The impact of heat stress on intestinal function and productivity in grow-finish pigs

2015 ◽  
Vol 55 (12) ◽  
pp. 1403 ◽  
Author(s):  
N. K. Gabler ◽  
S. C. Pearce
Keyword(s):  
Heat Stress ◽  
Gastrointestinal Tract ◽  
Well Being ◽  
Growing Pigs ◽  
Intestinal Function ◽  
Transport Pathways ◽  
Altered Expression ◽  
Intestinal Integrity ◽  
Increased Risk ◽  
The Impact

Heat stress is a physiological condition when animals can no longer regulate their internal euthermic temperature. When livestock such as pigs are subjected to this environmental stress, it can be detrimental to performance, health and well-being, and if severe enough even death. Growing pigs are particularly susceptible to heat stress and one of the major organs first affected by heat stress is the gastrointestinal tract. As a result, reductions in appetite, intestinal function and integrity and increased risk of endotoxemia can modify post-absorptive metabolism and tissue accretion. These changes in intestinal integrity may be a result of altered expression of tight junction proteins, increased circulating endotoxin concentrations and markers of cellular stress (heat shock and hypoxia response), which is evident as early on as 2 h after heat-stress onset. Due to restricted blood flow, the ileum is more severely affected compared with the colon. Interestingly, many of the negative effects of heat stress on intestinal integrity appear to be similar to those observed with pigs reared under reduced nutrient and caloric intakes. Altogether, these depress pig performance and health, and extend days to market. Despite this impact on the gastrointestinal tract, under heat-stress conditions, intestinal glucose transport pathways are upregulated. This review discussed how heat stress (directly and indirectly via reduced feed intake) affects intestinal integrity and how heat stress contributes to decreased growth performance in growing pigs.

scholarly journals Review: Impacts of shade on cattle well-being in the beef supply chain

2020 ◽  
Author(s):  
Lily N Edwards-Callaway ◽  
M Caitlin Cramer ◽  
Caitlin N Cadaret ◽  
Elizabeth J Bigler ◽  
Terry E Engle ◽  
...  
Keyword(s):  
Supply Chain ◽  
Heat Stress ◽  
Beef Cattle ◽  
Production Systems ◽  
Construction Materials ◽  
Well Being ◽  
Third Party ◽  
Ambient Temperatures ◽  
Stress Susceptibility ◽  
The Impact

ABSTRACT Shade is a mechanism to reduce heat load providing cattle with an environment supportive of their welfare needs. Although heat stress has been extensively reviewed, researched, and addressed in dairy production systems, it has not been investigated in the same manner in the beef cattle supply chain. Like all animals, beef cattle are susceptible to heat stress if they are unable to dissipate heat during times of elevated ambient temperatures. There are many factors that impact heat stress susceptibility in beef cattle throughout the different supply chain sectors, many of which relate to the production system, i.e. availability of shade, microclimate of environment, and nutrition management. The results from studies evaluating the effects of shade on production and welfare are difficult to compare due to variation in structural design, construction materials used, height, shape, and area of shade provided. Additionally, depending on operation location, shade may or may not be beneficial during all times of the year, which can influence the decision to make shade a permanent part of management systems. Shade has been shown to lessen the physiologic response of cattle to heat stress. Shaded cattle exhibit lower respiration rates, body temperatures, and panting scores compared to un-shaded cattle in weather that increases the risk of heat stress. Results from studies investigating the provision of shade indicate that cattle seek shade in hot weather. The impact of shade on behavioral patterns is inconsistent in the current body of research, some studies indicating shade provision impacts behavior and other studies reporting no difference between shaded and un-shaded groups. Analysis of performance and carcass characteristics across feedlot studies demonstrated that shaded cattle had increased ADG, improved feed efficiency, HCW, and dressing percentage when compared to cattle without shade. Despite the documented benefits of shade, current industry statistics, although severely limited in scope, indicate low shade implementation rates in feedlots and data in other supply chain sectors do not exist. Industry guidelines and third party on-farm certification programs articulate the critical need for protection from extreme weather but are not consistent in providing specific recommendations and requirements. Future efforts should include: updated economic analyses of cost versus benefit of shade implementation, exploration of producer perspectives and needs relative to shade, consideration of shade impacts in the cow-calf and slaughter plant segments of the supply chain, and integration of indicators of affective (mental) state and preference in research studies to enhance the holistic assessment of cattle welfare.

