scholarly journals SOSIALISASI SEDIAAN KRIM EKSTRAK DAUN NANGKA (ARTOCARPUS HETEROPHYLLUS L.) TERHADAP BAKTERI PROPIONIBACTERIUM ACNE

2021 ◽  
Vol 1 (1) ◽  
pp. 31-33
Author(s):  
Fahma Shufyani ◽  
Dewi Kartika ◽  
Jhon Patar Sinurat
Keyword(s):  
Extraction Method ◽  
Research Method ◽  
Physical Stability ◽  
Inhibition Zone ◽  
Stability Test ◽  
Artocarpus Heterophyllus ◽  
Propionibacterium Acne ◽  
Activity Test ◽  
Physical Preparation ◽  
Made In

Jackfruit leaf is (Artocarpus heterophyllus L) is one of the natural ingredients that can be used as a therapeutic treatment of acne. To facilitate is use the extract is made in the form of a cream. This study aims to determine the antibacterial activity of anti-acne cream jackfruit leaf extract against propionibacterium acne with concentrations of 30%, 50%, 70%, and 90%. Compounds that act as antibacterials on jackfruit leaves include flavonoids, tannins, saponins. This research method is an ANOVA one way method. The extraction method used is the maceration method. The tests include physical stability test and anti-acne activity test. Physical preparation stability test is carried out every 6 days for 3 weeks. While the anti acne activity observation test was carried out on bacteria of Propionibacterium acne. Based on organoleptic observation got formulations 1 and 2 there was no change, while 3,4,5 there was a change. Anti acne activity test showed that formulations 1 and 2 were more effective than formulations 3, 4, 5 with average inhibition zone of 9,5 mm.

scholarly journals FORMULASI DAN UJI EFEKTIVITAS KRIM ANTIBAKTERI EKSTRAK DAUN NANGKA (Artocarpus heterophyllus Lam.) TERHADAP BAKTERI Staphylococcus aureus

PHARMACON ◽  
2019 ◽  
Vol 8 (1) ◽  
pp. 225
Author(s):  
Nurul S Majid ◽  
Paulina V. Y. Yamlean ◽  
Gayatri Citraningtyas
Keyword(s):  
Staphylococcus Aureus ◽  
Leaf Extract ◽  
Physical Stability ◽  
Ethanol Extract ◽  
Inhibition Zone ◽  
Quality Test ◽  
Antibacterial Compounds ◽  
Artocarpus Heterophyllus ◽  
Test Parameters

ABSTRACT Jackfruit leaves contain saponins, flavonoids and tannins. Which are know to have antibacterial compounds. The purpose of this study is to make cream of jackfruit leaf extract with a concentration of 5%, 10% and 15% and test the quality of preparations of  jackfruit leaf extract cream and  there is antibacterial effectiveness against Staphylococcus aureus bacteria. The method used is the ethanol extract of Jackfruit leaves by formulating it as an M/A type cream. The results showed the cream of  jackfruit leaf extract fulfilled all the physical stability tests of the cream and in the antibacterial testing of cream of Jackfruit leaf extract could inhibit the effectiveness of Staphylococcus aureus bacteria. As concluded, the Jackfruit leaf extract Conclusions obtained by jackfruit leaf extract can be formulated as a cream with a concentration of 5%, 10% and 15%, and cream preparations meet the cream quality test parameters, for testing the effectiveness of antibacterial to the biggest inhibition zone Staphylococcus aureus is 10.5 mm at 15% concentration. Keywords: Jackfruit leaves, cream antibacterial, Staphylococcus aureus. ABSTRAK Daun Nangka memiliki kandungan saponin, flavonoid dan tannin yang berperan sebagai senyawa antibakteri. Tujuan penelitian ini yaitu membuat krim ekstrak daun Nangka dengan konsentrasi 5%, 10% dan 15%, menguji mutu  dan efektivitas antibakteri krim ekstrak daun Nangka terhadap bakteri Staphylococcus aureus. Metode yang digunakan yaitu ekstrak etanol daun Nangka dengan memformulasikan sebagai krim dengan tipe M/A. Hasil penelitian menunjukkan krim ekstrak daun Nangka memenuhi semua uji kestabilan fisik krim dan dalam pengujian antibakteri krim ekstrak daun Nangka dapat menghambat efektivitas bakteri Staphylococcus aureus. Kesimpulan yang diapat ekstrak daun Nangka dapat diformulasikan sebagai krim dengan konsentrasi 5%, 10% dan 15%, dan  sediaan krim memenuhi parameter uji kualitas krim, untuk pengujian efektivitas antibakteri terhadap Staphylococcus aureus zona hambat terbesar yaitu 10,5 mm pada konsentrasi 15%. Kata kunci: Daun Nangka, krim antibakteri, Staphylococcus aureus.

