scholarly journals Antimicrobial Properties of Magnesium Open Opportunities to Develop Healthier Food

Nutrients ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 2363 ◽  
Author(s):  
Keren Demishtein ◽  
Ram Reifen ◽  
Moshe Shemesh
Keyword(s):  
Human Body ◽  
Biofilm Formation ◽  
Dairy Products ◽  
Antibacterial Effect ◽  
Antimicrobial Properties ◽  
Enzymatic Reactions ◽  
Bacterial Cells ◽  
Magnesium Ions ◽  
The Past ◽  
New Information

Magnesium is a vital mineral that takes part in hundreds of enzymatic reactions in the human body. In the past several years, new information emerged in regard to the antibacterial effect of magnesium. Here we elaborate on the recent knowledge of its antibacterial effect with emphasis on its ability to impair bacterial adherence and formation complex community of bacterial cells called biofilm. We further talk about its ability to impair biofilm formation in milk that provides opportunity for developing safer and qualitative dairy products. Finally, we describe the pronounced advantages of enrichment of food with magnesium ions, which result in healthier and more efficient food products.

scholarly journals Antibacterial properties of graphene and its derivatives

2020 ◽  
Vol 68 (4) ◽  
pp. 69-84
Author(s):  
Anna Romiszewska ◽  
Aneta Bombalska
Keyword(s):  
Reactive Oxygen Species ◽  
Graphene Oxide ◽  
Biofilm Formation ◽  
Culture Medium ◽  
Antibacterial Effect ◽  
Antibacterial Properties ◽  
Oxygen Species ◽  
Bacterial Cells ◽  
Reduced Graphene ◽  
Sharp Edges

The work presents a literature review on the use of graphene and its derivatives as the potential protection against bacterial microflora. Addressed issues relate to an attempt to explain the mechanisms of impact of graphene and its derivatives: graphene oxide (GO) and reduced graphene oxide (rGO) on the bacterial cells. Interaction of graphene materials (G, GO, rGO) with Gram(+) and Gram(-) were compared with regard to the concentration of the preparations, the nature of the culture medium and surface of graphene deposition. Issues related to the development of reactive oxygen species (ROS) were discussed, the effect of sharp edges of GM’s (nano-knife), biofilm formation and the potential application of graphene in nanomedicine. Keywords: biomedicine, graphene, graphene oxide antibacterial effect, biofilm

Research of Antibacterial Properties about Liquid Detergent on the Surface of the Silk Fabric

2013 ◽  
Vol 796 ◽  
pp. 148-151
Author(s):  
Hong Chao Miao ◽  
Wei Shen ◽  
Cai Di Xu
Keyword(s):  
Antibacterial Effect ◽  
Natural Fiber ◽  
Laundry Detergent ◽  
Antibacterial Properties ◽  
Antimicrobial Properties ◽  
Liquid Detergent ◽  
E Coli ◽  
The Past ◽  
Liquid Laundry Detergent ◽  
Fiber Fabric

The researchers of liquid detergent are most focused on detergency in the past, and the research on antibacterial activity of liquid detergent is rare. This research choose famous and common brands liquid laundry detergent in the market and studied their antimicrobial properties, test their antibacterial properties on the surface of the natural fiber fabric about Staphylococcus aureus (positive) and Escherichia coli (negative), analysis the antibacterial effect of the various brands, and the consumers have more reliable basis for purchase such goods. The antibacterial rate of liquid detergent against Galanz negative bacteria (E. coli) is generally higher, but the antibacterial rate against Galanz positive bacteria (S.aureus) is not good. The brand of Lan Yue Liang has excellent performance in this experiment, the antibacterial rate against E. coli and S.aureus reached to 96.25% and 95%.

