scholarly journals Novel Remedial Approaches Against Virulent Corona Viruses

2020 ◽  
Keyword(s):  
Virus Disease ◽  
The Body ◽  
Health Concern ◽  
High Morbidity ◽  
Respiratory Pathogens ◽  
Corona Virus ◽  
Group I ◽  
The World ◽  
Group Ii ◽  
Corona Viruses

Novel Corona virus disease (COVID-19) was first identified in China, which eventually became a major global health concern due to its pathogenicity and widespread distribution around the world. In the mid-sixties of the previous century, the first two human Corona viruses (HCoV) were identified: HCoV-229E and HCoV-OC43. These two human Corona viruses were studied extensively from approximately 1965 to the mid-1980s. HCoV-229E is a member of the group I Corona viruses, and HCoV-OC43 is a member of group II. 1Besides the human Corona viruses, there are several group I and group II animal corona viruses that infect cattle, pigs, cats, dogs, mice, and other animals. There is one additional branch, the group III Corona viruses, which are found exclusively in birds. By infecting healthy volunteers, researchers learned that infection with HCoV-229E or HCoV-OC43 results in a common cold, and since then, HCoVs have been considered to be relatively harmless respiratory pathogens. This image was roughly disturbed when severe acute respiratory syndrome (SARS)-CoV was introduced into the human population in the winter of 2002 to 2003 in China. SARS-CoV causes a severe respiratory illness with high morbidity and mortality. Currently, the Novel Corona Virus disease COVID 19 spreads around the world, killing people and turning them into corpses. The best way to do this in India, that is what it is there are many types of alkaloids in our Indian Medicinal Plants, which kill the virus of any kind and dispose of it. The alkaloids – Piperine, Curcumin, Allicin, Alliin, Allylsulfide, Allyldisulfide, Citric Acid, Acorbic Acid, Menthol, Gingerols, Shogaols, zingerone, oleanolic acid, ursolic acid, rosmarinic acid, eugenol, carvacrol, linalool, β-caryophyllene etc., the alkaloids that are mentioned are not only killing the virus but also stimulate, and activate the immune system in the body and at the same develops human energy to fight against COVID 19. The preparation and methodologies of simple medicine briefly explained in the topic Novel Remedial Approaches against Virulent Corona Viruses.

scholarly journals A COMPARATIVE CLINICAL EFFICACY STUDY OF TRIPHALA KWATH AND TRIKATU CAPSULES IN THE MANAGEMENT OF MEDOROGA W.S.R TO DYSLIPIDEMIA

AYUSHDHARA ◽  
2020 ◽  
Author(s):  
Anjli Sharma ◽  
Anjana Mishra ◽  
Manik Soni ◽  
Vijay Chaudhary
Keyword(s):  
The Body ◽  
Trial Period ◽  
Inclusion Criteria ◽  
Way Of Life ◽  
Modern Times ◽  
Group I ◽  
The World ◽  
Group Ii ◽  
Different Parts ◽  
Excessive Accumulation

Medoroga is a condition in which there is an excessive accumulation of Meda Dhatu in the body. Accumulation of Medo Dhatu in different parts of the body causes blockage of Strotsa which ultimately leads to poor nourishment of other Dhathus. Lack of exercises and Kaphavardhak Ahar Viharar are the two main causes of Medoroga. In modern times, way of life has changed drastically to quick nourishments and inactive tendencies throughout the world. Because of these factors, accumulation of Meda dhatu happens immensely. In Ayurveda, dyslipidemia is considered under Medoroga. Dyslipidemia is an emerging serious health abnormality associated with co-morbidities including CVD that continues to be the leading cause of death worldwide. It is characterized by an increase in cholesterol, triglycerides, LDL levels, and a decrease in HDL levels. The present study has been designed to compare the efficacy of Triphala Kwath and Trikatu capsules on various clinical parameters in the management of Medoroga w.s.r to dyslipidemia. Twenty patients fulfilling the inclusion criteria were randomly selected for the trial and put into two groups of ten patients each. Trikatu capsules were given to patients in group I and Triphla kwath with Madhu and Trikatu capsules in combination were given to patients of group II for 8 weeks. Patients were thoroughly assessed on various scientific parameters during the complete trial period. In group II, a significant (p<0.001) improvement was observed in subjective parameters and serum cholesterol, triglycerides, LDL, VLDL levels while in group I, a significant (p<0.001) improvement was observed in HDL only. It may affirmatively be construed from the study that the best impact of the trial drugs was observed with Triphala Kwatha with Madhu and Trikatu Capsule together (i.e. Group II). This combination therapy was most effective in reducing the overall lipid profile with substantial gains related to subjective as well as objective parameters without any adverse effects.

