Study on Metabolic Parameters in Obese Patients Compared to Normal Weight Subjects Before and After Joint Replacement Surgery

2018 ◽  
Vol 69 (4) ◽  
pp. 944-947
Author(s):  
Mariana Cornelia Tilinca ◽  
Septimiu Voidazan ◽  
Kinga Nyulas ◽  
Raluca Maria Tilinca ◽  
Eniko Nemes Nagy
Keyword(s):  
Uric Acid ◽  
Plasma Glucose ◽  
Normal Weight ◽  
Metabolic Parameters ◽  
Obese Patients ◽  
Sample Mean ◽  
Plasma Uric Acid ◽  
Short Period ◽  
Significant Difference ◽  
Before And After

Surgical interventions represent an important stress for the organism. Metabolic parameters can exhibit important changes in a short period of time related to surgery. Differences might occur between normal weight and obese patients. Weight excess represents a risk factor for osteoarthritis.The aim of the study was to assess metabolic parameters before and after total hip and knee replacement in patients with osteoarthritis. The study was performed during 2016-2017 at the Clinic of Orthopedics and Traumatology of the Emergency County Hospital in Tirgu Mures. The study group was divided, based on body mass index values, in normal weight (43 patients) and obese individuals (52 patients). Plasma uric acid level, glycemia and lipid profile (triglycerides, total cholesterol) were determined for each patient before surgery and one day after the intervention, the values being compared. Differences between the metabolic parameters of the two subgroups were also determined. In case of obese individuals, all followed metabolic parameters were significantly different one day after the intervention compared to the values obtained before the surgery: plasma uric acid, cholesterol and triglyceride values decreased, glycemia increased. In the group of normal weight subjects the level of plasma lipids and uric acid differed significantly between the first and second sample, mean values being decreased in the second one. Comparing the two subgroups, significant difference occured regarding plasma glucose levels one day after the intervention, the mean value being higher in case of obese patients, also a higher percentage of hyperuricemia has been found in the group of obese patients. Dynamics of the followed metabolic parameters shows important changes on short term following surgical intervention. Hyperglycemia and hyperuricemia was most common in obese patients, plasma glucose showing increasing tendency after surgery.

scholarly journals How is Satiety Affected When Consuming Food While Working on A Computer?

Nutrients ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 1545 ◽  
Author(s):  
Lily Ding ◽  
Nazimah Hamid ◽  
Daniel Shepherd ◽  
Kevin Kantono
Keyword(s):  
Energy Intake ◽  
Eating Behavior ◽  
Normal Weight ◽  
Restrained Eating ◽  
Computer Work ◽  
Meal Intake ◽  
Significant Difference ◽  
Before And After ◽  
And Control ◽  
The Impact

More people working at offices are choosing to eat meals at their desks, making “desktop dining” an increasingly common phenomenon. Previous studies have reported that environmental distractors, such as television viewing, can influence meal intake and subsequent snack intake. However, the impact of stressful mental tasks on eating behavior has received relatively less attention, focusing only on subsequent meal intake or concurrent snack intake. This study sets out to determine whether eating while working influenced current meal energy intake. This research also examined the relationship between dietary restraint status and energy intake. A crossover experimental design was employed requiring participants (14 males and 29 females) to eat pizza quietly and at rest (control), and while working on a computer (work). Measurements included BMI, energy intake, state anxiety, restrained eating behavior, stress levels (pre- and post-eating), and appetite (before and after both work and control sessions). The findings showed that consuming food while working on a computer significantly increased stress but had no influence on energy intake compared to the control condition. However, post-eating hunger levels were significantly higher in the work condition compared to the control condition. As expected, satiety levels decreased significantly from pre- to post-eating for both work and control conditions. In addition, no significant relationship was observed between restrained eating behavior and energy intake in both work and control conditions. These results suggest that eating while working affected satiety of normal weight participants, as indicated by the significant difference in post-meal satiety levels between work and control conditions.

scholarly journals The association between obesity and hematologic inflammatory markers in the first trimester pregnancies