scholarly journals 231 Impact of Brachyspira hyodysentariae on intestinal function and integrity

2020 ◽  
Vol 98 (Supplement_3) ◽  
pp. 116-116
Author(s):  
Emma T Helm ◽  
Susanne J Lin ◽  
Nicholas Gabler ◽  
Eric R Burrough
Keyword(s):  
Ex Vivo ◽  
Potato Starch ◽  
Nutrient Digestibility ◽  
High Morbidity ◽  
Post Inoculation ◽  
Intestinal Function ◽  
Treatment Groups ◽  
Intestinal Integrity ◽  
Beet Pulp ◽  
The Impact

Abstract Swine dysentery (SD) induced by Brachyspira hyodysentariae (Bhyo) causes colitis and mucohemorrhagic diarrhea in grow-finish pigs, however little is known about the physiological changes that occur to the gastrointestinal tract during Bhyo infection. Thus, the objective of this study was to evaluate the impact of a Bhyo challenge on intestinal function and integrity of pigs fed two divergent diets. A total of 36 Bhyo negative gilts (24.3 ± 3.6 kg BW) were selected and assigned to one of three treatment groups (n=12 pigs/trt): 1) Bhyo negative, 20% DDGS diet (CON), 2) Bhyo challenged, 20% DDGS diet (DDGS), and 3) Bhyo challenged, 10% DDGS, 5% beet pulp and 5% resistant potato starch diet (RS). Pigs were fed diets 21 days prior to challenge and on days post inoculation (dpi) 0 and 1, pigs were inoculated with Bhyo or sham. Fecal samples were collected for ATTD and pigs were euthanized for colon collection within 72 hours of initial observation of clinical SD, or at the end of the study (dpi 10-16). Tissues were assessed for ex vivo measures of intestinal integrity and mitochondrial function. The challenge resulted in high morbidity, with 88% of DDGS and RS pigs developing clinical SD. Colon transepithelial resistance was increased in DDGS pigs compared with CON and RS pigs (P=0.005), and colon macromolecule permeability was reduced in both DDGS and RS pigs compared with CON pigs (P=0.006), likely due to mucoid discharge. Colonic mitochondrial oxygen consumption was not impacted by treatment (P >0.10). Further, ATTD of DM, OM, N, and GE were reduced in DDGS pigs compared with CON pigs (P< 0.001), whilst nutrient digestibility was not reduced in RS pigs. Taken together, these data show Bhyo does not appear to reduce ex vivo colonic integrity. Further, the RS diet may reduce severity of a Bhyo challenge.

scholarly journals Radical Response: Effects of Heat Stress-Induced Oxidative Stress on Lipid Metabolism in the Avian Liver

Antioxidants ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 35
Author(s):  
Nima K. Emami ◽  
Usuk Jung ◽  
Brynn Voy ◽  
Sami Dridi
Keyword(s):  
Oxidative Stress ◽  
Heat Stress ◽  
Lipid Metabolism ◽  
Egg Production ◽  
Well Being ◽  
Enzymatic Reactions ◽  
Poultry Production ◽  
Hepatic Lipid Metabolism ◽  
Hepatic Lipid ◽  
The Impact

