Evaluate Survival Rate of Hepatocellular Carcinoma in Yazd from 1390 to 1394

2021 ◽  
Vol 15 (8) ◽  
pp. 2339-2345
Author(s):  
Shokoh Taghipour ◽  
Marzieh Ghane Ezabadi ◽  
Vahid Rakhshandeh
Keyword(s):  
Risk Factors ◽  
Hepatocellular Carcinoma ◽  
Survival Rate ◽  
Liver Cancer ◽  
Significant Relationship ◽  
Cox Regression ◽  
Disease Risk ◽  
Cross Sectional ◽  
Common Cancer ◽  
History Of

Objectives: Liver cancer is one of the five most common cancer and the second leading cause of cancer death in men worldwide and the seventh most common cancer and the sixth leading cause of death in women from cancers. Liver cancer was the tenth most common cancer in Yazd in 1388 to 19% in women and 26% of males that has been more prevalent than in other provincial capitals. Methods: This cross-sectional descriptive study is a census of patients with hepatocellular carcinoma who referred to Yazd hospital pathology centers. All samples that have complete data from 1390 to 1394 were enrolled in the study. Information including age, sex, method of treatment and numbers of patients collected and then analyzed using statistical software spss 16 is placed. The aim of this study was to determine the survival rate of liver cancer patients according to age, sex, treatment, race and disease risk factors. Results: Of the 48 patients, 47.9% were female and 52.1% male during the five years . the average of age in this study was 62.81years. of the patients studied was 62.81 years .93.8% of patients were Iranian race. In this study, median survival was 7.43 months. The diabetes melitus with a prevalence of 18.8% was most common among the risk factors. alcohol consumption and the prevalence of hepatitis C has the lowest prevalence that was 1.9%. 83% of patients in this study were treated but other don’t come satisfaction for any treatment. Conclusion: In this study, like other studies, the incidence of liver cancer in men was higher than women. Most were Iranian people and the relationship between race and survival was no significant relationship between age, type of treatment, such as surgery, radiotherapy or chemotherapy with survival rate was not significant. But after Cox regression between age, family history of liver cancer, diabetes and treatment with survival in patients with hepatocellular carcinoma, there was a significant relationship. Keywords: HCC, Yazd, Survival

Prevalence of Risk Factors of Major NonCommunicable Diseases among Adolescents of Higher Secondary Schools of Kaski, District

2018 ◽  
Vol 16 (3) ◽  
pp. 307-312
Author(s):  
Dipendra Kumar Yadav ◽  
Bhoopendra Sharma ◽  
Naveen Shrestha ◽  
Isha Karmacharya ◽  
Saroj Yadav
Keyword(s):  
Risk Factors ◽  
Family History ◽  
Secondary Students ◽  
Disease Risk ◽  
Communicable Disease ◽  
Noncommunicable Diseases ◽  
Cluster Sampling ◽  
Cross Sectional ◽  
High Prevalence ◽  
History Of

Background: The main aim of this study is to determine the prevalence of major Non communicable disease risk factors among higher secondary school students.Methods: A cross-sectional study was conducted among higher secondary students of grade 11 and 12 of Kaski district in Nepal. The study period was from July 2016 to June 2017. Total sample 640 higher secondary students were recruited through two-stage cluster sampling. Self-administrated questionnaire was used for the data collection tool along with other tools which were used such as UNICEF electronic weighing scale, stature meter and mechanical aneroid sphygmomanometer. Ethical approval was obtained from IRC, Pokhara University. Data were entered into EpiData software and analysis was performed with the help of the Statistical Package for Social Science (SPSS).Results:  The prevalence of smoking was 6.1% which was high in male (11.9%) than female (0.6%). Alcohol consumption practice among the adolescents was 18.9%. Family history of hypertension was seen higher than family history of diabetes.The prevalence of hypertension was 11.7%.High prevalence of abnormal values of systolic and diastolic BP was found in male than female students. Overweight was seen in 6.1% students. Prevalence of obesity was almost equal in both groups.Conclusions: There is high prevalence of smoking, alcoholism among adolescents. Hypertension was more common than diabetes among adolescents.

scholarly journals An lncRNA Model for Predicting the Prognosis of Hepatocellular Carcinoma Patients and ceRNA Mechanism

