Study of the effect of Baricitinib on the Course of COVID-19

The aim of the study was to determine the effect of the inhibitor of janus kinase – baricitinib ("Olumiant") on the course of COVID-19. This drug baricitinib is able to suppress the systemic inflammatory response, which is one of the common causes of death in COVID-19, is an urgent problem of the study. The study was carried out in the Regional Specialized Budget Infectious Diseases Hospital of Stavropol (Russian Federation, Stavropol Region). In a multivariate analysis, it was shown that the use of baricitinib was associated with a decrease in the frequency of the primary endpoint of death/need for invasive lung ventilation. The use of baricitinib was quite safe, but in some patients there was an increase in the level of transaminases. No cases of hypercoagulation have been reported while taking baricitinib. It was found that patients with a normal BMI are more sensitive to therapy than those who are overweight.75% of patients in the first group had a temperature above 38.0oC. However, against the background of taking the standard treatment regimen and baricitinib, it was noted that the temperature stabilized during the day and did not rise again. Against the background of taking baricitinib, the elimination of the phenomena of respiratory failure and the refusal of an oxygen mask occurred 3.1 times more often than without baricitinib. The authors concluded that the use of baricitinib can be considered as an additional therapy for moderate forms of pneumonia in patients over 65 years or in patients with concomitant chronic diseases in order to suppress the reactions of systemic inflammation and the development of serious respiratory and other system lesions caused by COVID-19.

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Paramedics’ perceptions and educational needs with respect to palliative care

Australasian Journal of Paramedicine ◽

10.33151/ajp.12.5.218 ◽

2015 ◽

Vol 12 (5) ◽

Cited By ~ 6

Author(s):

Ian R Rogers ◽

Freya R Shearer ◽

Jeremy R Rogers ◽

Gail Ross-Adjie ◽

Leanne Monterosso ◽

...

Keyword(s):

Palliative Care ◽

End Of Life ◽

Causes Of Death ◽

Ethical Issues ◽

Symptom Control ◽

Educational Needs ◽

Palliative Approach ◽

Common Causes ◽

The Common ◽

End Of Life Communication

IntroductionTo identify and measure paramedics’ perspectives and educational needs regarding palliative care provision, as well as their understanding of the common causes of death.MethodsAll St John Ambulance Western Australia paramedics were invited to complete a mixed methods qualitative and quantitative survey using a tool previously validated in studies involving other emergency care providers. Quantitative results are reported using descriptive statistics, while Likert-type scales were converted to ordinal variables and expressed as means +/- SD. Qualitative data was analysed using content analysis techniques and reported as themes. ResultsCompleted surveys were returned by 29 paramedics. They considered palliative care to be strongly focussed on end-of-life care, symptom control and holistic care. The dominant educational needs identified were ethical issues, end-of-life communication and the use of structured patient care pathways. Cancer diagnoses were overrepresented as conditions considered most suitable for palliative care, compared with their frequency as a cause of death. Conditions often experienced in ambulance practice, such as heart failure, trauma and cardiac arrhythmias were overestimated in their frequency as causes of death. ConclusionsParamedics have a sound grasp of some important aspects of palliative care including symptom control and the holistic nature of the palliative approach. They did however tend to equate palliative care with that occurring in the terminal phase and saw it as being particularly applied to cancer diagnoses. Paramedic palliative care educational efforts should focus on ethical issues and end-of-life communication, as well as increasing understanding of the common causes of death and those where a palliative approach might be beneficial.

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CHARACTERISTICS OF THE DYNAMICS OF LIPID PEROXIDATION, ANTIOXIDANT PROTECTION, AND PHAGOCYTIC ACTIVITY OF NEUTROPHILS IN THE TREATMENT OF ACUTE ODONTOGENIC OSTEOMYELITIS OF THE JAW

"Medical & pharmaceutical journal "Pulse" ◽

10.26787/nydha-2686-6838-2020-22-9-26-30 ◽

2020 ◽

pp. 26-30

Author(s):

Aliev K.I. ◽

Toboev G.V.