2021 ◽  
Vol 28 (1) ◽  
pp. 17-22
Author(s):  
Feyza Nur İncesu Çintesun
Keyword(s):  
Blood Cell ◽  
White Blood Cell ◽  
Inflammatory Markers ◽  
Demographic Data ◽  
First Trimester ◽  
Normal Weight ◽  
Obese Patients ◽  
Distribution Width ◽  
Lymphocyte Ratio ◽  
Significant Difference

Objective Obesity is the defined as the abnormal or excessive accumulation of the fat which is harmful for the health, and its prevalence has been increasing. Many studies have shown that obesity alone leads to inflammation and causes poor gestational outcomes. In our study, we aimed to investigate the association between basic hematologic markers and obesity in the first trimester pregnancies. Methods A total of 321 pregnant women who admitted to the clinic of gynecology and obstetrics in a tertiary state hospital were included in the study. The patients were separated into three groups, which were normal weight (BMI: 18–24.9 kg/m2), overweight (BMI: 25–29.9 kg/m2), and obese (BMI>30 kg/m2). Of the patients, the demographic data (age, gravida, and parity) and the parameters of hemoglobin, hematocrit, white blood cell, neutrophil, lymphocyte, platelet (PLT), eosinophil, basophil, mean platelet volume (MPV), platelet distribution width (PDW), neutrophil/lymphocyte ratio (NLR), red blood cell distribution width (RDW), plateletcrit (PCT) and platelet/lymphocyte ratio (PLR) measured in the complete blood count which was checked in the first trimester routinely during the pregnancy follow-up were analyzed. The three groups were compared in terms of inflammatory markers. Results The patients were evaluated in three groups: 108 patients with normal weight (Group 1), 109 overweight patients (Group 2) and 104 obese patients (Group 3). No significant difference was found in terms of age, parity and gravida when the demographic data were analyzed among the groups (p>0.05). When the groups were compared in terms of hematologic markers, similar values were found in the markers other than white blood cell, neutrophil, lymphocyte, PLT and PCT values. The difference among white blood cell, neutrophil, lymphocyte, PLT and PCT values were between the patients with normal weight and obese patients, and the values of these markers were found higher in overweight / normal weight patient groups than the normal group (p<0.05). Conclusion The values of white blood cell, neutrophil, lymphocyte, PLT and PCT which were shown to be associated with inflammation were higher in the obese patients.

scholarly journals MON-161 Body Weight Reduction Not Always Reduced Adrenal Gland Volume in Obese Patients

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Tao Chen
Keyword(s):  
Weight Loss ◽  
Body Weight ◽  
Sleeve Gastrectomy ◽  
Adrenal Gland ◽  
Morphological Changes ◽  
Normal Weight ◽  
Obese Patients ◽  
Gland Volume ◽  
Significant Difference ◽  
Adrenal Gland Volume

Abstract Recent studies have shown that obesity is a major risk factor for idiopathic hyperaldosteronism (IHA). IHA patients have greater AGV than normal controls. However, it is unclear whether such changes are caused by obesity and whether losing weight could reverse the morphological and functional abnormalities of the adrenal gland. This study was to investigate the association of obesity with adrenal gland volume (AGV) and the effects of weight loss on AGV. This study recruited obese patients (N=25) who underwent sleeve gastrectomy and age- and sex-matched normal-weight (N=25) and overweight healthy volunteers (HV) (N=21). Thin-slice computed tomography was used to evaluate adrenal morphological changes. AGV was measured semiautomatically based on the digital imaging and communications in medicine (DICOM) image. The effects of weight loss on AGV were evaluated in patients for one year or more after sleeve gastrectomy. The results showed that left, right and total AGV were larger in obese patients than those in overweight and normal- weight HVs (6.77±0.36, 5.76±0.31, and 12.53±0.64 cm3 vs. 3.88±0.14, 3.09± 0.13 and 6.97± 0.24 cm3 vs. 3.38±0.23, 2.67±0.15 and 6.04±0.36 cm3). No statistically significant difference was identified between overweight and normal-weight HVs. Sleeve gastrectomy significantly reduced body weight (-27.1±2.5 kg), left AGV (-0.80±0.26 cm3), and right AGV (-0.88±0.20 cm2). However, the adrenal volume in five patients was not reduced, despite significant weight loss postsurgery. In brief, obesity leads to increased AGV, and in some cases, this effect seems to be irreversible. We speculate that obesity causes permanently adrenal morphological changes (increased volume or hyperplasia), and under certain circumstances, it results in excessive aldosterone secretion via altered adipokines (leptin, CTRP1, etc.).

