scholarly journals Polymer Micro and Nanoparticles Containing B(III) Compounds as Emissive Soft Materials for Cargo Encapsulation and Temperature-Dependent Applications

Nanomaterials ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 3437
Author(s):  
Frederico Duarte ◽  
Cristián Cuerva ◽  
Carlos Fernández-Lodeiro ◽  
Javier Fernández-Lodeiro ◽  
Raquel Jiménez ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Water Solubility ◽  
Colloidal Suspension ◽  
Soft Materials ◽  
Colloidal Dispersions ◽  
Radiative Processes ◽  
Highly Hydrophobic ◽  
Average Size ◽  
Increasing Temperature ◽  
Styrene Butadiene

Polymer nanoparticles doped with fluorescent molecules are widely applied for biological assays, local temperature measurements, and other bioimaging applications, overcoming several critical drawbacks, such as dye toxicity, increased water solubility, and allowing imaging of dyes/drug delivery in water. In this work, some polymethylmethacrylate (PMMA), polyvinylpyrrolidone (PVP) and poly(styrene-butadiene-styrene) (SBS) based micro and nanoparticles with an average size of about 200 nm and encapsulating B(III) compounds have been prepared via the reprecipitation method by using tetrahydrofuran as the oil phase and water. The compounds are highly hydrophobic, but their encapsulation into a polymer matrix allows obtaining stable colloidal dispersions in water (3.39 µM) that maintain the photophysical behavior of these dyes. Although thermally activated non-radiative processes occur by increasing temperature from 25 to 80 °C, the colloidal suspension of the B(III) particles continues to emit greenish light (λ = 509 nm) at high temperatures. When samples are cooling back to room temperature, the emission is restored, being reversible. A probe of concept drug delivery study was conducted using coumarin 6 as a prototype of a hydrophobic drug.

Improved drug delivery system for cancer treatment by D-glucose conjugation with eugenol from natural product

2020 ◽  
Vol 17 ◽  
Author(s):  
Mas Amira Idayu Abdul Razak ◽  
Haslinda Abdul Hamid ◽  
Raja Nor Izawati Raja Othman ◽  
Shaik Alaudeen Mohd Moktar ◽  
Azizi Miskon
Keyword(s):  
Drug Delivery ◽  
Water Solubility ◽  
Osteosarcoma Cell ◽  
Drug Effectiveness ◽  
H Nmr ◽  
Proliferative Effect ◽  
Conventional Drug ◽  
Ic50 Value ◽  
Glucose Conjugation ◽  
Diphenyl Tetrazolium Bromide

Introduction: Bioconjugations are swiftly progressing and are being applied to solve several limitations of conventional drug delivery systems (DDS) such as lack of water solubility, non-specific, and poor bioavailability. The main goals of DDS are to achieve greater drug effectiveness and minimize toxicity to the healthy tissues. Objectives: In this study, D-glucose was conjugated with eugenol to target the cancer cells. To identify the implication of the anticancer effect, osteosarcoma (K7M2) cells were cultured and the anti-proliferative effect was performed using MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay] test in order to evaluate the viability and toxicity on cells with various concentrations of eugenol and D-glucose-eugenol conjugate in 24-hour incubation. Results: It was found that, the successful confirmation of the conjugation between D-glucose and eugenol was obtained by 1 H NMR spectroscopy. MTT assay showed inhibitory concentration (IC50 value) of D-glucose-eugenol was at 96.2 µg/ml and the decreased of osteosarcoma cell survival was 48%. Conclusion: These findings strongly indicate that K7M2 cells would be affected by toxicity of D-glucose-eugenol. Therefore, the present study suggests that D-glucose-eugenol has high potential to act as an anti-proliferative agent who may promise a new modality or approach as the drug delivery treatment for cancer or chemotherapeutic agent.

scholarly journals Application of Dendrimers for Treating Parasitic Diseases

Pharmaceutics ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 343
Author(s):  
Veronica Folliero ◽  
Carla Zannella ◽  
Annalisa Chianese ◽  
Debora Stelitano ◽  
Annalisa Ambrosino ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Water Solubility ◽  
Parasitic Infection ◽  
Three Dimensional ◽  
Medical Knowledge ◽  
High Ratio ◽  
Molecular Volume ◽  
Parasitic Infections ◽  
Parasitic Diseases ◽  
Wide Range

