scholarly journals Bacterial Template Synthesis of Multifunctional Nanospindles for Glutathione Detection and Enhanced Cancer-Specific Chemo-Chemodynamic Therapy

Research ◽  
2020 ◽  
Vol 2020 ◽  
pp. 1-15 ◽  
Author(s):  
Yan-Wen Bao ◽  
Xian-Wu Hua ◽  
Jia Zeng ◽  
Fu-Gen Wu
Keyword(s):  
Limit Of Detection ◽  
Low Cost ◽  
Synthetic Methods ◽  
Reaction Conditions ◽  
Environmental Friendliness ◽  
Disinfection Process ◽  
Living Organisms ◽  
Inhibition Performance ◽  
First Time ◽  
Tumor Eradication

Biological synthetic methods of nanoparticles have shown great advantages, such as environmental friendliness, low cost, mild reaction conditions, and enhanced biocompatibility and stability of products. Bacteria, as one of the most important living organisms, have been utilized as bioreducing nanofactories to biosynthesize many metal nanoparticles or compounds. Here, inspired by the disinfection process of KMnO4, we for the first time introduce bacteria as both the template and the reducing agent to construct a novel tumor microenvironment-responsive MnOx-based nanoplatform for biomedical applications in various aspects. It is found that the bacterium/MnOx-based nanospindles (EM NSs) can efficiently encapsulate the chemotherapeutic agent doxorubicin (DOX), leading to the fluorescence quenching of the drug. The as-formed DOX-loaded EM NSs (EMD NSs) are proven to be decomposed by glutathione (GSH) and can simultaneously release DOX and Mn2+ ions. The former can be utilized for sensitive fluorescence-based GSH sensing with a limit of detection as low as 0.28 μM and selective cancer therapy, while the latter plays important roles in GSH-activated magnetic resonance imaging and chemodynamic therapy. We also demonstrate that these nanospindles can generate oxygen in the presence of endogenous hydrogen peroxide to inhibit P-glycoprotein expression under hypoxia and can achieve excellent tumor eradication and tumor metastasis inhibition performance. Taken together, this work designs a multifunctional bacterially synthesized nanomissile for imaging-guided tumor-specific chemo-chemodynamic combination therapy and will have implications for the design of microorganism-derived smart nanomedicines.

scholarly journals Cr(VI) Sorption from Aqueous Solution: A Review

2020 ◽  
Vol 10 (18) ◽  
pp. 6477
Author(s):  
Angelo Fenti ◽  
Simeone Chianese ◽  
Pasquale Iovino ◽  
Dino Musmarra ◽  
Stefano Salvestrini
Keyword(s):  
Electrostatic Interactions ◽  
Low Cost ◽  
Ease Of Use ◽  
Polluted Water ◽  
Critical Survey ◽  
Environmental Friendliness ◽  
Endothermic Process ◽  
Pseudo Second Order ◽  
Main Determinants ◽  
Living Organisms

Hexavalent chromium (Cr(VI)) in water systems is a major hazard for living organisms, including humans. The most popular technology currently used to remove Cr(VI) from polluted water is sorption for its effectiveness, ease of use, low cost and environmental friendliness. The electrostatic interactions between chromium species and the sorbent matrix are the main determinants of Cr(VI) sorption. The pH plays a central role in the process by affecting chromium speciation and the net charge on sorbent surface. In most cases, Cr(VI) sorption is an endothermic process whose kinetics is satisfactorily described by the pseudo second-order model. A critical survey of the recent literature, however, reveals that the thermodynamic and kinetic parameters reported for Cr(VI) sorption are often incorrect and/or erroneously interpreted.

