scholarly journals Nanostructured Lipid Carriers-Hydrogels System for Drug Delivery: Nanohybrid Technology Perspective

Molecules ◽  
2022 ◽  
Vol 27 (1) ◽  
pp. 289
Author(s):  
Sharifah Nurfadhlin Afifah Syed Azhar ◽  
Siti Efliza Ashari ◽  
Norhazlin Zainuddin ◽  
Masriana Hassan
Keyword(s):  
Drug Delivery ◽  
Mechanical Strength ◽  
Hybrid System ◽  
Scientific Knowledge ◽  
Nanostructured Lipid Carriers ◽  
Significant Progress ◽  
Component Development ◽  
Potential Applications

Advanced hybrid component development in nanotechnology provides superior functionality in the application of scientific knowledge for the drug delivery industry. The purpose of this paper is to review important nanohybrid perspectives in drug delivery between nanostructured lipid carriers (NLC) and hydrogel systems. The hybrid system may result in the enhancement of each component’s synergistic properties in the mechanical strength of the hydrogel and concomitantly decrease aggregation of the NLC. The significant progress in nanostructured lipid carriers–hydrogels is reviewed here, with an emphasis on their preparation, potential applications, advantages, and underlying issues associated with these exciting materials.

An Update on Recent Advances in Cubosome: A Novel Drug Delivery System

2021 ◽  
Vol 21 ◽  
Author(s):  
Madhukar Garg ◽  
Anju Goyal ◽  
Sapna Kumari
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Lipid Bilayers ◽  
Delivery System ◽  
Liquid Crystalline ◽  
Three Dimensional ◽  
Biologically Active ◽  
Potential Applications ◽  
Health Related ◽  
Novel Drug

: Cubosomes are highly stable nanostructured liquid crystalline dosage delivery form derived from amphiphilic lipids and polymer-based stabilizers converting it in a form of effective biocompatible carrier for the drug delivery. The delivery form comprised of bicontinuous lipid bilayers arranged in three dimensional honeycombs like structure provided with two internal aqueous channels for incorporation of number of biologically active ingredients. In contrast liposomes they provide large surface area for incorporation of different types of ingredients. Due to the distinct advantages of biocompatibility and thermodynamic stability, cubosomes have remained the first preference as method of choice in the sustained release, controlled release and targeted release dosage forms as new drug delivery system for the better release of the drugs. As lot of advancement in the new form of dosage form has bring the novel avenues in drug delivery mechanisms so it was matter of worth to compile the latest updates on the various aspects of mentioned therapeutic delivery system including its structure, routes of applications along with the potential applications to encapsulate variety drugs to serve health related benefits.

Clodronate-loaded liposomal and fibroblast-derived exosomal hybrid system for enhanced drug delivery to pulmonary fibrosis

Biomaterials ◽  
2021 ◽  
Vol 271 ◽  
pp. 120761
Author(s):  
Lingna Sun ◽  
Mingrui Fan ◽  
Dong Huang ◽  
Bingqin Li ◽  
Ruoting Xu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Pulmonary Fibrosis ◽  
Hybrid System

scholarly journals Focused ultrasound in neuro-oncology: the role of the Focused Ultrasound Foundation in driving adoption and innovation

2021 ◽  
Author(s):  
Emily C. Whipple ◽  
Camille A. Favero ◽  
Neal F. Kassell
Keyword(s):  
Drug Delivery ◽  
Brain Tumors ◽  
Focused Ultrasound ◽  
Clinical Evidence ◽  
Neurological Injury ◽  
High Concentration ◽  
Potential Applications ◽  
Tumor Agent

Abstract Introduction Intra-arterial (lA) delivery of therapeutic agents across the blood-brain barrier (BBB) is an evolving strategy which enables the distribution of high concentration therapeutics through a targeted vascular territory, while potentially limiting systemic toxicity. Studies have demonstrated lA methods to be safe and efficacious for a variety of therapeutics. However, further characterization of the clinical efficacy of lA therapy for the treatment of brain tumors and refinement of its potential applications are necessary. Methods We have reviewed the preclinical and clinical evidence supporting superselective intraarterial cerebral infusion (SSJACI) with BBB disruption for the treatment of brain tumors. In addition, we review ongoing clinical trials expanding the applicability and investigating the efficacy of lA therapy for the treatment of brain tumors. Results Trends in recent studies have embraced the use of SSIACI and less neurotoxic chemotherapies. The majority of trials continue to use mannitol as the preferred method of hyperosmolar BBB disruption. Recent preclinical and preliminary human investigations into the lA delivery of Bevacizumab have demonstrated its safety and efficacy as an anti-tumor agent both alone and in combination with chemotherapy. Conclusion lA drug delivery may significantly affect the way treatment are delivered to patients with brain tumors, and in particular GBM. With refinement and standardization of the techniques of lA drug delivery, improved drug selection and formulations, and the development of methods to minimize treatment-related neurological injury, lA therapy may offer significant benefits for the treatment of brain tumors.