scholarly journals Preparation of essential oil ointment of lime leaves (Citrus amblycarpa) and stability test on base type used

2017 ◽  
Vol 14 (2) ◽  
pp. 63-68
Author(s):  
NINDYA NARESWARI ◽  
ANANG KUNCORO
Keyword(s):  
Essential Oil ◽  
Physical Stability ◽  
Volatile Oil ◽  
Water Soluble ◽  
Stability Test ◽  
The Difference ◽  
Semi Solid ◽  
The Stability ◽  
Acidity Level ◽  
Made In

Nareswari N, Kuncoro A. 2016. Preparation of essential oil ointment of lime leaves (Citrus amblycarpa) and stability test on base type used. Biofarmasi 14: 63-68. Citrus lime has a content of volatile oil contained in the leaves and the skin. Essential oils from the leaves of citrus lime-containing β-pinene, linalool, citronellal, and geraniol citronellol. The yield of essential oil of citrus lime leaves 0,47% could inhibit the growth of bacteria S.aureus with KBM and the MIC values of 0,039% (v / v).This research is design experimental that used Pre Test Post Test Control Desain. The essential oil for skin medication has to be made in practical and stable preparation. Ointment is a semi-solid preparation which is easy to be applied and to be used as the external medicine.The use of essential oil of citrus lime leaf was made in ointment preparation with three varieties of basis, those are water-soluble basis, absorptive bases and base hydrocarbon, in order for the ointment to be easily applied into skin. The physical stability test series which consisted of the homogeneity, the organoleptic, the viscosity the adhesiveness, and the dispersiveness and the acidity level (pH) of the ointment preparation was tested for 8 weeks in order to investigate the most stable ointment basis out of the three formulae to make the ointment of the essential oil of citrus lime (Citrus amblycarpa (Hassk) Ochse). Next, the stability of the ointment preparations was investigated from the data which contained the results of the observation from the first week to the eighth week. The data were analyzed statistically by using the Kolmogorov-Smirnov analysis technique. Finally, the data were analyzed by using the one-way Analysis of Variance (ANOVA) in order to investigate the effect of the difference in the basis of the ointment on the stability of the ointment preparations. The results of the research indicate that all three types of base oils used in ointment citrus lime leaves have a good physical stability test based on the results of the viscosity, the acidity level (pH), the dispersiveness and the adhesiveness.

PENGUJIAN EFEKTIFITAS FORMULA GEL EKSTRAK DAUN BELUNTAS (Pluchea indica (L.) Less) DENGAN VARIASI KONSENTRASI GELLING AGENT SEBAGAI KANDIDAT SEDIAAN ANTI JERAWAT

2020 ◽  
Vol 6 (2) ◽  
pp. 312
Author(s):  
Andi Ulfah Magefirah Rasyid ◽  
Zahira Amody
Keyword(s):  
Experimental Research ◽  
Leaf Extract ◽  
Propionibacterium Acnes ◽  
Physical Stability ◽  
Average Diameter ◽  
Inhibition Zone ◽  
Stability Test ◽  
Gelling Agent ◽  
Antimicrobial Compounds ◽  
Accelerated Stability

