Antifungal and Antioxidant Activities of Lipophilic Compounds from Swietenia mahagoni (l.) Jacq. Leaves

The investigation on the n-hexane lipophilic extractives of Swietenia mahagoni, alongside the antifungal and antioxidant properties was conducted. The leaf sample was collected from 2- and 3-years-old trees in Perhutani enterprise of Temanggung, Central Java, Indonesia. In addition, the antifungal activity was tested using the white-rot of Phanerochaete chrysosporium, while the antioxidant property involved the DPPH (1,1-diphenyl-2-picrylhydrazyl) method. The results show antifungal of 28.6% and 37.5% growth inhibition in 2- and 3 -years-old leaf, respectively, while 21.7% and 25.4% antioxidant activity were also recorded. Furthermore, the GC-MS results showed the domination of S. mahagoni leaf by fatty acids and hydo-carbons, while the terpenoids and steroids were in minor quantities. These components possibly exhibit growth inhibitory and antioxidant effects against P. chrysosporium and DPPH radicals, respectively.

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Black goji berry (Lycium ruthenicum) tea has higher phytochemical contents and in vitro antioxidant properties than red goji berry (Lycium barbarum) tea

Food Quality and Safety ◽

10.1093/fqsafe/fyaa022 ◽

2020 ◽

Vol 4 (4) ◽

pp. 193-201

Author(s):

Bei Liu ◽

Qingqing Xu ◽

Yujing Sun

Keyword(s):

Antioxidant Capacity ◽

Bioactive Compounds ◽

Antioxidant Activities ◽

Antioxidant Properties ◽

Antioxidant Property ◽

Lycium Barbarum ◽

Antioxidant Power ◽

Goji Berry ◽

Good Habit

Abstract Goji berry tea, a traditional herbal tea, is the main ate mode of goji berry in Asia, yet few studies in comparison with red goji berry tea and black goji berry tea are carried out. This study investigated the effects of water temperature and soak time on the colour, phytochemicals, and the antioxidant capacity [2,2-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), 2,2-diphenyl-1-picrylhydrazyl radical (DPPH), and the ferric-reducing antioxidant power (FRAP)] of two goji berry tea. A comparison of the bioactive compounds and antioxidant activities between black and red goji berry tea was conducted. Results showed that both red and black goji berry tea were rich in phytochemicals, giving high antioxidant ability. The levels of bioactive compounds and the antioxidant activity of the two goji berry tea increased as the increases in soak temperature and time. Black goji berry tea had higher phytochemicals and antioxidant property than those of red goji berry tea. Infused at 100° water for the same time, the levels of total polysaccharides (150 mg/100 ml), total polyphenols (238 mg/ml), and antioxidant capacity (550 μmol/100 ml) of black goji berry tea were 3.5, 2, and 5 times higher, respectively, in comparison with red goji berry tea. The results of this study demonstrate that hot drink of goji berry in China is a good habit and black goji berry tea may be a better choice.

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Comparison of Antioxidant and Anticancer Properties of Soft Coral-Derived Sinularin and Dihydrosinularin

Molecules ◽

10.3390/molecules26133853 ◽

2021 ◽

Vol 26 (13) ◽

pp. 3853

Author(s):

Sheng-Chieh Wang ◽

Ruei-Nian Li ◽

Li-Ching Lin ◽

Jen-Yang Tang ◽

Jui-Hsin Su ◽

...

Keyword(s):

Cancer Cells ◽

Soft Coral ◽

Antioxidant Activities ◽

Antioxidant Properties ◽

Antioxidant Property ◽

Radical Scavenger ◽

Anticancer Properties ◽

Liver Cancer Cells ◽

Radical Scavenger Activity ◽

Scavenger Activity

Marine natural products are abundant resources for antioxidants, but the antioxidant property of the soft corals-derived sinularin and dihydrosinularin were unknown. This study aimed to assess antioxidant potential and antiproliferation effects of above compounds on cancer cells, and to investigate the possible relationships between them. Results show that sinularin and dihydrosinularin promptly reacted with 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2-azinobis (3-ethyl-benzothiazoline-6-sulfonic acid) (ABTS), and hydroxyl (•OH), demonstrating a general radical scavenger activity. Sinularin and dihydrosinularin also show an induction for Fe+3-reduction and Fe+2-chelating capacity which both strengthen their antioxidant activities. Importantly, sinularin shows higher antioxidant properties than dihydrosinularin. Moreover, 24 h ATP assays show that sinularin leads to higher antiproliferation of breast, lung, and liver cancer cells than dihydrosinularin. Therefore, the differential antioxidant properties of sinularin and dihydrosinularin may contribute to their differential anti-proliferation of different cancer cells.

