scholarly journals Cefquinome Controlled Size Submicron Particles Precipitation by SEDS Process Using Annular Gap Nozzle

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Kefeng Xiao ◽  
Weiqiang Wang ◽  
Dedong Hu ◽  
Yanpeng Qu ◽  
Zhihui Hao ◽  
...  
Keyword(s):  
Particle Size ◽  
Xrd Analysis ◽  
Solution Concentration ◽  
Operating Conditions ◽  
Submicron Particles ◽  
Optimal Operating ◽  
Surface Appearance ◽  
Precipitation Temperature ◽  
Annular Gap ◽  
Feeding Speed

An annular gap nozzle was applied in solution enhanced dispersion by supercritical fluids (SEDS) process to prepare cefquinome controlled size submicron particles so as to enhance their efficacy. Analysis results of orthogonal experiments indicated that the concentration of solution was the primary factor to affect particle sizes in SEDS process, and feeding speed of solution, precipitation pressure, and precipitation temperature ranked second to fourth. Meanwhile, the optimal operating conditions were that solution concentration was 100 mg/mL, feeding speed was 9 mL/min, precipitation pressure was 10 MPa, and precipitation temperature was 316 K. The confirmatory experiment showed that D50 of processed cefquinome particles in optimal operating conditions was 0.73 μm. Moreover, univariate effect analysis showed that the cefquinome particle size increased with the increase of concentration of the solution or precipitation pressure but decreased with the increase of solution feeding speed. When precipitation temperature increased, the cefquinome particle size showed highest point. Moreover, characterization of processed cefquinome particles was analyzed by SEM, FT-IR, and XRD. Analysis results indicated that the surface appearance of processed cefquinome particles was flakes. The chemical structure of processed cefquinome particles was not changed, and the crystallinity of processed cefquinome particles was a little lower than that of raw cefquinome particles.

Liquid antisolvent recrystallization and solid dispersion of flufenamic acid with polyvinylpyrrolidone K-30

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Rahul Kumar ◽  
Sanjay Kumar ◽  
Pranava Chaudhari ◽  
Amit K. Thakur
Keyword(s):  
Particle Size ◽  
Dissolution Rate ◽  
Solid Dispersion ◽  
Fine Particles ◽  
Xrd Analysis ◽  
Solution Concentration ◽  
Injection Rate ◽  
Size Reduction ◽  
Flufenamic Acid ◽  
Particle Size Reduction

Abstract Flufenamic acid (FFA) is a Biopharmaceutical Classification System- II (BCS-II) class drug with poor bioavailability and a lower dissolution rate. Particle size reduction is one of the conventional approaches to increase the dissolution rate and subsequently the bioavailability. The use of the liquid antisolvent method for particle size reduction of FFA was studied in this work. Ethanol and water were used as solvent and antisolvent, respectively. Experimental parameters such as solution concentration (10–40 mg/ml), flow rate (120–480 ml/h), temperature (298–328 K) and stirring speed (200–800 rpm) were investigated. Furthermore, the solid dispersion of FFA was prepared with polyvinylpyrrolidone K-30 (PVP K-30) with different weight ratios (1:1, 1:2, 1:3 and 1:4) and samples were characterized using SEM, FTIR and XRD techniques. The experimental investigation revealed that higher values of concentration, injection rate, stirring speed, along with lower temperature favored the formation of fine particles. SEM analysis revealed that the morphology of raw FFA changed from rock-like to rectangular-like after liquid antisolvent recrystallization. FTIR analysis validated the presence of hydrogen bonding between FFA and PVP in solid dispersion. XRD analysis showed no significant change in the crystallinity of the processed FFA.

scholarly journals Optimal Operating Conditions for Adsorption of Heavy Metals from an Aqueous Solution by an Agriculture Waste

2021 ◽  
Vol 22 (2) ◽  
pp. 27-35
Author(s):  
Khalid Khazzal Hummadi
Keyword(s):  
Heavy Metals ◽  
Aqueous Solution ◽  
Particle Size ◽  
Adsorption Capacity ◽  
Operating Conditions ◽  
Polluted Water ◽  
Batch Adsorption ◽  
Scale Production ◽  
Optimal Operating ◽  
Date Pits

