The effectiveness of a monopreparation containing a combination of ciprofloxacin – ornidazole in the treatment of infectious-inflammatory and dysbiotic vagina diseases

Introduction. Infectious inflammatory and dysbiotic diseases of the vagina represent a major concern facing obstetric and gynecological science. Individually, the two most common specific diseases can be distinguished, namely: bacterial vaginosis (BV) and nonspecific vaginitis (NV). The therapeutic strategy for these diseases requires a word of clarification and adjustment.Objective. To conduct a comparative analysis of treatment with the combination drug Orcepol WM (ciprofloxacin (500 mg) and ornidazole (500 mg)) and a combination of monopreparations in a dosage form similar to Orcepol WM.Materials and methods. As a comparison object, we used the method of simultaneous administration by patients of tablet forms of ciprofloxacin and ornidazole as mono-preparations in a dosage of 500 mg similar to Orcepol. The study included 64 patients with diagnoses of “bacterial vaginosis” or “nonspecific vaginitis” or "decompensated mixed vaginal dysbiosis". The average age of the patients was 35.34 ± 5.95 years. The patients were divided into two groups: group 1 (n = 32) received the combination drug Orcepol WM, group 2 (n = 32) received ciprofloxacin and ornidazole with two mono-preparations. The drugs were prescribed as a five-day course, two times a day. The patients were followed up by a doctor during two visits and one remote interview on day 30–45 after the end of treatment (visit 2).Results. In both groups, all patients received a full course of antibacterial therapy. There were no adverse drug reactions. In both groups, there was an improvement in clinical symptoms from the first to the second visit: discomfort, itching, burning, dyspareunia, hyperemia of the mucous membrane against the background of normalization of laboratory findings of the vaginal microbiocenosis condition. At the same time, the best results were higher in group 1. Manifestation of mycotic vaginitis with the development of strong clinical symptomatology on days 3 and 4 of treatment respectively were recorded in 4 (12.5%) patients from group 1 and 7 (21.9%) from group 2. The results of comparative observation showed that the number of relapses after the end of therapy were the same in group 1 (8 out of 32 patients, 25%) and in group 2 (9 out of 32 patients, 28%). The relapse occurred on average day 12 and 17 after the end of therapy, respectively.Сonclusion. Thus, the use of Orcepol WM showed a greater therapeutic efficacy as compared to the use of tablet forms of ciprofloxacin and ornidazole in similar dosages as a single-drug administration, which can be explained by a stronger patients' adherence to the treatment.

Analisis Fungsi Peribahsa Jepang Yang Mengandung Unsur Binatang

Japanesse proverb(kotowaza) is an expression which is figurately expressed by someone to another one as an insinuation, advice, life experience, and a game. There are a lot of Japanesse proverb use the parable / comparison, one of the parable/ comparison object used in it is animals. Japenesse proverb is one of the subjects that hard to learned and umderstood, especially for the foreign learner ( example indonesian ). This research discuss the analysis of Japeness proverb which contain the word animals taken from happy lilac websitae . The purpose of this research is to know about what kind of animal that contain in kotozawa and its function. The data in this research is the kotozawa that contain of animal words which taken from happy lilac website and the methodein this research is qualitative descriptive. The data collection technique in this research is the library technique. Based on the resaerch result 23 from 210 kotozawa that contain of animal words, 7 of them contain the offensive function (kougekiteki kotowaza), 6 kotowaza contain empiric function (keikenteki kotowaza), 10 kotowaza dictative function (kyoukunteki kotowaza) and none of kotowaza that contain the game (kyoukunteki kotowaza)

Justification of Tools for Assessing the Quality of Recreational Resources Reserves

In modern conditions, the criteria for assessing the level of development of the tourism and spa sector in the Russian regions, their tourist attractiveness and tourist potential, popularity among domestic and foreign tourists is tourist uniqueness. Uniqueness is ensured by the availability of recreational resources (cultural and historical heritage sites, climatic conditions, balneological resources, and developed main and supporting infrastructures) and their quality level. A comparative analysis of the assessment methods showed that an objective quantitative assessment of the quality of tourist and spa-forming resources is possible using the qualimetry method. The principles of qualimetry, the system of indicators, and mathematical tools of the method do not contradict the goals and objectives of the study. The method of qualimetry does not require the presence of a comparison object since it forms a reference image; it does not require a long time series to obtain a reliable result. Assessing the quality of recreational resources reserves of the competitiveness of tourism and sanatorium organizations is a multicriteria task that is solved within the framework of the qualimetry method. The qualimetry method is a set of comparable methods (the expert assessment method, the graphical method, scaling, the analytical method). The obtained results of assessing the quality level of reserves of recreational resources allow researchers to make informed management decisions.