scholarly journals Effect of whitening dentifrices on the surface roughness of a nanohybrid composite resin

2016 ◽  
Vol 10 (02) ◽  
pp. 170-175 ◽  
Author(s):  
Gabriela Migliorin da Rosa ◽  
Luciana Mendonça da Silva ◽  
Márcio de Menezes ◽  
Hugo Felipe do Vale ◽  
Diego Ferreira Regalado ◽  
...  
Keyword(s):  
Surface Roughness ◽  
Composite Resin ◽  
Wilcoxon Test ◽  
Control Group ◽  
Mean Values ◽  
Short Period ◽  
Significant Difference ◽  
Before And After ◽  
Nanohybrid Composite ◽  
One Way Anova

ABSTRACT Objectives: The present study verified the influence of whitening dentifrices on the surface roughness of a nanohybrid composite resin. Materials and Methods: Thirty-two specimens were prepared with Filtek™ Z350 XT (3M/ESPE) and randomly divided into four groups (n = 08) that were subjected to brushing simulation equivalent to the period of 1 month. The groups assessed were a control group with distilled water (G1), Colgate Total 12 Professional Clean (G2), Sensodyne Extra Whitener Extra Fresh (G3), and Colgate Luminous White (G4). A sequence of 90 cycles was performed for all the samples. The initial roughness of each group was analyzed by the Surface Roughness Tester (TR 200-TIME Group Inc., CA, USA). After the brushing period, the final roughness was measured, and the results were statistically analyzed using nonparametric Kruskal–Wallis and Dunn tests for intergroup roughness comparison in the time factor. For intragroup and “Δ Final − Initial” comparisons, the Wilcoxon test and (one-way) ANOVA were, respectively, performed (α = 0.05). Results: The roughness mean values before and after brushing showed no statistically significant difference when the different dentifrices were used. None of the dentifrices analyzed increased significantly the nanohybrid composite resin surface roughness in a 1 month of tooth brushing simulation. Conclusions: These results suggest that no hazardous effect on the roughness of nanohybrid composite resin can be expected when whitening dentifrices are used for a short period. Similar studies should be conducted to analyze other esthetic composite materials.

Impact of obesity in patients with metastatic urothelial carcinoma.

2015 ◽  
Vol 33 (7_suppl) ◽  
pp. 346-346
Author(s):  
Amanda Leiter ◽  
John Doucette ◽  
Susanne Krege ◽  
Chia-Chi Lin ◽  
Noah M. Hahn ◽  
...  
Keyword(s):  
Adverse Events ◽  
Urothelial Cancer ◽  
Normal Weight ◽  
Phase Iii ◽  
Survival Outcomes ◽  
Similar Response ◽  
Obese Patients ◽  
Metastatic Urothelial Cancer ◽  
Significant Difference ◽  
The Impact

346 Background: Obesity has been associated with worse outcomes in patients with clinically localized urothelial cancer. However, the impact of obesity on outcomes of patients with metastatic disease has not previously been evaluated. Methods: Data from 537 patients were aggregated from eight phase II and phase III clinical trials investigating first-line cisplatin-based combination therapy in metastatic urothelial cancer. Chemotherapy regimen, adverse events, treatment response, and survival outcomes were compared across body mass index (BMI) and body surface area (BSA) categories. Results: BMI was classified according to WHO criteria (<18.5 underweight (4.1 % of patients), 18.5-24.99 normal weight (42.8%), 25-29.99 overweight (41.0%), >30 obese (12.1%)). BSA was classified as either below (56.8% of patients) or greater than or equal to (43.2%) the European average (1.91 m2 for males and 1.71 m2 for females). There was no significant difference in number of chemotherapy cycles across BMI and BSA categories. Patients’ treatment regimens significantly differed across BMI (p=0.02) and BSA (p<0.01) categories, with patients with higher BMI category and average or above BSA more likely to receive gemcitabine-cisplatin-based therapy rather than MVAC (methotrexate, vinblastine, doxorubicin, and cisplatin)-based or other therapy regimens. There was no significant difference in adverse events across BMI categories, but the incidence of embolic events was significantly higher in patients with an average or higher BSA (6.6%) than those with a lower than average BSA (2.7%) (p=0.03). There was no significant difference in response rate or survival outcomes (overall and progression-free) amongst BMI and BSA categories. Conclusions: Obese patients with metastatic urothelial cancer on cisplatin-based therapies have similar response rates and survival outcomes to non-obese patients. Toleration of cisplatin-based therapy is similar across BMI and BSA categories, with the exception of a higher incidence of embolic events in patients with an above average BSA.