Keyword(s):

Lipid Peroxidation ◽

Phagocytic Activity ◽

Antioxidant Defense ◽

Standard Treatment ◽

Maxillofacial Surgery ◽

Antioxidant Protection ◽

Seeking Help ◽

The Common ◽

Peroxidation Processes ◽

Standard Treatment Regimen

At the present stage, odontogenic osteomyelitis is one of the common purulent-inflammatory pathologies of the maxillofacial region. There is a tendency to change the nature of the clinical course of the disease: there is a predominance of a sluggish process with a tendency to chronicity and the development of complications. An unexpressed picture of the diagnosis of acute odontogenic osteomyelitis is difficult, which explains the delay in seeking help. The aim of the study was to determine and compare indicators of lipid peroxidation, antioxidant defense and phagocytic activity of neutrophils in patients with acute odontogenic osteomyelitis who received standard and combination treatment with Melaxen. The study was conducted on 30 patients with an established diagnosis of the Department of Maxillofacial Surgery of the Republican Clinical Hospital in Vladikavkaz. The indicators of lipid peroxidation, antioxidant protection, and phagocytic activity of neutrophils in patients with acute odontogenic osteomyelitis who received standard treatment and combined with the use of the drug “Melaxen” were evaluated. It was found that the disease can cause an increase in the concentration of malondialdehyde and hydroperoxides and a decrease in catalase activity. Under the influence of pathology, the absorption and digestion functions of neutrophils are inhibited. The efficacy of the use of the drug "Melaxen" in the treatment of acute odontogenic osteomyelitis due to its ability to suppress lipid peroxidation processes, restore antioxidant defense and phagocytic activity of neutrophils has been proven. the inclusion of Melaxen in the standard treatment regimen allows for faster reduction of oxidative stress and restoration of antioxidant protection, and also helps to normalize the phagocytic activity of neutrophils in a shorter time.

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The new method of pelvic packing against continuing intrapelvic bleeding resulting from the unstable pelvic ring fractures

Bulletin of Russian State Medical University ◽

10.24075/brsmu.2019.031 ◽

2019 ◽

pp. 76-80

Author(s):

K. A. Egiazaryan ◽

D. I. Gordienko ◽

D. A. Starchik ◽

A. M. Lysko

Keyword(s):

Clinical Case ◽

Causes Of Death ◽

Pelvic Ring ◽

New Method ◽

Concomitant Injuries ◽

Pelvic Packing ◽

Balloon Tamponade ◽

Pelvic Ring Fractures ◽

Common Causes ◽

The Common

Unstable pelvic ring fractures are one of the common causes of death of patients with concomitant injuries. The existing methods applied to treat such conditions can cause a number of complications and have contraindications. We have described a successful clinical case of intrapelvic hemorrhage arrest in a patient with multiple injuries. in this case, we applied the new method combining minimally invasive angioembolization and easily applicable and effective balloon tamponade.

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Suicidal Death Autopsy Analysis at Dhaka Medical College

Bangladesh Medical Journal ◽

10.3329/bmj.v40i1.9957 ◽

1970 ◽

Vol 40 (1) ◽

pp. 18-21 ◽

Cited By ~ 1

Author(s):

MN Hossain ◽

Z Rahman ◽

S Akhter

Keyword(s):

Forensic Medicine ◽

Causes Of Death ◽

Cross Sectional Study ◽

Age Group ◽

Sectional Study ◽

Cross Sectional ◽

Medical College ◽

Autopsy Report ◽

Common Causes ◽

Suicidal Death

A cross sectional study was carried out at the department of Forensic Medicine in Dhaka Medical College during the period of January 2008 to December 2009. Data were collected from 3rd copy of the post mortem reports which were preserved in the department of Forensic Medicine with the verbal consent of the doctors who performed autopsy report. During this period total 5114 autopsies were conducted. Out of this 970 cases (19%) were suicidal in nature. It was noticed that all suicidal deaths occurred from 10 years to all age group respectively, but top amongst age group of suicidal deaths occurred in between 21 to 30 years of people. Suicidal deaths are more common in female than male. Suicidal deaths due to hanging is highest, next common causes of death due to organophosphorus compund poisoning. Suicidal deaths by hanging is more in female than male but in poisoning cases male are more lvictimised than female. Objectives of our study are to see the occurrence and methods of suicidal death. DOI: http://dx.doi.org/10.3329/bmj.v40i1.9957 BMJ 2011; 40(1): 18-21