scholarly journals Autonomic Function test in person with Obesity aAmong Mid-Western Population of Nepal

2017 ◽  
Vol 15 (2) ◽  
pp. 18-22
Author(s):  
Bhawana Neupane Pant ◽  
Rajesh Kumar Goit ◽  
Manoj Panta ◽  
Ashish Neupane ◽  
Pushpa Bhargava
Keyword(s):  
Heart Rate ◽  
Autonomic Dysfunction ◽  
Cold Water ◽  
The Body ◽  
Health Concern ◽  
Obese Person ◽  
Predisposing Factor ◽  
Indirect Measure ◽  
Group I ◽  
Group Ii

Objective: Autonomic dysfunction qualifies a major public health problems owing to their high prevalence and incidence globally. Among many predisposing factor of autonomic neuropathy such as age, gender, genetic, diabetes etc, obesity also has significant . impact Although a lot of progress has been achieved in past decade on accessibility and awareness about health, the obesity remains impending and burgeoning health concern in Nepal. With this trend, we can foresee that the Body Mass Index (BMI) one of the commonly used indirect measure of obesity, might potentially turn out to be one of the leading factor of autonomic dysfunction. Methods: 100 healthy subjects were screened and divided into 2 groups- Group I (BMI>30) and Group II (BMI< 30). Height & weight were measured & BMI was calculated. Resting heart rate (RHR) was recorded with Lead II of ECG. Blood pressure (BP) and Heart Rate (HR) were recorded in supine position and on immediate standing. Cold pressure test (CPT): Resting BP was recorded in sitting position. Then the subjects were asked to immerse the hand in cold water, and the BP was measured from other hand. Data was analyzed using SPSS 16 (Statistical Package for Social Science). Result: Our result showed that RHR of Group I (79.32±4.22) was higher than that of Group II (74.38±7.26). However, on student –T test, BP and HR response to immediate standing (P=0.34 &P=0.23 respectively) were non-significant between group I and group II person. When the correlation was done for the change in BP in response to CPT in between obese and non-obese person it was found to be significant (P=0.04). Conclusion: Our data suggests that the BMI can be a predictor of autonomic dysfunction.  

scholarly journals The Culture of Thahârah in the Corona Virus Disease Pendemic: an Offer to Prevent the Spread of Covid-19 with Islamic Jurisprudence Approach

2021 ◽  
Vol 24 (2) ◽  
pp. 223
Author(s):  
Zurifah Nurdin
Keyword(s):  
Research Method ◽  
Preventive Measures ◽  
Virus Disease ◽  
Spiritual Health ◽  
The Body ◽  
Routine Activity ◽  
Literary Research ◽  
Corona Virus ◽  
Islamic Jurisprudence ◽  
The World

