scholarly journals FREQUENCY AND CORRELATES OF MYOPATHY IN PATIENTS WITH DIABETES TAKING ATORVASTATIN

2021 ◽  
Vol 71 (2) ◽  
pp. 482-85
Author(s):  
Kamil Rehman Butt ◽  
Andaleeb Khan ◽  
Ali Muhammad ◽  
Jawad Khan ◽  
Ejaz Ali ◽  
...  

Objective: To determine the myopathy in patients with diabetes taking atorvastatin and look for the factors correlated with the presence of myopathy among these patients. Study Design: Cross sectional analytical study. Place and Duration of Study: Department of Medicine, Pak Emirates Military Hospital Rawalpindi from, Jul to Dec 2018. Methodology: A total of 166 patients of both genders with type 2 diabetes mellitus taking atorvastatin for at least three to twelve months were included. Blood samples were drawn and Creatinine kinase (CK) levels were determined by automated analysis by colorimetry. Myopathy was taken as muscle symptoms associated with elevations in Creatinine Kinase at least 10 times the upper limit of normal. Results: Mean age of patients was 51.530 ± 5.70 years with age range from 40-70 years with. Mean duration of diabetes was 6.174 ± 2.27 years, mean duration of taking atorvastatin 7.186 ± 2.17 months and mean creatinine kinase levels were 1760.325 ± 5111.71 IU/L. Males were 68.7% as compare to females 31.3%. Myopathy was seen in 8.4% patients. Long duration of Diabetes Mellitus and atorvastatin use was statistically significantly related with the presence of myopathy. Conclusion: Myopathy was found in a significant number of patients taking atorvastatin. High risk population in our study emerged out to be patients with long duration of Diabetes Mellitus and long use of atorvastatin.

2020 ◽  
Vol 8 (1) ◽  
pp. 16
Author(s):  
Sruthi Kare ◽  
Vishwanath N. Reddy ◽  
Thejdeep Mahamkali

Background: India is one of the epicentres of the global diabetes mellitus pandemic. Rapid socioeconomic development and demographic changes, along with increased susceptibility for Indian individuals, have led to the explosive increase in the prevalence of diabetes mellitus in India over the past four decades. Diabetic Nephropathy is a common consequence of long-standing diabetes mellitus. The development of diabetic nephropathy has a dramatic increase on the morbidity and mortality of patients with diabetes. Objective of this study was to evaluate the prevalence of microalbuminuria in patients with diabetes mellitus patients.  Methods: This cross-sectional study was conducted on T 2 diabetes mellitus patients visiting medicine OPD of R L Jalappa hospital constituent hospital of Sri Deveraj Urs Medical College, Tamaka, Kolar from May 2016 to July 2016. A total of 60 type-2 diabetes patients were enrolled in the study.Results: Average duration of diabetes among study group was 8 years and most of the patients were between 6-10 years. In type 2DM patients, microalbuminuria and glycemic control have shown a significant linear correlation with duration of diabetes (p<0.05). Also, micro albuminuria has a significant correlation with increase in level of glycosylated haemoglobin.  Conclusions: The prevalence of microalbuminuria in diabetic patients was found to be high and being a developing country; there is a dire need that microalbuminuria and HbA1c testing should be done in both, newly diagnosed as well as already diagnosed type 2DM patients as an early marker of renal risk factor.


2019 ◽  
Vol 6 (8) ◽  
pp. 2941
Author(s):  
Anilkumar Bellad ◽  
Kartik Sahu

Background: One of the independent risk factor for erectile dysfunction is diabetes mellitus. The present study planned to determine the prevalence and factors associated with ED in DM.Methods: A one year cross-sectional study on a total of 208 patients with type 1 or 2 diabetes. National Institutes of Health (NIH) approved questionnaire for International Index of Erectile Function (IIEF) was used to interview each patient to assess for ED.Results: In this study 12.98% of patients had ED score between 13 to 18 suggestive of mild to moderate ED and 9.62% with 19 to 24 scores suggestive of mild degree. The prevalence of erectile dysfunction was 32.21%. The mean age in patients with erectile dysfunction was significantly high (58.40±10.96 years) compared to those without erectile dysfunction (51.00±11.16 years) (p<0.001) Of the 119 patients with duration of diabetes between one to five years 42.02% had ED and of the 3 patients with duration of more than five years 66.67% had ED (p<0.001). Prevalence of ED was higher in patients with HbA1c levels between 7.0 to 8.5 (32.76%) and >8.5 (37.07%). Prevalence of erectile dysfunction was higher in patients with history of smoking (63.64%) (p<0.001) and alcohol intake (51.85%) (p<0.001). The prevalence of erectile dysfunction was also significantly high in patients with history of hypertension (59.7%) (p<0.001).Conclusions: The ED in patients with diabetes mellitus was significantly prevalent with age, duration of diabetes, history of hypertension, cardiovascular disease, glycemic control and hypertriglyceridemia.


