scholarly journals POS1377 SOME PARAMETERS OF ENDOTHELIAL FUNCTION IN PATIENTS WITH IDIOPATHIC AVASCLAR NECROSIS

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 970.2-971
Author(s):  
K. Gudkevich ◽  
N. Martusevitch ◽  
E. Dashkevich
Keyword(s):  
Femoral Head ◽  
Endothelial Function ◽  
Vitamin B12 ◽  
Microvascular Dysfunction ◽  
Control Group ◽  
Secondary Osteoarthritis ◽  
Treatment And Prevention ◽  
Study Results ◽  
And Gender ◽  
Femoral Condyles

Background:Avascular necrosis (AN) is a disease, which is the result of blood flow disturbance and necrosis of the bone tissue. It affects predominantly men of working age and steadily progresses to secondary osteoarthritis. AN is a multifactorial disease. In the context of vascular hypothesis it is of particular interest to evaluate homocysteine and its metabolism in patients with AN.Objectives:The aim of the present study was to evaluate some parameters of endothelial function in patients with AN of the femoral head or femoral condyles in order to determine possible treatment and prevention options.Methods:We included 53 patients with AN of the femoral head or femoral condyles into the study. The patients were aged 49 (35-62) years, 58,49% (n=31) were male. The inclusion criteria was diagnosis of AN confirmed by X-Ray, CT or MRI. The exclusion criteria were: traumatic AN, Legg-Calve-Pertes disease, connective tissue systemic diseases. We recruited 51 patients into the control group. The groups were comparable by age and gender. In order to analyse engothelial function in the groups we investigated the following serum parameters: homocysteine, vitamin B12, folate. In order to analyse the data obtained we used non-parametric statistics.Results:We determined a higher level of homocysteine in patients with AN (12,15 (7,55-14,60) vs. 8,18 (6,57-10,70) mcmol/l in the control group, p=0,04). Also we observed almost equal levels of vitamin B12 in patients with AN an in the control group (531,95 (340,80-793,55) vs. 532,75 (417,60-669,7) pg/ml, p=0,99). The level of folate was lower in the study group (5,66 (3,83-6,83) vs. 6,99 (5,02-10,38) ng/ml, p=0,01).Conclusion:The data obtained show that homocysteine level in patients with AN is higher. This can be a consequence of folate deficiency, which takes part in homocysteine metabolism. Therefore, homocysteine metabolism disturbances can lead to endothelial dysfunction, which results in cardiovascular events in the heart, brain, kidneys [1] as well as in the bone, according to the study results. Folate supplement is the possible way of AN treatment and prevention.References:[1]Nowroozpoor A, Gutterman D, Safdar B. Is microvascular dysfunction a systemic disorder with common biomarkers found in the heart, brain, and kidneys? - A scoping review. Microvasc Res. 2021 Mar;134:104123. doi: 10.1016/j.mvr.2020.104123. Epub 2020 Dec 15. PMID: 33333140.Disclosure of Interests:None declared

scholarly journals Thiol-disulphide homeostasis in essential thrombocythemia patients

2019 ◽  
Vol 38 (4) ◽  
pp. 475-480 ◽  
Author(s):  
Aysun Şentürk Yıkılmaz ◽  
Şule Mine Bakanay ◽  
Sema Akinci ◽  
Murat Alisik ◽  
Özcan Erel ◽  
...  
Keyword(s):  
Platelet Function ◽  
Control Group ◽  
Essential Thrombocytosis ◽  
Jak2 Mutation ◽  
Total Thiol ◽  
Study Results ◽  
The Status ◽  
Thrombotic Complications ◽  
And Gender ◽  
Oxidation Mechanisms

Summary Background This study aimed to show the status of thioldisulphide homeostasis in essential thrombocytosis patients, which is known to play a role in platelet function. Methods The study included 27 ET patients and a control group of 36 healthy subjects. Serum total (–SH + –S–S–) and native (–SH) thiol levels were measured in all subjects using an automatic method. Results Age and gender distribution were similar in both groups. Compared with the control group, in the ET group, there were increased native thiol and total thiol levels (p = 0.001, p = 0.046). There was no correlation between thiol, total thiol and disulphide ratios with Jak2 mutation, hemorrhage and thrombosis. A positive correlation was determined between thrombosis and thiol disulphide homeostasis (p = 0.058). The study results showed that thiol-disulphide homeostasis shifted to the proliferative side in ET, in which ineffective erythropoiesis was predominant. It is also known that platelets are more active in ET cases and thiol disulphide balance is important in platelet function. Conclusions This result suggests that thrombotic complications may be reduced if the formation is achieved of mechanisms (oxidation mechanisms) that will trigger the increase of disulphide groups. However, more extensive research is needed on this subject.