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CHEMICAL COMPOSITION AND ANTIOXIDANT ACTIVITIES OF BEETROOT PEEL.

African Journal of Engineering and Environment Research ◽

10.37703/ajoeer.org.ng/q12021/05 ◽

2020 ◽

Vol 2 (1) ◽

Keyword(s):

Crude Protein ◽

Antioxidant Activities ◽

Antioxidant Properties ◽

Analytical Techniques ◽

Antioxidant Property ◽

Ash Content ◽

The Body ◽

Good Source ◽

Mineral Contents ◽

Detectable Range

Proximate, mineral and antioxidant properties of beetroot (Beta vulgaris) peel were investigated using standard analytical techniques. Result for proximate revealed that moisture content was 30.88%, ash content (10.58%), crude fat (3.29%), crude fiber (6.98%), crude protein (4.10%) and carbohydrate (44.17%). The mineral composition (mg/g) also showed that sodium was 4.17%, iron (26.46%), copper (0.21%), magnesium (5.91%), potassium (13.82%) and phosphorus (11.57%) while zinc and calcium were not at detectable range of AAS. There was no activity for its antioxidant property. The results obtained from this analysis shows that Beetroot peel is a good source of carbohydrates, protein, ash, fiber, lipid and moisture, it also contained some mineral contents such as copper, phosphorous and iron which are required by the body to function effectively. Its consumption is therefore advertised instead of regarding it as a waste material. Keywords: antioxidant, investigation, mineral, peel, proximate

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Formulation and Evaluation of Polyherbal Cream Containing Cinnamomum zeylanicum Blume, Glycyrrhiza glabra L and Azadirachta indica A. Juss. Extracts to Topical Use

Journal of Institute of Science and Technology ◽

10.3126/jist.v25i2.33738 ◽

2020 ◽

Vol 25 (2) ◽

pp. 61-71

Author(s):

Rajendra Gyawali ◽

Rupesh Kumar Gupta ◽

Sahana Shrestha ◽

Rajendra Joshi ◽

Prem Narayan Paudel

Keyword(s):

Azadirachta Indica ◽

Antioxidant Properties ◽

Flow Property ◽

Antioxidant Property ◽

Glycyrrhiza Glabra ◽

Cinnamomum Zeylanicum ◽

Cream Formulation ◽

Glycyrrhiza Glabra L ◽

Lipid Peroxidase ◽

Dpph Scavenging

Alcoholic extracts of medicinal plants Cinnamomum zeylanicum Blume, Glycyrrhiza glabra L, and Azadirachta indica A. Juss were subjected to the evaluation of antioxidant properties and combined for the cream formulation. The antioxidant property was determined by using the 2, 2-diphenyl-1-picrylhydrazyl (DPPH) assay and inhibition of lipid peroxidase assays. The cream formulation was designed using Minitab software and a central composite design was used to study the effect of dependent variables, steric acid and cetyl alcohol on the response variables such as, viscosity, pH, and spreadability. The phytochemical screening of extracts showed the presence of tannin, phenol, flavonoids, saponins, and alkaloids. Antioxidant properties of the extracts and their relative composition were found variable. Composition F3 (C. zeylanicum Blume: G. glabra L: A. indica A. Juss; 01: 02: 01) possessed the highest antioxidant capacity compared to other ratios. The cream prepared from this composition was found stable for pH, viscosity as well as antioxidant activity under normal condition (25) and accelerated condition (40 ). The cream with DPPH scavenging activity of 93.86 % at 15 µg/mL (IC50 8.58±0.30) and lipid peroxidase assay 90.93 % at 200 µg/mL (IC50 72.30±0.60) with pH 5.50 was found with a non-Newtonian positive thixotropic flow property. Parameters like pH, viscosity, and spreadability of the cream were within the acceptance range, and found stable and permeable

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Antioxidant activity of cookiessupplemented with sugarbeet dietary fiber

Sugar Industry ◽

10.36961/si11177 ◽

2011 ◽

pp. 151-157 ◽

Cited By ~ 2

Author(s):

Marijana B. Saka ◽

Julianna F. Gyura ◽

Aleksandra Mišan ◽

Zita I. Šereš ◽

Biljana S. Pajin ◽

...