2013 ◽  
Vol 20 (05) ◽  
pp. 804-809
Author(s):  
RAHEEL IFTIKHAR ◽  
SULTAN MEHMOOD KAMRAN ◽  
KUMAIL ABBASS, ◽  
Ehtesham Haider,

Objective: To determine frequency of Hypomagnesaemia in patients of type 2 diabetes mellitus in our population. DataSource: Random selection of DM II patients from Outpatient Department CMH, Kharian. Design: Cross sectional study. Setting:Combined Military Hospital Kharian, Department of Medicine. Duration of study: January 2011 to December 2011. Materials &Methods: We selected outdoor patients of DM-2 from both gender between 40 to 70 yrs of age by random sampling. Those selected,were subjected to blood fasting and random glucose measurements as well as serum magnesium levels. Blood samples were collectedusing full aseptic measures and within one hour, samples were transported to Armed Forces institute of Pathology (AFIP) for analysis.Serum magnesium level estimation was done by timed endpoint method using calmagite dye. DXC 600 automated analyzer was used.The results were verified by Pathologist. Results: The overall frequency of Hypomagnesemia was 32.2% (124 out of the 385 subjects)using the cutoff value of less than 0.6mmol/l for Hypomagnesaemia, whereas 67.8% (261 out of the 385 individual) had normal serummagnesium levels. Conclusions: Significant number of patients with type 2 diabetes mellitus suffers from Hypomagnesaemia. Thesepatients have increased risk risk of poor Glycemic control and diabetic complications due to Hypomagnesemia. Therefore, it isrecommended that serum magnesium levels should be checked regularly in patients with type 2 diabetes mellitus and oral magnesiumreplacement should be done.


2021 ◽  
Vol 71 (3) ◽  
pp. 853-56
Author(s):  
Kamran Ali ◽  
Sajid Ali Shah ◽  
Syed Murtaza Ali ◽  
Raja Jibran Akbar ◽  
Syed Qasim Raza ◽  
...  

Objective: To compare the effect of age, gender and duration of diabetes mellitus on thyroid dysfunction in patients of diabetic Study Design: Comparative cross sectional study. Place and Duration of Study: Medicine department, Combined Military Hospital, Peshawar, from Oct 2015 to Oct 2017. Methodology: The study was conducted after taking permission from hospital ethical review committee. Information was entered in the proforma, which included demographic information like age in years, gender, duration of disease and type of diabetes mellitus (DM) type. Already diagnosed patients with diabetes mellitus were included in the study. Thyroid function tests were carried out by standard laboratory procedure. Results: A total of 179 patients were included in our study, 114 (63.7%) were female and 65 (36.3%) were male. Mean body mass index in our study was 29.85 ± 3.88 kg/m2. Out of 179 patients 46 (25.7%) had thyroid dysfunction (TD). Out of the 46 patients with thyroid dysfunction, 14 patients (7.8%) had clinical hypothyroidism, while subclinical hypothyroidism was seen in 25 patients (14%). Clinical hyperthyroidism was reported in 3 (1.7%), while subclinical hyperthyroidism in 4 (2.2%) patients respectively. Conclusion: Age of patients, gender and duration of disease affect thyroid functions in patients with diabetes mellitus. Thyroid profile should be carried out in diabetic patients whose blood sugar level is difficult to control.