Lipid metabolism in avian species places unique demands on the liver in comparison to most mammals. The avian liver synthesizes the vast majority of fatty acids that provide energy and support cell membrane synthesis throughout the bird. Egg production intensifies demands to the liver as hepatic lipids are needed to create the yolk. The enzymatic reactions that underlie de novo lipogenesis are energetically demanding and require a precise balance of vitamins and cofactors to proceed efficiently. External stressors such as overnutrition or nutrient deficiency can disrupt this balance and compromise the liver’s ability to support metabolic needs. Heat stress is an increasingly prevalent environmental factor that impairs lipid metabolism in the avian liver. The effects of heat stress-induced oxidative stress on hepatic lipid metabolism are of particular concern in modern commercial chickens due to the threat to global poultry production. Chickens are highly vulnerable to heat stress because of their limited capacity to dissipate heat, high metabolic activity, high internal body temperature, and narrow zone of thermal tolerance. Modern lines of both broiler (meat-type) and layer (egg-type) chickens are especially sensitive to heat stress because of the high rates of mitochondrial metabolism. While this oxidative metabolism supports growth and egg production, it also yields oxidative stress that can damage mitochondria, cellular membranes and proteins, making the birds more vulnerable to other stressors in the environment. Studies to date indicate that oxidative and heat stress interact to disrupt hepatic lipid metabolism and compromise performance and well-being in both broilers and layers. The purpose of this review is to summarize the impact of heat stress-induced oxidative stress on lipid metabolism in the avian liver. Recent advances that shed light on molecular mechanisms and potential nutritional/managerial strategies to counteract the negative effects of heat stress-induced oxidative stress to the avian liver are also integrated.

scholarly journals COPD, Depression and COVID-19 Pandemic: A Harrowing, Demoralizing and Deleterious Triad

2021 ◽  
Vol 3 (8) ◽  
pp. 01-06
Author(s):  
Iqbal Akhtar Khan ◽  
Hamza Iltaf Malik
Keyword(s):  
Hospital Admissions ◽  
Hospital Readmissions ◽  
Public Health Problem ◽  
Well Being ◽  
Care Utilization ◽  
Global Public Health ◽  
Increased Risk ◽  
Co Morbidity ◽  
Pulmonary Manifestations ◽  
The Impact

COPD is a highly incapacitating global public health problem, with pulmonary and extra-pulmonary manifestations and usually associated with significant concomitant chronic diseases. With enhanced understanding, it has extensively been reported as a complex, heterogeneous and dynamic disease affecting patients’ health beyond pulmones. Depression, with prevalence of 322 million people, is a major contributor to the overall global burden of disease. In various epidemiological and clinical studies, its prevalence among patients with COPD varies from 18% to 80%. This deadly duo leads to excessive health care utilization rates and costs including increased rates of exacerbation, sub-optimal adherence to prescribed medications, increased hospital admissions, longer hospital stays and increased hospital readmissions. Moreover, there is increased risk of suicidal ideation, suicidal attempts, and suicidal drug overdose. It is a pity that, in significant cases, the co-morbidity remains under-recognized and under-treated. The impact of prevailing COVID 19 pandemic, on the dual burden of COPD and depression, and possible remedial measures including “The 6 ways to boost one’s well-being-by Mental Heath UK, “The Living with the Times” toolkit--by WHO” and innovative add-ons like Dance Movement Therapy and Musical Engagement Therapy have been discussed.

scholarly journals The impact of coronavirus disease 2019 (COVID-19) on older adults with an intellectual disability during the first wave of the pandemic in Ireland

2021 ◽  
Vol 4 ◽  
pp. 93
Author(s):  
Mary McCarron ◽  
Darren McCausland ◽  
Retha Luus ◽  
Andrew Allen ◽  
Fintan Sheerin ◽  
...  
Keyword(s):  
Intellectual Disability ◽  
Repeated Measures ◽  
Well Being ◽  
Adverse Outcomes ◽  
Multiple Infection ◽  
Similar Proportion ◽  
Related Data ◽  
Increased Risk ◽  
The Impact ◽  
Health And Well Being