Despite advances in medical knowledge, parasitic diseases remain a significant global health burden and their pharmacological treatment is often hampered by drug toxicity. Therefore, drug delivery systems may provide useful advantages when used in combination with conventional therapeutic compounds. Dendrimers are three-dimensional polymeric structures, characterized by a central core, branches and terminal functional groups. These nanostructures are known for their defined structure, great water solubility, biocompatibility and high encapsulation ability against a wide range of molecules. Furthermore, the high ratio between terminal groups and molecular volume render them a hopeful vector for drug delivery. These nanostructures offer several advantages compared to conventional drugs for the treatment of parasitic infection. Dendrimers deliver drugs to target sites with reduced dosage, solving side effects that occur with accepted marketed drugs. In recent years, extensive progress has been made towards the use of dendrimers for therapeutic, prophylactic and diagnostic purposes for the management of parasitic infections. The present review highlights the potential of several dendrimers in the management of parasitic diseases.

Effects of Fe3O4 Nano Particles Addition in High Temperature Superconductor YBa2Cu3O7-δ

2012 ◽  
Vol 501 ◽  
pp. 309-313 ◽  
Author(s):  
Siti Nurdalila Abd-Ghani ◽  
Roslan Abd-Shukor ◽  
Wei Kong
Keyword(s):  
Transport Properties ◽  
Solid State Reaction Method ◽  
Nano Particles ◽  
Magnetic Impurities ◽  
Oxide Powders ◽  
Nano Fe3o4 ◽  
Activated Flux ◽  
Average Size ◽  
Increasing Temperature ◽  
Magnetic Nano Particles

The effects of nano particles Fe3O4 addition on the superconducting and transport properties of YBa2Cu3O7-δ (YBCO) were studied. YBa2Cu3O7-δ superconductor powders were prepared by using high purity oxide powders via solid state reaction method. Nano Fe3O4 with 0.01 – 0.05 wt.% with average size 28 nm was added into YBCO. The transition temperatures (Tc) of the samples were measured by using four point probe method. The critical current (Ic) of the samples has been determined by using the 1 μV/cm criterion from 30 – 77 K. Sample with 0.02 wt.% nano Fe3O4 showed the highest Tc at 87 K. It is interesting to note the same sample also exhibited the highest Jc at 77 K up to 1683 mA/cm2. Nano Fe3O4 has acted as effective flux pinning centers in YBCO. A small amount of nano particles Fe3O4 addition has successfully improved the superconducting and transport properties of YBCO. The excessive addition of nano Fe3O4 (> 0.02 wt.%) suppressed the Tc and Jc. Overall, Jc decreases with increasing temperature (30 – 77 K) as a consequence of thermally activated flux creep. Magnetic impurities normally suppress superconductivity. However, by adding magnetic nano particles, current carrying capacity of superconductors YBCO was enhanced significantly.

A Review on Formulation and Development of Solid Self-Nano Emulsifying Drug Delivery Systems

2021 ◽  
Vol 14 (4) ◽  
pp. 5519-5228
Author(s):  
Sunitha M Reddy ◽  
Sravani Baskarla
Keyword(s):  
Drug Delivery ◽  
Dissolution Rate ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Water Solubility ◽  
Drug Loading ◽  
Aqueous Solubility ◽  
Delivery Systems ◽  
Particle Size Reduction

This article describes current strategies to enhance aqueous solubility and dissolution rate of poor soluble drugs. Most drugs in the market are lipophilic with low or poor water solubility. There are various methods to enhance solubility: co-solvency, particle size reduction, salt formation and Self Nanoemulsifying drug delivery systems, SEDDS is a novel approach to enhance solubility, dissolution rate and bioavailability of drugs. The study involves formulation and evaluation of solid self-Nano emulsifying drug delivery system (S-SNEDDS) to enhance aqueous solubility and dissolution rate. Oral route is the most convenient route for non-invasive administration. S-SNEDDS has more advantages when compared to the liquid self-emulsifying drug delivery system. Excipients were selected depends upon the drug compatibility oils, surfactants and co surfactants were selected to formulate Liquid SNEDDS these formulated liquid self-nano emulsifying drug delivery system converted into solid by the help of porous carriers, Melted binder or with the help of drying process. Conversion process of liquid to solid involves various techniques; they are spray drying; freeze drying and fluid bed coating technique; extrusion, melting granulation technique. Liquid SNEDDS has a high ability to improve dissolution and solubility of drugs but it also has disadvantages like incompatibility, decreased drug loading, shorter shelf life, ease of manufacturing and ability to deliver peptides that are prone to enzymatic hydrolysis.  