scholarly journals Evaluation of Oral-Dental Health in Patients with Periodontal Pathology and Diabetes

2021 ◽  
Vol 26 (2) ◽  
pp. 59-61
Author(s):  
Andreea Dinu ◽  
Manuela Mihalache
Keyword(s):  
Research Group ◽  
Rural Areas ◽  
Dental Health ◽  
Diagnostic Techniques ◽  
Health Condition ◽  
Control Group ◽  
Treatment And Prevention ◽  
Study Results ◽  
Urban And Rural Areas ◽  
Questionnaire Method

Abstract The present research attempts to assess the orodental health status of patients in the research group. The research group has been composed of 210 subjects, from both urban and rural areas, having periodontal pathologies and disorders of the glucidic metabolism. In order to obtain information about the orodental health condition as well as the orodental hygiene, we have applied the questionnaire method, this being well individualized and adapted to be relevant to the present study. Following the statistical analysis of the results, it appears that the subjects of the research group show a more pronounced periodontal pathology comparative to the control group. The study results highlight the importance of dentists’ knowledge of diagnostic techniques, treatment and prevention of orodental pathologies on patients with diabetes.

Is There a Supporting Value of Platelet Distribution Width and Plateletcrit in the Diagnosis of Acute Appendicitis in Children?

2019 ◽  
Vol 14 (04) ◽  
pp. 176-179
Author(s):  
Salim Bilici ◽  
Tülin Öztaş ◽  
Ahmet Dursun
Keyword(s):  
Acute Appendicitis ◽  
Demographic Data ◽  
Diagnostic Value ◽  
Control Group ◽  
Healthy Children ◽  
Platelet Distribution Width ◽  
Blood Cell Count ◽  
Distribution Width ◽  
Study Results ◽  
And Gender

AbstractThis study was designed to investigate the diagnostic value of platelet distribution width (PDW) and plateletcrit (PCT) for acute appendicitis in childhood. A retrospective review was conducted of the records of 373 patients younger than 18 years who underwent appendectomy. Demographic data, white blood cell count, neutrophil count, and PDW and PCT values were recorded for all patients. A control group was formed of age- and gender-matched healthy children. The study results showed that the PDW level is not valuable as a marker for the diagnosis of acute appendicitis in children. PCT levels were determined to be statistically significantly increased in pediatric acute appendicitis with low specificity.

scholarly journals Effektivnost' primeneniya preparata«Magnerot®» pri proyavleniyakh sindromasosudistykh narusheniy i gemorragicheskogosindroma u bol'nykh s idiopaticheskimprolapsom mitral'nogo klapana

2011 ◽  
Vol 2 (1) ◽  
pp. 13-17
Author(s):  
Evgeniya Vladimirovna Akatova ◽  
Olesya Petrovna Nikolin ◽  
Anatoliy Ivanovich Martynov
Keyword(s):  
Severe Form ◽  
Controlled Study ◽  
Control Group ◽  
Study Group ◽  
Vascular Disorders ◽  
Study Results ◽  
Comprehensive Examination ◽  
The Mean ◽  
And Gender ◽  
Single Blind

Summary. Aim. To evaluate the efficiency of placebo-controlled magnerot use on vascular and hemorrhagic manifestations in patients with idiopathic mitral valve prolapse (MVP). Subjects and methods. Seventy-four patients (31,7% males and 68,3% women) with idiopathic MVP were examined during a single-blind placebo-controlled study. They were randomized into 2 groups: 1) magnerot (a study group) and 2) placebo (a control group). The mean age of the study group patients was 30,80,4 years. The placebo group was matched by age (mean age 31,10,2) and gender. There was a female preponderance among the examinees in both groups. The study group patients received MagnerotR tablets containing 500 mg of Mg orotate (32,8 Mg of elementary Mg) in a daily dose of 3000 mg (196,8 mg of elementary Mg) for 6 months. All the patients underwent comprehensive examination before and 6 months after the study. Results. A clinical significant reduction in the degree of vascular disorders was noted in 71,3% of the patients with MVP. The incidence of vascular disorders remained virtually unchanged in the study group. Vascular disorders were significantly alleviated after the therapy. If before the therapy, mild, moderate, and severe vascular disorders were diagnosed in 30,2, 55,9, and 13,9% of cases, respectively; whereas after the therapy these were absent in 16,3% of cases; the patients with mild vascular disorders increased by 2,5-fold and their severe form was undetected. The clinical effect of the therapy on the severity of hemorrhagic syndrome was observed in 81,4% of patients (75% males and 89,5% females) and the therapeutic efficiency that very frequently corresponded to clinical improvement was seen in 2,3%. Conclusion. The effect of magnerot therapy is shown to significantly reduce the incidence and degree of vascular disorders and hemorrhagic syndrome and their clinical picture as a whole.

