The article is devoted to the study of the features of the use of modern process technologies for managing business projects in the context of transformational changes in the national economic environment. Modern conditions for conducting economic activities force enterprises to resort to the use of more progressive tools for the implementation of organizational measures of a project or program nature. The article examines the main international organizations that formed the theoretical basis for the development of project management, identifies the main types of project management technologies in accordance with the nature of their target orientation, in particular, management technologies of qualification, specialized, object and organizational orientation. Provided a detailed description of the key technologies of process management of business projects, which are actively used in the economic practice of modern enterprises, namely Waterfall, Agile, Scrum and Kanban, in the context of their key essential characteristics, as well as inherent advantages and disadvantages in practical application. However, taking into account the specific features of each of the process management methods of business projects, as well as the high level of influence of external factors, which is observed in modern market conditions, business entities will certainly face a number of systemic problems associated with ensuring the effective implementation of these management technologies and maximizing the results obtained from such actions. The authors of the article identify and reveal in detail the main problems faced by domestic enterprises in the process of implementing project management measures caused by the influence of destructive factors of the external economic environment. An expanded list of recommendatory measures has been formed to overcome the designated management problems, both from the standpoint of effectively countering the complex macroeconomic and post-pandemic economic realities of functioning, and with respect to the specifics of the selection of certain project management techniques.