FORMULASI GELHAND SANITIZER DARI KITOSAN DENGAN BASIS NATRIUM KARBOKSIMETILSELULOSA

2017 ◽  
Vol 1 (1) ◽  
pp. 31
Author(s):  
Supomo Supomo ◽  
Yullia Sukawati ◽  
Fredi Basyar
Keyword(s):  
Phase Separation ◽  
Side Effect ◽  
Physical Stability ◽  
Biocompatible Polymers ◽  
Homogeneity Test ◽  
Consistency Test ◽  
Hand Sanitizer ◽  
Gel Preparation ◽  
Dispersive Power ◽  
Chitosan Gel

Chitosan has been widely used in industrial, food, pharmaceuticals and agriculture. Chitosan is a natural biocompatible polymers means that as nature does not have the side effect, non-toxic, can not be easily digested and broken down by microbes (biodegradable). This study aims to determine whether the chitosan may be formulated into dosage gel hand sanitizer that meets the requirements of the physical stability of the gel.Chitosan is formulated with 3 varying concentrations of Na CMC basis of 3%, 4.5% and 6%. Tests conducted gel formulation is the physical stability test which includes organoleptic test, homogeneity, pH test, test dispersive power, viscosity test and test consistency. Testing is done every week for 4 weeks of storage.Results of testing physical properties of chitosan gel hand sanitizer has the shape and color stable but the resulting aroma change during storage. pH gel meet the requirements, the consistency test of phase separation does not occur, the homogeneity test showed no homogeneous gel, gel dispersive power does not meet the requirements, the viscosity of the gel preparation third formula does not meet the requirements of viscosity gel

scholarly journals Formulation of handsanitizer with antibacterials substance from n-hexane extract of soursop leaves (Annona Muricata Linn)

2017 ◽  
Vol 13 (1) ◽  
Author(s):  
Dian Riana Ningsih ◽  
Zusfahair Zusfahair ◽  
Dwi Kartika ◽  
Amin Fatoni
Keyword(s):  
Antibacterial Activity ◽  
Diffusion Method ◽  
Homogeneity Test ◽  
Annona Muricata ◽  
Consistency Test ◽  
Power Test ◽  
Hand Sanitizer ◽  
Organoleptic Test ◽  
Dispersive Power ◽  
Growth Of Bacteria

One of the plants which are efficacious as antibacterial is the soursop leaves. Soursop leaves were extracted by maceration using n-hexane. The extract was evaporated using rotary evaporator. Soursop leaves extract was then formulated in a gel dosage form. This study aims toformulate hand sanitizer from soursop leaves extract based on Growing Minimum Inhibitory Concentrations (MIC) of n-hexaneextract of soursop leaves, and to know the evaluation result of gel dosage with the active substance of soursop leaves extract. Testing of physical properties of the gel includes organoleptic test, dispersive power test, homogeneity, pH, and consistency test. Antibacterial activity was tested by using a diffusion method. The evaluation of the gel showed SNI standards which wereable for topical use. The organoleptic test resultedthat the dosage is odorless, transparent and gel. Homogeneity test resulted that all gel dosage concentrations are homogenous. The pH tests at concentrations of 1, 5 and 10 ppm respectively are 5.38 to 6.22; 5.48 to 6.28; and from 5.29 to 5.90. The dispersive power test resulted for 6.47 to 7 cm; 6.20 to 6.87 cm; and 6.09 to 6.59 cm. The consistency test resulted that all gel dosages are consistent in gel form.Gel dosage with extract concentrations of 1, 5 and 10 ppm can inhibit the growth of bacteria P. acne with antibacterial activity of 3.53; 3.26 and 2.20 mm. 

scholarly journals FORMULASI DAN UJI STABILITAS SEDIAAN GEL HAND SANITIZER EKSTRAK ETANOL BUAH MENTIMUN (Cucumis sativus L.)