Solid lipid nanoparticles of stearic acid for the drug delivery of paliperidone

RSC Advances ◽  
2015 ◽  
Vol 5 (84) ◽  
pp. 68743-68750 ◽  
Author(s):  
Sacheen Kumar ◽  
Jaspreet Kaur Randhawa
Keyword(s):  
Drug Delivery ◽  
Stearic Acid ◽  
Antipsychotic Drug ◽  
Solid Lipid Nanoparticles ◽  
Water Solubility ◽  
Lipid Nanoparticles ◽  
Solid Lipid ◽  
Poor Water Solubility

Paliperidone is an antipsychotic drug having poor water solubility and bioavailability. Solid lipid nanoparticles of stearic acid loaded with paliperidone were prepared to enhance the bioavailability.

Basic Concepts of Nanoemulsion and its Potential application in Pharmaceutical, Cosmeceutical and Nutraceutical fields

2021 ◽  
pp. 3938-3946
Author(s):  
Heba S. Elsewedy ◽  
Bandar E. Al-Dhubiab ◽  
Mahmoud A. Mahdy ◽  
Hanan M. Elnahas
Keyword(s):  
Drug Delivery ◽  
Colloidal Dispersions ◽  
Immiscible Liquids ◽  
Pharmaceutical Dosage Form ◽  
Regulatory Aspects ◽  
Conventional Drug ◽  
Emulsifying Agent ◽  
Basic Concepts ◽  
Physical And Chemical

One of the widely efficient and noteworthy nanocarriers that could draw a great attention toward pharmaceutical fields is nanoemulsions (NEs). NEs are thermodynamically stable colloidal dispersions composed of two immiscible liquids, oil and water that mixed together using emulsifying agent (surfactant and co-surfactant). It regarded as pharmaceutical dosage form having droplet size within a nanometer range, hence it has extensively considered as carrier for delivering active agents. Such carrier is fabricated in order to overcome some obstacles associated with conventional drug delivery systems especially low bioavailability. The objective of this review is to present an overview about NE and its latest applications in diverse areas such as drug delivery, cosmeceutical and nutraceutical. Clarifications about different mechanisms of NEs development that are frequently used were provided. Correspondingly, popular characterization techniques for NEs such as determination of particle size, polydispersity index (PDI), zeta potential and viscosity were reviewed. Eventually, summary of physical and chemical instability in addition to the regulatory aspects of NE were provided.

Vesicular Drug Delivery Systems

2017 ◽  
pp. 121-147
Author(s):  
Preeti Khulbe
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Colloidal Dispersions ◽  
Polyphenolic Compounds ◽  
Future Prospects ◽  
Lipid Complex ◽  
Research Experiences ◽  
Drug Molecules ◽  
Pass Through ◽  
Drug Incorporation

Pharmacosomes are the colloidal dispersions of drugs covalently bound to lipids and may exist as ultrafine vesicular, micellar or hexagonal aggregates, depending on the chemical structure of the drug lipid complex. The term pharmacosomes is explicitly used to describe the zwitterion, amphiphilic stoichiometric complexes of polyphenolic compounds with phospholipids. The system is formed by linking a drug (pharmakon) to a carrier (soma), they are called pharmacosomes. Pharmacosomes can pass through biomembranes efficiently and possess advantages over the use of other vesicular systems such as transferosomes liposomes and noisome. Pharmacososmes are design to avoid the unusual problems associated with the liposomal entrapment of polar drug molecules like low drug incorporation, leakage and solubility. This chapter includes the basic introduction, applications, method of preparation, characterisation, advantages, some research experiences and future prospects of pharmacosomes.

