scholarly journals Implications of the Immune Polymorphisms of the Host and the Genetic Variability of SARS-CoV-2 in the Development of COVID-19

Viruses ◽  
2022 ◽  
Vol 14 (1) ◽  
pp. 94
Author(s):  
Jesús Zepeda-Cervantes ◽  
Daniel Martínez-Flores ◽  
Josué Orlando Ramírez-Jarquín ◽  
Ángeles C. Tecalco-Cruz ◽  
Noé Santiago Alavez-Pérez ◽  
...  
Keyword(s):  
Viral Entry ◽  
Genetic Factors ◽  
Structural Characteristics ◽  
Clinical Signs ◽  
Severe Pneumonia ◽  
Epigenetic Factors ◽  
Infected People ◽  
The World ◽  
Almost All

The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for the current pandemic affecting almost all countries in the world. SARS-CoV-2 is the agent responsible for coronavirus disease 19 (COVID-19), which has claimed millions of lives around the world. In most patients, SARS-CoV-2 infection does not cause clinical signs. However, some infected people develop symptoms, which include loss of smell or taste, fever, dry cough, headache, severe pneumonia, as well as coagulation disorders. The aim of this work is to report genetic factors of SARS-CoV-2 and host-associated to severe COVID-19, placing special emphasis on the viral entry and molecules of the immune system involved with viral infection. Besides this, we analyze SARS-CoV-2 variants and their structural characteristics related to the binding to polymorphic angiotensin-converting enzyme type 2 (ACE2). Additionally, we also review other polymorphisms as well as some epigenetic factors involved in the immunopathogenesis of COVID-19. These factors and viral variability could explain the increment of infection rate and/or in the development of severe COVID-19.

DAMPAK COVID -19 TERHADAP PENERAPAN PENDIDIKAN KARAKTER DAN PENDIDIKAN ISLAM

2021 ◽  
Vol 5 (1) ◽  
pp. 114-124
Author(s):  
Miftahul Ulfah
Keyword(s):  
Character Education ◽  
Islamic Education ◽  
World Health ◽  
Literature Study ◽  
Infected People ◽  
Global Pandemic ◽  
The World ◽  
Even Order ◽  
Health Organization ◽  
Almost All

ABSTRACTThe spreading of a new corona virus named Covid-19 has caused so many death tolls to almost all countries in the world. Researchers suspect that this virus originated from the traditional market in China's Wuhan City selling a wide variety of fresh wet animals traded for consumption, including bats and pangolins which ultimately transmit the virus to humans. The World Health Organization has confirmed that Covid-19 transmission through droplets or sparks from infected people through talking, sneezing or coughing. With such causes, world governments recommend and even order the citizens to always maintain health and hygiene by washing hands, wearing masks, and covering mouths when sneezing or coughing. While in Islam, there are also procedures for behaving to maintain health and cleanliness. This literature study used qualitative method to examine the relevance of the global pandemic to the Islamic character education. This study then found that the influence of Covid-19 on the application of character education and Islamic education. This conclusion could be seen from the factors that influence the majority of characters carried out during the Covid-19 plague including instincts, habits, wills and conscience.Keywords: Application, Character Education, Covid-19, Islamic Education

scholarly journals Endocrine, Lifestyle, and Genetic Factors in the Development of Metabolic Syndrome

2013 ◽  
Vol 64 (4) ◽  
pp. 581-591 ◽  
Author(s):  
Zorana Slanovic-Kuzmanović ◽  
Ivan Kos ◽  
Ana-Marija Domijan
Keyword(s):  
Metabolic Syndrome ◽  
Central Obesity ◽  
Genetic Factors ◽  
Current Knowledge ◽  
Premature Death ◽  
Disease Development ◽  
The World ◽  
Endocrine Factors

Abstract Metabolic syndrome (MetS) is a chronic, multi-component disease characterised by central obesity, hyperglycaemia, dyslipidaemia, and hypertension. Since MetS leads to type 2 diabetes, cardiovascular disease, development of certain cancers, and eventually to premature death, it is not surprising that it draws the attention of scientists around the world. The aetiopathology of MetS is complex and still not fully understood. This review focuses on the role of endocrine factors such as cortisol and insulin in the development of MetS. It also takes a look at some of the contributing lifestyle and genetic factors as well as at the current knowledge about its treatment.