   The aim of this work is to detect the best operating conditions that effect on the removal of Cu2+, Zn2+, and Ni2+ ions from aqueous solution using date pits in the batch adsorption experiments. The results have shown that the Al-zahdi Iraqi date pits demonstrated more efficient at certain values of operating conditions of adsorbent doses of 0.12 g/ml of aqueous solution, adsorption time 72 h, pH solution 5.5 ±0.2, shaking speed  300 rpm, and smallest adsorbent particle size needed for removal of metals.  At the same time the particle size of date pits has a little effect on the adsorption at low initial concentration of heavy metals. The adsorption of metals increases with increasing the initial of metal concentration while above the 85 ppm, the removal efficiency was decreased. The phenomenon of adsorption of heavy metals on to Al-Zahdi Iraqi Date pits is exothermic process. The maximum adsorption capacity according to the Langmuir equation was 0.21, 0.149, and 0.132 mmol/g for Cu2+, Zn2+, and Ni2+ respectively. The adsorption equilibrium was well described by the Freundlich model. The results of Freundlich constants indicated that the adsorption capacity and adsorption intensity of Copper is larger than the Zinc and Nickel. The intraparticle diffusion was involved is this process but it is not the controlling step. The results of this study may inspire to find the optimal operating conditions for adsorption and develop that with large-scale production to clean the polluted water with heavy metals.

scholarly journals Experimental Investigation of the Fluidization Reduction Characteristics of Iron Particles Coated with Carbon Powder under Pressurized Conditions

Molecules ◽  
2020 ◽  
Vol 25 (8) ◽  
pp. 1810 ◽  
Author(s):  
Qiyan Xu ◽  
Zhiping Li ◽  
Zhanghan Gu
Keyword(s):  
Particle Size ◽  
Iron Ore ◽  
Powder Coating ◽  
Linear Velocity ◽  
Operating Conditions ◽  
Spherical Particles ◽  
Carbon Powder ◽  
Reduction Temperature ◽  
Optimal Operating ◽  
Fine Iron

The purpose of this study was to comprehensively analyze the effects of the carbon powder coating mass fraction, pressure, reduction temperature, reduction time, gas linear velocity, and particle size on fluidization reduction. Brazilian fine iron ore particles were the experimental object, and reduction experiments were performed under added carbon powder coating and pressure conditions. A six-factor, three-level orthogonal experiment method was used to obtain the optimal operating conditions and investigate the adhesion and inhibition mechanisms of fine iron ore during reduction. The experimental results show that with the addition of a carbon powder coating, an appropriate increase in pressure can increase the metallization rate, improve the fluidization state, and reduce the sticking ratio. The optimal operating conditions for pure hydrogen to reduce Brazilian fine iron ore was found to be a reduction temperature of 923–1023 K, the linear velocity of the reducing gas was 0.6 m/s, the reducing time was 30–50 min, the reducing pressure was 0.25 MPa, the mass content of the coated carbon powder was 2–6% (accounting for the mass of the mineral powder), and the particle size of the carbon powder was 4–7 µm. Iron whiskers cohesion and agglomeration were the main reasons for the adhesion of ore powder particles. It was found that carbon powder coating can effectively change the morphology of metal iron, as metal iron generates spherical particles around the carbon powder to improve the fluidization state.

scholarly journals Selection of Optimal Operating Conditions for Extraction of Myrtus Communis L. Essential Oil by the Steam Distillation Method

Molecules ◽  
2020 ◽  
Vol 25 (10) ◽  
pp. 2399 ◽  
Author(s):  
Durmuş Alpaslan Kaya ◽  
Mihaela Violeta Ghica ◽  
Elena Dănilă ◽  
Şevket Öztürk ◽  
Musa Türkmen ◽  
...  
Keyword(s):  
Particle Size ◽  
Essential Oil ◽  
Steam Distillation ◽  
Operating Conditions ◽  
Statistical Experimental Design ◽  
Occupancy Rate ◽  
Myrtus Communis ◽  
Distillation Method ◽  
Optimal Operating ◽  
Myrtus Communis L

Myrtus communis L. is one of the important aromatic and medicinal species from the Mediterranean area. It is used in various fields such as culinary, cosmetic, pharmaceutical, therapeutic, and industrial applications. Thus, a Box–Wilson experimental plan was used in this study to select the optimal operating conditions in order to obtain high volumes of essential oils. The factorial design method was applied to evaluate at an industrial scale the effect of major process variables on the essential oil extraction from Myrtus communis L. herbs by the steam distillation method. The input variables considered as significant operating conditions were: X1—boiler occupancy rate (boilers were filled to 50%, 75%, and 100%), X2—distillation duration (distillation was continued 60, 75, and 90 min), and X3—particle size (herbs were cut in sizes of 10, 20, and 30 mm via guillotine). The dependent variable selected, coded as Y, was the essential oil volume obtained (mL). The steps of the classical statistical experimental design technique were complemented with the Taguchi method to improve the extraction efficacy of essential oil from Myrtus communis L., and the optimum parameter conditions were selected: boiler occupancy rate 100%, distillation duration 75 min, and particle size 20 mm. Following the optimum parameters, the GC-MS assay revealed for the Myrtus communis L. essential oil two predominant components, α-pinene—33.14% and eucalyptol—55.09%.