Islamic teachings explain comprehensively how to purify, clean the body and the environment from uncleanness, and to use water and other washing media in a measured manner. In the concept of Islamic theory, this purification activity is known as thahârah. Due to the wide transmission of the Corona Virus Disease 2019 or Covid-19 throughout the world, this article offered preventive measures to restrain the spread of Covid-19 by practicing thahârah consistently based on a fiqh perspective. This study employed literary research method which traced a number of books by Islamic scholars related to the thahârah or purification procedures. After the data was collected, the analysis was carried out by analyzing, processing, and interpreting the data into a conclusion. The results revealed that in addition to eliminating hadaṡ, dirt, and impurity, thahârah activities such as wudhu, tayamum, titual bathing, and teeth brushing benefit for physical and spiritual health. If thahârah is practiced consistently; as a cleaning up routine activity, it will diminish the spread of Covid-19. Instead of just washing hands, for instance, it is recommended to do wudhu even if it is not for praying. Viruses sticking to the hands and face will be washed away and disappear if a person performs wudhu properly according to the teachings of the Prophet Muhammad.  The research has shown that wudhu contains tremendous benefits for health as it can stimulate energy in the body and improve blood circulation.Ajaran Islam secara rinci menjelaskan bagaimana bersuci, membersihkan badan dan lingkungan dari najis, dan bagaimana menggunakan air dan media pencuci lainnya dengan terukur. Aktivitas bersuci tersebut dalam konsep Islam disebut thahârah. Sehubungan dengan telah menyebarnya virus corona 2019 atau Covid-19 yang melanda ke seluruh dunia, artikel ini menawarkan upaya tindakan preventif pencegahan tertularnya Covid-19 dengan membudayakan thahârah  secara konsisten berdasarkan perspektif fikih. Penelitian ini menggunakan metode literary research, yakni menelusuri sejumlah buku-buku karya ulama Islam yang berhubungan dengan ṭahârah atau tatacara bersuci menurut fikih Islam. Setelah data terkumpul, dilakukan analisis dengan mengkalisifikasi, mengolah, dan menginterpretasi data menjadi suatu kesimpulan. Dari hasil analisis tersebut dapat disimpulkan bahwa selain bertujuan menghilangkan hadas, kotoran, dan najis, kegiatan thahârah seperti wudhu, tayamum, mandi, dan bersiwak bermanfaat untuk kesehatan jasmani dan rohani. Jika aktivitas thahârah ini dibudayakan secara konsisten, dalam arti dijadikan aktivitas yang rutin dalam membersihkan sesuatu, penyebaran Covid-19 akan tertekan menjadi minimal. Daripada mencuci tangan saja, misalnya, lebih baik sekalian berwudhu walaupun tidak untuk melakukan salat. Virus yang menempel di tangan dan wajah akan terbasuh dan lenyap jika seseorang melakukan wudhu dengan benar sesuai dengan ajaran Nabi Muhammad Saw. Penelitian membuktikan bahwa wudhu mengandung manfaat yang besar bagi kesehatan karena mampu merangsang dan menstimulus energi dalam tubuh serta melancarkan peredaran darah.

scholarly journals COVID-19: A Global Pandemic of 21st Century

2020 ◽  
Vol 10 (3-s) ◽  
pp. 311-321
Author(s):  
Prabhakar Budholiya ◽  
Abdul Wajid Ali ◽  
Deepshikha Gunwan ◽  
Sana Sahil ◽  
C.K. Tyagi ◽  
...  
Keyword(s):  
Virus Disease ◽  
Respiratory Illness ◽  
World Health ◽  
Severe Illness ◽  
Director General ◽  
Corona Virus ◽  
The World ◽  
Control And Prevention ◽  
Health Organization ◽  
Corona Viruses