Keyword(s):

Antioxidant Activity ◽

Shelf Life ◽

Dietary Fiber ◽

Wheat Flour ◽

Room Temperature ◽

Antioxidant Activities ◽

Radical Scavenging Activity ◽

Antioxidant Properties ◽

Radical Scavenging ◽

Functional Characteristics

The antioxidant activity of cookies prepared by the addition of sugarbeet dietary fibers was investigated in order to estimate their influence on functional characteristics and shelf-life of cookies. Treated fiber (TF) was obtained from sugarbeet by extraction with sulfurous acid (75 °C at pH = 5.7during 60 min) and treatment with hydrogen peroxide (20 g/LH2O2 at pH = 11 during 24 h). The fiber obtained was dried (80 °C), ground and sieved. TF was investigated in comparison with commercially available Fibrex®. The cookies were prepared by the addition of 0, 7, 9 and 11% of sugarbeet dietary fiber as a substitute for wheat flour in the formulation of cookies. The antioxidant properties of cookies were tested every 7 days using a DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging activity test during 6 weeks of storage at room temperature (23 ± 1 ºC). The obtained results indicated that substitution of wheat flour with Fibrex® in the formulation of cookies upgraded the antioxidant activity, i.e. the functional characteristics of Fibrex®-enriched cookies and could prolong their shelf-life. In contrast, TF did not increase the antioxidant activity of TF-enriched cookies. The better antioxidant activities of Fibrex®-enriched cookies could be attributed to the presence of ferulic acid.

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Chemical variability and antioxidant activities of the essential oils of the aerial parts of Ammoides verticillata and the roots of Carthamus caeruleus and their synergistic effect in combination

Combinatorial Chemistry & High Throughput Screening ◽

10.2174/1386207323666200606213057 ◽

2020 ◽

Vol 23 ◽

Author(s):

Imane Rihab Mami ◽

Noria Merad-Boussalah ◽

Mohammed El Amine Dib ◽

Boufeldja Tabti ◽

Jean Costa ◽

...

Keyword(s):

Essential Oil ◽

Essential Oils ◽

Antioxidant Activities ◽

Radical Scavenging Activity ◽

Antioxidant Properties ◽

Radical Scavenging ◽

Natural Food ◽

Chemical Compositions ◽

Chemical Variability ◽

Ammoides Verticillata

Aim and Objective: Oxidative stress is implicated in the development and progression of many disease. Some of appropriate actions that could be initiated to taken to resolve the problem of these diseases are search for new antioxidant substances isolated from plants. The aims of this study were to study the intraspecies variations of A. verticillata and C. caeruleus essential oils from 8 locations using statistical analysis, the in vitro antioxidant properties of collective essential oils and in combinations. Materials and Methods: The essential oils were analyzed by GC and GC-MS. The intraspecies variations of the essential oil compositions were discussed using principal component analysis (PCA) and cluster analysis (CA). The antioxidant properties were evaluated DPPH-radical scavenging activity and β-carotene bleaching test. Results: The main components of Ammoides verticillata collective essential oil (Coll EO) were thymol (30.5%), carvacrol (23.2%), p-cymene (13.1%), limonene (12.5%) and terpinene-4-ol (12.3%). While roots of Carthamus caeruleus essential oil were dominated by carline oxide (86.2%). The chemical variability allowed the discrimination of two main Groups for both Coll EOs. A direct correlation between the altitudes, climate and the chemical compositions was evidenced. Ammoides verticulata and Carthamus caeruleus Coll Eos showed good antioxidant activity. In binary mixture, the interaction both Coll Eos and between oils rich of thymol and/or carvacrol with carlina oxide produced the best synergistic effects, compared to individual essential oils and the synthetic antioxidant (BHT). Conclusion: Ammoides verticillata and Carthamus caeruleus essential oil blends can be used as a natural food preservative and alternative to chemical antioxidants.