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From “Technical Newbies” to “Optimistic Politicians”

International Journal of Managing Projects in Business ◽

10.1108/ijmpb-01-2019-0007 ◽

2019 ◽

Vol ahead-of-print (ahead-of-print) ◽

Author(s):

James Prater ◽

Konstantinos Kirytopoulos ◽

Tony Ma

Keyword(s):

Information Technology ◽

Quantitative Research ◽

Valuable Insight ◽

Scheduling Problems ◽

Information Technology Projects ◽

Content Type ◽

Common Causes ◽

The Common ◽

Project Estimation ◽

Engineering Projects

Purpose Despite the advent of sophisticated control methods, there are still significant issues regarding late delivery of information technology projects. The purpose of this paper is to investigate the common causes of scheduling problems specifically in the information technology projects context. Design/methodology/approach Through a quantitative research, the importance of those causes, as well as the underpinning factors driving them, is explored. The causes are ranked according to their relative important index, and exploratory factor analysis is employed to reveal underlying dimensions (factors) of these causes. Findings From the analysis, four factors were extracted, namely, “Dataless Newbie,” “Technical Newbie,” “Pragmatic Futurist” and “Optimistic Politician.” These factors explain the different latent conditions that lead to scheduling problems in information technology projects. Practical implications The key contribution of this research is that it enlightens the latent conditions underpinning scheduling problems. Also, the evidence provides that schedule development for information technology projects is impacted by the same causes that impact engineering projects, and that applying a number of mitigation techniques widely used within the engineering area, such as reference class, would, no doubt, not only improve information technology schedules but also reduce the political pressures on the project manager. Originality/value This research provides a valuable insight into understanding the underlying factors for poor project estimation.

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Advances in the understanding of trauma-induced coagulopathy

Blood ◽

10.1182/blood-2016-01-636423 ◽

2016 ◽

Vol 128 (8) ◽

pp. 1043-1049 ◽

Cited By ~ 120

Author(s):

Ronald Chang ◽

Jessica C. Cardenas ◽

Charles E. Wade ◽

John B. Holcomb

Keyword(s):

Animal Studies ◽

Causes Of Death ◽

Endothelial Activation ◽

The United States ◽

Trauma Patients ◽

Platelet Dysfunction ◽

Intracranial Injury ◽

Trauma Induced Coagulopathy ◽

Common Causes

Abstract Ten percent of deaths worldwide are due to trauma, and it is the third most common cause of death in the United States. Despite a profound upregulation in procoagulant mechanisms, one-quarter of trauma patients present with laboratory-based evidence of trauma-induced coagulopathy (TIC), which is associated with poorer outcomes including increased mortality. The most common causes of death after trauma are hemorrhage and traumatic brain injury (TBI). The management of TIC has significant implications in both because many hemorrhagic deaths could be preventable, and TIC is associated with progression of intracranial injury after TBI. This review covers the most recent evidence and advances in our understanding of TIC, including the role of platelet dysfunction, endothelial activation, and fibrinolysis. Trauma induces a plethora of biochemical and physiologic changes, and despite numerous studies reporting differences in coagulation parameters between trauma patients and uninjured controls, it is unclear whether some of these differences may be “normal” after trauma. Comparisons between trauma patients with differing outcomes and use of animal studies have shed some light on this issue, but much of the data continue to be correlative with causative links lacking. In particular, there are little data linking the laboratory-based abnormalities with true clinically evident coagulopathic bleeding. For these reasons, TIC continues to be a significant diagnostic and therapeutic challenge.