Beluntas (Pluchea indica (L.) Less) is a plant that is often used in traditional medicine because of the presence of several substances that have activity as antimicrobial compounds. Beluntas leaves contain secondary metabolite compounds such as flavonoids, alkaloids, tannins, steroids, terpenoids and saponins which can function as antibacterial. This experimental research aimed at obtaining beluntas leaf extract gel and to determine the physical stability and the effectiveness of beluntas extract gel against Propionibacterium acnes. The first step is drying the beluntas leaves and and extracted by maceration method with 70% ethanol solvent. The extract obtained was then formulated into a gel and evaluated, the evaluation results show that formula 1 is the most stable. The results showed that beluntas leaf extract gel was effective in inhibiting the growth of Propionibacterium acnes, the inhibition zone obtained was categorized as strong, where the average diameter before the accelerated stability test was 12.02 mm and 11.58 mm after the accelerated stability test.

scholarly journals The Potential of Endophytic Fungi Isolated from Leaves, Stems, Mangrove Roots Avicennia marina as a Producer of Antibiotics

2019 ◽  
Vol 6 (1) ◽  
pp. 83
Author(s):  
Kustiasih Lestari ◽  
Anthoni Agustien ◽  
Akmal Djamaan
Keyword(s):  
Endophytic Fungi ◽  
Inhibition Zone ◽  
Avicennia Marina ◽  
Antibiotic Activity ◽  
Microbiology Laboratory ◽  
Inhibitory Zone ◽  
Fungal Isolation ◽  
Activity Test ◽  
Mangrove Roots ◽  
Source Of Information

This study provides an overview of the potential of endophytic fungi isolated from leaves, stems, mangrove roots A. marina as a producer of antibiotics tested for Staphylococcus aureus, Escherichia coli, Candida albicans. This research was carried out in the microbiology laboratory of the Health Polytechnic of the Ministry of Health of Riau from March to June 2017. This study used a laboratory experimental method, the data presented in descriptive form. The stages of the study were: identification of A. marina plants, fungal isolation, qualitative tests of flavonoids isolates from endophytic fungal, and antibacterial activity test. The results showed that from 15 isolates of endophytic fungi, 5 isolates producing antibiotics. FAA 3 isolate showed the highest antibiotic activity with 24 mm the diameter of the inhibitory zone, while the lowest inhibition zone was FAA 4 isolate by forming a diameter of inhibitory zone of 7 mm and the results of qualitative tests of metabolites showed as secondary flvonoid metabolites. This research can be used as a source of information for the community in utilizing mangrove plants as an alternative in improving health.

Uji Daya Hambat Ekstrak Etanol Daun Belimbing Wuluh (Averrhoa blimbi L.) Terhadap Pertumbuhan Staphylococcus epidermidis

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Irma Zarwinda ◽  
Fauziah Fauziah ◽  
Shara Shevalinda ◽  
Dwi Putri Rejeki
Keyword(s):  
Staphylococcus Epidermidis ◽  
Research Method ◽  
Inhibitory Concentration ◽  
Sampling Technique ◽  
Ethanol Extract ◽  
Inhibition Zone ◽  
Chemistry Laboratory ◽  
Diffusion Method ◽  
Disk Diffusion Method ◽  
Training And Education

Startfruit (Averrhoa bilimbi L.) is one the kind of plant that is widely used as a traditional herbal medicineto overcome various diseases i.e. diabetes mellitus, cough, rheumatism, thrush, diabetes, toothache, acne, etc. The secondary metabolites of the starfruit leaves contain flavonoids and tannins, whereby these activecompounds can be used as an antibacterial. This study aimed to determine the inhibiting power of starfruit leaf ethanol extract against Staphylococcus epidermidis at concentrations of 25%, 50%, 75%, and 100%. The research was conducted at the  AKAFARMA Laboratory and the Chemistry Laboratory , Faculty of Teacher Training and Education, Syiah Kuala University from June to July 2020. The research method was laboratory experimental using the disk diffusion method. The population of starfruit leaves was obtained from Lhokseumawe  using a purposive sampling technique. Ethanol extract of starfruit leaves with concentrations of 25%, 50%, 75%, and 100%. The diameter of the inhibition zone of the ethanol extract  from the starfruit leaves at  concentrations of 100%, 75%, 50%, and 25% were 15 mm, 12 mm, 11 mm and 10 mm, respectively. It can be concluded that  ethanol extract of starfruit leaves can inhibit the growth  of  Staphylococcus  epidermidis  with  a  maximum inhibitory concentration  of  100%,  which is classified  as a strong category.