scholarly journals Psychological Discomfort in Nursing Degree Students as a Consequence of the COVID-19 Pandemic

2021 ◽  
Vol 10 (23) ◽  
pp. 5467
Author(s):  
Fernando Espina-López ◽  
Emilia Moreno-Sánchez ◽  
Francisco-Javier Gago-Valiente ◽  
Jesús Sáez-Padilla ◽  
Vanesa Salado-Navarro ◽  
...  
Keyword(s):  
Nursing Students ◽  
Screening Method ◽  
High Sensitivity ◽  
Cross Sectional ◽  
Health Crisis ◽  
Infected People ◽  
The World ◽  
Spanish Universities ◽  
High Level ◽  
Almost All

Students are a population at risk of developing psychological complications, such as psychological discomfort, stress, and anxiety, among other problems, especially during the current health crisis due to the COVID-19 pandemic. The present study’s objective was to analyze the effects of the COVID-19 pandemic on the psychological discomfort of final-year nursing students. A cross-sectional descriptive observational study was carried out. To analyze the psychological discomfort of the participants, the Kessler test (previously validated) was used. The results of this test were divided into two levels (High ≥ 21/Low < 21), showing high sensitivity as a screening method for anxiety and depression. Questionnaires were sent via email to final-year nursing students of Spanish and South American universities, inviting them to participate voluntarily. The sample consisted of 400 students, with an average age of 23.29 years and a sex proportion of 82.75% women and 17.28% men. Almost all participants (n = 396) belonged to Spanish universities, and the greatest participation corresponded to Andalusian universities (64.5%). The average psychological discomfort was high (M = 27.94). Statistically significant relationships were detected between age, sex, and feeling ready for the world of work, observing no relationships with the rest of the studied variables. The sample of 4th-year students of the Degree of Nursing presented a high level of psychological discomfort. This pathology does not seem to be related to having suffered from COVID-19 or being in contact with infected people during the practicum and is more strongly related to personal sociodemographic variables and students’ preparation for the world of work.

scholarly journals Visceral Leishmaniasis: Asymptomatic Facts

2021 ◽  
Author(s):  
Medhavi Sudarshan ◽  
Sumit Sharan
Keyword(s):  
Visceral Leishmaniasis ◽  
Leishmania Donovani ◽  
Clinical Symptoms ◽  
Clinical Signs ◽  
Protozoan Parasite ◽  
Diagnostic Techniques ◽  
Asymptomatic Infection ◽  
Infected People ◽  
Time Period ◽  
Almost All

Visceral Leishmaniasis (VL) caused by protozoan parasite Leishmania is a vector borne disease and infection is limited not to human but also to animals worldwide. For infection identification and prevalence in both Leishmania endemic and nonendemic regions, several serological and genetic techniques are used. Although diagnostic techniques and clinical symptoms can establish illness status, it is extremely difficult to diagnose infection in the absence of symptoms. Asymptomatic are healthy people who have an infection but are unaware of it. The epidemiology of asymptomatic Leishmaniasis is critical for its eradication. Only a small percentage of infected people are clinically suspected of having VL, as the majority of them may not show any symptoms and remain asymptomatic. Some asymptomatic infections may go away after a while, or they may linger for years, or they may develop to illness with clinical signs. Asymptomatic infection varies per endemic location, but almost all of them point to this hidden category of parasite infection. It is now critical to understand many factors such as diagnostic markers, genetic markers, and immunological markers along with different risk factors. All of these criteria, as well as some innovative techniques to diagnosing and controlling asymptomatic leishmaniasis, will be covered in this chapter. The main focus will be on asymptomatic condition of Indian Visceral Leishmaniasis, which is caused by Leishmania donovani and spreads via female sand fly P. argentipes biting. The numerous criteria that play a role in asymptomatic to symptomatic conversion in a specific time period will also be discussed in this chapter.