2020 ◽  
Vol 14 (1) ◽  
pp. 8-16
Author(s):  
Eka Yudha Chrisanto ◽  
Sapti Ayubbana ◽  
Yola Anjani

Detection of hypoglycemia by adult with diabetes mellitus.Background : The increasing prevalence of people with diabetes mellitus occurs every year along with the increasing prosperity of a country, especially in developing countries because the wrong lifestyle changes can cause obesity which is one of the risk factors for diabetes.Purpose: Know factors that are related to Detection of hypoglycemia by adult with diabetes mellitus.Method: This is a descriptive correlational study, a cross sectional research design. The population in this study was the number of patients with diabetes mellitus of 40 respondents. The sample technique used was accidental sampling, research instruments using a questionnaire, with data analysis namely the chi square test.Results: Finding that there was no relationship of age (p-value 0.071) and availability of glucometer with (p-value 0.052), there was a relationship with education (p-value 0.026), duration of suffering of DM (p-value 0.016 ), there is a relationship of gender with (p-value 0.010), there is a relationship of knowledge (p-value 0.008). In detecting episodes of hypoglycemia (p-value 0.052).Conclusion: Several factors in detecting episodes of hypoglycemia in the context of nursing care are closely related such as; education, duration of diabetes, gender, and knowledge.Keywords: Detection; Hypoglycemia; Adult; Diabetes mellitus.Pendahuluan: Hipoglikemia terjadi karena peningkatan insulin dalam darah dan penurunan kadar glukosa. Terapi insulin yang tidak adekuat disebabkan oleh ketidaksempurnaan terapi insulin saat ini, dimana pemberian insulin masih belum sepenuhnya dapat menirukan (mimicking) pola sekresi insulin yang fisiologis. Hipoglikemia diabetik lebih sering terjadi pada pasien diabetes tipe 1, namun dapat juga terjadi pada pasien diabetes tipe 2 yang mendapatkan terapi insulin, dan merupakan faktor penghambat utama dalam penanganan diabetes mellitus.Tujuan: Mengetahui faktor faktor yang berhubungan dengan kemampuan pasien diabetes mellitus dalam melakukan deteksi episode hipoglikemia dalam konteks asuhan keperawatan .Metode: Penelitian dilakukan pada Juli 2019 dengan menggunakan metode Cross Sectional. Melibatkan 40 responden di Poli Penyakit Dalam Rumah Sakit Umum Daerah Dr. H. Abdul Moeloek Propinsi Lampung. Pengumpulan data dilakukan dengan cara wawancara langsung menggunakan kuisioner pengetahuan tentang Hipoglikemia untuk menilai tingkat pengetahuan dan kuisioner kemampuan deteksi hipoglikemia untuk menilai kemampuan melakukakn deteksi episode hipoglikemia pada responden.Hasil: Tidak terdapat hubungan usia (p-value 0.071) dan ketersediaan alat glukometer dengan (p-value 0.052), terdapat hubungan pendidikan dengan (p-value 0,026), lama menderita DM dengan (p-value 0,016), jenis kelamin dengan (p-value 0,010), dan pengetahuan (p-value 0,008) dalam melakukan deteksi episode hipoglikemia dalam konteks asuhan keperawatan (p-value 0,052).Simpulan: Beberapa faktor dalam melakukan deteksi episode hipoglikemia dalam konteks asuhan keperawatan sangat erat berhubungan seperti; pendidikan, lama menderita DM, jenis kelamin, dan pengetahuan


2012 ◽  
Vol 19 (02) ◽  
pp. 259-263
Author(s):  
RAHEEL IFTIKHAR ◽  
MUHAMMAD ADNAN MANZAR ◽  
Fatima SAEED

Objectives: Determine frequency of hypertension in type 2 diabetics. Determine pattern of hypertension in type 2 diabetics.Study design: Cross sectional survey. Setting: The study was conducted in the out patient department of Combined Military Hospital, Lahore.Duration of study: Study was carried out over a period of 01 year from July 2010 to July 2011. Material and methods: Total 700 cases wererecruited in this study. Blood pressure of all the patients was recorded in a sitting position with a mercurial sphygmomanometer 4–6 hours apart.It was interpreted as prehypertension, stage 1 and stage 2 according to operational definitions. Results: Out of total 700 patients, 490 (70.0%)were hypertensive .Pattern of hypertension showed 100 (20.4%) pre-hypertension, 160 (32.6%) stage-I and 230 (47.0%) stage-II .Majority ofthe patients i.e. 245 (50.0%) were between 41-50 years and minimum 9 patients (1.8%) were 20-30 years old with mean age of 55.9±3.7 .Out of700 patients, 350 (50.0%) were male while remaining 350 (50.0%) were females. Married patients were 400 (57.1%) and unmarried 300(42.9%). Conclusions: Patients with diabetes mellitus have increased risk of developing hypertension than normal population.