Synthesis, structure, photophysical, electrochemical properties and antibacterial activity of brominated BODIPYs as an inhibitor of DNA gyrase B of S. aureus

2019 ◽  
Vol 23 (06) ◽  
pp. 645-654
Author(s):  
Dijo Prasannan ◽  
Chennakkandathil Sareena ◽  
Chellaiah Arunkumar ◽  
Suchithra Tharamel Vasu
Keyword(s):  
Morphological Analysis ◽  
Antibacterial Effect ◽  
Antimicrobial Properties ◽  
Dna Gyrase ◽  
Docking Studies ◽  
Antibacterial Drug ◽  
Bacterial Cells ◽  
Mechanistic Investigation ◽  
Meso Position

BODIPYs with 3-thienyl and 4-acetamido phenyl groups substituted at the meso-position are subjected to regioselective bromination using three equivalents of [Formula: see text]-bromosuccinimide (NBS) to yield their 2-mono and 2,6-di bromoderivatives. Their photophysical, electrochemical and antimicrobial properties are investigated. This paper presents a mechanistic investigation of the antibacterial effect of brominated BODIPYs, particularly against Staphylococcus aureus. Fluorescence microscopic images reveal that the compounds are internalized effectively within the bacterial cells, making it an ideal antibacterial drug. Morphological analysis of the bacterial cells after the treatment with the test compounds showed that the compounds did not affect the cell membrane or cell wall and the antibacterial effect of these compounds is achieved via a different mechanism. The most effective compound was selected to explore the target of action. Molecular docking studies were performed on 22 selected proteins in S. aureus and the in silico results were validated by in vitro experiments. It was observed that the supercoiling activity of DNA gyrase was completely inhibited by the 2,6-dibromo-1,3,5,7-tetramethyl-8-(4-acetamido)-4-bora-3a,4a-diaza-[Formula: see text]-indacene, 3c by forming H-bonds with the ASP 81 residue of the enzyme.

scholarly journals The Advantages and Challenges of Using Endolysins in a Clinical Setting

Viruses ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 680
Author(s):  
Ellen Murray ◽  
Lorraine A. Draper ◽  
R. Paul Ross ◽  
Colin Hill
Keyword(s):  
Biofilm Formation ◽  
Multidrug Resistant ◽  
Resistance Mechanisms ◽  
Bacterial Cells ◽  
Lytic Enzymes ◽  
Viable Option ◽  
Antibiotic Resistant ◽  
Gram Positive Bacteria ◽  
The Past ◽  
Peptidoglycan Hydrolases

Antibiotic-resistant pathogens are increasingly more prevalent and problematic. Traditional antibiotics are no longer a viable option for dealing with these multidrug-resistant microbes and so new approaches are needed. Bacteriophage-derived proteins such as endolysins could offer one effective solution. Endolysins are bacteriophage-encoded peptidoglycan hydrolases that act to lyse bacterial cells by targeting their cell’s wall, particularly in Gram-positive bacteria due to their naturally exposed peptidoglycan layer. These lytic enzymes have received much interest from the scientific community in recent years for their specificity, mode of action, potential for engineering, and lack of resistance mechanisms. Over the past decade, a renewed interest in endolysin therapy has led to a number of successful applications. Recombinant endolysins have been shown to be effective against prominent pathogens such as MRSA, Listeria monocytogenes, Staphylococcus strains in biofilm formation, and Pseudomonas aeruginosa. Endolysins have also been studied in combination with other antimicrobials, giving a synergistic effect. Although endolysin therapy comes with some regulatory and logistical hurdles, the future looks promising, with the emergence of engineered “next-generation” lysins. This review will focus on the likelihood that endolysins will become a viable new antimicrobial therapy and the challenges that may have to be overcome along the way.

Process Description of an Unconventional Biofilm Formation by Bacterial Cells Autoagglutinating Through Sticky, Long, and Peritrichate Nanofibers

2019 ◽  
Author(s):  
Yoshihide Furuichi ◽  
Shogo Yoshimoto ◽  
Tomohiro Inaba ◽  
Nobuhiko Nomura ◽  
Katsutoshi Hori
Keyword(s):  
Formation Process ◽  
Biofilm Formation ◽  
Extracellular Polymeric Substances ◽  
Waste Treatment ◽  
Large Cell ◽  
Dlvo Theory ◽  
Bacterial Cells ◽  
Chemical Production ◽  
Discontinuous Surface ◽  
Cell Cell