Studies of microbial acclimation to hard chemicals on the basis of respiratory quinone profiles and kinetic analyses

1996 ◽  
Vol 34 (5-6) ◽  
pp. 249-256 ◽  
Author(s):  
Hong-Ying Hu ◽  
Mamie Nozawa ◽  
Koichi Fujie ◽  
Tsuyoshi Makabe ◽  
Kohei Urano
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Population Dynamics ◽  
Volatile Substance ◽  
Operating Conditions ◽  
Biological Wastewater Treatment ◽  
Basic Information ◽  
Optimal Operating ◽  
Respiratory Quinone ◽  
Treatment Processes ◽  
Quinone Profile

The population dynamics of microbes in the biological wastewater treatment processes such as a submerged biofilter was investigated to obtain basic information to determine the optimal operating conditions. The effects of coexistence of biodegradable substances such as glucose and peptone on the acclimation of microbes in the biofilm to hard chemicals such as acrylonitrile (AN), which is poorly biodegradable and a volatile substance, was investigated on the basis of the respiratory quinone profile. Kinetic study of the removal of AN in the course of acclimation of microbes was investigated using a laboratory-scale submerged biofilter as well. It was ascertained that the acclimation of the microbes to AN was accelerated by coexistence of biodegradable substances, and the microbial phase after acclimation differed from those with the coexistence of glucose and peptone. The quinone profiles in the acclimation showed that Brevibacterium sp. and Pseudomonas aeruginosa, of which the predominant quinone of the respiratory chain is menaquinone-8(H2) and ubiquinone-9, respectively, multiplied selectively in the acclimation course without and with the coexistence of glucose and peptone, respectively. It was also made clear that there were few kinds and number of protozoa and metazoa in the biofilter treating the wastewater containing AN.

The circulating floating bed reactor: effect of particle size distribution of the carrier on ammonia conversion

2000 ◽  
Vol 41 (4-5) ◽  
pp. 393-400 ◽  
Author(s):  
J.M. Garrido-Fernandez ◽  
R. Méndez ◽  
J.M. Lema ◽  
V. Lazarova
Keyword(s):  
Particle Size ◽  
Size Distribution ◽  
G Protein ◽  
Biomass Concentration ◽  
Biomass Accumulation ◽  
Ammonia Removal ◽  
Operating Conditions ◽  
Nitrification Rate ◽  
Ammonia Conversion ◽  
Biomass Activity

Three Circulating Floating Bed Reactors (CFBR) R1, R2 and R3 with 20% v/v of a plastic carrier with different size distribution were operated to study the effect of the particles size of the carrier on biomass accumulation and nitrification performance. Operating conditions were similar in the three systems: ammonia concentrations around 50 mg-N–NH4+/ L, ammonia loading rates up to 1.2 kg N–NH4+/m3·d and temperatures between 14 and 27°C. Accumulation of nitrite was observed until day 65th. This w as result both of the inhibition of nitrite oxidation by free ammonia until day 20th and the insignificant accumulation of a biomass with low nitrite oxidising capacity between days 20 and 65th. Ammonia conversion rate and removal efficiency were higher in the reactor with lower particle size, R3 (nitrification rate of 1.1 kg N–NH4+/m3·d and ammonia removal of 97% at 16°C), than in R2 or R1 (nitrification rate of 1.0 kg N–NH4+/m3·d and ammonia removal of 90% at 16°C). The better efficiency in R3 was obtained as a result of the higher specific surface of the biofilm developed. Biomass activity was similar in the three reactors (2.2 and 1.12 g N/g protein · d at 30 and 15°C, respectively). Both the biomass evolution with time and biomass retention in the systems was practically not influenced by the size of particle. Biomass concentration of 1.2 g protein/L was retained in the carrier and up to 20% of the newly produced biomass was retained in the CFBRs.

scholarly journals Evaporator Optimization of Refrigerator Systems Using Quality Analysis

Energies ◽  
2021 ◽  
Vol 14 (3) ◽  
pp. 555
Author(s):  
Sangkyung Na ◽  
Sanghun Song ◽  
Seunghyuk Lee ◽  
Jehwan Lee ◽  
Hyun Kim ◽  
...  
Keyword(s):  
Power Consumption ◽  
Operating Time ◽  
Cooling Capacity ◽  
Operating Conditions ◽  
Quality Analysis ◽  
Lubricating Oil ◽  
Optimal Operating ◽  
Compressor Piston ◽  
Refrigerator Temperature ◽  
Visualization Experiments

