Khat chewing, cardiovascular diseases and other internal medical problems: The current situation and directions for future research

AbstractThe aims of this systematic review and meta-analysis were to describe prevalence of cardiovascular disease in gout, compare these results with non-gout controls and consider whether there were differences according to geography. PubMed, Scopus and Web of Science were systematically searched for studies reporting prevalence of any cardiovascular disease in a gout population. Studies with non-representative sampling, where a cohort had been used in another study, small sample size (< 100) and where gout could not be distinguished from other rheumatic conditions were excluded, as were reviews, editorials and comments. Where possible meta-analysis was performed using random-effect models. Twenty-six studies comprising 949,773 gout patients were included in the review. Pooled prevalence estimates were calculated for five cardiovascular diseases: myocardial infarction (2.8%; 95% confidence interval (CI)s 1.6, 5.0), heart failure (8.7%; 95% CI 2.9, 23.8), venous thromboembolism (2.1%; 95% CI 1.2, 3.4), cerebrovascular accident (4.3%; 95% CI 1.8, 9.7) and hypertension (63.9%; 95% CI 24.5, 90.6). Sixteen studies reported comparisons with non-gout controls, illustrating an increased risk in the gout group across all cardiovascular diseases. There were no identifiable reliable patterns when analysing the results by country. Cardiovascular diseases are more prevalent in patients with gout and should prompt vigilance from clinicians to the need to assess and stratify cardiovascular risk. Future research is needed to investigate the link between gout, hyperuricaemia and increased cardiovascular risk and also to establish a more thorough picture of prevalence for less common cardiovascular diseases.

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NURSING HOME TELEED INTERVENTION: ADVANCING NEW CARE MODELS

Innovation in Aging ◽

10.1093/geroni/igz038.1225 ◽

2019 ◽

Vol 3 (Supplement_1) ◽

pp. S337-S338

Author(s):

Charlene C Quinn ◽

Anthony Roggio ◽

Barr Erik ◽

Ann Gruber-Baldini

Keyword(s):

Medical Center ◽

Business Case ◽

Admission Policy ◽

Care Utilization ◽

Future Research ◽

Technical Equipment ◽

Nursing Facilities ◽

Medical Problems ◽

Provider Satisfaction ◽

Care Models

Abstract New reimbursement and managed care models demonstrate the need to reduce avoidable Emergency Department (ED) use and limit preventable inpatient admissions for older adults in Skilled Nursing Facilities (SNF). The objective was to develop an ED telemedicine consultation intervention for SNF residents with acute medical problems. Secondary objectives including evaluation of health care utilization, provider satisfaction. Demonstration evaluation in three urban SNFs, telemedicine linked to university medical center ED. Mobile telemedicine cart equipment assessed SNF residents for any change in condition. ED physicians used tablets with secure access to conduct the resident assessment. Provider satisfaction measures imbedded in EMRs were completed at consultation visit end. 460 patients had changes in condition, 327 resulted in 911 calls, 85 deemed eligible for telemedicine consult. Conducted 57 telehealth consults. Forty (70%) telemedicine consult residents remained in the SNF. Fourteen residents were transferred to the ED. Average satisfaction scores were 5.8/7 for SNF nurses (n=49) and 5.6 for ED physicians (n=45). Lower-rated items related to technical equipment problems. ED physicians reported residents transferred to ED after telehealth visit had better continuity of care. The intervention was effective in preventing or delaying transfer of acutely ill, medically complex SNF residents. Implementation of the intervention identified need for SNF admission policy and procedure changes; weekly telemedicine training; SNF clinical advocates; on-site tracking and linkage of EMRs across providers; HIPAA shared medical record concerns. Future research plans include analyses of detailed SNF resident characteristics and business case assessment for reduction of transfers, ED and hospital utilization.

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Are Ancestral Medical Practices the Future Solution to Today’s Medical Problems?

Molecules ◽

10.3390/molecules26154701 ◽

2021 ◽

Vol 26 (15) ◽

pp. 4701

Author(s):

José A. Lupiáñez ◽

Eva E. Rufino-Palomares ◽

Amalia Pérez-Jiménez

Keyword(s):

Metabolic Syndrome ◽

Cardiovascular Diseases ◽

Hostile Environment ◽

Medical Problems ◽

Significant Deterioration ◽

Irreversible Damage ◽

Medical Practices ◽

The Metabolic Syndrome ◽

The Future ◽

Inadequate Nutrition

Our cells and organs are threatened and, in most cases, constantly subjected to the aggression of numerous situations, both endogenous, characterized by unfavorable genetics, and exogenous, by deficient or inadequate nutrition, and even by a hostile environment; in most cases, they ultimately cause a cascade of degenerative and cardiovascular diseases, cancer, and infections, as well as those related to the metabolic syndrome, all of which eventually generate irreversible damage to the organism and, consequently, a significant deterioration in its survival [...]