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Extraction, Chemical Composition, Antioxidant Property and In vitro Anticancer Activity of Silymarin from Silybum Marianum On Kb and A549 Cell Lines

Current Drug Discovery Technologies ◽

10.2174/1570163817666200827111127 ◽

2020 ◽

Vol 17 ◽

Author(s):

Mojgan Azadpour ◽

Mohammad Mehdi Farajollahi ◽

Ali Mohammad Varzi ◽

Pejman Hashemzadeh ◽

Hossein Mahmoudvand ◽

...

Keyword(s):

Anticancer Activity ◽

Cell Lines ◽

A549 Cell ◽

Hplc Analysis ◽

Antioxidant Properties ◽

Radical Scavenging ◽

Antioxidant Property ◽

Silybum Marianum ◽

Stable Free Radical

Introduction: This study aimed to evaluate the antioxidant property of silymarin (SM) extracted from the seed of Silybum marianum and its anticancer activity on KB and A549 cell lines following 24, 48, and 72 h of treatment. Methods: Ten grams of powdered S. marianum seeds were defatted using n-hexane for 6 hours and then extracted by methanol. The silymarin extracted of extraction components The extracted components of silymarin were measured by spectrophotometric assay and HPLC analysis. 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, phenol content, total flavonoid content, and total antioxidant capacity were measured to detect the antioxidant properties of SM. The anticancer activity of the SM on cell lines evaluated by MTT. Results: In HPLC analysis, more than 50% of the peaks were related to silibin A and B. SM was reducedDPPH (the stable free radical) with a 50% inhibitory concentration (IC50) of 6.56 μg/ ml in comparison with butylated hydroxyl toluene (BHT), which indicated an IC50 of ~3.9 μg/ ml.The cytotoxicity effect of SM on the cell lines was studied by MTT assay. The cytotoxicity effect of the extracted silymarin on KB and A549 cell lines was observed up to 80 and 70% at 156 and 78 µg/ml, respectively. The IC50 value of the extracted SM on KB and A549 cell lines after 24 hours of treatment was seen at 555 and 511 µg/ml, respectively. Conclusion: Due to the good antioxidant and anticancer properties of the isolated silymarin, its use as an anticancer drug is suggested.

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Punica granatum as a Source of Natural Antioxidant and Antimicrobial Agent; a Comprehensive Review on Related Investigations

Current Drug Discovery Technologies ◽

10.2174/1570163817666200430001822 ◽

2020 ◽

Vol 17 ◽

Author(s):

Atefeh Jalali ◽

Mohammadreza Kiafar ◽

Masih Seddigh ◽

Mohammad M. Zarshenas

Keyword(s):

Antioxidant Activities ◽

Antioxidant Properties ◽

Radical Scavenging ◽

Natural Antioxidants ◽

Punica Granatum ◽

Antimicrobial Activities ◽

Natural Antioxidant ◽

Antiviral Activities ◽

Natural Foods

Background: The consumption of natural antioxidants is increasing due to the demand and tendency to natural foods. Punica granatum L. [Punicaceae] is a fruit with various bioactive ingredients. The effectiveness of this plant has been proved against various disorders such as hyperglycemia, hyperlipidemia, blood coagulation, infections, cancer, and dentistry. Among them, there are numerous researches on antimicrobial and antioxidant properties. Subsequently, the present study aimed to compile a review of those properties to outline this herb as a possible natural antioxidant and preservative. Methods: Synchronically, keywords "Punica granatum" with antimicrobial, or antibacterial, antifungal, antiviral, antioxidant and radical scavenging were searched through "Scopus" database up to 31st September 2019. Papers focusing on agriculture, genetics, chemistry, and environmental sciences were excluded and also related papers were collected. Results: Among 201 papers focusing on related activities, 111 papers have dealt with antioxidant activities focusing based on DPPH assay, 59 with antibacterial, on both gram+ and gram- bacteria, 24 with antifungal effects, mostly on Aspergillus niger and Candida albicans, and 7 papers with antiviral activities. There were about 50 papers focusing on in-vivo antioxidant activities of this plant. Conclusion: Taken together, botanical parts of P. granatum have possessed notable radical scavenging and antimicrobial activities that with these properties, this plant can be introduced as a natural safe source of preservative and antioxidant. Accordingly, P. granatum can be applied as excipient with the aforementioned properties in the pharmaceutical and food industries.