ORGANIZATIONAL, REGULATORY AND LEGAL ASPECTS OF EUROPEAN INTEGRATION OF HIGHER MEDICAL EDUCATION IN UKRAINE: A CRITICAL REVIEW

The aim: The main purpose of this research is to conduct the theoretical and applied study of the legal profile enforcement for state attestation of medical graduates, the relevant legislative system, and its effectiveness; to identify the issues of special legislative requirements, as well as the search for ways to resolve it. Materials and methods: Basic methods: analysis, synthesis and comparison. Object of research: system of state certification of graduates of medical sciences. Investigation of this topic in the paper is carried out in the following logical sequence: firstly, the basic principles of the state integrated qualification exam were determined and analyzed; then the legal enforcement for integrated state qualification exam of master’s degree in discipline “22 Health Care” was considered. Also, a critical review of Ukrainian normative base for holding the state attestation of medical graduates was conducted. Conclusions: In view of foregoing, we can make a conclusion that in the modern globalization world, competition of national educational services should be ensured by a range of different activities: legal, organizational, financial, etc. The legal direction, domestic rules should correspond to similar, uniform rules and practices of the most effective state (regional, international) systems.

The optimization of the composition of fertilizers based on milled phosphorites

The phosphorites of many domestic deposits can be used as cheap natural phosphorus fertilizers of regional importance. The limitation of their use is due to the low solubility and, consequently, low agrochemical effectiveness. To increase the solubility of phosphorites (activation), it is proposed to use the method of granulation of phosphorite flour (PF) with an organomineral additive containing milled sulfur, glauconite and highly decomposed peat, dispersed by hydrodynamic cavitation. Phosphate activation is ensured by acids formed in the process of microbiological oxidation of sulfur in soils (convert insoluble phosphates to more soluble hydrophosphates), glauconite (promotes adsorption and ion exchange binding of cations that form insoluble phosphates, activates soil microbiota) and humic acid peat (oxides into stable complexes, stimulate the activity of soil microorganisms). In laboratory conditions, samples of the corresponding organic-mineral fertilizer were obtained. As phosphate raw materials, the PF of the Vyatka-Kama deposit (Russia) and the Khneifis deposit (Syria) were used. The study of the effect of fertilizer on the chemical composition of soils was carried out in a laboratory experiment. As a comparison object, simple superphosphate was used. Fertilizers were applied to the soil in an amount of 0.1 g per 1 kg of air-dried soil. It was revealed that already 7 days after fertilizing, the mobility of phosphorus increases by 31-45%, while the pH of the soil solution does not change. The sulfate content in soils increased by an average of 33%. In all variants of the experiment, the application of activated PF in the soil led to the same result as the application of simple superphosphate. Based on PF and an activating organomineral additive, a granular form of phosphorus fertilizer with sulfur and humic substances can be obtained that is not inferior in effectiveness to simple superphosphate. The production of appropriate fertilizer can be arranged at small enterprises and directly at phosphate mines, which will create new jobs and provide regional crop production with relatively cheap and fairly effective forms of phosphate fertilizers that comply with the principles of green chemistry. The composition and technology of fertilizer production make it possible to position it as a natural organic-mineral fertilizer for organic farming.

Contesting commensuration

Purpose The purpose of this paper is to explore how actors subjected to public performance evaluations may “contest commensuration,” i.e. may seek to influence how such ratings and rankings will be construed among important stakeholders. Design/methodology/approach A qualitative study of press releases, and interviews with department heads, is used as a basis for the analysis. Findings The empirically derived taxonomy of public responses to a state-initiated performance evaluation of educational programs shows that actors may mobilize an array of commensuration management tactics so as to maintain or improve one’s relative positional status. Such tactics may have at least three different foci, namely, on the comparison object (i.e. on the new grouping of actors), the comparison dimension (i.e. the standardized format for comparison) and the comparison rate (i.e. the rate received), respectively. The authors also find that not only are threats to positional status likely to spur commensuration management tactics, but also the opportunity to exploit a good rate. Originality/value The paper augments recent research that has problematized the so-called “reactive conformance thesis” by focusing on how evaluated organizations may directly try to influence external stakeholders through public responses. The study is also one of the first that analytically disentangles how they may skillfully exploit different forms of “plasticity” that are inherent in any type of commensuration.