Background: People with intellectual disability have increased risk of exposure to and adverse outcomes from coronavirus disease 2019 (COVID-19).They also face challenges to mental health and well-being from COVID-19-related social restrictions and service closures. Methods: Data from a supplemental COVID-19 survey from the Intellectual Disability Supplement to the Irish Longitudinal Study on Ageing (IDS-TILDA) (n=710) was used to assess outcomes from the first infection wave of COVID-19 among adults with intellectual disability aged 40+ years in Ireland. Data was gathered on testing, for symptoms and outcomes; procedures to manage COVID-19; and both stress/anxiety and positive experiences during the pandemic. Demographic and health-related data from the main IDS-TILDA dataset was included in analyses. Results: High rates were identified of health conditions associated with poorer COVID-19 outcomes, including overweight/obesity (66.6%, n=365), high cholesterol (38.6%, n=274) and cardiovascular disease (33.7%, n=239). Over half (53.5%, n=380) reported emotional, nervous or psychiatric disorders. Almost two-thirds (62.4%, n=443) were tested for COVID-19, with 10% (n=71) reporting symptoms and 2.5% (n=11) testing positive. There were no instances of COVID-19 related mortality. Common symptoms included fatigue, fever, and cough. Some participants (7.8%, n=55) moved from their usual home, most often to isolate (n=31) or relocate to a family home (n=11). Three-quarters (78.7%) of those who were symptomatic or who tested positive had plans to manage self-isolation and two-thirds were able to comply with guidelines. Over half (55%, n=383) reported some COVID-19 related stress/anxiety; and a similar proportion reported positive aspects during this period (58%, n=381). Conclusions: Our data suggests that people with intellectual disability avoided the worst impacts of COVID-19 during the first infection wave in Ireland. Nevertheless, participants’ health profiles suggest that this population remains at high risk for adverse infection outcomes. Repeated measures are needed to track health and well-being outcomes across multiple infection waves.

The impact of fly-in, fly-out (FIFO) on the health and well-being of employees: what organisations can do to mitigate the risks and improve outcomes

2020 ◽  
Vol 60 (2) ◽  
pp. 397
Author(s):  
Elizabeth Brook ◽  
Melanie Freeman ◽  
Graeme Ditchburn
Keyword(s):  
Mental Health ◽  
Well Being ◽  
Perceived Support ◽  
Work Family Conflict ◽  
Code Of Practice ◽  
Increased Risk ◽  
Work Family ◽  
The Impact ◽  
Levels Of Support ◽  
Health And Well Being

Concerns about the increased risk to mental health in fly-in, fly-out (FIFO) workers in the construction and resources industries led to increased public and government scrutiny, resulting in Western Australia’s adoption of a code of practice. In general, research has found that a higher incidence of psychological distress in FIFO workers has resulted from high compression rosters and work–family conflict, as well as feelings of isolation. Risk controls, such as perceived levels of support, have been found to be significantly related to improved mental health and organisational outcomes. Organisations need to address the non-financial needs of their workers and look to develop their perceived support, job satisfaction and adjustment to the FIFO lifestyle. This paper outlines practical risk controls and interventions organisations can take to improve psychological and organisational outcomes.

scholarly journals The Potential Therapeutic Value of Medicinal Plants in the Management of Metabolic Disorders

Molecules ◽  
2020 ◽  
Vol 25 (11) ◽  
pp. 2669 ◽  
Author(s):  
Trevor T. Nyakudya ◽  
Thulani Tshabalala ◽  
Rachael Dangarembizi ◽  
Kennedy H. Erlwanger ◽  
Ashwell R. Ndhlala
Keyword(s):  
Risk Factors ◽  
Medicinal Plants ◽  
South African ◽  
Health Benefits ◽  
Well Being ◽  
High Energy ◽  
Biologically Active ◽  
Potential Health ◽  
Increased Risk ◽  
The Impact