<p></p><p>Biofilms are used in environmental biotechnologies including waste treatment and environmentally friendly chemical production. Understanding the mechanisms of biofilm formation is essential to control microbial behavior and improve environmental biotechnologies. <i>Acinetobacter </i>sp. Tol 5 autoagglutinate through the interaction of the long, peritrichate nanofiber protein AtaA, a trimeric autotransporter adhesin. Using AtaA, without cell growth or the production of extracellular polymeric substances, Tol 5 cells quickly form an unconventional biofilm. In this study, we investigated the formation process of this unconventional biofilm, which started with cell–cell interactions, proceeded to cell clumping, and led to the formation of large cell aggregates. The cell–cell interaction was described by DLVO theory based on a new concept, which considers two independent interactions between two cell bodies and between two AtaA fiber tips forming a virtual discontinuous surface. If cell bodies cannot collide owing to an energy barrier at low ionic strengths but approach within the interactive distance of AtaA fibers, cells can agglutinate through their contact. Cell clumping proceeds following the cluster–cluster aggregation model, and an unconventional biofilm containing void spaces and a fractal nature develops. Understanding its formation process would extend the utilization of various types of biofilms, enhancing environmental biotechnologies.</p><p></p>

Pengenalan Berbagai Olahan Susu Sebagai Alternatif Usaha yang Menjanjikan di Masyakarat Desa Cisempur Jatinangor Sumedang Jawa Barat

2020 ◽  
Vol 1 (4) ◽  
pp. 299-305
Author(s):  
Primiani Edianingsih ◽  
Raden Febrianto Christi
Keyword(s):  
Human Body ◽  
Dairy Products ◽  
Public Awareness ◽  
Active Participation ◽  
Nutritional Content ◽  
Milk Products ◽  
Pasteurized Milk ◽  
The People ◽  
Post Test

Abstrak: Susu merupakan produk hasil ternak berupa cairan putih dengan kandungan gizi yang lengkap serta memberikan manfaat bagi tubuh manusia. Sebagai upaya dalam meningkatkan kesadaran masyarakat dalam pemahaman berbagai produk olahan susu maka diadakan penyuluhan. Pengabdian ini telah dilaksanakan kepada masyarakat Desa Cisempur Kecamatan Jatinangor dengan diikuti sebanyak 22 peserta yang terdiri atas kalangan ibu rumah tangga. Metode pelaksanaan dengan cara partisipasi aktif dari peserta dengan pengenalan berbagai produk olahan susu. Tahapan dimulai dengan sebaran kuisioner pre test  sebelum kegiatan dilakukan dengan 20 pertanyaan yang diajukan, lalu pemaparan materi berbagai olahan susu mulai dari pendahuluan terkait susu sampai produk olahan susu, Penyebaran kuisioner Post test kepada peserta setelah acara selesai dengan pertanyaan yang sama seperti pre test. Kemudian membuat salah satu produk susu kepada peserta berupa susu pasteurisasi. Hasil menunjukkan bahwa terjadi peningkatan pengenalan produk olahan susu pada masyarakat Desa Cisempur Kecamatan Jatinangor yang hadir setelah melakukan pre test dan post test.Abstract: Milk is a livestock product in the form of a white liquid with complete nutritional content and provides benefits to the human body. As an effort to increase public awareness in understanding various dairy products, counseling was held. This service has been carried out for the community of Cisempur Village, Jatinangor District, followed by 22 participants consisting of housewives. The method of implementation is by means of active participation of the participants with the introduction of various dairy products. The stages began with the distribution of pre-test questionnaires before the activity was carried out with 20 questions, then the presentation of various dairy products, from the introduction to milk to dairy products, the distribution of post test questionnaires to participants after the event was over with the same questions as the pre test. Then make one of the milk products for the participants in the form of pasteurized milk. The results showed that there was an increase in the introduction of dairy products in the people of Cisempur Village, Jatinangor District who attended after doing the pre test and post test.

Antibiotics Application Strategies to Control Biofilm Formation in Pathogenic Bacteria

2020 ◽  
Vol 21 (4) ◽  
pp. 270-286 ◽  
Author(s):  
Fazlurrahman Khan ◽  
Dung T.N. Pham ◽  
Sandra F. Oloketuyi ◽  
Young-Mog Kim
Keyword(s):  
Biofilm Formation ◽  
Pathogenic Bacteria ◽  
Extracellular Polymeric Substances ◽  
Quorum Quenching ◽  
Resistance Mechanisms ◽  
Bacterial Biofilm ◽  
Bacterial Cells ◽  
High Concentration ◽  
Biofilm Inhibition ◽  
Abiotic Surfaces