scholarly journals CÓMO DETECTAR SARS-CoV-2 EMPLEANDO PRUEBAS DE LABORATORIO

2020 ◽  
Vol 3 (9) ◽  
pp. 87-104
Author(s):  
JAZMIN DE LA LUZ ARMENDARIZ ◽  
LUIS GÓMEZ NÚÑEZ ◽  
Catalina Tufiño Loza ◽  
Manuel Zapata Moreno ◽  
María Concepción Chávez Flores ◽  
...  
Keyword(s):  
Clinical Signs ◽  
Control Measures ◽  
World Health ◽  
Serum Samples ◽  
Serological Tests ◽  
Infected People ◽  
Degree Of Protection ◽  
The World ◽  
Health Organization ◽  
The Impact

The SARS-CoV-2 virus is an emerging coronavirus identified in 2019 and is responsible for the disease called COVID-19, which was declared a global pandemic, in 2020 by the World Health Organization (WHO). At the beginning of May 2020, more than 4 million infected people have been confirmed in the world and more than 278 thousand deaths, estimating an economic impact of more than 3 billion dollars. In Mexico, a total of 36,327 positive cases have been confirmed. The impact of this disease is mainly associated with the rapid spread among the human population and the severity of the clinical signs, which, if not treated, can lead to death. Currently, there is no vaccine available to prevent the disease and its control is based on the clinical diagnosis, which must be carried out by a specialist. This diagnosis must be confirmed by laboratory tests, which are of two types, mainly: for the detection of the etiological agent (virological and molecular) and serological (detection of antibodies), both tests must be carried out by institutions approved by the InDRE. The objective of molecular diagnosis (which is the most widely used worldwide) is to identify a fragment of the viral genome, which would indicate that the individual has had exposure and has been infected with SARS-CoV-2. In the case of serological tests, the diagnosis is based on identifying the presence of specific antibodies in serum samples from patients in the convalescent phase, with this test the degree of protection in a population can be evaluated. Both types of tests can be performed in patients with or without symptoms and are of utmost importance for the establishment of prevention and control measures for this pandemic.

scholarly journals An observational study to evaluate the efficacy of Rookasha Poorvaka Virechana Karma followed by Nasya Karma in the management of frozen shoulder (Avabahuka) in Madhumedha w.s.r. to DM Type-2

2019 ◽  
Vol 4 (06) ◽  
Author(s):  
Deepanjali T ◽  
Kiran M. Goud ◽  
Shreyas D. M.
Keyword(s):  
Diabetes Mellitus ◽  
Musculoskeletal Disorder ◽  
Clinical Presentation ◽  
Frozen Shoulder ◽  
P Value ◽  
Restricted Movement ◽  
The World ◽  
Almost All ◽  
Dm Type 2

The prevalence of diabetes and its complication is increasing all over the world particularly in developing countries. The latest estimates shows a global prevalence of 382 million people with diabetes in 2013 ,expected to rise 592 million by 2035. Diabetes mellitus is a multi system involving disease whose effects are seen by means of severe complication, commonest is musculoskeletal disorder. Diabeties is know to affect the shoulder in many ways commonest among them is Avabuhuka (frozen shoulder). Avabahuka is a disease of amsa sandhi with the clinical presentation such was Stambha, Shula, Shosha which can be correlated with the symptom of frozen shoulder, with no radiographic change only characterized by pain and restricted movement of shoulder joint. Prameha is a babhudoshaja vyadi mainly the meda and kapha are involved at the first it is necessary to bring rookshana effect before Shodhana that is Virechana karma to remove the kapha from kostha. Nasya is a main Chikitsa sutra mentioned in Avabahuka. Hence in the present study Rookshanapoorva Shodhana in the form of Udwartana followed by Virechana karma as kostha shodhanaartha followed by Nasya karma has been adopted. Statistical analysis showed highly significant results p value (less than 0.0001) in almost all subjective and objective parameters of Avabahuka.

Globalization and interconfessional communications

2001 ◽  
pp. 13-17
Author(s):  
Serhii Viktorovych Svystunov
Keyword(s):  
21St Century ◽  
Global Economy ◽  
Modern World ◽  
The World ◽  
Target Set ◽  
Almost All ◽  
Over Time ◽  
Rapid Appearance

In the 21st century, the world became a sign of globalization: global conflicts, global disasters, global economy, global Internet, etc. The Polish researcher Casimir Zhigulsky defines globalization as a kind of process, that is, the target set of characteristic changes that develop over time and occur in the modern world. These changes in general are reduced to mutual rapprochement, reduction of distances, the rapid appearance of a large number of different connections, contacts, exchanges, and to increase the dependence of society in almost all spheres of his life from what is happening in other, often very remote regions of the world.