Metabolic syndrome (MetS) is a prevalent, multifactorial and complex disease that is associated with an increased risk of developing diabetes and other major cardiovascular complications. The rise in the global prevalence of MetS has been attributed to genetic, epigenetic, and environmental factors. The adoption of sedentary lifestyles that are characterized by low physical activity and the consumption of high-energy diets contributes to MetS development. Current management criteria for MetS risk factors involve changes in lifestyle and the use of pharmacological agents that target specific biochemical pathways involved in the metabolism of nutrients. Pharmaceutical drugs are usually expensive and are associated with several undesirable side effects. Alternative management strategies of MetS risk factors involve the use of medicinal plants that are considered to have multiple therapeutic targets and are easily accessible. Medicinal plants contain several different biologically active compounds that provide health benefits. The impact of phytochemicals present in local medicinal plants on sustainable health and well-being of individuals has been studied for many years and found to involve a plethora of complex biochemical, metabolic, and physiological mechanisms. While some of these phytochemicals are the basis of mainstream prescribed drugs (e.g., metformin, reserpine, quinine, and salicin), there is a need to identify more medicinal plants that can be used for the management of components of MetS and to describe their possible mechanisms of action. In this review, we assess the potential health benefits of South African ethnomedicinal plants in protecting against the development of health outcomes associated with MetS. We aim to provide the state of the current knowledge on the use of medicinal plants and their therapeutically important phytochemicals by discussing the current trends, with critical examples from recent primary references of how medicinal plants are being used in South African rural and urban communities.

scholarly journals The Impact of Novel Anticoagulants on the Upper Gastrointestinal Tract Mucosa

Medicina ◽  
2020 ◽  
Vol 56 (7) ◽  
pp. 363
Author(s):  
Lubomir Mihalkanin ◽  
Branislav Stancak
Keyword(s):  
Gastrointestinal Tract ◽  
Protective Factor ◽  
Bleeding Risk ◽  
Endoscopic Biopsy ◽  
Upper Gastrointestinal Tract ◽  
Bleeding Detection ◽  
Increased Risk ◽  
Clinically Significant ◽  
The Impact ◽  
Upper Gastrointestinal

Background and objectives: Although treatment with novel oral non-vitamin K antagonist 3anticoagulants (NOACs) is associated with an overall decrease in hemorrhagic complications compared to warfarin, the incidence of gastrointestinal bleeding remains contradictory. Materials and Methods: After the exclusion of patients with pre-existing pathological lesions in the upper gastrointestinal tract (GIT) on esophageal-gastroduodenoscopy (EGD) at entry, a cohort of 80 patients (mean age of 74.8 ± 2.0 years) was randomly divided into four equivalent groups, treated with dabigatran, rivaroxaban, apixaban, or warfarin. Patients were prospectively followed up for three months of treatment, with a focus on anamnestic and endoscopic signs of bleeding. In addition, bleeding risk factors were evaluated. Results: In none of the patients treated with warfarin or NOACs was any serious or clinically significant bleeding recorded within the follow-up period. The incidence of clinical bleeding and endoscopically detected bleeding in the upper GT after three months of treatment was not statistically different among groups (χ2 = 2.8458; p = 0.41608). The presence of Helicobacter pylori (HP) was a risk factor for upper GIT bleeding (p < 0.05), while the use of proton pump inhibitors (PPIs) was a protective factor (p = 0.206; Spearman’s correlation coefficient = 0.205). We did not record any post-biopsy continued bleeding. Conclusions: No significant GIT bleeding was found in any of the treatment groups, so we consider it beneficial to perform routine EGD before the initiation of any anticoagulant therapy in patients with an increased risk of upper GIT bleeding. Detection and eradication of HP as well as preventive PPI treatment may mitigate the occurrence of endoscopic bleeding. Endoscopic biopsy during the NOAC treatment is safe.

scholarly journals Towards Heat Stress Management in Small Ruminants – A Review

2017 ◽  
Vol 17 (1) ◽  
pp. 59-88 ◽  
Author(s):  
Amani Al-Dawood
Keyword(s):  
Heat Stress ◽  
Small Ruminants ◽  
Well Being ◽  
Economic Losses ◽  
Natural Immunity ◽  
Animal Products ◽  
Sheep And Goats ◽  
Agriculture Sector ◽  
Hot Climate ◽  
The Impact