scholarly journals Tanggung Jawab Notaris Dalam Pembuatan Akta Otentik Dengan Bahasa Asing

Acta Comitas ◽  
2020 ◽  
Vol 5 (3) ◽  
pp. 526
Author(s):  
Arya Bagus Khrisna Budi Santosa Putra ◽  
I Made Dedy Priyanto
Keyword(s):  
Foreign Language ◽  
Research Method ◽  
Foreign Languages ◽  
The Republic ◽  
Made In

In Law on the Occupation of Notary Article 43, there are 2 (two) contradicting Paragraphs, namely Paragraph (1) and Paragraph (3). In Paragraph (1) it is stated that "deeds must be made in Indonesian", while in Paragraph (3) it states "if the parties wish, the deed can be drawn up in a foreign language". The disharmony of the 2 (two) rules could potentially reduce the perfection of the deed. As for the problems raised in this study regarding what is the notary's responsibility in making authentic deeds in foreign languages? and what is the urgency of using Indonesian in making authentic deeds? Then the objective of this research is to knowing the Notary's responsibility in making authentic deeds in foreign languages ??and to find out how much urgency the use of Indonesian is in making authentic deeds. This study is using a normative research method with statutory approach. Through this research it is known that the responsibility of notaries in making authentic deeds in foreign languages ??can be classified into administrative, civil and criminal responsibilities, then it is known that the urgency of using Indonesian in making deeds is very important because the regulation of the applicatian of Indonesian in the territory of the Indonesian state is clearly stated in Article 36 of the 1945 Constitution of the Republic of Indonesia.

scholarly journals UJI AKTIVITAS ANTIOKSIDAN DAN PENENTUAN TOTAL KANDUNGAN FENOLIK EKSTRAK ETANOL DAUN NANAMUHA (Bridelia monoica Merr)

PHARMACON ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 178
Author(s):  
Julia Elsa Lakoro ◽  
Max R. J. Runtuwene ◽  
Paulina V. Y. Yamlean
Keyword(s):  
Antioxidant Activity ◽  
Extraction Method ◽  
Total Phenol ◽  
Total Phenolic ◽  
Total Phenol Content ◽  
Phenol Compounds ◽  
Activity Test ◽  
Ic50 Value ◽  
Dpph Method ◽  
Ethanol Extracts

ABSTRACTNanamuha (Bridelia monoica Merr.) is a plant that was used as a cancer and tumor drug by the Sangihe Islands community. This plant contains phenol compounds, flavonoids, alkaloids and tannins. The purpose of this study was to determine the potential of nanamuha leaves that grow in the Sangihe Island to have antioxidant activity and determine the total phenolic ethanol extracts of nanamuha leaf. The extraction method used is maceration with ethanol solvent p.a. The extracts obtained was determined total phenolic and antioxidant activity test using DPPH method. Based on the results obtained, the ethanol extracts of nanamuha leaves has antioxidant activity with an IC50 value of 75,03 µg / mL and the result showed that the total phenol content the ethanol extracts of nanamuha leaves of  53,34 mg / L.  Keywords : Nanamuha leaf, total phenol, antioxidant activity, DPPH  ABSTRAKNanamuha (Bridelia monoica Merr.) merupakan tanaman yang dimanfaatkan sebagai obat kanker dan tumor oleh masyarakat Kepulauan Sangihe. Tanaman ini memiliki kandungan senyawa fenol, flavonoid, alkaloid dan tanin. Tujuan dari penelitian ini adalah unutuk mengetahui potensi dari daun nanamuha yang tumbuh di Kepulaun Sangihe ini memiliki aktivitas antioksidan dan menentukan total fenolik dari ekstrak etanol daun nanamuha. Metode ekstraksi yang digunakan adalah maserasi dengan pelarut etanol p.a. Ekstrak yang diperoleh ditentukan total fenolik dan uji aktivitas antioksidan dengan metode DPPH. Berdasarkan hasil yang didapatkan ekstrak etanol daun nanamuha memiliki aktivitas antioksidan dengan nilai IC50 75,03 µg/mL dan hasil penelitian menunjukan total kandungan fenolik ekstrak etanol daun nanamuha sebesar 53,34 mg/L. Kata kunci : Daun Nanamuha, Total fenol, Aktivitas antioksidan, DPPH

scholarly journals Studi Kasus Penanganan Pembiayaan Bermasalah di Baitul Maal wa Tamwil (BMT) Hubbul Wathon pada Masa Pandemi Covid-19