A Research on Synthesis of Microorganism Template Nano-Selenium Material

2013 ◽  
Vol 443 ◽  
pp. 639-642
Author(s):  
Ya Li Zhang ◽  
Wei Xia ◽  
Ai Hua Ren
Keyword(s):  
Low Cost ◽  
Synthetic Methods ◽  
X Ray Diffraction ◽  
Environmental Friendliness ◽  
Preparation Methods ◽  
X Ray ◽  
E Coli ◽  
Physical Chemical ◽  
Harsh Conditions

At present there are various kinds of synthetic methods of nanomaterials including physical, chemical and composite method derived from the former two kinds. However, these preparation methods require harsh conditions and produce low yield. Besides, they cause environmental pollution easily. Therefore the microorganism template synthesis is favored highly due to its rich resources, low cost and availability, environmental friendliness and unique configuration and high morphology repeatability. In this thesis E. coli strains are successfully adopted as the template to synthesize nanoselenium material. Such inspection methods as scanning electron microscope, X-ray diffraction and ultraviolet are used for the characterization of samples. It aims to explore a new synthetic green way for nanoselenium material.

Green Synthesis and Spectroscopic Studies of Ag-rGO Nanocomposites for Highly Selective Mercury (II) Sensing

2018 ◽  
Vol 9 (1) ◽  
pp. 101-108 ◽  
Author(s):  
Shubhangi J. Mane-Gavade ◽  
Sandip R. Sabale ◽  
Xiao-Ying Yu ◽  
Gurunath H. Nikam ◽  
Bhaskar V. Tamhankar
Keyword(s):  
Green Synthesis ◽  
Color Change ◽  
Limit Of Detection ◽  
Aqueous Media ◽  
Suitable Condition ◽  
Cost Effective ◽  
Spectroscopic Studies ◽  
Calibration Plot ◽  
First Time

Introduction: Herein we report the green synthesis and characterization of silverreduced graphene oxide nanocomposites (Ag-rGO) using Acacia nilotica gum for the first time. Experimental: We demonstrate the Hg2+ ions sensing ability of the Ag-rGO nanocomposites form aqueous medium. The developed colorimetric sensor method is simple, fast and selective for the detection of Hg2+ ions in aqueous media in presence of other associated ions. A significant color change was noticed with naked eye upon Hg2+ addition. The color change was not observed for cations including Sr2+, Ni2+, Cd2+, Pb2+, Mg2+, Ca2+, Fe2+, Ba2+ and Mn2+indicating that only Hg2+ shows a strong interaction with Ag-rGO nanocomposites. Under the most suitable condition, the calibration plot (A0-A) against concentration of Hg2+ was linear in the range of 0.1-1.0 ppm with a correlation coefficient (R2) value 0.9998. Results & Conclusion The concentration of Hg2+ was quantitatively determined with the Limit of Detection (LOD) of 0.85 ppm. Also, this method shows excellent selectivity towards Hg2+ over nine other cations tested. Moreover, the method offers a new cost effective, rapid and simple approach for the detection of Hg2+ in water samples.

scholarly journals A review of biomass materials for advanced lithium–sulfur batteries

2019 ◽  
Vol 10 (32) ◽  
pp. 7484-7495 ◽  
Author(s):  
Huadong Yuan ◽  
Tiefeng Liu ◽  
Yujing Liu ◽  
Jianwei Nai ◽  
Yao Wang ◽  
...  
Keyword(s):  
Recent Progress ◽  
Low Cost ◽  
High Abundance ◽  
Chemical Adsorption ◽  
Environmental Friendliness ◽  
Lithium Sulfur Batteries ◽  
Biomass Materials ◽  
Physical And Chemical ◽  
Lithium Sulfur

This review summarizes recent progress of biomass-derived materials in Li–S batteries. These materials are promising due to their advantages including strong physical and chemical adsorption, high abundance, low cost, and environmental friendliness.