scholarly journals Reduced Levels of Circulating 7α-Hydroxy-Dehydroepiandrosterone in Treated Adolescent Obese Patients

2014 ◽  
pp. 95-101
Author(s):  
L. MÁČOVÁ ◽  
M. BIČÍKOVÁ ◽  
H. ZAMRAZILOVÁ ◽  
M. HILL ◽  
H. KAZIHNITKOVÁ ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Body Mass Index ◽  
Adipose Tissue ◽  
Hydroxysteroid Dehydrogenase ◽  
Obese Patients ◽  
Significant Difference ◽  
Before And After ◽  
Reductive Treatment ◽  
Circulating Levels

Elevated levels of glucocorticoids lead to the development of obesity and metabolic syndrome. Local glucocorticoid levels are regulated through the enzyme 11β-hydroxysteroid dehydrogenase 1 (11β-HSD 1), an enzyme that regenerates active cortisol from inert cortisone. Increased expression of 11β-HSD 1 in adipose tissue promotes higher body mass index (BMI), insulin resistance, hypertension, and dyslipidemia. Human 11β-HSD 1 is also responsible for inter-conversion of 7-hydroxylate metabolites of dehydroepiandrosterone (7-OH-DHEA) to their 7-oxo-form. To better understanding the mechanism of the action, we focused on 7-OH- and 7-oxo-DHEA, and their circulating levels during the reductive treatment in adolescent obese patients. We determined plasma levels of 7α-OH-DHEA, 7β-OH-DHEA, and 7-oxo-DHEA in 55 adolescent patients aged 13.04-15.67 years, BMI greater than 90th percentile. Samples were collected before and after one month of reductive therapy. Circulating levels of 7α-OH-DHEA decreased during the reductive therapy from 1.727 (1.614; 1.854, transformed mean with 95 % confidence interval) to 1.530 nmol/l (1.435; 1.637, p<0.05) in girls and from 1.704 (1.583; 1.842) to 1.540 nmol/l (1.435; 1.659, p<0.05) in boys. With regard to the level of 7-oxo-DHEA, a significant reduction from 1.132 (1.044; 1.231) to 0.918 nmol/l (0.844; 1.000, p<0.05) was found after the treatment, but only in boys. No significant difference in 7β-OH-DHEA levels was observed. In conclusions, diminished levels of 7α-OH-DHEA indicate its possible effect on activity of 11β-HSD 1. Further studies are necessary to clarify whether competitive substrates for 11β-HSD 1 such as 7α-OH-DHEA could inhibit production of glucocorticoids and may be involved in metabolic processes leading to reduction of obesity.

scholarly journals Biochemical reference intervals in broiler chickens according to age and strain

2021 ◽  
Vol 13 (4) ◽  
pp. 357-364
Author(s):  
N. Arzour-Lakehal ◽  
A. Boudebza
Keyword(s):  
Uric Acid ◽  
Broiler Chickens ◽  
Reference Intervals ◽  
Biochemical Variables ◽  
Plasma Uric Acid ◽  
Estimated Parameters ◽  
Age Related ◽  
Significant Difference ◽  
Different Strains ◽  
Related Increase