2021 ◽  
Vol 7 (1) ◽  
pp. 333
Author(s):  
Winda Hidayanti ◽  
Hesty Juan Kirana ◽  
Anisya May Yustitia ◽  
Harnum Widyaningrum ◽  
Tulasmi Tulasmi ◽  
...  
Keyword(s):  
Economic Crisis ◽  
Financial Institutions ◽  
Research Method ◽  
Financial Institution ◽  
Qualitative Approach ◽  
Interview Techniques ◽  
Made In ◽  
Descriptive Qualitative

The research is a Case Study of Troubled Financing Handling at BMT Hubbul Wathon in the Covid-19 Pandemic. The research method uses a descriptive qualitative approach. In collecting data, researchers used interview techniques with BMT about policies to deal with the economic crisis during the Covid-19 Pandemic. BMT Hubbul Wathon Sumowono is one of the non-bank syari'ah financial institutions that issues a lot of financing products, such as Mudharabah, Musyarakah, Murabahah, and Ijarah financing. In providing financing to customers, an agreement is made in the BMT institution, in which there are several provisions that must be agreed upon by both parties. During the Covid-19 Pandemic, BMT Hubbul Wathon experienced a decrease in both savings, financing and installments. In the Covid-19 Pandemic as well, problematic financing at BMT Hubbul Wathon Sumowono increased by 5% when compared to the financing provided before the Covid-19 Pandemic. Therefore, this non-bank syari'ah financial institution issued several measures or policies including maintaining liquidity, restrictions in providing financing, and also by adding new customer members.

scholarly journals Antibacterial Activity Test of Bacteriocin from Lactobacillus brevis, Lactobacillus casei and Lactobacillus plantarum Against Gram Positive Pathogenic Bacteria

2018 ◽  
Vol 3 (3) ◽  
pp. 85
Author(s):  
Novi Permata Sari ◽  
Rafika Sari ◽  
Eka Kartika Untari
Keyword(s):  
Antibacterial Activity ◽  
Lactobacillus Plantarum ◽  
Lactobacillus Casei ◽  
Pathogenic Bacteria ◽  
Heating Temperature ◽  
Lactobacillus Brevis ◽  
Inhibition Zone ◽  
Diffusion Method ◽  
Activity Test ◽  
Ph Range

Bacteriocin is a secondary metabolite product of lactic acid bacteria (LAB) which have an antimicrobial and potentially as a natural preservative. LAB isolates used in this study were Lactobacillus brevis, Lactobacillus casei and Lactobacillus plantarum. This study aimed to determine the antibacterial activity of bacteriocin produced by each isolate of LAB including the influence of pH and heating variation against Bacillus cereus, Bacillus subtilis and Staphylococcus epidermidis. Antibacterial activity test was done by using disc diffusion method. method. Confirmation test using proteolytic enzyme aimed to analyse that the inhibition zone produced from the activity of bacteriocin. The inhibition zone produced from L. brevis, L. casei and L. plantarum against B. cereus were 15.70, 16.43 and 14.50 mm, against B. subtilis were 13.37, 14.10 and 12.53 mm and against S. epidermidis were 11.37, 14.50 and 12.45 mm. The activity of each bacteriocin decreased with the addition of trypsin and catalase, bacteriocin was active in the pH range of 2-10 and heating temperature of 40-121oC. Statistical test showed that the addition of trypsin, catalase and the variation of pH also heating had significant differences (p<0.05) to antibacterial activity produced by bacteriocin from L. brevis, L. casei and L. plantarum. 

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