scholarly journals ANTIBACTERIAL ACTIVITY OF THE ETHANOL EXTRACT OF Eugenia dysenterica DC (MYRTACEAE)

2019 ◽  
Vol 16 (32) ◽  
pp. 257-262
Author(s):  
Thaís Paula Rodrigues GONÇALVES ◽  
William Gustavo LIMA ◽  
Izabela Caputo Assis SILVA ◽  
Adriano Guimarães PARREIRA ◽  
Luciana Alves Rodrigues dos Santos LIMA
Keyword(s):  
Bacterial Resistance ◽  
Ethanol Extract ◽  
New Drugs ◽  
Bactericidal Action ◽  
Phytochemical Screening ◽  
Biological Potential ◽  
Important Field ◽  
Phytochemical Profile ◽  
Eugenia Dysenterica ◽  
Antibacterial Potential

The large variety of plant specimens found in Brazil with still unexplored medicinal potential, combined with the increase in bacterial resistance to antimicrobials traditionally employed, opens an important field of research aimed at prospecting new drugs. In this context the objective of this work was to evaluate the antibacterial potential of Eugenia dysenterica and to characterize its phytochemical profile. Ethanolic extracts were obtained by drying, grinding, turbo-extraction and lyophilization of the leaves of the plant. The CIM and CBM tests were performed to evaluate the antimicrobial potential on the following strains: Proteus mirabilis ATCC 15290, Echerichia coli ATCC25922, Staphylococcus aureus ATCC29213 and Staphylococcus epidermides ATCC 12228. E. dysenterica presented bactericidal action at 2mg.ml-1 against S. aureus and bacteriostatic at 1mg.ml-1 against P. mirabilis. Several phenolic compounds were detected in the phytochemical screening, and the presence of these compounds may justify the biological potential of this plant.

Antioxidant and Antibacterial Activity of Sulfonamides Derived from Carvacrol: A Structure-Activity Relationship Study

2020 ◽  
Vol 20 (3) ◽  
pp. 173-181 ◽  
Author(s):  
Aldo S. de Oliveira ◽  
Luiz F. S. de Souza ◽  
Ricardo J. Nunes ◽  
Susana Johann ◽  
David L. Palomino-Salcedo ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Biological Activity ◽  
Molecular Docking ◽  
Small Molecule ◽  
Bacterial Resistance ◽  
Mechanisms Of Action ◽  
New Drugs ◽  
Structure Activity ◽  
Relationship Study ◽  
Antibacterial Potential

Background: Bacterial resistance to antibiotics is a growing problem in all countries and has been discussed worldwide. In this sense, the development of new drugs with antibiotic properties is highly desirable in the context of medicinal chemistry. Methodology: In this paper we investigate the antioxidant and antibacterial potential of sulfonamides derived from carvacrol, a small molecule with drug-like properties. Most sulfonamides had antioxidant and antibacterial potential, especially compound S-6, derived from beta-naphthylamine. Result: To understand the possible mechanisms of action involved in biological activity, the experimental results were compared with molecular docking data. Conclusion: This research allows appropriate discussion on the identified structure activity relationships.

scholarly journals Antibacterial potential and ethnomedical relevance of Kumaun Himalayan Gymnosperms

2016 ◽  
Vol 5 (5) ◽  
pp. 190-200
Author(s):  
Savita Joshi ◽  
◽  
S.C. Sati ◽  
Parikshit Kumar ◽  
◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Pathogenic Bacteria ◽  
Ethanol Extract ◽  
Chloroform Extract ◽  
New Drugs ◽  
Diffusion Method ◽  
Taxus Baccata ◽  
Cedrus Deodara ◽  
Kumaun Himalaya ◽  
Antibacterial Potential