Green water-based binders for LiFePO4/C cathode in Li-ion batteries: a comparative study

2021 ◽  
Author(s):  
Xiaojing Zhang ◽  
xinyi Ge ◽  
Zhigang Shen ◽  
Han Ma ◽  
Jingshi Wang ◽  
...  
Keyword(s):  
Comparative Study ◽  
Polyvinylidene Fluoride ◽  
Low Cost ◽  
Green Water ◽  
Li Ion Batteries ◽  
Environmental Friendliness ◽  
Water Based ◽  
Li Ion

Compared with environmentally harmful binder polyvinylidene fluoride (PVDF) in Li-ion batteries (LIBs), water-based binders have many advantages, such as low cost, rich sources and environmental friendliness. In this study, various...

scholarly journals A rapid, accurate, scalable, and portable testing system for COVID-19 diagnosis

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Guanhua Xun ◽  
Stephan Thomas Lane ◽  
Vassily Andrew Petrov ◽  
Brandon Elliott Pepa ◽  
Huimin Zhao
Keyword(s):  
Limit Of Detection ◽  
Low Cost ◽  
High Volume ◽  
N Gene ◽  
Testing System ◽  
Target Sequence ◽  
One Pot ◽  
Sequence Detection ◽  
Highly Sensitive ◽  
Speed Accuracy

AbstractThe need for rapid, accurate, and scalable testing systems for COVID-19 diagnosis is clear and urgent. Here, we report a rapid Scalable and Portable Testing (SPOT) system consisting of a rapid, highly sensitive, and accurate assay and a battery-powered portable device for COVID-19 diagnosis. The SPOT assay comprises a one-pot reverse transcriptase-loop-mediated isothermal amplification (RT-LAMP) followed by PfAgo-based target sequence detection. It is capable of detecting the N gene and E gene in a multiplexed reaction with the limit of detection (LoD) of 0.44 copies/μL and 1.09 copies/μL, respectively, in SARS-CoV-2 virus-spiked saliva samples within 30 min. Moreover, the SPOT system is used to analyze 104 clinical saliva samples and identified 28/30 (93.3% sensitivity) SARS-CoV-2 positive samples (100% sensitivity if LoD is considered) and 73/74 (98.6% specificity) SARS-CoV-2 negative samples. This combination of speed, accuracy, sensitivity, and portability will enable high-volume, low-cost access to areas in need of urgent COVID-19 testing capabilities.

scholarly journals A Sustainable Improvement of ω-Bromoalkylphosphonates Synthesis to Access Novel KuQuinones

Organics ◽  
2021 ◽  
Vol 2 (2) ◽  
pp. 107-117
Author(s):  
Mattia Forchetta ◽  
Valeria Conte ◽  
Giulia Fiorani ◽  
Pierluca Galloni ◽  
Federica Sabuzi
Keyword(s):  
Metal Oxides ◽  
Phosphonic Acid ◽  
Organic Molecules ◽  
Building Blocks ◽  
Reaction Conditions ◽  
Phosphonic Acids ◽  
Sustainable Improvement ◽  
Phosphonate Esters ◽  
First Time ◽  
Complex Organic

Owing to the attractiveness of organic phosphonic acids and esters in the pharmacological field and in the functionalization of conductive metal-oxides, the research of effective synthetic protocols is pivotal. Among the others, ω-bromoalkylphosphonates are gaining particular attention because they are useful building blocks for the tailored functionalization of complex organic molecules. Hence, in this work, the optimization of Michaelis–Arbuzov reaction conditions for ω-bromoalkylphosphonates has been performed, to improve process sustainability while maintaining good yields. Synthesized ω-bromoalkylphosphonates have been successfully adopted for the synthesis of new KuQuinone phosphonate esters and, by hydrolysis, phosphonic acid KuQuinone derivatives have been obtained for the first time. Considering the high affinity with metal-oxides, KuQuinones bearing phosphonic acid terminal groups are promising candidates for biomedical and photo(electro)chemical applications.

scholarly journals Rapid and Sensitive Detection of miRNA Based on AC Electrokinetic Capacitive Sensing for Point-of-Care Applications