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A NEW METHOD OF EPISTAXIS MANAGEMENT USING NASAL GEL: A SINGLE CENTER, RANDOMIZED CLINICAL TRIAL

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2018.v11i3.22462 ◽

2018 ◽

Vol 11 (3) ◽

pp. 104 ◽

Cited By ~ 2

Author(s):

Mehdi Torabi ◽

Ava Roughani Esfahani ◽

Shiva Moeinaddini ◽

Mohammad Reza Baneshi

Keyword(s):

Clinical Trial ◽

Side Effects ◽

Randomized Clinical Trial ◽

Patients Satisfaction ◽

Stop Time ◽

Common Causes ◽

Procedural Time ◽

Nasal Bleeding ◽

The Common ◽

Discharge Length

Objective: Epistaxis is one of the common causes of patients’ referral to the emergency departments. In the majority of cases, epistaxis is managed by traditional methods. We investigated the efficacy of nasal gel (NG) in comparison to anterior nasal packing (ANP) to stop mild-to-moderate anterior nasal bleeding.Methods: In this prospective, randomized clinical trial, patients were divided into two groups of ANP (n=60) and NG (n=40). We determined and compared the efficacy of treatment (bleeding stop time and recurrence), patients’ satisfaction at discharge (length of stay in the hospital, pain during the procedure, and procedural time), and safety (less side effects) in both groups.Results: The procedural time ≤2 min was observed in 90% and 58.33 % of NG group and ANP group, respectively (p<0.001). Pain score during procedure ≤4 and patients’ satisfaction ≥7 were, respectively, seen in 87.5% and 65% of NG group, but it was 43.33% and 41.7% in ANP group, respectively (p<0.001, p=0.02). The side effects in ANP group were 35%; however, no side effects were observed in NG group.Conclusion: In the management of mild-to-moderate anterior nasal bleeding although NG efficacy is equivalent to ANP, using NG may be more convenient and satisfactory for patients. In addition, the use of this gel may result in more safety and fewer side effects.

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Paediatric brought-in-dead at a tertiary health facility in South western Nigeria: Patterns and drivers

Nigerian Journal of Paediatrics ◽

10.4314/njp.v48i2.2 ◽

2021 ◽

Vol 48 (2) ◽

pp. 66-73

Author(s):

Oladele S. Olatunya ◽

Adefunke O. Babatola ◽

Adewuyi T. Adeniyi ◽

Adebukola B. Ajite ◽

Isaac O. Oluwayemi ◽

...

Keyword(s):

Health Facility ◽

Causes Of Death ◽

Severe Anaemia ◽

Hospital Treatment ◽

Cross Sectional ◽

Over The Counter ◽

Pediatric Health Care ◽

Duration Of Illness ◽

Common Causes ◽

Southwest Nigeria

Background: ‘Brought- in-dead’ (BID) refers to the demise of an individual before presentation to a health facility. This study assessed the pattern of paediatric BID cases seen at a tertiary health facility in southwest Nigeria. Method: A cross-sectional, descriptive study was done at the Children Emergency Ward (CEW) of the hospital between January 2014 and December 2018. The patterns of BID cases and presumed causes of death were determined using a standardized checklist adapted from the WHO verbal autopsy instrument. Results: Ninety-eight BID cases were seen during the study, constituting 2.5% of total patients seen during the period. The median (IQR) age of cases was 24.0 (8.75 – 63.0) months and 72.4% were under-fives. Most had symptoms related to the haematologic (36.7%), respiratory (24.5%) or digestive (20.4%) systems. Severe anaemia 31(31.6%), gastroenteritis 19 (19.4) and aspiration 17 (17.3%) were the most common causes of death. The median (IQR) duration of illness before presentation was 3.0 (1.0 – 7.0) days but most presented from 4 – 7 days of illness. A significant relationship was found between the duration of illness and whether or not pre-hospital treatment was received (p < 0.0001). Unprescribed drugs purchased over the counter were the most commonly used treatment in 79.1% of cases (p < 0.0001). Conclusion: This study has highlighted the prevalence and pattern of paediatric BID in a tertiary health facility in southwest Nigeria and the factors that were associated with it. More efforts need to be geared towards community sensitization and pediatric health care to prevent factors drivingits menace.