Ethnomedicinal information is one of the powerful criteria for new drugs discoveries therefore; present investigation was carried out to evaluate the ethnomedicinal and antibacterial potential of traditional Kumaun Himalayan gymnosperms. Besides, an antibacterial value index and relative antibacterial activity of studied plants have been established. Forty four plant leaves extracts in different organic solvents (methanol, ethanol, chloroform and hexane) of 11 gymnosperms (Araucaria cunninghamii, Biota orientalis, Cedrus deodara, Cephalotaxus griffithi, Cryptomeria japonica Cupressus torulosa, Ginkgo biloba, Juniperus communis, Picea smithiana, Pinus wallichiana and Taxus baccata) occurring in Kumaun Himalaya were screened for their antimicrobial activity against five pathogenic bacteria using disc diffusion method. The antibacterial activity of studied gymnospermic plant extracts against a panel of bacteria was found effective at 1000 µg/ml. The MIC and MBC values of each extract (where ZOI ≥ 15 mm) were also determined. The methanol extract of screened gymnosperms were found the most effective against all the bacteria (54% to 81%), followed by ethanol extract (45-72%), hexane extract (18-27%), while in chloroform extract it ranged 9-27% only. The extracts of G. biloba exhibited superior Relative Antibacterial Activity (RAA, 20%), followed by A. cunninghamii and P. wallichiana (12% RAA, each). The lowest RAA value was observed for C. torulosa (1%). All data were also analyzed for determination of an Antibacterial Value Index (ABVI) for each studied species of gymnosperm. G. biloba had maximum ABVI i.e. 90 % followed by A. cunninghamii and P. wallichiana (ABVI, 55% each). C. torulosa showed the least ABVI and RAA i.e. 5% and 11%, respectively. The present work fully highlighted the utility of traditionally known 11 gymnosperms of Kumaun Himalaya for their antibacterial activities against pathogenic bacteria.

scholarly journals Uji Aktivitas Antibakteri Ekstrak Etanol Propolis Lebah Trigona (Trigona Spp) terhadap Propionibacterium acnes Penyebab Jerawat

2017 ◽  
Vol 1 (1) ◽  
pp. 9-14
Author(s):  
Denia Pratiwi ◽  
Isna Wardaniati
Keyword(s):  
Bacterial Resistance ◽  
Propionibacterium Acnes ◽  
Ethanol Extract ◽  
Chemical Compounds ◽  
Developed Countries ◽  
New Drugs ◽  
Environmental Threats ◽  
Global Problems ◽  
Inhibitory Power ◽  
Active Substances

Bacterial resistence is one of the global problems  both in developed countries and devoloping countries. The high cases of resistence to antibiotics require the discovery of new active  substances such as antibiotics agents. Therefore, to prevent the occurence of bacterial resistance to antibacterials need to be developed research in the disovery of new drugs derived from nature one of them is propolis. Propolis is a substance produced by bees  to protect the nest from variety of threats, either unfavorable environmental threats or other organism attacks. One of type of bee that produces propolis is Trigona bee ( Trigona spp). The type of chemical  compounds contained in propolis  are very complex, among others alkaloid, flavonoid, steroid, saponin and tannin. This research is laboratory experimental study that aim to determine the antibacterial activity of ethanol extract of Trigona spp bee propolis against Propionibacterium acnes by disc diffusion methode. The concentration of ethanol extract of propolis used was 10 %, 20%, 30 %, 40 % with positif positive using clindamycin. From the result of the research, the inhibitory power of of ethanol extract of Trigona spp bee propolis with concentration 10 %, 20 %, 30 % dan 40 % is 11,7 mm, 12,3 mm, 13,6 mm and 14, 3 mm.

scholarly journals Microbiological evaluation of isolated compounds from the bark of Maytenus guianensis Klotzsch ex Reissek (Celastraceae)

2016 ◽  
Vol 20 (1) ◽  
pp. 592 ◽  
Author(s):  
Renato Abreu Lima ◽  
Fernanda Bay-Hurtado ◽  
Dionatas Ulises de Oliveira Meneguetti ◽  
João Bezerra Facundo ◽  
Júlio Sancho Linhares Teixeira Militão ◽  
...  
Keyword(s):  
Soxhlet Extraction ◽  
Antimicrobial Activities ◽  
Inhibitory Effect ◽  
New Drugs ◽  
Antimicrobial Substances ◽  
Diffusion Technique ◽  
Biological Potential ◽  
Resistant Strains ◽  
New Compounds ◽  
Antibacterial Potential