scholarly journals Presence and absence of carbohydrate metabolism disorders as a factor influencing development of vitamin B12 deficiency

2020 ◽  
Vol 37 (4) ◽  
pp. 5-10
Author(s):  
A. R. Guseinova
Keyword(s):  
Risk Factor ◽  
Vitamin B12 ◽  
Carbohydrate Metabolism ◽  
Vitamin B12 Deficiency ◽  
Control Group ◽  
Study Results ◽  
B12 Deficiency ◽  
Mild Deficiency ◽  
Presence And Absence ◽  
Biochemical Indices

Objective. To study the significance of the presence and absence of carbohydrate metabolism disorders as a factor affecting the development of vitamin B12 deficiency. Materials and methods. The data of 206 subjects, forming two main groups were analyzed: the group of carbohydrate metabolism disorders (CMDs), which included 76 women and 71 men (n = 147); the control group, which included 33 women and 26 men (n = 59). The inclusion criteria were the following: age over 35, availability of anamnestic data on pharmacotherapy, availability of data to clarify the state of carbohydrate metabolism, availability of data on vitamin B12 and some other biochemical indices. Vitamin B12 levels 221 pmol / l were considered normal, vitamin B12 levels from 148 pmol / l to 221 pmol/l were considered borderline (or mild deficiency), and levels of 148 pmol / l or less were considered severe vitamin B12 deficiency. Results. The group of absent carbohydrate metabolism disorders included 59 persons and the group of carbohydrate metabolism disorders (CMDs) included T2DM patients (n = 123) and individuals with prediabetes (n = 24), i.e. the total number of the examined persons in CMD group was equal to 147. The average level of vitamin B12 in the control group (n = 59) was 401.6 and 138.06 pmol / l, and in CMD group (n = 147) it was equal to 342.1 133.10 pmol/l. The differences between the groups were statistically significant (p 0.01), that suggested the significance of CMDs as a risk factor for vitamin B12 deficiency. Vitamin B12 deficiency was combined with the presence of CMDs in 32 (21.8 %) cases. In 115 cases (78.2 %), the presence of CMDs was combined with the absence of vitamin B12 deficiency. In 8 cases (13.5 %), there were no CMDs, but there was vitamin B12 deficiency. In 51 cases (86.4 %), no CMDs and vitamin B12 deficiency was noted. Conclusions. Despite the presence of a statistically significant decrease in vitamin B12 levels in CMD group (342.1 133.10 pmol / l vs 401.6 and 138.06 pmol/ l; p 0.01) and a high incidence rate of vitamin B12 deficiency in CMD group (21.8 % and 13.5 %, respectively), the study results do not allow us to consider the presence of CMDs to be the risk factor for vitamin B12 deficiency.

Penatalaksanaan IMD pada Ibu Postpartum Sectio Caesarea Mempengaruhi Status Gizi dan Kecepatan Produksi ASI

2020 ◽  
Vol 2 (2) ◽  
pp. 112-120
Author(s):  
Nursari Abdul Syukur ◽  
Susi Purwanti
Keyword(s):  
Breast Milk ◽  
Nutritional Status ◽  
Milk Production ◽  
Quantitative Research ◽  
Milk Protein ◽  
Sectio Caesarea ◽  
Control Group ◽  
P Value ◽  
Study Results