Comparison of Microstructure and Properties of In-Situ TiN- and WC-Reinforced NiCrBSi Composite Coatings Prepared by Plasma Spraying

In this study, NiCrBSi-30 wt.% TiN composite (NTC) coating was produced on carbon steel via plasma spraying, with NiCrBSi-30 wt.% WC composite (NWC) coating as the comparison object. The microstructure and phase constituents of the composite coatings were characterized using scanning electron microscopy (SEM) coupled with energy dispersive spectroscopy (EDS) techniques, transmission electron microscopy (TEM) and x-ray diffraction (XRD). Atomic force microscopy (AFM) was used to measure electronic work functions. The microhardness and wear performance of coatings were also investigated. The average microhardness of the NTC and NWC coatings was 1000 HV and 850 HV, respectively. In addition, the NTC coating had a wear volume loss of 0.8118 mm3, less than 1.4772 mm3, the volume loss of the NWC coating. This was due to the presence of TiN in the form of nanograins in the composite coating and tighter binding to the matrix.

PERBANDINGAN ANTARA FILSAFAT EKONOMI ISLAM DAN BARAT

Economic philosophy is an undeveloped theme in department of economy. Whereas during the 20th Century there is a clash of two big ideologies that caused by differences in economic philosophy, they are the capitalism and the socialism. These Two big streams often used as comparison object. This Writing, look at the two big streams in a same frame, that is the thought that arise in western worldview which different with Islamic worldview. So it is interesting to study the comparison between philosophy of Islamic economic and western economic through branchs of philosopy, they are ontology, epistemology and axiology.

Indikasi Budaya Hoabinh pada Alat Litik Temuan Singkapan di Situs Loyang Mendale

Trought the lithic tool, the indication of cultural periodization and the development of culture could be refered to. Also, by the finding of a lithic tool in Loyang Mendale site. It can indicate time and cultural periodization which was growing at the time. Those understanding can be achieved by doing the description of the morphology and the technology on lithic equipment. In addition to the description, the comparison object can be done trought the lithic tool-making stages of processing compared with lithic tool around Loyang Mendale site that has a contemporary culture. Based on morphological and lithic technology in a tool of cultural sites hoabinh lowland and highland hoabinh culture sites produced relativaly similar morphology. In addition, the same technology as the technology during mesolithic culture that developed on the Loyang Mendale site has compatility with the hoabinh culture.

PEPINDHAN TENTANG AKTIVITAS MANUSIA DALAM BAHASA JAWA (JAVANESE PEPINDHAN OF HUMAN ACTIVITY)

Penelitian ini merupakan penelitian linguistik interdisipliner untuk menemukan hubungan antara bahasa dan budaya, yakni budaya Jawa. Tujuan khusus yang ingin dicapai ialah (1) mendeskripsikan bentuk-bentuk pepindhan aktivitas manusia, (2) menemukan objek pembanding pepindhan aktivitas manusia, serta (3) mendeskripsikan unsur-unsur budaya yang tampak dalam pepindhan aktivitas manusia. Proses analisis data dilakukan dengan pendekatan linguistik antropologi. Berdasarkan kajian yang dilakukan dapat disebutkan bahwa aktivitas manusia yang di-pepindhan-kan meliputi aktivitas kaki, mulut, tangan, dan aktivitas tubuh secara keseluruhan. Kosakata yang digunakan sebagai pembanding dalam pepindhan diambil dari benda atau sesuatu yang dikenal baik oleh masyarakat Jawa dan mencerminkan kondisi budaya masyarakat Jawa. Penanda perbandingan yang muncul ialah kaya, kadya, pindha, semu, serta penasalan dan penambahan imbuhan hanuswara. Unsur budaya Jawa yang tercermin dari penggunaan kosakata dalam pepindhan ialah matapenca-harian, peralatan hidup, kesenian, dan pengetahuan.This study is interdisciplinary linguistic research that is aimed to find out the relation between language and the culture, particularly Javanese culture. The specific objectives are (1) to describe forms of human activity pepindhan, (2) to discover comparison object of human activity pepindhan, and (3) to describe cultural elements that appear in human activity pepindhan. Data analysis process is carried out by linguistic anthropology approach. Based on the study, it can is found out that human activity pephindan are leg activity, mouth activity, hand activity, and a whole body activity. The comparison vocabularies in pepin-dhan are taken from something that are familiar in Javanese community and these words reflect Javanese culture society condition. The comparison markers are kaya, kadya, pindha, semu, and nasalization with hanuswara affix. Javanese cultural elements reflected in pepindhan vocabularies are livelihood, equipment life, arts, and knowledge.