Background: The establishment of a biofilm by most pathogenic bacteria has been known as one of the resistance mechanisms against antibiotics. A biofilm is a structural component where the bacterial community adheres to the biotic or abiotic surfaces by the help of Extracellular Polymeric Substances (EPS) produced by bacterial cells. The biofilm matrix possesses the ability to resist several adverse environmental factors, including the effect of antibiotics. Therefore, the resistance of bacterial biofilm-forming cells could be increased up to 1000 times than the planktonic cells, hence requiring a significantly high concentration of antibiotics for treatment. Methods: Up to the present, several methodologies employing antibiotics as an anti-biofilm, antivirulence or quorum quenching agent have been developed for biofilm inhibition and eradication of a pre-formed mature biofilm. Results: Among the anti-biofilm strategies being tested, the sub-minimal inhibitory concentration of several antibiotics either alone or in combination has been shown to inhibit biofilm formation and down-regulate the production of virulence factors. The combinatorial strategies include (1) combination of multiple antibiotics, (2) combination of antibiotics with non-antibiotic agents and (3) loading of antibiotics onto a carrier. Conclusion: The present review paper describes the role of several antibiotics as biofilm inhibitors and also the alternative strategies adopted for applications in eradicating and inhibiting the formation of biofilm by pathogenic bacteria.

Modulation of Gut Microbiota through Dietary Phytochemicals as a Novel Anti-infective Strategy

2020 ◽  
Vol 17 (4) ◽  
pp. 498-506 ◽  
Author(s):  
Pavan K. Mujawdiya ◽  
Suman Kapur
Keyword(s):  
Microbial Community ◽  
Quorum Sensing ◽  
Population Density ◽  
Gut Microbiota ◽  
Biofilm Formation ◽  
Chemical Interaction ◽  
Bacterial Species ◽  
Critical Role ◽  
Bacterial Cells ◽  
Gut Microbes

: Quorum Sensing (QS) is a phenomenon in which bacterial cells communicate with each other with the help of several low molecular weight compounds. QS is largely dependent on population density, and it triggers when the concentration of quorum sensing molecules accumulate in the environment and crosses a particular threshold. Once a certain population density is achieved and the concentration of molecules crosses a threshold, the bacterial cells show a collective behavior in response to various chemical stimuli referred to as “auto-inducers”. The QS signaling is crucial for several phenotypic characteristics responsible for bacterial survival such as motility, virulence, and biofilm formation. Biofilm formation is also responsible for making bacterial cells resistant to antibiotics. : The human gut is home to trillions of bacterial cells collectively called “gut microbiota” or “gut microbes”. Gut microbes are a consortium of more than 15,000 bacterial species and play a very crucial role in several body functions such as metabolism, development and maturation of the immune system, and the synthesis of several essential vitamins. Due to its critical role in shaping human survival and its modulating impact on body metabolisms, the gut microbial community has been referred to as “the forgotten organ” by O`Hara et al. (2006) [1]. Several studies have demonstrated that chemical interaction between the members of bacterial cells in the gut is responsible for shaping the overall microbial community. : Recent advances in phytochemical research have generated a lot of interest in finding new, effective, and safer alternatives to modern chemical-based medicines. In the context of antimicrobial research various plant extracts have been identified with Quorum Sensing Inhibitory (QSI) activities among bacterial cells. This review focuses on the mechanism of quorum sensing and quorum sensing inhibitors isolated from natural sources.

Enabling Batteryless Wearable Devices by Transferring Power Through The Human Body

2021 ◽  
Vol 24 (3) ◽  
pp. 30-34
Author(s):  
Rishi Shukla ◽  
Neev Kiran ◽  
Rui Wang ◽  
Jeremy Gummeson ◽  
Sunghoon Ivan Lee
Keyword(s):  
Energy Source ◽  
Low Power ◽  
Human Body ◽  
Wearable Sensors ◽  
Primary Energy ◽  
Wearable Devices ◽  
Ultra Low Power ◽  
The Past ◽  
Key Barrier

Over the past few decades, we have witnessed tremendous advancements in semiconductor and MEMS technologies, leading to the proliferation of ultra-miniaturized and ultra-low-power (in micro-watt ranges) wearable devices for wellness and healthcare [1]. Most of these wearable sensors are battery powered for their operation. The use of an on-device battery as the primary energy source poses a number of challenges that serve as the key barrier to the development of novel wearable applications and the widespread use of numerous, seamless wearable sensors [5].

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