Many mothers who give birth to Sectio Caesarea (SC) do not Initiate Early Breastfeeding (IMD), which fails exclusive breastfeeding. This study aimed to determine the effect of IMD management in postpartum SC mothers on nutritional status, speed of milk production, and quality of breast milk protein. Method: quantitative research with quasi approach experiment. The research design used was a pre-post-test control non-equivalent control group. A sampling of this study used the Consecutive method sampling with a sample of 20 mothers who gave birth by cesarean section (SC). Hypothesis testing uses the independent t-test and the Mann-Whitney test. The study results showed an influence on the management of IMD in postpartum SC mothers on the speed of ASI production (p-value=0.004) and nutritional status (p-value=0.028). There was no effect of IMD management on postpartum SC mothers on the quality of breast milk protein (p-value = 0.543). This study recommends that the hospital implement an IMD promotion program before the abdominal wall is closed as a form of intervention to increase milk production and maternal nutritional status

Modern approaches to the treatment of mastitis in women of reproductive age

2016 ◽  
pp. 191-108
Author(s):  
A.A. Sukhanova ◽  
◽  
Yu.M. Melnik ◽  
O.O. Karlova ◽  
◽  
...  
Keyword(s):  
Ultrasound Examination ◽  
Clinical Signs ◽  
Reproductive Age ◽  
Herbal Remedies ◽  
Control Group ◽  
Women Of Reproductive Age ◽  
Clinical Method ◽  
Gynecological Examination ◽  
Study Results ◽  
Observation Period

The aim of the study: to study the efficacy and safety of use Mastofemin in the treatment of various forms of mastitis in women of reproductive age. Materials and methods. The study included 62 women of reproductive age (mean age of 33.5±2.3 years) who were screened in the Kiev city center reproductive and perinatal medicine. Women were divided into 2 groups. The first (main) group consisted of 32 patients who received the proposed treatment using herbal remedies Mastofemin 1 capsule 2 times per day for 3 months; 30 patients of the second (control) group were under observation and received no treatment. These groups were representative and homogeneous on age, clinical symptoms and sonographic characteristics. The clinical method included evaluation of complaints of patients, anamnesis, presence of concomitant gynecologic pathology, inspection, palpation of the lymph nodes and the breast and obtaining a discharge from the nipples to conduct cytological examination, which allowed excluding from the study women with suspected malignancy of the process. All the patients were performed ultrasound examination of the breast. The review was supplemented with vaginal gynecological examination and ultrasound examination of small pelvis organs to assess the condition of the uterus and its appendages, the diagnosis of gynecological diseases. Results. Summarizing obtained in this study results one should stress the positive long-term effect of applying Mastofemin for the treatment of proliferative changes of the breast in women of reproductive age. This is manifested by a decrease in the intensity of clinical signs of mastitis, consistent with the results of sonographic control. Established positive dynamics in the treatment of cystic mastitis, dectective and when combined cystic mastopathy with dectective. In the control group of patients for a given observation period (6 months) no significant changes in clinical signs of mastitis and sonographic characteristics. Regression of disease has not occurred in any of the patients, in 2 patients increased sensitivity of the breast after 6 months moved to the soreness. Sonographic characteristics of mastitis during the observation period did not change. Thus, the use of Mastofemin aimed at pathogenetic treatment of mastitis and prevention of breast cancer. Conclusion. Application of Mastofemin during the treatment of mastitis in women of reproductive age significantly improves the clinical condition of patients; reduce the subjective and objective symptoms of the disease. The positive effect of the treatment with Mastofemin proved in the case of the treatment of sonographic following forms of mastitis: cystic mastopathy, cystic mastopathy with dectectasy. Mastofemin may be the drug of choice for complex conservative monotherapy in women of reproductive age with proliferative changes in the breast, and can also be used as part of complex treatment in patients with diffuse changes of the breast when combined with hyperplastic processes of the myometrium and endometrium. Keywords: mastopathy, breast gland, herbal medicine, herbal remedies, Mastofemin.

Brief psycho-education for caregivers of persons with first episode psychosis

2018 ◽  
Vol 9 (01) ◽  
Author(s):  
Praful Prabhuappa Kapse ◽  
Manisha Kiran
Keyword(s):  
First Episode Psychosis ◽  
First Episode ◽  
Control Group ◽  
Episode Psychosis ◽  
Study Results ◽  
Before And After ◽  
Quasi Experimental ◽  
Expressed Emotions ◽  
Experimental Group ◽  
Group Family

Caring for the persons with first episode psychosis is challenging and demanding. It may lead to the increased burden, expressed emotions among the caregivers. The numerous studies have shown that high burden and negative expressed emotions among caregivers can lead to early relapse in the patients with first episode psychosis. To evaluate the effects of the brief psychoeducation on the caregivers burden and expressed emotions. A quasi experimental - before and after with control group research design was adopted for the study. A total of 60 caregivers have participated in the study, of which 30 caregivers in experimental group and 30 caregivers in the control group. Family Burden Interview Schedule (Pai and Kapoor, 1981) and Attitude Questionnaire (Sethi et al., 1981) was used to assess caregiver's burden and expressed emotions. At end of the psychoeducation intervention, burden among caregivers and negative expressed emotions of the caregivers have significantly reduced. The positive expressed emotions have been increased. Study results demonstrates the importance of psychoeducation intervention in reducing the burden and negative expressed emotions.