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PENYULUHAN PENTINGNYA PEMERIKSAAN IVA PADA WUS (Wanita Usia Subur) DI DESA SUKAMAJU KABUPATEN MUARO JAMBI TAHUN 2018

Jurnal BINAKES ◽

10.35910/binakes.v1i1.368 ◽

2020 ◽

Vol 1 (1) ◽

pp. 1-4

Author(s):

Lia Artika Sari ◽

Enny Susilawati

Keyword(s):

Cervical Cancer ◽

Community Service ◽

Causes Of Death ◽

Hpv Infection ◽

Reproductive Age ◽

Women Of Childbearing Age ◽

Childbearing Age ◽

Women Of Reproductive Age ◽

Common Causes ◽

Post Test

ABSTRAK Latar Belakang: Kanker merupakan salah satu penyebab kematian yang paling utama di dunia, sekitar 40 wanita tiap harinya terdiagnosa kanker leher rahim. Kanker leher rahim disebabkan oleh virus HPV, infeksi HPV sendiri sering kali tidak menimbulkan gejala. Desa Suka Maju merupakan salah satu desa yang terdapat di Kabupaten Muaro Jambi dan mempunyai jumlah wanita usia subur berjumlah 820 orang, namun hanya 17,11% wanita usia subur yang baru memanfaatkan pelayanan IVA.Metode: Dengan memberikan penyuluhan kepada wanita usia subur dengan (WUS) sebanyak 40 orang, dan diberikan pre dan post test untuk mengevaluasi pengetahuan wanita usia subur mengenai pemeriksaan IVA Hasil: terjadi kenaikan pengetahuan wanita usia subur di Desa Sukamaju sebesar 87,5%.Kesimpulan: Penyuluhan dapat meningkatkan pengetahuan wanita usia subur terhadap pentingnya pemeriksaan IVA. ABSTRACT Background: Cancer is one of the most common causes of death in the world. About 40 women are diagnosed with cervical cancer every day. Cervical cancer is caused by the HPV virus, HPV infection itself often causes no symptoms. Suka Maju Village is one of the villages in Muaro Jambi Regency that has 820 women of childbearing age, but only 17.11% of women of childbearing age have just used IVA services.Methods: employed in community service was to provide counseling to women of reproductive age with (WUS) as 40 women, and then given pre and posttests to evaluate the knowledge of women of childbearing age After being given counseling on IVA examinations. In brief,Result: There was an increase in the knowledge of women of childbearing age in Sukamaju Village by 87.5 %. Conclusion: Health education can increasedthe knowledge of women of childbearing age on the importance of IVA Chencking

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Clinicopathological study of patients with pancytopenia

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20205837 ◽

2020 ◽

Vol 9 (1) ◽

pp. 169

Author(s):

Y. Srinivas ◽

Mohammed Elyas

Keyword(s):

Bone Marrow ◽

Blood Cells ◽

Reticulocyte Count ◽

Megaloblastic Anemia ◽

Bone Marrow Failure ◽

General Medicine ◽

Large Sample Size ◽

Age Group ◽

Common Causes ◽

The Common

Background: Pancytopenia is due to bone marrow failure characterized by anemia, leukopenia, and thrombocytopenia. It a common hematological disorder. Low blood counts in the bone marrow failure disease result from deficient hematopoiesis. Marrow damage and dysfunction also may be secondary to infection, inflammation, or cancer. Pancytopenia has an extensive differential diagnosis and it can result from damage to bone marrow destruction of preformed blood cells peripherally with increased reticulocyte count. Aim of the study were to study the different etiological conditions and clinical features of pancytopenia in rural medical college.Methods: This study has been conducted in the department of general medicine in association with the pathology department and between March 2019 to February 2020, 45 patients were included in this study. males were 27 and females were 18. The age group is between 20 years and 60 years. 2 ml of anticoagulant blood send for HB% total count, platelet count, packed cell volume, and RBC indices.Results: The total no. of patients included in this study were 45 among these 45 patients, males were 27, and females were 18. The common age group is between 20 and 60 years and the common causes of aplastic anemia in our study are megaloblastic anemia.Conclusions: Pancytopenia is a common hematological problem in India. In our study megaloblastic anemia is the most common cause of pancytopenia females are affected during pregnancy. So, periodical clinically examined and investigations may reduce the incidence. of further research with a large sample size and meticulous investigations required to replicate the finding of the study.

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