2021 ◽  
Vol 8 ◽  
Author(s):  
Hao Zhang ◽  
Renzheng Liu ◽  
Lin Sun ◽  
Xiao Hu
Keyword(s):  
Hepatocellular Carcinoma ◽  
Survival Rate ◽  
Liver Cancer ◽  
Cox Regression ◽  
Characteristic Curve ◽  
Risk Groups ◽  
The Cancer Genome Atlas ◽  
Cancer Genome Atlas ◽  
The Difference ◽  
Experimental Group

Liver cancer is a highly malignant tumor. Notably, recent studies have found that long non-coding RNAs (lncRNAs) play a prominent role in the prognosis of patients with liver cancer. Herein, we attempted to construct an lncRNA model to accurately predict the survival rate in liver cancer. Based on The Cancer Genome Atlas (TCGA) database, we first identified 1066 lncRNAs with differential expression. The patient data obtained from TCGA were divided into the experimental group and the verification group. According to the difference in lncRNAs, we used single-factor and multi-factor Cox regression to select the genes needed to build the model in the experimental group, which were verified in the verification group. The results showed that the model could accurately predict the survival rate of patients in the high and low risk groups. The reliability of the model was also confirmed by the area under the receiver operating characteristic curve. Our model is significantly correlated with different clinicopathological features. Finally, we built a ceRNA network based on lncRNAs, which was used to display miRNAs and mRNAs related to lncRNAs. In summary, we constructed an lncRNA model to predict the survival rate of patients with hepatocellular carcinoma.

scholarly journals Cáncer hepático, problema de salud subestimado

Tequio ◽  
2018 ◽  
Vol 1 (2) ◽  
pp. 69-77
Author(s):  
Adriana Ramírez-Cosmes ◽  
Gabriela Carrasco Torres ◽  
José Fernando Sánchez Pino ◽  
Irving Martínez Contreras ◽  
Rafael Baltierrez Hoyos ◽  
...  
Keyword(s):  
Risk Factors ◽  
Survival Rate ◽  
High Risk ◽  
Liver Cancer ◽  
Diagnostic Methods ◽  
Cancer Death ◽  
The Third ◽  
Common Cancer ◽  
Incidence And Mortality ◽  
Inadequate Nutrition

Liver cancer is the second most common cancer death cause worldwide, the fourth with the highest incidence, and the third most lethal in Mexico. Due to the bad habits and inadequate nutrition of the Mexican population, it is at a high risk of developing this type of disease. At present, it is difficult to make a practical and safe diagnosis of liver cancer in later stages, and it is even more difficult in early stages. This situation, added to the scarce viability and effectiveness of the treatments, and the lack of reliable national incidence records, anticipate a very low survival rate. That is why it requires a greater attention and understanding of this condition, for the identification of therapeutic targets and new timely treatments. In this article we review the main risk factors for liver cancer, their biological characteristics, current diagnostic methods and new proposals for their detection, allowing us to know the contemporary panorama and contribute to research on this health problem and reduce the high rates of incidence and mortality.

scholarly journals HUBUNGAN BEBERAPA FAKTOR RISIKO PENYAKIT JANTUNG KORONER DENGAN LAJU FILTRASI GLOMERULUS PADA PASIEN INFARK MIOKARD LAMA

e-CliniC ◽  
2014 ◽  
Vol 2 (1) ◽  
Author(s):  
Yanti Manoy
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Glomerular Filtration Rate ◽  
Significant Relationship ◽  
Filtration Rate ◽  
Cross Sectional ◽  
Old Myocardial Infarction ◽  
History Of