2021 ◽  
Vol 3 (2) ◽  
pp. 110-125
Author(s):  
Yani Ambari ◽  
◽  
Hanik Endah Paramita ◽  
Arista Wahyu Ningsih ◽  
◽  
...  
Keyword(s):  
Physical Stability ◽  
Ethanol Extract ◽  
Homogeneity Test ◽  
Adhesion Test ◽  
Cucumis Sativus L ◽  
Antibacterial Compounds ◽  
Hand Sanitizer ◽  
Cucumber Fruit ◽  
Gel Preparation ◽  
Made In

Hand Sanitizers generally contain chemicals in the form of alcohol and triclosan. However, the use of these two ingredients can cause danger if they are used continuously, therefore the Hand Sanitizer antiseptic product was innovated using ethanol extract of cucumber fruit which contains antibacterial compounds to reduce the use of both ingredients. The purpose of this study was to make a Hand Sanitizer gel formulation from ethanol extract of cucumber fruit and to determine the physical stability of the preparation during storage. Hand Sanitizer Gel of cucumber fruit ethanol extract is made in three formulations withdifferent extract concentrations, namely F1 (1.5%), F2 (2.5%), and F3 (3.5%). The results of the organoleptic test included the three formulations, namely that the three of them did not change during storage. The results of the homogeneity test included F1 and F2 which were stated to be homogeneous while F3 was not homogeneous. The results of the pH test included that during storage the three had decreased until week 3 and increased thepH again at week 4. The results of the spreadabilitytest of the three preparations met the requirements for the gel preparation, but in the adhesion test the three preparations did not meet the adhesion requirements of the gel preparation.

FORMULA DAN EVALUASI GEL PEMBERSIH TANGAN EKSTRAK BAWANG TIWAI (Eleutherine bulbosa (Mill.) Urb)

2017 ◽  
Vol 3 (1) ◽  
pp. 77
Author(s):  
Yullia Sukawaty ◽  
Anita Apriliana ◽  
Husnul Warnida
Keyword(s):  
Physical Properties ◽  
Active Ingredient ◽  
Physical Stability ◽  
Diffusion Method ◽  
Disc Diffusion ◽  
Disc Diffusion Method ◽  
E Coli ◽  
Hand Sanitizer ◽  
Gel Preparation ◽  
Dispersive Power

Bawang tiwai (Eleutherine bulbosa (Mill.) Urb.) acts as an antibacterial because it contains a class of alkaloids, flavonoids, saponins, tannins, glycosides, triterpinoida / steroid, anthraquinone glycosides.Bawang tiwai onions can be used as an antibacterial active ingredient formulated in a gel hand sanitizer. The purpose of this study to determine the effect of varying concentrations of alcohol on the physical properties of gel preparation and inhibition of E.coli bacteria which are formulated in the form of a gel hand sanitizer bawang tiwai extract. Research conducted on fomula gel hand sanitizer bawang tiwai extract with various concentrations of alcohol F1 0%, F2 10%, F3 20%, F4 60% include (organoleptic, homogeneity, pH, dispersive power, consistency and viscosity) and continued with test inhibition of E. coli using disc diffusion method (Kirby-Bauer) in F1 0%, 10% F2, F3 20%, K (-) 60% and K (+) Triclosan 0.1%. Data were analyzed with SPSS 16.0 using Kruskal Wallis test with a level of 95%, α = 0.05. Gel hand sanitizer contains bawang tiwai extract 20% meets the requirements of the physical stability and have antibacterial inhibition of E. Coli

scholarly journals FORMULASI SEDIAAN GEL EKSTRAK ETANOL DAUN KALIANDRA (Calliandra surinamensis Benth) SEBAGAI ANTIBAKTERI

PHARMACON ◽  
2019 ◽  
Vol 8 (4) ◽  
pp. 801
Author(s):  
Yulita Ni Nyoman Tri Sukartiningsih ◽  
Hosea Jaya Edi ◽  
Jainer P. Siampa
Keyword(s):  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Physical Stability ◽  
Homogeneity Test ◽  
Adhesion Test ◽  
Cycling Test ◽  
Physical Evaluation ◽  
Before And After ◽  
Gel Preparation ◽  
Ethanol Extracts