Sensors ◽  
2021 ◽  
Vol 21 (12) ◽  
pp. 3985
Author(s):  
Nan Wan ◽  
Yu Jiang ◽  
Jiamei Huang ◽  
Rania Oueslati ◽  
Shigetoshi Eda ◽  
...  
Keyword(s):  
Limit Of Detection ◽  
Point Of Care ◽  
Low Cost ◽  
Clinical Diagnostics ◽  
Detection Methods ◽  
Capacitive Sensing ◽  
Application Potential ◽  
Mirna Detection ◽  
Mirna 25 ◽  
Low Sensitivity

A sensitive and efficient method for microRNAs (miRNAs) detection is strongly desired by clinicians and, in recent years, the search for such a method has drawn much attention. There has been significant interest in using miRNA as biomarkers for multiple diseases and conditions in clinical diagnostics. Presently, most miRNA detection methods suffer from drawbacks, e.g., low sensitivity, long assay time, expensive equipment, trained personnel, or unsuitability for point-of-care. New methodologies are needed to overcome these limitations to allow rapid, sensitive, low-cost, easy-to-use, and portable methods for miRNA detection at the point of care. In this work, to overcome these shortcomings, we integrated capacitive sensing and alternating current electrokinetic effects to detect specific miRNA-16b molecules, as a model, with the limit of detection reaching 1.0 femto molar (fM) levels. The specificity of the sensor was verified by testing miRNA-25, which has the same length as miRNA-16b. The sensor we developed demonstrated significant improvements in sensitivity, response time and cost over other miRNA detection methods, and has application potential at point-of-care.

Sulfonyl Radical Triggered Selective Iodosulfonylation and Bicycli-zations of 1,6-Dienes

2021 ◽  
Author(s):  
Shi-Ping Wu ◽  
Dong-Kai Wang ◽  
Qing-Qing Kang ◽  
Guo-Ping Ge ◽  
Hongxing Zheng ◽  
...  
Keyword(s):  
Functional Group ◽  
High Selectivity ◽  
Reaction Conditions ◽  
First Time

A novel sulfonyl radical triggered selective iodosulfonylation and bicyclizations of 1,6-dienes has been described for the first time. High selectivity and efficiency, mild reaction conditions, excellent functional group compatibility, and...

scholarly journals UV Inscription and Pressure Induced Long-Period Gratings through 3D Printed Amplitude Masks

Sensors ◽  
2021 ◽  
Vol 21 (6) ◽  
pp. 1977
Author(s):  
Ricardo Oliveira ◽  
Liliana M. Sousa ◽  
Ana M. Rocha ◽  
Rogério Nogueira ◽  
Lúcia Bilro
Keyword(s):  
State Of The Art ◽  
Low Cost ◽  
Resonance Wavelength ◽  
Complex Structures ◽  
Pressing Method ◽  
Long Period ◽  
Long Period Gratings ◽  
3D Printed ◽  
Mechanical Pressing ◽  
First Time

In this work, we demonstrate for the first time the capability to inscribe long-period gratings (LPGs) with UV radiation using simple and low cost amplitude masks fabricated with a consumer grade 3D printer. The spectrum obtained for a grating with 690 µm period and 38 mm length presented good quality, showing sharp resonances (i.e., 3 dB bandwidth < 3 nm), low out-of-band loss (~0.2 dB), and dip losses up to 18 dB. Furthermore, the capability to select the resonance wavelength has been demonstrated using different amplitude mask periods. The customization of the masks makes it possible to fabricate gratings with complex structures. Additionally, the simplicity in 3D printing an amplitude mask solves the problem of the lack of amplitude masks on the market and avoids the use of high resolution motorized stages, as is the case of the point-by-point technique. Finally, the 3D printed masks were also used to induce LPGs using the mechanical pressing method. Due to the better resolution of these masks compared to ones described on the state of the art, we were able to induce gratings with higher quality, such as low out-of-band loss (0.6 dB), reduced spectral ripples, and narrow bandwidths (~3 nm).

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