Maytenus guianensis Klotzsch ex Reissek is a brazilian Amazon plant widely used in tradicional medicine to treat malaria, leishmaniasis and cancer. Due to the increasing number of resistant strains of microorganisms to known antimicrobial substances, various extracts of medicinal plants are being assayed with the purpose of developing new compounds with antimicrobial activities. Thus, the present work aimed to evaluate the biological potential of isolated substances of the bark of M. guianensis on bacteria. The barks were collected at the Reserva Florestal Adolpho Ducke, in Manaus-AM. After, they were dried and grinded, being subjected to Soxhlet extraction with different solvants according to their polarity degree. The isolated substances were diluted with DMSO 2 %, and for the evaluation of the antibacterial potential, the agar well diffusion technique was used. The design was totally randomized with two replicas per treatment. The evaluation consisted on measuring bacteria colonial growth after 24 hours of the beginning of the experiment. The results obtained from the isolated substances of M. guianensis presented inhibitory effect against at least four out of the five bacteria tested, where satisfactory inhibition halos were noted. The results highlight the antimicrobial potential of this plant, which may be promising for the development of new drugs.

scholarly journals QUANTIFICATION OF QUERCETIN AND CHLOROGENIC ACID IN PAPAYA SEED ETHANOL EXTRACT

2019 ◽  
pp. 151-153
Author(s):  
RATIH PUSPORINI ◽  
HANAA OMAR BAABDULLAH ◽  
VERU ANDYKA
Keyword(s):  
Chlorogenic Acid ◽  
Ethanolic Extract ◽  
Ethanol Extract ◽  
Phytochemical Analysis ◽  
Phytochemical Screening ◽  
Liquid Chromatography Mass Spectrometry ◽  
Quantitative Examination ◽  
Papaya Seed ◽  
Antibacterial Potential

Objective: The objective of the study was to quantify the quercetin and chlorogenic contained in the ethanolic extract of papaya seed. Methods: Papaya seeds were extracted using the maceration method; then, the qualitative phytochemical analysis was obtained from standard phytochemical screening; furthermore, liquid chromatography–mass spectrometry (LC–MS) examination was used to determine the number of its bioactive compounds. Results: The quantitative examination using LC–MS showed that the content of chlorogenic acid was greater than the quercetin level. Further studies have to be carried out regarding the papaya seed ethanolic extract in vitro inhibition compare to the antibacterial potential of the commercial antibiotics on the tested bacteria species. Conclusion: Our results suggest that papaya seed ethanolic extract quantitatively contains chlorogenic acid greater than quercetin.

Investigation of Phytochemical Profile and Antibacterial Potential of Prosopis glandulosa

2019 ◽  
Vol 51 (03) ◽  
pp. 459--464
Author(s):  
S. QAIMKHANI ◽  
M. A. MOGHAL ◽  
A. H. MOGHAL ◽  
M. Q. SAMEJO, ◽  
A. A. BHUTTO ◽  
...  
Keyword(s):  
Prosopis Glandulosa ◽  
Phytochemical Profile ◽  
Antibacterial Potential

UJI AKTIVITAS ANTIOKSIDAN FRAKSI N-HEKSAN DAUN AFRIKA (Vernonia amygdalina Del.) DENGAN METODE DPPH

2020 ◽  
Vol 5 (2) ◽  
pp. 250-257
Author(s):  
Nurul Fatimah ◽  
◽  
Reksi Sundu
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Activity ◽  
Free Radicals ◽  
Ethanolic Extract ◽  
Ethanol Extract ◽  
Hexane Fraction ◽  
Phytochemical Screening ◽  
Vernonia Amygdalina ◽  
Tropical Africa ◽  
Ic50 Value