Abstract: Old myocardial infarction (OMI) is a major disease of pre hospitalization. The patients who suffer OMI disease have a pain and mortality rate higher than those who do not. This is due to have as many OMI disease risk factors for coronary heart disease (CHD) is owned and usually decrease the glomerular filtration rate (GFR). Methods: This is a descriptive study with cross sectional analytic use the data of medical records at the heart of poly Hospital prof. Dr. R. D. Kandou Manado. Results: There were 205 patients from a total of 330 patients OMI period January 2013 - December 2013 is included as a sample in this study. The results showed that patients aged 60-69 OMI most with 77 people (38 %) with decreased GFR (p=0.000). Patients with a history of hypertension, there are 148 people (72 %) with decreased GFR (p=0,048). Patients with increased LDL there are 166 people (80.9 %) with decreased GFR (p=0.088). Patients who have a history of diabetes, there are 50 men (24.4 %) with decreased GFR (p=0.333). Patients with a history of smoking are 41 people (20 %) with decreased GFR (p=0.103). Conclusion: There is a significant relationship between age and history of hypertension in patients OMI with GFR. There was no significant relationship between hyperlipidemia, diabetes mellitus and a history of smoking history in patients OMI with  GFR.Keywords: Risk factors of Coronary Heart Disease, Glomerular Filtration Rate, Old Myocardial Infarction. Abstrak: Infark miokard lama/Old myocardial infarction (OMI) merupakan penyakit utama prehospitalisasi. Pasien yang mempunyai penyakit OMI memiliki angka kesakitan dan kematian lebih tinggi dibanding yang tidak karena banyaknya faktor risiko penyakit jantung koroner (PJK) yang dimiliki dan biasanya menurunkan laju filtrasi glomerulus (LFG). Metode: Ini adalah penelitian yang bersifat deskriptif analitik cross sectional dengan menggunakan data rekam medik di poli jantung RSUP Prof. Dr. R. D. Kandou Manado. Hasil: Terdapat 205 pasien dari total 330 pasien OMI periode Januari 2013 – Desember 2013 yang dimasukan sebagai sampel dalam penelitian ini. Hasil penelitian menunjukan bahwa pasien OMI paling banyak  berusia 60-69 dengan 77 orang (38%) memiliki LFG menurun (p=0,000). Pasien dengan riwayat hipertensi terdapat 148 orang (72%) dengan LFG menurun (p=0,048). Pasien dengan LDL meningkat terdapat 166 orang (80,9%) dengan LFG menurun (p=0,088). Pasien yang mempunyai riwayat DM terdapat 50 orang (24,4%) dengan LFG menurun (p=0,333). Pasien dengan riwayat merokok terdapat 41 orang (20%) dengan LFG menurun (p=0,103). Kesimpulan: Terdapat hubungan yang signifikan antara usia dan riwayat hipertensi  dengan LFG pada pasien OMI. Tidak terdapat hubungan yang signifikan antara hiperlipidemia, riwayat DM dan riwayat merokok dengan LFG pada pasien OMI.Kata Kunci: Faktor Risiko Penyakit Jantung Koroner, Laju Filtrasi Glomerulus, Infark Miokard Lama.

scholarly journals Awareness and knowledge about glaucoma among patients visiting the screening clinic in Jeddah Eye Hospital, Saudi Arabia

2021 ◽  
Vol 14 (6) ◽  
pp. 887-895
Author(s):  
Saleh M. Alqahtani ◽  
◽  
Ahmed Almanjoumi ◽  
Sami H. Alzahrani ◽  
◽  
...  
Keyword(s):  
Risk Factors ◽  
Clinical Features ◽  
Disease Risk ◽  
Knowledge Score ◽  
Cross Sectional Study ◽  
Care Hospital ◽  
Cross Sectional ◽  
History Of ◽  
Screening Clinic ◽  
University Degree

AIM: To explore levels and determinants of awareness and knowledge about glaucoma among patients. METHODS: This was a cross-sectional study that included adult patients from October to the end of December 2018. A semi-structured questionnaire was designed by the researchers to measure the levels of awareness and knowledge about 18 basic information about glaucoma. The sheet was divided into 4 domains: types of glaucoma, risk factors, clinical features, and management. A knowledge score (KS, range=0-18) was calculated, with higher scores indicating higher levels. RESULTS: A total of 383 patients responded to the questionnaire, 61.9% males, mean±SD age was 38.5±12.94 years old, and 61.6% had a university degree or higher. Of them, 6.3% and 23.2% reported personal and family history of glaucoma, respectively. The most frequently reported source of information about glaucoma was another person with glaucoma (28.2%), followed by physicians (24.8%) and TV (19.6%). Knowledge by item ranged from 3.1% to 82.5% correctness rate, while KS showed mean=5.91 and median=5; and reliability testing of the knowledge scale showed Cronbach’s alpha=0.782. Higher KS were found among respondents with higher educational level (P=0.036), diabetes history (P=0.025), and personal (P<0.001) and family (P<0.001) history of glaucoma. CONCLUSION: This study reveals low awareness and knowledge levels about glaucoma among the attendees of a local eye care hospital, where several misconceptions about disease risk factors, clinical features, and management are identified.

scholarly journals Risk Factors for Stunting Children Aged 6-59 Months In Pulau Panggung District, South Sumatera, Indonesia