From the Tower of London to the Thomas More Society of Buenos Aires: “Give me thy grace, good Lord, to set the world at nought”

Moreana ◽  
2005 ◽  
Vol 42 (Number 164) (4) ◽  
pp. 187-206
Author(s):  
Clare M. Murphy
Keyword(s):  
Buenos Aires ◽  
Short History ◽  
Thomas More ◽  
Tower Of London ◽  
Hebrew Poetry ◽  
Prayer Book ◽  
The World ◽  
History Of ◽  
Book Of Hours ◽  
Almost All

The Thomas More Society of Buenos Aires begins or ends almost all its events by reciting in both English and Spanish a prayer written by More in the margins of his Book of Hours probably while he was a prisoner in the Tower of London. After a short history of what is called Thomas More’s Prayer Book, the author studies the prayer as a poem written in the form of a psalm according to the structure of Hebrew poetry, and looks at the poem’s content as a psalm of lament.

Auto Markets in the World and Strategy of Japan’s Companies

2019 ◽  
Vol 10 (10) ◽  
pp. 1003-1008
Author(s):  
Hiroyuki Matsuoka ◽  
Keyword(s):  
Saudi Arabia ◽  
Electric Vehicle ◽  
New Technologies ◽  
Auto Industry ◽  
Domestic Market ◽  
Automatic Driving ◽  
The World ◽  
Almost All ◽  
Made In

In the world auto market, top three companies are VW(Volkswagen), Runault-Nissan-Mistubishi, and Toyota. About some selected countries and areas, China, England, Italy, Australia, Germany, Turkey, Russia, Sweden, USA, Brazil, UAE, Japan, Vietnam and Thailand are more competitive. However, the situation is different. Seeing monopolistic market countries and areas, Saudi Arabia, Taiwan, Korea, Malaysia, France, India, and Pakistan, in particular, the influence of Japan to Taiwan, India, and Pakistan is very big. But in Korea and France, their own companies’ brands occupy the market. In Japan domestic market, the overall situation is competitive. Almost all vehicles made in Japan are Japanese brand. From now on, we have to note the development of electric vehicle (EV) and other new technologies such as automatic driving and connected car. That is because they will give a great impact on the auto industry and market of Japan. Now Japan’s auto industry is going to be consolidated into three groups, Honda, Toyota group, and Renault-Nissan-Mitsubishi group for seeking the scale merit of economy. Therefore, I will pay attention to the worldwide development of EV and other new technologies and the reorganization of auto companies groups.

THE 2019 NOVEL PANDEMIC OF CORONAVIRUS DISEASE (COVID-19): A STUDY OF EXISTING EVIDENCE IN THE INDIAN POPULATION

2020 ◽  
Vol 7 (2) ◽  
pp. 199-204
Author(s):  
Shrikant Verma ◽  
Mohammad Abbas ◽  
Sushma Verma ◽  
Syed Tasleem Raza ◽  
Farzana Mahdi
Keyword(s):  
Disease Transmission ◽  
Indian Population ◽  
Respiratory Infections ◽  
Clinical Signs ◽  
Case Fatality ◽  
Public Health Emergency ◽  
The World ◽  
And Control ◽  
General Wellbeing ◽  
Different Parts

A novel spillover coronavirus (nCoV), with its epicenter in Wuhan, China's People's Republic, has emerged as an international public health emergency. This began as an outbreak in December 2019, and till November eighth, 2020, there have been 8.5 million affirmed instances of novel Covid disease2019 (COVID-19) in India, with 1,26,611 deaths, resulting in an overall case fatality rate of 1.48 percent. Coronavirus clinical signs are fundamentally the same as those of other respiratory infections. In different parts of the world, the quantity of research center affirmed cases and related passings are rising consistently. The COVID- 19 is an arising pandemic-responsible viral infection. Coronavirus has influenced huge parts of the total populace, which has prompted a global general wellbeing crisis, setting all health associations on high attentive. This review sums up the overall landmass, virology, pathogenesis, the study of disease transmission, clinical introduction, determination, treatment, and control of COVID-19 with the reference to India.

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