Physicochemical and Morphological Properties of Extruded Adlay (Coix lachryma-jobi L) Flour

2019 ◽  
Vol 2019 ◽  
pp. 1-10
Author(s):  
Gaopeng Zhang ◽  
Yangyue Ding ◽  
Chunlei Ni ◽  
Qingfeng Ban ◽  
Li Xu ◽  
...  
Keyword(s):  
Moisture Content ◽  
Water Solubility ◽  
Basic Structure ◽  
Morphological Properties ◽  
X Ray Diffraction ◽  
Relative Crystallinity ◽  
Job’S Tears ◽  
Twin Screw ◽  
And Function ◽  
Increasing Temperature

The effects of extrusion treatment on the structure and properties of adlay (Job’s tears) were investigated. Adlay flour was extruded through a twin-screw extruder with different parameters, including barrel temperature (80–160°C), moisture content (19–27%), and screw speed (170–330 rpm). The results showed that although the expansion index increased with increasing temperature, an increase in moisture content significantly decreased the EI (p<0.05). Extrusion improved the water solubility index and water absorption index of adlay flour (p<0.05). Furthermore, analysis of the gelating properties revealed that the structure and function of adlay flour had radically changed. After extrusion, the viscosity of the adlay flour decreased (peak viscosity decreased by more than 1000 cP), and its fluidity increased. The rheological data were modeled by the Herschel–Bulkley model. X-ray diffraction experiments showed that extrusion contributed to a decrease in relative crystallinity. Scanning electron microscopy revealed that extrusion damaged the basic structure of adlay flour, causing holes and pits on the extrudate surface. Compared to the native adlay flour, the extrusion resulted in significantly changing the pasting, gelating, thermal, rheological, and morphological properties of adlay flour. In conclusion, the extrusion can alter adlay characteristics, but it is necessary to choose appropriate conditions to attain the desired properties.

Drug Delivery Devices and Targeting Agents for Platinum(II) Anticancer Complexes

2008 ◽  
Vol 61 (9) ◽  
pp. 675 ◽  
Author(s):  
Anwen M. Krause-Heuer ◽  
Maxine P. Grant ◽  
Nikita Orkey ◽  
Janice R. Aldrich-Wright
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Anticancer Agents ◽  
Drug Transport ◽  
Water Solubility ◽  
Controlled Drug Release ◽  
Drug Bioavailability ◽  
Platinum Drug ◽  
Drug Delivery Devices

An ideal platinum-based delivery device would be one that selectively targets cancerous cells, can be systemically delivered, and is non-toxic to normal cells. It would be beneficial to provide drug delivery devices for platinum-based anticancer agents that exhibit high drug transport capacity, good water solubility, stability during storage, reduced toxicity, and enhanced anticancer activity in vivo. However, the challenges for developing drug delivery devices include carrier stability in vivo, the method by which extracellular or intracellular drug release is achieved, overcoming the various mechanisms of cell resistance to drugs, controlled drug release to cancer cells, and platinum drug bioavailability. There are many potential candidates under investigation including cucurbit[n]urils, cyclodextrins, calix[n]arenes, and dendrimers, with the most promising being those that are synthetically adaptable enough to attach to targeting agents.

Polymeric nanoparticles as carrier for targeted and controlled delivery of anticancer agents

2019 ◽  
Vol 10 (8) ◽  
pp. 527-550 ◽  
Author(s):  
Vahid Taghipour-Sabzevar ◽  
Tahere Sharifi ◽  
Mehrdad Moosazadeh Moghaddam
Keyword(s):  
Adverse Effect ◽  
Drug Delivery ◽  
Controlled Release ◽  
Anticancer Agents ◽  
Blood Circulation ◽  
Enzymatic Degradation ◽  
Water Solubility ◽  
Polymeric Nanoparticles ◽  
Controlled Delivery ◽  
Drug Adverse Effect

In recent decades, many novel methods by using nanoparticles (NPs) have been investigated for diagnosis, drug delivery and treatment of cancer. Accordingly, the potential of NPs as carriers is very significant for the delivery of anticancer drugs, because cancer treatment with NPs has led to the improvement of some of the drug delivery limitations such as low blood circulation time and bioavailability, lack of water solubility, drug adverse effect. In addition, the NPs protect drugs against enzymatic degradation and can lead to the targeted and/or controlled release of the drug. The present review focuses on the potential of NPs that can help the targeted and/or controlled delivery of anticancer agents for cancer therapy.

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