Abstract. The objective of the research was to study the physiological pattern of biochemical variables and to obtain reference intervals for young (less than 1 month) and adult (more than 1 month) broiler chickens of 2 strains. From the jugular vein, blood for analysis was collected, separated, and then immediately analyzed. The influence of age was significant for the majority of the investigated variables in the 2 groups. In Isa15 strain, a significant age-related decrease in plasma uric acid, glucose, cholesterol, triglycerides, phosphorus, potassium and iron was established. Also, a significant age-related increase in plasma calcium and ASAT was obtained in the same broiler strain. In Arbor Acres Plus strain, a significant age-related decrease in plasma glucose, cholesterol, triglycerides and phosphorus was observed. A significant age-related increase in plasma total protein, calcium and ASAT has also been reported in this broiler strain. A significant difference between the two strains was reported for plasma uric acid, glucose, cholesterol, phosphorus, magnesium and iron (p<0.05). For most estimated parameters in the 2 strains, calculation of separate reference intervals for young and adult animals was appropriate. Except for potassium in young Isa15 strain, and phosphorus in young Arbor Acres Plus strain, all variables did not follow a normal distribution. Reference intervals are presented for both ages using non-parametric or robust method. 90% confidence intervals for both groups were calculated non-parametrically, or by the bootstraping method. The established reference intervals will be a useful guide for interpreting plasma biochemical variables in different strains of broiler chickens raised in Algeria, and reared in a mild Mediterranean climate.

scholarly journals Intra Articular Ozone Modulates Inflammation and Has Anabolic Effect on Knee Osteoarthritis: IL-6 and IGF-1 as Pro-Inflammatory and Anabolic Biomarkers

Processes ◽  
2022 ◽  
Vol 10 (1) ◽  
pp. 138
Author(s):  
Marcos E. Fernández-Cuadros ◽  
Olga S. Pérez-Moro ◽  
María J. Albaladejo-Florín ◽  
María M. Tobar-Izquierdo ◽  
Amelia Magaña-Sánchez ◽  
...  
Keyword(s):  
Uric Acid ◽  
Knee Osteoarthritis ◽  
Real World ◽  
Secondary Outcome ◽  
Womac Pain ◽  
Anabolic Effect ◽  
Obese Patients ◽  
Knee Oa ◽  
Before And After ◽  
Anti Inflammatory

Objectives: (1) to demonstrate the anti-inflammatory and anabolic effect of Ozone by determining in serum samples the biochemical levels of IL-6 and IGF-1 in knee osteoarthritis (OA) patients in a real world rehabilitation setting; (2) to differentiate Ozone effect in diabetic (DM)/obese and non-DM/non-obese patients; (3) to evaluate clinical effectiveness by visual analog scale (VAS) and WOMAC scale, and biochemical effect by C-reactive protein (CRP), uric acid and erythrocyte sedimentation rate (ESR). Material and methods: 65 patients with knee OA Kellgren Lawrence (KL) grade 2 or more were analyzed in a retrospective observational study. The study ran from January 2018 to September 2021. Inclusion criteria: (a) patients 18 years or older; (b) with knee OA KL 2° or more; (c) biochemical analysis before-and-after treatment; (d) pain more than 3 on VAS. Exclusion Criteria: (a) previous knee surgery; (b) favism; (c) pregnancy; (d) any other disease that originates lack of collaboration for infiltration. Primary Outcome variables: (a) IL-6; (b) IGF-1 in diabetes mellitus (DM)/obese and non-DM/non-obese patients; both before-and-after Ozone treatment. Secondary Outcome variables: (a) CRP, (b) ESR, (c) uric acid, (d) VAS pain, (e) WOMAC pain, function and stiffness. Ozone protocol consisted of four sessions (once a week) of an intra-articular infiltration of 20 mL (20 µg/mL concentration) of a gas mixture of Oxygen-Ozone 95-5% (produced by Ozone generator Ozonosan-α Plus®). For biochemical evaluation, SNIBE MAGLUMI ™ IL-6 (CLIA) and SNIBE MAGLUMI ™ IGF-1 (CLIA) kits were used. CRP and uric acid were analyzed by a Abbott Alinity c kit; and ESR was evaluated by DIESSE VES MATIC CUBE 30. Results: There is a linear correlation between age and OA severity. IL-6 decreased both in DM and non-DM patients and in all OA KL grades (from 2.70 to 1.59 pg/mL). IGF-1 decreased in total group (OA + DM + obesity) from 112.09 to 107.19 ng/mL. When only non-DM/non-obese knee OA patients were analyzed, Ozone improved IGF-1 levels (from 100.17 to 102.03 ng/mL). Ozone decreased CRP, ESR, uric acid, and improved VAS pain, WOMAC pain, function and stiffness (p < 0.05). Conclusions: Ozone is a valid option for the management of knee osteoarthritis in a real world rehabilitation setting, because of its anti-inflammatory, metabolic and anabolic properties. Ozone tends to downregulate pro-inflammatory IL-6 cytokine. Ozone has a metabolic/hypoglycemic effect on obese/diabetic knee osteoarthritis patients by reducing IGF-1. Ozone has an anabolic effect on non-diabetic/non-obese patients by improving IGF-1. Ozone reduces other biomarkers of inflammation (CRP, ESR and uric acid) and improves, pain, function and quality of life.