2018 ◽  
Vol 2 (2) ◽  
pp. 61-67
Author(s):  
Prihatina Anjela ◽  
Rachmat Hidayat ◽  
Debby Handayanti Harahap
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Significant Relationship ◽  
Female Gender ◽  
Chi Square ◽  
Cross Sectional ◽  
Regression Test ◽  
History Of ◽  
Chi Square Analysis ◽  
Logistic Regression Test

Background :. Stunting among children is one of the major health problems in developing countries. Globally, 45% of deaths among children are caused by malnutrition, meanwhile stunting, as one of the factors, plays an important role. Children who experience stunting can not achieve optimal growth and cognitive potential. Hence, that will have an impact on future productivity. Muara Enim district is included in one district with stunting prevalence, which is above 20%, i.e. 26.9%. This study was to identify the risk factors of stunting children in Pulau Panggung district, Muara Enim, South Sumatera. Methods: This study applied observational analytic research using cross sectional design. It was conducted on August to October 2017 at public health center in Pulau Panggung district, Muara Enim. There were 83 children who fullfilled the inclusion criteria. The relationship between risk factors and stunting was analyzed using  Chi square test and Logistic Regression test was applied to identify the risk factor that play the most role to stunting. Results: 49,4% out of 83 children suffer from stunting, with a mean age of 29,37±13,69 months where the number of children stunting with male gender is 53.7% while female gender is 46.3%. Chi square analysis showed that there was a significant relationship among birth weight, birth length, mother's occupation, history of infection, exclussive breastfeeding and stunting  (p< 0.05) but no significant relationship was found among sex, mother's education, maternal height and income with stunting (p> 0.05). Multivariate Logistic Regression test showed that mother's occupation and history of infection are the risk factors that contibute the most to stunting among children aged 6-59 months in Pulau Panggung district. The risk of stunting among working mothers is higher 5 times than unworking  mothers and children with infection history have risk of stunting 3 times compared to children without infection history. Conclusion: Mother's occupation and infection history are risk factors that contribute the most to stunting among children at Pulau Panggung district, Muara Enim, South Sumatera.

The burden of cardiovascular disease risk factors in the Middle East: A systematic review and meta-analysis focusing on primary prevention

2020 ◽  
Vol 18 ◽  
Author(s):  
Akshaya Srikanth Bhagavathula ◽  
Abdullah Shehab ◽  
Anhar Ullah ◽  
Jamal Rahmani
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Cardiovascular Disease ◽  
Family History ◽  
Primary Prevention ◽  
Middle East ◽  
Disease Risk ◽  
Meta Analysis ◽  
Middle Eastern ◽  
History Of

Background: The increasing incidence of cardiovascular disease (CVD) threatens the Middle Eastern population. Several epidemiological studies have assessed CVD and its risk factors in terms of the primary prevention of CVD in the Middle East. Therefore, summarizing the information from these studies is essential. Aim: We conducted a systematic review to assess the prevalence of CVD and its major risk factors among Middle Eastern adults based on the literature published between January 1, 2012 and December 31, 2018 and carried out a meta-analysis. Methods: We searched electronic databases such as PubMed/Medline, ScienceDirect, Embase and Google Scholar to identify literature published from January 1, 2012 to December 31, 2018. All the original articles that investigated the prevalence of CVD and reported at least one of the following factors were included: hypertension, diabetes, dyslipidaemia, smoking and family history of CVD. To summarize CVD prevalence, we performed a random-effects meta-analysis. Results: A total of 41 potentially relevant articles were included, and 32 were included in the meta-analysis (n=191,979). The overall prevalence of CVD was 10.1% (95% confidence interval (CI): 7.1-14.3%, p<0.001) in the Middle East. A high prevalence of CVD risk factors, such as dyslipidaemia (43.3%; 95% CI: 21.5-68%), hypertension (26.2%; 95% CI: 19.6-34%) and diabetes (16%; 95% CI: 9.9-24.8%), was observed. The prevalence rates of other risk factors, such as smoking (12.4%; 95% CI: 7.7-19.4%) and family history of CVD (18.7%; 95% CI: 15.4-22.5%), were also high. Conclusion: The prevalence of CVD is high (10.1%) in the Middle East. The burden of dyslipidaemia (43.3%) in this region is twice as high as that of hypertension (26.2%) and diabetes mellitus (16%). Multifaceted interventions are urgently needed for the primary prevention of CVD in this region.