Preparation and evaluation of adapalene nanostructured lipid carriers for targeted drug delivery in acne

2021 ◽  
Author(s):  
Saman Ahmad Nasrollahi ◽  
Faezeh Koohestani ◽  
Atefeh Naeimifar ◽  
Aniseh Samadi ◽  
Alireza Vatanara ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Nanostructured Lipid Carriers ◽  
Targeted Drug ◽  
Preparation And Evaluation

scholarly journals Metal-Organic Framework-Based Engineered Materials—Fundamentals and Applications

Molecules ◽  
2020 ◽  
Vol 25 (7) ◽  
pp. 1598 ◽  
Author(s):  
Tahir Rasheed ◽  
Komal Rizwan ◽  
Muhammad Bilal ◽  
Hafiz M. N. Iqbal
Keyword(s):  
Drug Delivery ◽  
Metal Organic Framework ◽  
High Surface ◽  
High Surface Area ◽  
Co2 Reduction ◽  
Biological Species ◽  
Crystalline Materials ◽  
Potential Applications ◽  
Metal Organic ◽  
Catalytic Chemistry

Metal-organic frameworks (MOFs) are a fascinating class of porous crystalline materials constructed by organic ligands and inorganic connectors. Owing to their noteworthy catalytic chemistry, and matching or compatible coordination with numerous materials, MOFs offer potential applications in diverse fields such as catalysis, proton conduction, gas storage, drug delivery, sensing, separation and other related biotechnological and biomedical applications. Moreover, their designable structural topologies, high surface area, ultrahigh porosity, and tunable functionalities all make them excellent materials of interests for nanoscale applications. Herein, an effort has been to summarize the current advancement of MOF-based materials (i.e., pristine MOFs, MOF derivatives, or MOF composites) for electrocatalysis, photocatalysis, and biocatalysis. In the first part, we discussed the electrocatalytic behavior of various MOFs, such as oxidation and reduction candidates for different types of chemical reactions. The second section emphasizes on the photocatalytic performance of various MOFs as potential candidates for light-driven reactions, including photocatalytic degradation of various contaminants, CO2 reduction, and water splitting. Applications of MOFs-based porous materials in the biomedical sector, such as drug delivery, sensing and biosensing, antibacterial agents, and biomimetic systems for various biological species is discussed in the third part. Finally, the concluding points, challenges, and future prospects regarding MOFs or MOF-based materials for catalytic applications are also highlighted.

scholarly journals Mesoporous Silica Nanoparticles: Their Projection in Nanomedicine

2012 ◽  
Vol 2012 ◽  
pp. 1-20 ◽  
Author(s):  
María Vallet-Regí
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Surrounding Medium ◽  
Stimuli Responsive ◽  
Guest Molecules ◽  
Different Types ◽  
Potential Applications ◽  
Inorganic Nanomaterials

Mesoporous silica nanoparticles are receiving growing attention by the scientific biomedical community. Among the different types of inorganic nanomaterials, mesoporous silica nanoparticles have emerged as promising multifunctional platforms for nanomedicine. Since their introduction in the drug delivery landscape in 2001, mesoporous materials for drug delivery are receiving growing scientific interest for their potential applications in the biotechnology and nanomedicine fields. The ceramic matrix efficiently protects entrapped guest molecules against enzymatic degradation or denaturation induced by pH and temperature as no swelling or porosity changes take place as a response to variations in the surrounding medium. It is possible to load huge amounts of cargo into the mesopore voids and capping the pore entrances with different nanogates. The application of a stimulus provokes the nanocap removal and triggers the departure of the cargo. This strategy permits the design of stimuli-responsive drug delivery nanodevices.

Synthesis and characterization of hyperbranched poly (sulfone-amine) modified β-cyclodextrin

e-Polymers ◽  
2006 ◽  
Vol 6 (1) ◽  
Author(s):  
Liang Chen ◽  
Peng He ◽  
Zhifeng Jia ◽  
Xinyuan Zhu ◽  
Deyue Yan
Keyword(s):  
Drug Delivery ◽  
Low Cost ◽  
Food Additives ◽  
Synthesis And Characterization ◽  
Good Solubility ◽  
Low Viscosity ◽  
Hyperbranched Poly ◽  
Potential Applications ◽  
Inclusion Ability

AbstractAn economical strategy to prepare hyperbranched poly(sulfone-amine) modified β-cyclodextrins (HPSA-m-CDs) from natural β-cyclodextrin (β-CD) and other commercially available materials has been reported. The final product has many good properties of hyperbranched poly(sulfone-amine)s (good solubility, low viscosity etc.), while its inclusion ability can also be well kept. It is a feasible approach to prepare functionalized modified cyclodextrin at very low cost, and may have potential applications in the fields of catalysis, drug delivery, food additives, etc.

scholarly journals Microgels and Nanoparticles: Where Micro and Nano Go Hand in Hand

2015 ◽  
Vol 229 (1-2) ◽  
Author(s):  
Beatriz H. Juarez ◽  
Luis M. Liz-Marzán
Keyword(s):  
Magnetic Nanoparticles ◽  
Optical Tweezers ◽  
Hybrid System ◽  
Inorganic Nanoparticles ◽  
Stimuli Responsive ◽  
Single Particles ◽  
Nanoscale Systems ◽  
Different Types ◽  
Potential Applications ◽  
Very High

AbstractThe integration of different types of materials in a single hybrid system allows the combination of multiple functionalities, which can even be used in conjunction with each other. This strategy has been exploited in nanoscale systems for the creation of so-called smart nanomaterials. Within this category, the combination of inorganic nanoparticles with stimuli-responsive microgels is of very high interest because of the wide variety of potential applications. We present here a short overview of this type of materials in which the nano- and micro-scales get nicely integrated, with a great potential to expand the range of technological applications. We focus mainly on the integration of metal nanoparticles, either by themselves or in combination with semiconductor and magnetic nanoparticles. Various examples of the synergic properties that can be obtained are described, as well as the possibility to extract useful information when optical tweezers are used to manipulate single particles. We expect that this review will stimulate additional research in this field.

Sign in / Sign up

Export Citation Format

Share Document