Free radicals and reactive species are widely believed to contribute to the development of several diseases by causing oxidative stress and eventually oxidative. Vernonia amygdalina (Astereacea) is a small shrub or tree between 1 and 5m high growing throughout tropical Africa. Plants are generally known as bitter leaves is well cultivated and is a general market for merchandise in several countries. The purpose of this study was to determine the antioxidant activity of hexane fraction from ethanol extract od Frican leaves (Vernonia amygdalina Del.). The method used in this study was the DPPH (1,1-Diphenil-2-Picrylhydrazyl) method. The result of phytochemical screening showed that ethanolic extract of African leaves contained a composition of secondary metabolites of alkaloids, flavonoids, tannins, steroids/triterpenoids and saponins. The antioxidant activity of the extract of n-hexane fraction was classified as very weak with an IC50 value of 317.98 ppm.

Studies on antibacterial potential and phytochemical screening of different extract of Achyranthes aspera

2016 ◽  
Vol 5 (12) ◽  
pp. 5138
Author(s):  
Shyamji Shukla* ◽  
Priyanka Soni ◽  
Harish K. Kewat
Keyword(s):  
Methanolic Extract ◽  
Salmonella Typhi ◽  
Maximum Activity ◽  
Phytochemical Screening ◽  
Bacterial Strains ◽  
Antibacterial Compounds ◽  
Achyranthes Aspera ◽  
Biological Sources ◽  
Almost All ◽  
Antibacterial Potential

There is an alarming increase in the problem of resistance towards antibiotics amongst most of the pathogenic bacterial strains in recent years. This has drawn the attention of researchers around the world to search for novel and eco-friendly antibacterial compounds. Several biological sources have been explored in this respect but medicinal plants have taken a centre stage out of all. Plants have been known as a reservoir of number of bioactive compounds specially the antibacterial ones since time immemorial. Therefore, the present investigation was undertaken to analyze the antibacterial potential of the medicinal plant Achyranthes aspera. This study revealed that highest antibacterial activity was observed in the methanolic extract of stem against almost all test Bacteria. It showed maximum activity against E.coli (30 mm), followed by S. aureus (28 mm), Enterococcus sp.(25mm), Salmonella typhi ( 20 mm) and least activity was recorded in same extract against K.pneumoniae (6 mm). Four phytochemicals were screened in various solvent extracts. They are alkaloid, flavonoids, saponins and tannins.

scholarly journals Clinical Application and Efficacy of Silver Drug in Ophthalmology: A Literature Review and New Formulation of EYE Drops with Drug Silver (I) Complex of Metronidazole with Improved Dosage Form

Biomedicines ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 210
Author(s):  
Arleta Waszczykowska ◽  
Dominik Żyro ◽  
Justyn Ochocki ◽  
Piotr Jurowski
Keyword(s):  
Dosage Form ◽  
Complex Analysis ◽  
Bacterial Resistance ◽  
Eye Drops ◽  
Ophthalmic Diseases ◽  
The Stability ◽  
New Formulation ◽  
Additional Therapy ◽  
Antibacterial Potential

The use of silver preparations in medicine is becoming increasingly popular. The basic aim of this evaluation was to review the literature on the clinical (in vivo) and antibacterial potential of silver preparations in ophthalmic diseases. The second goal was to summarize the results of experimental research on the use of silver preparations in ophthalmology. The third objective was to present a method for stabilizing eye drops containing silver (I) complex. Analysis of the pH stability of the silver (I) complex with metronidazole in the prepared dosage form (eye drops) was carried out. Most silver preparations are clinically used for topical application. Few experimental results indicate the usefulness of intraocular or systemic administration of silver (I) preparations as an alternative or additional therapy in infectious and angiogenic eye diseases. The development of a new formulation increases the stability of the dosage form. New forms of silver (I) products will certainly find application in the treatment of many ophthalmic diseases. One of the most important features of the silver (I) complex is its capacity to break down bacterial resistance. The new eye drops formula can significantly improve comfort of use. Due to their chemical nature, silver (I) compounds are difficult to stabilize, especially in the finished dosage form.

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