scholarly journals Prevalence of bone fracture and its association with severe hypoglycemia in Japanese patients with type 1 diabetes

2021 ◽  
Vol 9 (1) ◽  
pp. e002099
Author(s):  
Yuji Komorita ◽  
Masae Minami ◽  
Yasutaka Maeda ◽  
Rie Yoshioka ◽  
Toshiaki Ohkuma ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 1 Diabetes ◽  
Fracture Risk ◽  
Bone Fracture ◽  
Severe Hypoglycemia ◽  
Japanese Patients ◽  
Anatomic Site ◽  
Cross Sectional ◽  
History Of

IntroductionType 1 diabetes (T1D) is associated with higher fracture risk. However, few studies have investigated the relationship between severe hypoglycemia and fracture risk in patients with T1D, and the results are controversial. Besides, none has investigated the risk factors for fracture in Asian patients with T1D. The aim of the present study was to investigate the prevalence of bone fracture and its relationship between severe hypoglycemia and other risk factors in Japanese patients with T1D.Research design and methodsThe single-center cross-sectional study enrolled 388 Japanese patients with T1D (mean age, 45.2 years; women, 60.4%; mean duration of diabetes, 16.6 years) between October 2019 and April 2020. The occurrence and circumstances of any fracture after the diagnosis of T1D were identified using a self-administered questionnaire. The main outcomes were any anatomic site of fracture and fall-related fracture. Severe hypoglycemia was defined as an episode of hypoglycemia that required the assistance of others to achieve recovery.ResultsA total of 92 fractures occurred in 64 patients, and 59 fractures (64%) were fall-related. Only one participant experienced fracture within the 10 years following their diagnosis of diabetes. In logistic regression analysis, the multivariate-adjusted ORs (95% CIs) of a history of severe hypoglycemia were 2.11 (1.11 to 4.09) for any fracture and 1.91 (0.93 to 4.02) for fall-related fracture. Fourteen of 18 participants with multiple episodes of any type of fracture had a history of severe hypoglycemia (p<0.001 vs no fracture).ConclusionsWe have shown that a history of severe hypoglycemia is significantly associated with a higher risk of bone fracture in Japanese patients with T1D.

scholarly journals Analysis of Sociodemographic and Clinical Factors Associated with Hospitalized Stroke Patients of Bangladesh

1970 ◽  
Vol 6 (1) ◽  
pp. 19-23 ◽  
Author(s):  
AM Hossain ◽  
NU Ahmed ◽  
M Rahman ◽  
MR Islam ◽  
G Sadhya ◽  
...  
Keyword(s):  
Risk Factors ◽  
Heart Disease ◽  
Ischaemic Heart Disease ◽  
Low Income ◽  
Heart Diseases ◽  
Previous History ◽  
Stroke Patients ◽  
College Hospital ◽  
Cross Sectional ◽  
History Of

A hospital based cross sectional study was carried out to analyze prevalence of risk factors for stroke in hospitalized patient in a medical college hospital. 100 patients were chosen using purposive sampling technique. Highest incidence of stroke was between the 6th and 7th decade. Patients came from both urban (54%) and rural (46%) areas and most of them belong to the low-income group (47%). In occupational category; service holder (28%) and retired person (21%) were the highest groups. Most of the study subjects were literate (63%). CT scan study revealed that the incidence of ischaemic stroke was 61% and haemorrhagic stroke 39%. Analysis indicated hypertension as major risk factor for stroke (63%) and major portion of the patients (42.85%) were on irregular or no treatment. Twenty four percent of the patients had heart diseases and out of 24 patients 45.83% were suffering from ischaemic heart disease. The present study detected diabetes in 21% patients. Fifty three percent of the study subjects were smoker, 39% patients had habit of betelnut chewing. Out of 26 female patients, only 23% had history of using oral contraceptives. Majority of the patients were sedentary workers (46%). Thirty seven percent of the stroke patients were obese. Among the stroke patients 9% had previous history of stroke and 3% had TIA respectively. Most of the patients (21%) were awake while they suffered from stroke and the time of occurrence was mostly in the afternoon (46%). This study found that hypertension, cigarette smoking, ischaemic heart disease and diabetes mellitus are the major risk factors prevalent in our community while other risk factors demand further study. Key words: stroke; risk factors; hospitalized patients; Bangladesh. DOI: 10.3329/fmcj.v6i1.7405 Faridpur Med. Coll. J. 2011;6(1): 19-23

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