ABSTRACT Kaliandra Leaf (Calliandra surinamensis Benth) contains flavonoid compounds, saponins and tannins which are able to inhibit the antibacterial activity. This study aims to test the antibacterial effectiveness of gel preparation of ethanol extracts of kaliandra leaf to obtain the greatest formula, and prove the Kaliandra leaf gel preparation has good physical stability. This study uses a laboratory experimental method. Gel formula is made as many as 5 formulas with variations in the concentration of 2%, 3%, 4%, 5%, and 6% of w : v. Kaliandra leaf extraction was carried out by maceration method using 96% ethanol. The antibacterial test of the ethanol extracts of Kaliandra leaf gel using the method of welling against Staphylococcus aureus bacteria produced a moderate inhibition of 7.0 ± 0.63 mm at a concentration of 6%. The physical evaluation of the preparation includes organoleptic test, homogeneity test, syneresis test, scatter power test, adhesion test, pH test, cycling test, and sterility test. All tests are carried out before and after the cycling test. The results of the study on the preparation fulfilled the physical evaluation requirements before and after the cycling test. It can be concluded that the concentration of 6% of ethanol extracts of Kaliandra leaves could be formulated as a gel preparation that is physically stable and has moderate antibacterial activity. Keywords: Kaliandra (Calliandra surinamensis Benth), Gel preparations, Staphylococcus aureus antibacterial.  ABSTRAK Daun Kaliandra (Calliandra surinamensus Benth) mengandung senyawa flavonoid, saponin dan tannin yang mampu menghambat aktivitas antibakteri. Penelitian ini bertujuan untuk menguji efektivitas antibakteri sediaan gel ekstrak etanol daun Kaliandra untuk mendapatkan formula terbesar, serta membuktikan sediaan gel daun Kaliandra mempunyai stabilitas fisik yang baik. Penelitian ini menggunakan metode ekperimental laboratorium. Formula sediaan gel dibuat sebanyak 5 formula dengan variasi konsentrasi 2%, 3%, 4%, 5%, dan 6% b/v. Ekstraksi daun Kaliandra dilakukan dengan metode maserasi menggunakan etanol 96%.  Penelitian uji antibakteri sediaan gel ekstrak etanol daun Kaliandra menggunakan metode sumuran pada bakteri staphylococcus aureus menghasilkan daya hambat yang sedang yaitu 7,0±0,63 mm pada konsentrasi 6%. Evaluasi fisik sediaan meliputi uji organoleptik, uji homogenitas, uji sineresis, uji daya sebar, uji daya lekat, uji pH, uji cycling test, dan uji sterilitas. Semua pengujian dilakukan sebelum dan sesudah cycling test. Hasil penelitian sediaan memenuhi persyaratan eveluasi fisik sebelum uji cycling test dan sesudah cycling test. Dapat disimpulkan pada kosentrasi 6% ekstrak etanol daun Kaliandra dapat diformulasi sebagai sediaan gel yang stabil secara fisik dan memiliki aktivitas antibakteri yang sedang. Kata kunci : Kaliandra (Calliandra surinamensis Benth), Sediaan Gel, Antibakteri Staphlococcous  aureus.

scholarly journals Optimization of SRC (Semi Refined Carrageenan) and Glucomannan Concentration as Gelling Agent to the Physical Stability Sunscreen Gel of Dry Corncob Extract (Zea mays L.)

2019 ◽  
Vol 7 (22) ◽  
pp. 3833-3836 ◽  
Author(s):  
Kori Yati ◽  
Yudi Srifiana ◽  
Asri Indah Lestari
Keyword(s):  
Zea Mays ◽  
Zea Mays L ◽  
Physical Stability ◽  
Optimal Concentration ◽  
Gelling Agent ◽  
Homogeneity Test ◽  
Corn Cob ◽  
Freeze Thaw ◽  
Organoleptic Test ◽  
Dispersive Power

BACKGROUND: Corncob is one of crude drug which containing phenolic compounds that can be used as an active ingredient for sunscreen preparations. In this study, extracts of dried corn cob made into a gel formulation using SRC (Semi Refined Carrageenan) and glucomannan as a gelling agent. AIM: This study aims to determine the optimal concentration of SRC (Semi Refined Carrageenan) and glucomannan to the physical stability of the gel. METHODS: Gel made into four formulas with a ratio of 1: 4 and the concentration of each formula was 1%, 1.5%, 2%, 2.5%. Each formula was evaluated for 6 weeks of storage that includes organoleptic test, homogeneity, pH, viscosity, dispersive power, freeze-thaw test and centrifugation. RESULTS: The results showed the fourth formula did not change the organoleptic test and homogeneity test. In the test separation of the freeze-thaw method, the fourth formula was stable, while in the centrifugation test formula 1 and 2 was been separation. pH and viscosity results obtained from statistics with a two-way ANOVA showed significant differences in each formula. CONCLUSION: From the results of this study concluded that the formula 3 with a concentration of 2% was the optimal concentration as a gelling agent.