In last of 2019, the Centers for Disease Control and Prevention started monitoring the outbreak of a new corona virus, SARS-CoV-2, which causes the respiratory illness now known as COVID-19. Authorities first identified the virus in Wuhan, China. More than 82542 case of Corona virus in China at 31 March 2020. Health authorities have identified many other people with COVID-19 around the world. On 31 March 2020, the virus spread more than 750890 People in the World. The World Health Organization (WHO) has declared a public health emergency relating to COVID-19. Since then, this strain has been diagnosed in several residents of world. The CDC have advised that it is likely to spread to more people. COVID-19 has affected at least 213 countries or territories or areas. The first people with COVID-19 had links to an animal and seafood market. This fact suggested that animals initially transmitted the virus to humans. However, people with a more recent diagnosis had no connections with or exposure to the market, confirming that humans can pass the virus to each other. Corona viruses will infect most people at some time during their lifetime. Corona viruses can mutate effectively, which makes them so contagious. Information on the virus is scarce at present. In the past, respiratory conditions that develop from corona viruses, such as SARS and MERS, have spread through close contacts. On 17 February 2020, the Director-General of the WHO presented at a media briefing the following updates on how often the symptoms of COVID-19.However, while some viruses are highly contagious, it is less clear how rapidly corona viruses will spread. Symptoms vary from person-to-person with COVID-19. It may produce few or no symptoms. However, it can also lead to severe illness and may be fatal. On 11 March 2020, WHO declared Novel Corona virus Disease (COVID-19) outbreak as a Pandemic. Keywords: WHO, ICMR, SARS-CoV-2, Bats, Wuhan City, Pneumonia, Respiratory Infection, Pandemic

scholarly journals Understanding COVID-19 through the Dental Lens

BioMedica ◽  
2020 ◽  
Vol 36 (2S) ◽  
pp. 185-193
Author(s):  
Sarah Ghafoor ◽  
Ansa Javed Akram
Keyword(s):  
Oral Cavity ◽  
Virus Disease ◽  
Professional Staff ◽  
The Body ◽  
World Health ◽  
Virus Infections ◽  
Corona Virus ◽  
The World ◽  
Precautionary Measures ◽  
Health Organization

<p>Corona virus Disease-19 (COVID-19) is a global health pandemic that has affected life of every individual in the world. It is caused by a novel Corona virus strain that has caused seventh Corona virus infection that has affected human population, named as &ldquo;COVID-19&rdquo; virus by the World Health Organization. Previously, six Corona virus infections have affected humans but those caused by SARS-CoV and MERS-CoV have proved to be more lethal. Angiotensin Converting Enzyme 2 (ACE2) has been found as the receptor for COVID-19 through which cellular entry of the virus is mediated into the body. These receptors are abundantly present in the oral cavity especially on the epithelial cells of the tongue, oral mucosa and the gingiva. Saliva is an oral bio-fluid of the oral cavity in which high titres of the virus have been identified during early and later stages of infection. Saliva collection is a non-invasion method and can act as a diagnostic tool for COVID-19 disease. Common oral symptoms of the disease include transient loss of taste, smell and dryness of mouth. Precautionary measures must be taken by dentist before carrying out any dental procedure for safety of the health care professional, staff and also the patient. Dental community must think of the &ldquo;new normal&rdquo; regarding clinical dental care in light of post-COVID-19 situation.</p>

COVID-19: The Unprecedented Malady-A Holistic Review

Coronaviruses ◽  
2020 ◽  
Vol 01 ◽  
Author(s):  
Viney Chawla ◽  
Pooja A Chawla
Keyword(s):  
Virus Disease ◽  
Drug Repurposing ◽  
Signs And Symptoms ◽  
Effective Vaccine ◽  
Runny Nose ◽  
Difficult Time ◽  
Holistic Review ◽  
The World ◽  
Spanish Flu ◽  
Corona Viruses

Background: Corona virus disease (COVID-19) is spreading rapidly at an unprecedented scale across continents and has emerged as the single biggest risk the world has faced in modern times. Some scientists are comparing it to Spanish flu that created havoc around a century ago. The fear of death by COVID-19 looms large at the world today. The disease has reached devastating proportions since its first reports in December 2019. Doctors are having a difficult time dealing with this challenge and the microbiologists are having sleepless nights to bring about an effective vaccine for this disease. Methods: A number of research and review articles have been exhaustively reviewed. The collected data was meticulously analysed and documented. Conclusion: This paper reviews the different types of corona viruses, the structure of SARS-CoV-2 responsible for COVID19, its transmission, virulence. Further, the article discusses the diagnosis, signs and symptoms like fever, breathlessness, cough, potential loss of taste or smell, sneezing, runny nose, fatigue, headache, sore throat and different treatment approaches including drug repurposing being tried by doctors around the globe that may come handy in the management of disease symptoms. The article describes the use of remdesivir, ribavarin, lopinavir, favipiravir, hydoxychloroquine, chloroquine, tocilizumab among others in treating COVID-19.