scholarly journals Grassland fire effect on soil organic carbon reservoirs in semiarid environment

2013 ◽  
Vol 5 (2) ◽  
pp. 883-895 ◽  
Author(s):  
A. Novara ◽  
L. Gristina ◽  
J. Rühl ◽  
S. Pasta ◽  
G. D'Angelo ◽  
...  
Keyword(s):  
Organic Carbon ◽  
Soil Organic Carbon ◽  
Soil Surface ◽  
Dry Weight ◽  
Grassland Management ◽  
Semiarid Environment ◽  
Short Period ◽  
Significant Difference ◽  
Before And After ◽  
Grassland Fire

Abstract. The aim of this work was to investigate the effect of a experimental fire, used for grassland management, on soil organic carbon (SOC) reservoirs. The study was carried out on Hyparrhenia hirta (L.) Stapf (Hh) grassland and Ampelodesmos mauritanicus (Desf.) T. Durand and Schinz (Am) grasslands, located in the north of Sicily. Soil samples were collected at 0–5 cm before and after experimental fire and SOC was measured. During grassland fire soil surface temperature was monitored. Biomass of both grasses was analyzed in order to determine dry weight and its chemical composition. The results showed that SOC varied significantly with vegetation cover, while it is not affected in the short period by grassland fire. Am grassland stored more SOC compared with Hh grassland thanks to lower content in biomass of labile carbon pool. No significant difference was observed in SOC before and after fire which could be caused by several factors: first, in both grassland types the measured soil temperature during fire was low due to thin litter layers; second, in semiarid environment higher mineralization rate results in lower soil carbon labile pool; and third, the C stored in the finest soil fractions, physical protected, is not affected by fire.

scholarly journals Effect of Cryotherapy Temperature on the Extension Performance of Healthy Adults’ Legs

Biology ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 591
Author(s):  
Yichen Lu ◽  
Yuqi He ◽  
Shanshan Ying ◽  
Qiaojun Wang ◽  
Jianshe Li
Keyword(s):  
Peak Power ◽  
Cold Treatment ◽  
Peak Force ◽  
P Value ◽  
Leg Extension ◽  
Cold Therapy ◽  
Short Period ◽  
Significant Difference ◽  
Before And After ◽  
Group A

Cryotherapy as a measurement of sports recovery and treatment has been utilized by more and more athletes and coaches. The aim of this study was to investigate the effect of different temperature cryotherapies on leg extension performance. Thirty-one male participants from a University volunteered to join two different temperature cryotherapies. The peak power and peak force of right leg extension performance of each participant was measured by Keiser, before and after cryotherapy, respectively. The results of this study show that there was a significant difference in peak power (t = −3.203, p value = 0.003) and peak force (t = −4.662, p value = 0) before and after 0 °C cryotherapy. In addition, there was a significant difference in peak force (t = −4.36, p value = 0) before and after −5 °C cryotherapy. Besides, the changing rates of peak power (3.03%) and peak force (11.51%) in the 0 °C group were higher than those of peak power (2.80%), as well as peak force (7.45%), in the −5 °C group. The PF in the 0 °C and −5 °C groups both significantly increased after cryotherapy. Peak power significantly increased after 0 °C cryotherapy, but did not significantly increase after −5 °C cryotherapy. The changing rates of peak power and peak force in the 0 °C group were both higher than the −5 °C group. A short period of cold treatment at 0 °C may increase the leg extension ability. A 0 °C cold therapy for a short period of time is more suitable than a −5 °C one for athletes to recover during the interval within a competition. Athlete and coach could choose an appropriate temperature to help increase performance of physical level and recovery.

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