock Genes ◽

Vascular Physiology ◽

Novel Concept ◽

The Impact

Chronic kidney disease is associated with extremely high cardiovascular mortality. The circadian rhythms (CR) have an impact on vascular function. The disruption of CR causes serious health problems and contributes to the development of cardiovascular diseases. Uremia may affect the master pacemaker of CR in the hypothalamus. A molecular circadian clock is also expressed in peripheral tissues, including the vasculature, where it regulates the different aspects of both vascular physiology and pathophysiology. Here, we address the impact of CKD on the intrinsic circadian clock in the vasculature. The expression of the core circadian clock genes in the aorta is disrupted in CKD. We propose a novel concept of the disruption of the circadian clock system in the vasculature of importance for the pathology of the uremic vasculopathy.

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A case control study of nasal passage changes in repaired cleft lip and/or plate deformity with persons without any such deformity

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20193881 ◽

2019 ◽

Vol 5 (5) ◽

pp. 1339

Author(s):

M. Ahmad

Keyword(s):

Nasal Obstruction ◽

Nasal Septum ◽

Cleft Lip ◽

Case Control Study ◽

Data Entry ◽

Case Control ◽

Nasal Passage ◽

Chi Square ◽

Chi Square Test ◽

Control Study

Background: Cleft lip with or without an associated cleft palate (CLP) is one of the most common congenital birth defects. Both the frequency with which it occurs and the high psychosocial and financial costs associated with CLP contribute to a significant public health interest in the condition. The aim of the present study is to assess the nasal passage changes in repaired cleft lip and/or plate deformity with persons without any such deformity.Methods: It was a case-control study comprising of 2 groups. Carried out in 25 patients with 15 years and above admitted in plastic surgery or ENT Department of Gandhi Memorial and associated hospital or in patients in whom surgery has been performed earlier. After taking written informed consents from family members or legal guardians detailed history with presenting complaints was taken. Data entry and statistical analysis were performed using the Microsoft Excel and SPSS windows version 16.0 software. Tests of significance like Chi-square test are applied to find out the results.Results: Mean age of cases in 25.8 years and control 28.7. Deviation of nasal septum was present in 68% cases and 28% in control. Nasal obstruction left side in higher in cases than control. Deviation of nasal septum (L) was more common in cleft because most of the patient had cleft in left side. Caudal dislocation was also common in cleft. It was opposite to the side of cleft. It was common on right side because most of the patients have cleft on left side.Conclusions: Nasal airflow analysis would be particularly helpful in such investigations. The commonest presenting symptom is nasal obstruction. It is due to deviation of nasal septum.

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Faktor-Faktor yang Berhubungan dengan Pernikahan Dini pada Wanita

Jurnal Ners dan Kebidanan Indonesia ◽

10.21927/jnki.2017.5(1).68-75 ◽

2017 ◽

Vol 5 (1) ◽

pp. 68

Author(s):

Kanella Ayu Wulanuari ◽

Anggi Napida Anggraini ◽

Suparman Suparman

Keyword(s):

Logistic Regression ◽

Case Control Study ◽

Sampling Technique ◽

Married Women ◽

Early Marriage ◽

Dominant Factor ◽

Exclusion Criteria ◽

Chi Square ◽

Chi Square Test ◽

Control Study

A study by UNICEF in Indonesia find that the number of early marriage for 15 years old is 11% and 18 years is 35%. Generally, early marriage is more common in women than men, it’s approximately 5% of boys get married before they are 19 years old. The purpose of this study was to determine factors relating to early marriage in women and the most significant factor relating to early marriage. The study used observational quantitative study with case-control study design. The population of the study was 132 married women, samples were selected by using total sampling technique with the inclusion and exclusion criteria. The respondents of this study were 53 women. Data were analysis by chi square test and logistic regression. The results of chi-square test showed variables that had relationship with early marriage were respondents' education (p=0.035), respondents’ income (p=0.000), and sexual pre marriage (p=0.006) whereas variables that did not have relationship with early marriage are father's education (p=0.436), mother’s education (p=0.290), parents’ income (p=0.356) and respondents’ religiosity (p=0.489). The result of logistic regression analysis showed that respondents’ income was the most dominant factor affecting early marriage in women. Conclusion the most significant factor related to early marriage was respondents’ income.

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The Association Between TP53 rs1625895 Polymorphism and the Risk of Sarcopenic Obesity in Iranian Older Adults: A Case-Control Study

10.21203/rs.3.rs-42273/v1 ◽

2020 ◽

Author(s):

Nima Montazeri-Najababady ◽

Mohammad Hossein Dabbaghmanesh ◽

Nasrin Nasimi ◽

Zahra Sohrabi ◽

Nazanin Chatrabnous

Keyword(s):

Case Control Study ◽

Handgrip Strength ◽

Sarcopenic Obesity ◽

P Value ◽

Anthropometric Parameters ◽

Chi Square ◽

Pcr Rflp ◽

Chi Square Test ◽

Adjusted Model ◽

Control Study

Abstract Background: Aging and obesity are the two major global health concerns. Sarcopenia, an age-linked disease, wherein a progressive loss of muscle volume, muscle strength, and physical activity occurs. In this study we evaluated the association of TP53 rs1625895 polymorphism with the susceptibility to sarcopenic obesity in Iranian old-age subjects. Total of 206 old individuals (45 sarcopenic and 161 non-sarcopenic) were recruited in this research and genotyped by PCR–RFLP. BMI, Skeletal Muscle Mass Index (SMI), body composition, Handgrip Strength (HGS), Gait Speed (GS), and biochemical parameters were measured. Chi-square test was done for genotypes and alleles frequency. Linear regression was applied to find the correlation between TP53 rs1625895 polymorphism, and biochemical and anthropometric parameters. The correlation between TP53 rs1625895 and the risk of sarcopenia and sarcopenic obesity was investigated by logistic regression.Results: G allele was significantly higher in sarcopenic obesity group [P =0.037, OR (CI 95%)=1.9 (1.03-3.5)] compared to A allele. BMI (P= 0.049) and LDL (P=0.04) were significantly differed between genotypes when GG was compared to AA/AG genotype. The results revealed when GG genotype compared to AA/AG genotype in adjusted model for age, the risk of sarcopenic obesity [P value= 0.011, OR (CI 95%); 2.72 (1.25-5.91)] increased. Similarly, GG/AG genotype increased the risk of sarcopenic obesity [P value= 0.028, OR (CI 95%); 2.43 (1.10-5.36)] in adjusted model for age compared to AA genotype.Conclusion: We concluded that TP53 rs1625895 polymorphism may increase the risk of sarcopenic obesity in Iranian population.

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