Hospitalitas Kristen Yang Hampir Hilang Pada Kasus Kematian Salah Satu Anggota Masyarakat Di Dusun Beringin, Luwu Utara, Sulawesi Selatan Akibat Covid-19

2021 ◽  
Author(s):  
desna rura sarapang
Keyword(s):  
Virus Disease ◽  
Social Distancing ◽  
Indonesian Government ◽  
Risk Of Death ◽  
The Earth ◽  
Corona Virus ◽  
The World ◽  
Global World ◽  
The Impact ◽  
Christian Hospitality

The emergence of a new virus in the global world at the end of 2019, namely Corona Virus Disease 2019, brought tremendous excitement to all inhabitants of the earth. The emergence of this virus brings tremendous concern and fear to the world because the spread of this virus is quite fast, even the most frightening is that the risk of death of people exposed to this virus is very large. Indonesia itself, cannot avoid the impact of this Covid-19 case. As a form of efforts to prevent and minimize transmission of the virus, the Indonesian government has issued a social distancing / physical distancing recommendation. This situation also causes the interaction between communities to be very limited. This situation seems to be able to eliminate hospitality among the community. This paper aims to emphasize the importance of maintaining the value of Christian hospitality in society amid the Covid-19 pandemic.

scholarly journals The Influence of Highly Dispersed Metal Forms on Calcium and Phosphorus Metabolism in Polygastric Animals

2022 ◽  
Author(s):  
Makaeva Ayna Maratovna ◽  
Sizova Elena Anatolevna ◽  
Atlanderova Ksenya Nikolaevna
Keyword(s):  
Feed Additives ◽  
The Body ◽  
Feed Additive ◽  
Utilization Rate ◽  
Control Group ◽  
Ruminal Fluid ◽  
Group I ◽  
Calcium And Phosphorus ◽  
Group Ii ◽  
Experimental Group

Determining which forms of mineral feed additives can increase farm animal productivity is a key area of research. This study assessed the mineral composition of ruminal fluid and the effectiveness of calcium and phosphorus used by animals after the introduction of finely dispersed particles (FDP) of SiO2 (group I) and FeCo (group II) with a hydrodynamic radius of 109.6 ± 16.6 and 265 ± 25 nm, respectively. The deposition and use of calcium and phosphorus in the body of the experimental animals exceeded the control values. In group I, 30.8% more calcium was deposited (p ≥ 0.05), and in group II, the value was 30.3% (p ≥ 0.01). In the experimental groups, the calcium utilization rate was 27.3% higher in group I (p ≥ 0.05), and 28.2% higher in group II (p ≥ 0.01) compared to in the control. Phosphorus deposition was 34% higher (p ≤ 0.01) in experimental group I and 6% higher in experimental group II, compared with the control. Group I had a high utilization rate of phosphorus from the feed (with a 29% difference compared to the control). Comparison of the experimental groups revealed that the introduction of SiO2 FDP promoted an increase in the concentration of silicon, phosphorus, and calcium in the ruminal fluid. The introduction of FeCo FDP was accompanied by a decrease in the concentration of iron and cobalt in the ruminal fluid. Thus, the use of feed additive in finely dispersed form in the diet of animals was accompanied by an increase in the use of calcium and phosphorus by the animal’s body, which is advisable when intensifying milk and meat productivity. The obtained results require further research. Keywords: finely dispersed forms of microelements, ruminants, calcium and phosphorus exchange, feeding

scholarly journals Comparison between Vinorelbine–Carboplatin and Vinorelbine–Cisplatin in Stage III–IV EGFR Mutations-Negative NSCLC