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Evaluation of Toxicity and Antioxidant Property of Cassia fistula Stem Bark Extracts in Zebrafish

Journal of Health and Allied Sciences NU ◽

10.1055/s-0040-1715995 ◽

2020 ◽

Vol 10 (03) ◽

pp. 109-115

Author(s):

Shreya Udaya ◽

Nishith Babu ◽

Dechamma Pandyanda Nanjappa ◽

Krithika Kalladka ◽

Gunimala Chakraborty ◽

...

Keyword(s):

Aqueous Extract ◽

Antioxidant Properties ◽

Ethanol Extract ◽

Antioxidant Property ◽

Stem Bark ◽

Oxygen Species ◽

Cassia Fistula ◽

Potential Applications ◽

Ethanol Extracts ◽

Stress Models

Abstract Objective This study was aimed at evaluating the toxicity and the antioxidant property of Cassia fistula stem bark extracts in zebrafish. Materials and Methods Crude aqueous and ethanol extracts of C. fistula stem bark were obtained following a standard solvent-based extraction method. The toxicity of these extracts on zebrafish embryonic development was determined and the LC50 values were calculated. Finally, the antioxidant property of C. fistula stem bark extracts was determined in arsenic-induced oxidative stress models of zebrafish. Results The aqueous extract of C. fistula stem bark showed a slightly larger LC50 value (213.6 ppm) compared with the ethanol extract (LC50 = 63.5 ppm), suggesting a lower toxicity of the aqueous extract. A significant reduction of reactive oxygen species (ROS) signal was observed in arsenic-exposed embryos treated with the aqueous extract, but not the ethanol extract, indicating that the antioxidant activity is present only in the aqueous extract of C. fistula stem bark. Conclusion Identification of antioxidants from natural sources is desirable because of increasing safety concerns associated with synthetic antioxidants. This study demonstrated that aqueous extract from C. fistula stem bark possesses antioxidant properties, which can be further characterized for mechanism of action and potential applications.

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Effect of particle size on phytochemical composition and antioxidant properties of Sargassum cristaefolium ethanol extract

Scientific Reports ◽

10.1038/s41598-021-95769-y ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

E. S. Prasedya ◽

A. Frediansyah ◽

N. W. R. Martyasari ◽

B. K. Ilhami ◽

A. S. Abidin ◽

...

Keyword(s):

Antioxidant Activity ◽

Particle Size ◽

Antioxidant Activities ◽

Antioxidant Properties ◽

Ethanol Extract ◽

Total Phenolic ◽

Particle Sizes ◽

Epicatechin Gallate ◽

Particle Size Reduction ◽

Phytochemical Composition

AbstractSample particle size is an important parameter in the solid–liquid extraction system of natural products for obtaining their bioactive compounds. This study evaluates the effect of sample particle size on the phytochemical composition and antioxidant activity of brown macroalgae Sargassum cristaefolium. The crude ethanol extract was extracted from dried powders of S.cristeafolium with various particle sizes (> 4000 µm, > 250 µm, > 125 µm, > 45 µm, and < 45 µm). The ethanolic extracts of S.cristaefolium were analysed for Total Phenolic Content (TPC), Total Flavonoid Content (TFC), phenolic compound concentration and antioxidant activities. The extract yield and phytochemical composition were more abundant in smaller particle sizes. Furthermore, the TPC (14.19 ± 2.08 mg GAE/g extract to 43.27 ± 2.56 mg GAE/g extract) and TFC (9.6 ± 1.8 mg QE/g extract to 70.27 ± 3.59 mg QE/g extract) values also significantly increased as particle sizes decreased. In addition, phenolic compounds epicatechin (EC), epicatechin gallate (ECG), epigallocatechin (EGC), and Epigallocatechin gallate (EGCG) concentration were frequently increased in samples of smaller particle sizes based on two-way ANOVA and Tukey’s multiple comparison analysis. These results correlate with the significantly stronger antioxidant activity in samples with smaller particle sizes. The smallest particle size (< 45 µm) demonstrated the strongest antioxidant activity based on DPPH, ABTS, hydroxyl assay and FRAP. In addition, ramp function graph evaluates the desired particle size for maximum phytochemical composition and antioxidant activity is 44 µm. In conclusion, current results show the importance of particle size reduction of macroalgae samples to increase the effectivity of its biological activity.

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