scholarly journals FORMULATION AND EFFECTIVENESS OF A HAND SANITIZER GEL PRODUCED USING SALAM BARK EXTRACT

2018 ◽  
Vol 10 (1) ◽  
pp. 216
Author(s):  
Silvia Surini ◽  
Nurul Isti Amirtha ◽  
Delly Chipta Lestari
Keyword(s):  
Minimum Inhibitory Concentration ◽  
Inhibitory Concentration ◽  
Physical Stability ◽  
Good Stability ◽  
Bark Extract ◽  
Hand Sanitizer ◽  
Number Of Bacteria ◽  
Better Than

Objective: The objectives of this study were to determine the minimum inhibitory concentration (MIC) of Salam bark extract against Staphylococcusaureus, formulate and evaluate hand sanitizer gels containing Salam bark extract, and determine the effectiveness of the gels against bacteria on thepalms of the hands.Methods: The gel base was optimized by preparing three formulations containing carbomer and triethanolamine at ratios of 0.25%:0.5%, 0.5%:1%,and 0.5%:2%. The best gel formulation was mixed with Salam bark extract. The physical stability of gels containing 4.04% (formulation 1) and 7.77%(formulation 2) Salam bark extract was measured at 4±2°C, 27±2°C, and 40±2°C for 12 weeks. The effectiveness of the gels was examined on the palmsof 30 respondents.Results: The MIC of Salam bark extract was 3.12%. The best gel base contained carbomer and triethanolamine at a ratio of 1–4 and a pH of 5.50.Formulations 1 and 2 gels had good stability for 12 weeks. Formulation 2 tended to decrease the number of bacteria (p=0.125) better than formulation1 (p=1.000). In the hedonic study, formulation 2 was preferred to formulation 1.Conclusion: Formulation 2 gel with 7.77% Salam bark extract was more effective than formulation 1 gel with 4.04% extract in decreasing the number ofbacteria on the palms.

Nanofibres and their Influence on Cells for Tissue Regeneration

2005 ◽  
Vol 58 (10) ◽  
pp. 704 ◽  
Author(s):  
Yanping Karen Wang ◽  
Thomas Yong ◽  
Seeram Ramakrishna
Keyword(s):  
Phase Separation ◽  
Cell Growth ◽  
Tissue Regeneration ◽  
Self Assembly ◽  
Biomedical Applications ◽  
Synthetic Polymer ◽  
Biocompatible Polymers ◽  
Mechanical Methods ◽  
The Matrix ◽  
Cell Growth And Proliferation

Synthetic polymer and biopolymer nanofibres can be fabricated through self-assembly, phase separation, electrospinning, and mechanical methods. These novel functional biocompatible polymers are very promising for a variety of future biomedical applications. There are many characteristics of nanofibres that would potentially influence cell growth and proliferation. As such, many studies have been carried out to elucidate the cell–nanofibre interaction with the purpose of optimizing the matrix for cell growth and tissue regeneration. In this Review, we present current literatures and our research on the interactions between cells and nanofibres, and the potentials of nanofibre scaffolds for biomedical applications.

Controlled Release of Natural Polyphenols in Oral Cavity Using Starch Pickering Emulsion

2014 ◽  
Vol 1688 ◽  
Author(s):  
Min S. Wang ◽  
Amol Chaudhari ◽  
Yuanjie Pan ◽  
Stephen Young ◽  
Nitin Nitin
Keyword(s):  
Phase Separation ◽  
Controlled Release ◽  
Oral Cavity ◽  
Oxygen Permeability ◽  
Physical Stability ◽  
Pickering Emulsion ◽  
Natural Polyphenols ◽  
Oil In Water ◽  
Complete Disruption ◽  
Potential Use

ABSTRACTThe goal of this study was to determine the potential use of starch Pickering emulsion as a vehicle to deliver a natural phenolic compound, curcumin in the oral cavity. To this end, an oil-in-water (o/w) emulsion was prepared using starch molecules as the stabilizer/emulsifier. The physical stability, oxygen permeability and release of curcumin from the starch Pickering emulsion in simulated saliva fluid (SSF) were determined. The results of this study showed that the starch stabilized o/w emulsions were stable for up to 2 weeks. The starch Pickering emulsion also provided better protection against oxidation than a surfactant-stabilized emulsion, and the digestion of the starch Pickering emulsion using amylase led to the complete disruption and phase separation of the emulsion.

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