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The Current Situation and Prospect Of Study Quality Evaluation Research in China in The Last 10 Years

EDUKATIF : JURNAL ILMU PENDIDIKAN ◽

10.31004/edukatif.v2i1.83 ◽

2020 ◽

Vol 2 (1) ◽

pp. 101-112

Author(s):

Wu Aixia ◽

Zhou Ying ◽

Tommy Tanu Wijaya

Keyword(s):

Quality Evaluation ◽

Evaluation Research ◽

Teaching Quality ◽

Current Situation ◽

Annual Number ◽

Future Research ◽

Existing Problems ◽

Content Analysis Method ◽

Future Research Directions

With the deepening of China's educational reform, the evaluation of teaching quality has become an important aspect of teaching reform.And the evaluation of students'learning quality is an important part of teaching evaluation. Research on it will help to improve the teaching quality of our country and promote the overall improvement of students' morality, intelligence, physical fitness and beauty.Therefore, this study takes 108 literatures related to the study of learning quality evaluation in China as the research object, uses content analysis method, carries out statistical analysis on the annual number of literatures, Journal distribution, author status, paper influence, research content, etc., analyzes the current situation and existing problems of the study of learning quality evaluation in China, and puts forward the need for further deepening.On the basis of these questions, possible future research directions are proposed.

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MicroRNAs: role in cardiovascular biology and disease

Clinical Science ◽

10.1042/cs20070211 ◽

2008 ◽

Vol 114 (12) ◽

pp. 699-706 ◽

Cited By ~ 78

Author(s):

Chunxiang Zhang

Keyword(s):

Cardiovascular Diseases ◽

Target Genes ◽

Future Research ◽

Cardiovascular Development ◽

Biological Functions ◽

Lesion Formation ◽

Regulate Gene Expression ◽

Proliferation And Apoptosis ◽

Cardiovascular Biology ◽

Non Coding Rnas

miRNAs (microRNAs) comprise a novel class of endogenous, small, non-coding RNAs that negatively regulate gene expression via degradation or translational inhibition of their target mRNAs. Recent studies have demonstrated that miRNAs are highly expressed in the cardiovascular system. Although we are currently in the initial stages of understanding how this novel class of gene regulators is involved in cardiovascular biological functions, a growing body of exciting evidence suggests that miRNAs are important regulators of cardiovascular cell differentiation, growth, proliferation and apoptosis. Moreover, miRNAs are key modulators of both cardiovascular development and angiogenesis. Consequently, dysregulation of miRNA function may lead to cardiovascular diseases. Indeed, several recent reports have demonstrated that miRNAs are aberrantly expressed in diseased hearts and vessels. Modulating these aberrantly expressed miRNAs has significant effects on cardiac hypertrophy, vascular neointimal lesion formation and cardiac arrhythmias. Identifying the roles of miRNAs and their target genes and signalling pathways in cardiovascular disease will be critical for future research. miRNAs may represent a new layer of regulators for cardiovascular biology and a novel class of therapeutic targets for cardiovascular diseases.

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An Overview of the Worldwide Rise and Expansion of Home Education Homeschooling

Global Perspectives on Home Education in the 21st Century - Advances in Early Childhood and K-12 Education ◽

10.4018/978-1-7998-6681-7.ch001 ◽

2021 ◽

pp. 1-18

Author(s):

Brian D. Ray

Keyword(s):

Current Situation ◽

Future Research ◽

Home Education ◽

Social And Emotional ◽

World Today ◽

Emotional Outcomes ◽

The World ◽

The Usa ◽

The Impact

This chapter outlines the current situation about homeschooling across the world today. It highlights its enormous growth over the last 40 or 50 years, since its reintroduction in the USA and the impact that has had on the world homeschooling movement. It describes the contested outcomes of home education, including the evidence that students' academic, social, and emotional outcomes are higher while also providing a solid basis for ‘graduates' of home education to experience success in adulthood. Theorizing the roots of this success, the chapter looks at the measures of success and the theoretical bases of the success of the mainstream schooled and explores how the features that make a successful graduate of mainstream schools are naturally and almost exclusively present in the home education setting, Finally, it considers how the current turn against home education and suggests how future research might be useful to counter these negative discourses about the practice while understanding this growing cohort of children across the world today.