Abstract Small ruminants (sheep and goats) play a predominant role in the economy of million people, and have provided meat, milk, skin, wool and fiber for centuries. Animals undergo various kinds of stressors, i.e. physical, nutritional, chemical, psychological and heat stress (HS). Among all, HS is the most concerning at present in the ever-changing climatic scenario. Climate change is the most serious long-term challenge faced by small ruminants’ owners worldwide. HS results in decreased growth, reproduction, production, milk quantity and quality, as well as natural immunity, making animals more vulnerable to diseases, and even death. Thus, HS results in great economic losses, emphasizing the necessity to objectively assess animal welfare. The increasing demand for animal products paralleled by the frequent hot climate is a serious threat for the agriculture sector. The ability of sheep and goats to cope with HS without harming their welfare and productive performance has been often overrated. To date, little attention has been paid to comprehensive detailed data on the adverse effect of HS on sheep and goats. Therefore, this review discusses in detail the sheep and goats’ behavioral, physiological, molecular/cellular, hematological, biochemical and immunological responses under HS conditions. In addition, this review also presents the adverse effects of HS on reproduction and fertility, milk quantity and quality, feed intake, and water consumption of sheep and goats. Finally, this review suggests various methods for HS alleviation. In conclusion, HS impairs productivity and well-being in sheep and goats. The improved understanding of the impact of HS on small ruminants will help in developing management techniques to alleviate HS and highlighting the need for future researches on HS in sheep and goats.

scholarly journals The Associations Between Preceptor Team Lead Relationships and Resident Wellness in an Academic Medicine Setting: An Exploratory Study

PRiMER ◽  
2017 ◽  
Vol 1 ◽  
Author(s):  
Cesar A. Gonzalez ◽  
Natalie E Gentile ◽  
Kurt B Angstman ◽  
Julia R Craner ◽  
Robert P. Bonacci
Keyword(s):  
Family Medicine ◽  
Self Care ◽  
Well Being ◽  
Increased Risk ◽  
Resident Wellness ◽  
Team Based Care ◽  
Perception Of Support ◽  
The Impact ◽  
The Relationship ◽  
Family Medicine Residents

Background: Lack of wellness among physicians has been associated with increased risk for physical and mental illness, interpersonal discord, and occupational liability. In academic primary care practices, physician wellness and self-care behaviors have been associated with improved patient outcomes. With the increase in team-based care structures in primary care clinics and residencies there may be opportunities to promote wellness among primary clinicians, particularly among resident physicians who are at increased risk for decreased well being. The primary objective of the study was to test an a priori hypothesis that family medicine residents’ perception of support from preceptor team leads would be associated with wellbeing. A secondary objective of the study was to test a post hoc hypothesis that examined whether the relationship between residents’ perception of support from their preceptor team leads would be associated with residents’ well being, while controlling for self-care behaviors. Methods: Our study utilized a prospective cross-sectional design with purposive sampling to survey family medicine residents. Data were collected in February 2016. The survey was sent out to 58 family medicine residents across three family medicine residencies at Mayo Clinic. The survey response rate was 55% (n=32); Ten (31.3%) residents reported being in their PGY-1, 11 (34.4%) in PGY-2; and 11 (34.4%) in PGY-3; participants included 19 (59.4%) women and 13 (40.6%) men. The Brief Resident Wellness Profile (BRWP) was utilized to assess family medicine residents’ perceived sense of professional accomplishment and mood in the past week. Results: In bivariate correlational analyses, increased perception of support from preceptor team leads (r=.40, P&lt;.01) and reporting a male gender (r=.43, P&lt;.01) was associated with increased resident wellness. In exploratory multivariate analysis, results suggested that while controlling for gender, frequency of self-care behaviors, and perceived preceptor team lead support, a one-point change on rating of perceived team leader support is associated with a 1.69 increase in resident wellness score on the BRWP. Conclusions: Our results provide preliminary evidence to support the relationship between preceptor team lead support and resident wellness in team-based care, above and beyond the impact that self-behaviors have on wellness. Our findings suggest evidence for the subsequent study of the impact of preceptor team lead relationship quality on resident wellness. 

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