2021 ◽  
Vol 18 (1) ◽  
pp. 14-19
Author(s):  
Nikola Savić ◽  
Igor Lukić ◽  
Jelena Mitrović ◽  
Zoran Jokić ◽  
Dušan Ružičić ◽  
...  

Objective. Diabetes mellitus is a chronic disease in which the body either does not produce or inadequately uses the hormone of the pancreas, insulin. Health education work with this population of patients is an important aspect of treatment and health care, it aims to change harmful health behavior and prevent complications. The aim of the research is to examine the information and health habits of patients with diabetes mellitus, to determine the presence of factors that can affect the worsening of the condition and lead to complications of the disease. Methods. The research was conducted according to the type of cross-sectional study. To collect data, a questionnaire for patients with diabetes mellitus was used, which the authors constructed for this research. The research was conducted in the population of patients with diabetes, in the period June-August 2018. at the General Hospital in Valjevo. The sample consisted of 110 respondents. Results. In the observed sample, almost 2/3 (63%) of the respondents are overweight, and almost 3/4 (74%) of the respondents regularly control their blood sugar values. More than 1/2 (56%) were educated for glycemic self-control, 70% were informed about signs of hyperglycemia, 87% were signs of hypoglycemia. More than 1/3 of respondents are exclusively on insulin therapy, 87% adhere to the therapeutic regimen, 87% of the subjects are trained for insulin self-application. 90% of respondents go to check-ups regularly, and 97% think that the information they receive from health workers is useful. Conclusion. Healthcare professionals of all profiles, primarily doctors and nurses, should continuously conduct health education work with people with diabetes. The largest number of patients in the observed sample were informed about their disease and hygienic dietary regime. In order to make the results even more encouraging, it is necessary to intensify health education work at all levels of health care.


Author(s):  
Girish I. ◽  
Vijeth S. B. ◽  
Nandini H. V.

Background: Microalbuminuria is an earliest marker of overt diabetic nephropathy, hence monitoring microalbuminuria in patients with diabetes mellites helps to predict and prevent overt diabetic nephropathy. This cross-sectional study was done to find out the prevalence of microalbuminuria in 200 patients with diabetes mellitus attending medicine OPD of Basaweshwara medical college hospital (BMCH), Chitradurga.Methods: 200 patients with Diabetes mellitus visiting the medicine OPD of BMCH, Chitradurga were considered for the study. Patients history and physical examination findings like duration of diabetes, hypertension, smoking and BMI were considered. Relevant blood investigations like fasting blood sugar, glycated haemoglobin (HbA1c), serum cholesterol and creatinine were done. Microalbuminuria was assessed using dipstick kits in an early morning urine samples.Results: The prevalence of normoalbuminuria was 71% and microalbuminuria was 29%. The prevalence of microalbuminuria increased with the increase in duration of diabetes.Conclusions: Prevalence of microalbuminuria among the patients with diabetes depends upon risk factors like blood pressure control, duration of diabetes, fasting blood sugar and HbA1c. Early identification of high risk patients and the subsequent initiation of renal and cardiovascular protective agents helps to reduce the burden of diabetic kidney disease. 


2010 ◽  
Vol 16 (2) ◽  
pp. 4 ◽  
Author(s):  
Bawo Onesirosan James ◽  
Joyce Ohiole Omoaregba ◽  
George Eze ◽  
Olufemi Morakinyo

<p><strong>Objectives.</strong> Depression is associated with diabetes mellitus and affects treatment goals negatively. We aimed to determine the prevalence of depression and identify its socio-demographic or clinical correlates among patients with diabetes mellitus attending an out-patient clinic in Nigeria.</p><p><strong>Methods.</strong> Two hundred consecutively recruited diabetes patients (index group) were compared with a similar number of apparently healthy controls in a cross-sectional survey. In both groups, in addition to obtaining socio-demographic details, depression was diagnosed using the Schedule for the Clinical Assessment in Neuropsychiatry (SCAN), while the Beck Depression Inventory (BDI) was used to assess depression symptom severity. <strong></strong></p><p><strong>Results.</strong> Sixty (30%) diabetes patients met a SCAN diagnosis for clinical depression, compared with 19 (9.5%) in the control group. Having a smaller income and more children were significantly correlated with higher depression symptoms on the BDI.</p><p><strong>Conclusion.</strong> Depression is highly co-morbid with diabetes mellitus. The care of individuals with diabetes mellitus should include the screening and possible treatment for depression in order to achieve and sustain treatment goals.</p>


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