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Inter-municipal cooperation in Latin America: current situation and future research challenges

Revista de Administração Pública ◽

10.1590/0034-761220180042x ◽

2019 ◽

Vol 53 (3) ◽

pp. 575-591

Author(s):

Karina Arias Yurisch ◽

Karina Retamal Soto ◽

Camila Ramos Fuenzalida

Keyword(s):

Latin America ◽

Current Situation ◽

Future Research ◽

Research Challenges ◽

Revisión Sistemática ◽

America Latina

Resumen Este artículo ofrece un panorama del estado de la investigación latinoamericana sobre cooperación intermunicipal, un fenómeno que ha adquirido relevancia empírica en la región desde la década de los años noventa. A partir de una revisión sistemática de la literatura y del análisis de contenido de 47 artículos publicados entre 2005 y 2016 en revistas indexadas en WOS, Scopus y LatinIndex, este trabajo informa acerca de los avances de la investigación sobre los condicionantes relevantes, las complejidades de la operación y los diferentes efectos de la cooperación intermunicipal en países de América Latina. Los resultados identifican las brechas de investigación en el estudio de las causas y los factores explicativos de la colaboración como modelo organizacional y gobernanza territorial, como también la falta de estudios de efectividad de dichos arreglos. La identificación de estas brechas permitirá orientar la agenda de investigación futura sobre cooperación entre municipios.

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Challenges in Using Circulating Micro-RNAs as Biomarkers for Cardiovascular Diseases

International Journal of Molecular Sciences ◽

10.3390/ijms21020561 ◽

2020 ◽

Vol 21 (2) ◽

pp. 561 ◽

Cited By ~ 5

Author(s):

Kyriacos Felekkis ◽

Christos Papaneophytou

Keyword(s):

Cardiovascular Diseases ◽

Diagnostic Tests ◽

Future Research ◽

Circulating Mirnas ◽

Significant Progress ◽

Factors Affecting ◽

Non Invasive ◽

Micro Rnas ◽

Specific Amplification ◽

Disease Specific

Micro-RNAs (miRNAs) play a pivotal role in the development and physiology of the cardiovascular system while they have been associated with multiple cardiovascular diseases (CVDs). Several cardiac miRNAs are detectable in circulation (circulating miRNAs; c-miRNAs) and are emerging as diagnostic and therapeutic biomarkers for CVDs. c-miRNAs exhibit numerous essential characteristics of biomarkers while they are extremely stable in circulation, their expression is tissue-/disease-specific, and they can be easily detected using sequence-specific amplification methods. These features of c-miRNAs are helpful in the development of non-invasive assays to monitor the progress of CVDs. Despite significant progress in the detection of c-miRNAs in serum and plasma, there are many contradictory publications on the alterations of cardiac c-miRNAs concentration in circulation. The aim of this review is to examine the pre-analytical and analytical factors affecting the quantification of c-miRNAs and provide general guidelines to increase the accuracy of the diagnostic tests in order to improve future research on cardiac c-miRNAs.

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Medical Conditions, Level of Care Needs, and Health-Related Outcomes of Persons with Mental Retardation: A Review

Journal of the Association for Persons with Severe Handicaps ◽

10.1177/154079699101600402 ◽

1991 ◽

Vol 16 (4) ◽

pp. 188-206 ◽

Cited By ~ 7

Author(s):

Mary F. Hayden ◽

Paris A. DePaepe

Keyword(s):

Mental Retardation ◽

Medical Care ◽

Policy Implications ◽

Future Research ◽

Level Of Care ◽

Medical Conditions ◽

Care Needs ◽

Medical Problems ◽

Provision Of Services ◽

Health Related

A literature review was conducted to analyze existing data on health needs of people with mental retardation and possible barriers to integration in the community. Information was obtained on medical conditions, level of care needed, and health-related outcomes. The type and range of medical care, resources, and support services needed to maintain individuals with medical problems were identified, as were barriers to and recommendations for the provision of community-based medical care. Although there are barriers to the provision of services to people with mental retardation and allied medical conditions, there are people who currently live in the community who have the same type of medical conditions and who require the same level of care needed as those who live in institutions. Medical services are typically, but not always, available to persons with mental retardation who reside in the community. Availability and access to services are addressed. Recommendations for future research and policy implications are presented.

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Foreign Immigration in Spanish Rural Areas and Small Towns: Current Situation and Perspectives

Finisterra ◽

10.18055/finis1559 ◽

2012 ◽

Vol 39 (77) ◽

Cited By ~ 2

Author(s):

Ricard Morén-Alegret ◽

Miguel Solana

Keyword(s):

Literature Review ◽

Rural Areas ◽

Settlement Patterns ◽

Small Towns ◽

Current Situation ◽

Future Research ◽

Sources Of Information ◽

Academic Literature ◽

Immigrant Populations ◽

Ways Of Life

The authors are currently coordinating a three-year researchproject on the changing settlement patterns and ways of life of foreign immigrant populations located in Spanish rural areas. This article offers a wide academic literature review, highlighting those issues that have been most studied and those under-researched or forgotten. Secondly, it approaches the rural areas where thereis a more significant presence of foreign immigrants, offering relevant data and indicating the main sources of information available for their study. Finally, some considerations that may be useful for carrying out future research are suggested.

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