Preliminary correlation between blood viscosity and pulsatility index in healthy population resident at high altitude (Cusco 3300 masl)
Background: Viscosity affects flows by increasing resistance to movement, therefore, blood viscosity (BV) could modify the pulsatility index (PI). Objectives: To determine the correlation between BV and PI. Design and setting: A cross-sectional study was conducted in clinically healthy young adults residing in Cusco (a city located at 3399 masl). Methods: A venous blood sample was taken to determine their BV levels, and a transcranial Doppler of right middle cerebral artery (R-MCA) was performed, with which the min, maximum and mean flow velocity (MFV), resistance and pulsatility indices (PI) were obtained. The BV levels were measured in centipoises (cP) using acone-plate viscometer at 40RPM. We present medians with interquartile ranges (IQR), the correlation was evaluated using the Spearman test. Results: 42 participants were included, 25 women (60%), the mean age was 26.2±5.5 years. The median of BV was 5.08cP [IQR: 4.55-5.77cP], the MFV was 56 m/s [IQR: 49- 61 m/s], and the PI was 0.94 [0.85-1.02]. BV was positively correlated with PI (r:0.38, p=0.045) and negatively with MFV (r: -0.37, p=0.011) Conclusions: The increase in blood viscosity has a small but significant impact on cerebral vascular resistance (PI) and its fluxes (MFV) in clinically healthy and young people. This could have a role in the pathogenesis of cerebral infarction in the elderly. The results presented here are preliminary and we intend to gather more data and increasing our number of participants.