In this study, evaporator optimization, via both experimental and simulation methods was conducted. To evaluate the evaporator performance, under the optimal system, the compressor operating time and the effects of oil on the refrigerator system were studied. If the temperature of the refrigerator chamber reaches the setting value, the compressor stops working and it leads to the temperature of the refrigerator chamber slowly increasing, due to the heat transfer to the ambient. When the refrigerator temperature is out of the setting range, the compressor works again, and the refrigerator repeats this process until the end of its life. These on/off period can be controlled through the compressor piston movement. To determine the optimal compressor operating conditions, experiments of monthly power consumption were conducted under various compressor working times and the lowest power consumption conditions was determined when the compressor worked continuously. Lubricating oil, the refrigerator system, using oil, also influenced the system performance. To evaluate the effect of oil, oil eliminated and oil systems were compared based on cooling capacity and power consumption. The cooling capacity of the oil eliminated system was 2.6% higher and the power consumption was 3.6% lower than that of the oil system. After determining the optimal operating conditions of the refrigerator system, visualization experiments and simulations were conducted to decide the optimal evaporator and the conventional evaporator size can be reduced by approximately 2.9%.

scholarly journals Chemical–Electrochemical Process Concept for Lead Recovery from Waste Cathode Ray Tube Glass

Materials ◽  
2021 ◽  
Vol 14 (6) ◽  
pp. 1546
Author(s):  
Árpád Imre-Lucaci ◽  
Melinda Fogarasi ◽  
Florica Imre-Lucaci ◽  
Szabolcs Fogarasi
Keyword(s):  
Flow Rate ◽  
Current Density ◽  
Complete Recovery ◽  
Electrochemical Process ◽  
Operating Conditions ◽  
General Effect ◽  
Optimal Operating ◽  
Recirculation Flow ◽  
Lead Recovery ◽  
Cathode Ray Tube

This paper presents a novel approach for the recovery of lead from waste cathode-ray tube (CRT) glass by applying a combined chemical-electrochemical process which allows the simultaneous recovery of Pb from waste CRT glass and electrochemical regeneration of the leaching agent. The optimal operating conditions were identified based on the influence of leaching agent concentration, recirculation flow rate and current density on the main technical performance indicators. The experimental results demonstrate that the process is the most efficient at 0.6 M acetic acid concentration, flow rate of 45 mL/min and current density of 4 mA/cm2. The mass balance data corresponding to the recycling of 10 kg/h waste CRT glass in the identified optimal operating conditions was used for the environmental assessment of the process. The General Effect Indices (GEIs), obtained through the Biwer Heinzle method for the input and output streams of the process, indicate that the developed recovery process not only achieve a complete recovery of lead but it is eco-friendly as well.

Investigation of the different particle size dust releases from rigid filter candles during pulse-jet cleaning

2021 ◽  
pp. 095440622110179
Author(s):  
Xin Luan ◽  
Zhongli Ji ◽  
Longfei Liu ◽  
Ruifeng Wang
Keyword(s):  
Particle Size ◽  
Critical Role ◽  
Operating Conditions ◽  
Solid Particles ◽  
Dust Particles ◽  
Cleaning Efficiency ◽  
Term Operation ◽  
Cleaning Performance ◽  
Experimental Apparatus ◽  
Pulse Jet

Rigid filters made of ceramic or metal are widely used to remove solid particles from hot gases at temperature above 260 °C in the petrochemical and coal industries. Pulse-jet cleaning of fine dust from rigid filter candles plays a critical role in the long-term operation of these filters. In this study, an experimental apparatus was fabricated to investigate the behavior of a 2050 mm filter candle, which included monitoring the variation of pressure dynamic characteristics over time and observing the release of dust layers that allowed an analysis of the cleaning performance of ISO 12103-1 test dusts with different particle size distributions. These results showed the release behavior of these dusts could be divided into five stages: radial expansion, axial crack, flaky release, irregular disruption and secondary deposition. The cleaning performance of smaller sized dust particles was less efficient as compared with larger sized dust particles under the same operating conditions primarily because large, flaky-shaped dust aggregates formed during the first three stages were easily broken into smaller, dispersed fragments during irregular disruption that forced more particles back to the filter surface during secondary deposition. Also, a “low-pressure and long-pulse width” cleaning method improved the cleaning efficiency of the A1 ultrafine test dust from 81.4% to 95.9%.

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