2021 ◽  
Author(s):  
Laksmi Wulandari ◽  
Gatot Soegiarto ◽  
Anna Febriani ◽  
Farah Fatmawati ◽  
Wirya Sastra Amran
Keyword(s):  
Lung Cancer ◽  
Body Weight ◽  
Evaluation Criteria ◽  
Growth Factor Receptor ◽  
The Body ◽  
Stage Iii ◽  
Egfr Mutations ◽  
Group I ◽  
Significant Difference ◽  
Group Ii

Abstract Introduction There are a substantial number of lung cancer patients with negative mutations in Indonesia. This type of cancer is deemed to be the major contributor of lung cancer patient’s death. However, reseaerch related to therapy using vinorelbine combined with platinum-based compounds is still scarce in Indonesia. The aim of this study was to compare the efficacy and tolerability between vinorelbine and carboplatin with vinorelbin and cisplatin in stage III-IV epidermal growth factor receptor (EGFR) mutations-negative non-small cell lung cancer (NSCLC). Methods The participants were divided into two groups—group I(vinorelbine–carboplatin) and group II (vinorelbine–cisplatin). The participants were assessed based on several measurement criteria. Not only Eq-5D was performed, but the body weight and response evaluation criteria for solid tumors (RECIST) were also examined. The participants received chemotherapy for four cycles (1 cycle = 21 days). Results The quality of life was considered stable in 60% of group I and 60% of group II (p=0.255). In both groups, 46.67% of participants had an increased body weight, while the other 20.00% was stable (p = 1.000). In terms of RECIST evaluation after the second cycle, 80.00% of group I and 86.67% of group II were considered to have a stable disease, with 20% of group I and none of group II had partial response (p = 0.027). However, after the fourth cycle, there were no significant difference between the groups (p = 0.734). Conclusion In EGFR mutation-negative NSCLC patients, the combination of vinorelbine and carboplatin showed comparable outcomes to vinorelbine and cisplatin chemotherapy with no significant differences.

scholarly journals Assessment of Relation between External Branch of Superior Laryngeal Nerve & Thyroid Gland- A Cadaveric Study

2020 ◽  
Vol 6 (2) ◽  
pp. 73-76
Author(s):  
Anurag ◽  
Vishnu Gupta
Keyword(s):  
Thyroid Gland ◽  
Cricoid Cartilage ◽  
Superior Laryngeal Nerve ◽  
Laryngeal Nerve ◽  
The Body ◽  
Superior Thyroid Artery ◽  
Group I ◽  
External Branch ◽  
The Mean ◽  
Group Ii

Background: The thyroid gland is essential for normal growth of the body. This study assessed relation of external branch of superior laryngeal nerve to the superior pole of the thyroid gland. Subjects and Methods: This study was conducted on 25 human cadavers having 50 superior thyroid poles of both genders. Cadavers were classified based on age groups, group I was those with age less than 39 years and group II cadavers were those with age more than 40 years of age. Various measurements were performed on cadavers. Results: 14 cadavers were I group I and 11 were in group II. The mean mass was 67.2 Kgs in group I and 59.5 Kgs in group II, time elapsed after death was 481.5 minutes in group I and 476.4 minutes in group II, mean height was 1.74 meters in group I and 1.69 meters in group II, mean BMI found to be 22.3 kg/m2in group I and 20.1 kg/m2in group II. Height found to be significant between both groups (P< 0.05). The mean distance from EBSLN to cranial point of the thyroid gland was 6.66 mm in group I and 8.96 mm in group II. The mean transverse distance from superior thyroid artery to EBSLN was 3.55 mm in group I and 5.12 mm side in group II. The mean distance of the crossing point between the most cranial point of the thyroid lobe was 6.40 mm in group I and 11.47 mm in group II. The mean distance from the EBSLN to the midline of the neck was 19.80 mm in group I and 18.58 mm in group II. The mean distance from the EBSLN to the midline of the neck on the most cranial point of the cricoid cartilage was 18.77 mm in group I and 17.80 mm in group II. Conclusion: Authors found variation in measurements in left and right side in both group I and group II.

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