HUBUNGAN TUNGAU DEBU RUMAH, PAPARAN ASAP ROKOK DAN RIWAYAT PENYAKIT KELUARGA TERHADAP KEJADIAN ASMA BRONKIAL PADA ANAK USIA 5 – 10 TAHUN DI WILAYAH KERJA PUSKESMAS LEMPAKE KOTA SAMARINDA TAHUN 2016

2018 ◽  
Vol 3 (1) ◽  
pp. 1
Author(s):  
Sri Evi New Yearsi Pangadongan ◽  
Agustina Rahyu ◽  
Selvy Pasulu
Keyword(s):  
Cigarette Smoke ◽  
Bronchial Asthma ◽  
Sampling Technique ◽  
Total Sample ◽  
Control Group ◽  
Case Group ◽  
Chi Square ◽  
History Of ◽  
Weather Changes ◽  
And Gender

Bronchial Asthma generally starts from childhood which is condition where respiration channel experiences constriction because of hyperactivity with some specific stimulation which cause inflammation. Some risk factors are smoking exposure of cigarette smoke, weather changes, mite on house dirt, pet and history of family sickness. The purpose of this research is to know Relation of mite on house dirt, exposure of cigarette smoke  and history of family sickness with bronchial asthma incident to child 5 – 10  years old on working area of Puskesmas Lempake Samarinda City in 2016. Method which used was analytic survey with Case Control approaching. The total sample was 36 children which consisted of 18 case group and 18 control group with matching by using age and gender which submitted with Purposive Sampling technique. Data Analysis used Chi Square with wrong degree α = 0,005. The result showed that there was relation of mite of house dirt (p = 0,006), history of family sickness (p = 0,001) and no relation with exposure of cigarette smoke (p = 0,370) with bronchial asthma incident to child 5 – 10 years old on working area of Puskesmas Lempake Samarinda City in 2016.

CLINICAL SIGNIFICANCE OF SERUM CAVEOLIN-1 LEVELS IN GASTRIC CANCER PATIENTS

2018 ◽  
Vol 40 (4) ◽  
pp. 323-327 ◽  
Author(s):  
F Tas ◽  
S Karabulut ◽  
K Erturk ◽  
D Duranyildiz
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Histological Grade ◽  
Clinical Importance ◽  
Disease Stage ◽  
Control Group ◽  
Tissue Samples ◽  
Caveolin 1 ◽  
Study Results ◽  
Gastric Cancer Patients

Aim: Caveolin-1 plays a significant role in the pathogenesis of various carcinomas and its expression affects the survival of cancer patients. However, the molecular function of caveolin-1 and its possible clinical importance has remained uncertain in gastric cancer. No clinical trial has examined serum caveolin-1 levels in gastric cancer patients so far, instead all available results were provided from studies conducted on tissue samples. In the current study, we analyzed the soluble serum caveolin-1 levels in gastric cancer patients, and specified its associations with the clinical factors and prognosis. Material and Methods: Sixty-three patients with pathologically confirmed gastric cancer were enrolled into the trial. Serum caveolin-1 concentrations were detected by ELISA method. Thirty healthy subjects were also included in the study. Results: The median age of patients was 62 years, ranging from 28 to 82 years. The serum caveolin-1 levels in gastric cancer patients were significantly higher than those in control group (p < 0.001). The common clinical parameters including patient age, sex, lesion localization, histopathology, histological grade, disease stage, and various serum tumor markers (e.g. LDH, CEA, and CA 19.9) were not found to be associated with serum caveolin-1 levels (p > 0.05). Similarly, no correlation existed between serum caveolin-1 concentration and chemotherapy responsiveness (p = 0.93). Furthermore, serum caveolin-1 level was not found to have a prognostic role (p = 0.16). Conclusion: Even though it is neither predictive nor prognostic, serum caveolin-1 level may be a valuable diagnostic indicator in patients with gastric cancer. Key

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