Collagen Grafts—Here Today and Gone Tomorrow

1986 ◽  
Vol 95 (5) ◽  
pp. 607-614 ◽  
Author(s):  
Paul J. Donald
Keyword(s):  
Immune System ◽  
Chronic Inflammation ◽  
Graft Rejection ◽  
Inflammatory Cells ◽  
The Body ◽  
Facial Contour ◽  
Alloplastic Materials ◽  
Major Disadvantage ◽  
Contour Defects ◽  
Autogenous Grafts

The ongoing search for the perfect graft to fill out facial contour defects has frustrated reconstructive surgeons for years. The list of autogenous, homologous, heterologous, and alloplastic materials Is extensive. All implantable materials have one or more classical principal drawbacks: shrinkage, extrusion, infection, absorption, and/or deformation. One of the major mechanisms of graft unacceptability is the phenomenon of tissue immunity and graft rejection. This has traditionally been the major disadvantage of homografts and heterografts. The host's Immune system recognizes the Implant as “non-self” an antibody-antigen reaction is triggered—usually by the antigenic stimulation provided by the proteinaceous component of the graft, and the implant is rejected or destroyed. Conversely, autogenous grafts experience the problem of resorption by the action of macrophages and chronic inflammatory cells. The immunologic sterility of alloplastic grafts is an advantage, but the body often rejects even the most Inert materials by the process of chronic inflammation.

Investigation of anti-arthritic potential of ethanol extract of Hibiscus platinifolius

2020 ◽  
Vol 9 (1) ◽  
pp. 5-9
Author(s):  
Jogu Chandrudu
Keyword(s):  
Immune System ◽  
Autoimmune Disease ◽  
Inflammatory Response ◽  
Chronic Inflammation ◽  
Ethanol Extract ◽  
The Body ◽  
Intervertebral Disks ◽  
Caudal Vertebrae ◽  
Medicinal Use ◽  
Serum Biochemical

Rheumatoid Arthritis is an autoimmune disease which causes chronic inflammation in the joints n even affects the healthy tissues in the body because their immune system attacks their body's tissues. This process creates an inflammatory response of the synovium, which is synovitis secondary to hyperplasia of the synovial cells. In their research, Locally available plants are verified on their therapeutic use. Arthritis is an autoimmune disease which causes chronic inflammation in the joints n even affects the healthy tissues in the body because their immune system attacks their body’s tissue. In Literature survey, it is revealed that the plant Hibiscus platinifolius (Malvaceae) is used as an ethnic folklore medicine for arthritis than other medicinal use. Primary inflammatory response consists of swelling of oedematous with multiple joints mainly in hind paws then within hours; it develops at the inoculation site. Later it involves the development of inflamed peri articular swelling in the limbs and of erythematous nodules and segmental radial swellings and ridgings which encircling the tail adjacent to the intervertebral disks of the caudal vertebrae. According to the reports, it has shown that the formation of bone was broadly reduced while bone resorption was increased in arthritic disease. In blood and liver, the FA activity increases then N-acetyltransferase (NAT) activity and it shows the effect not only on the serum biochemical parameters like SGOT, SGPT and ALP but also on haematological parameters such as RBC, WBC, Hb% and ESR.

Absence of pro-survival A1 has no impact on inflammatory cell survival in vivo during acute lung inflammation and peritonitis

2021 ◽  
Author(s):  
Marco Herold ◽  
Lahiru Gangoda ◽  
Robyn Schenk ◽  
Sarah Best ◽  
Christina Nedeva ◽  
...  
Keyword(s):  
Immune System ◽  
Defense Mechanism ◽  
Immune Cell ◽  
Inflammatory Cells ◽  
The Body ◽  
Wild Type ◽  
Acute Lung Inflammation ◽  
Protein Levels ◽  
Natural Defense

Abstract Inflammation is a natural defense mechanism of the body to protect against pathogens. It is induced by immune cells, such as macrophages and neutrophils, which are rapidly recruited to the site of infection, mediating host defense. The processes for eliminating inflammatory cells after pathogen clearance are critical in preventing sustained inflammation which can cause diverse pathologies. During chronic inflammation, excessive and uncontrollable activity of the immune system can cause extensive tissue damage. New therapies aimed at preventing this over-activity of the immune system could have major clinical benefit. Here, we investigated the role of the pro-survival Bcl-2 family member A1 in the survival of inflammatory cells under normal and inflammatory conditions using murine models of lung and peritoneal inflammation. Despite the robust upregulation of A1 protein levels in wild-type cells upon induction of inflammation, the survival of inflammatory cells was not impacted in A1 deficient mice compared to wild-type controls. These findings indicate that A1 does not play a major role in immune cell homeostasis during inflammation and therefore does not constitute a therapeutic target for such morbidities.

Immunity boosting diet during Covid 19

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 832-838
Author(s):  
Roshna Sukheoji Bhutada ◽  
Renu Rathi ◽  
Devyani Dasar
Keyword(s):  
Immune System ◽  
Food Studies ◽  
Egg Yolk ◽  
The Body ◽  
Leafy Vegetables ◽  
Green Leafy Vegetables ◽  
Custard Apple ◽  
The Right ◽  
Daily Physical Activities ◽  
Physiological Reactions

WHO declared Covid 19 /SARS -COV-2 as a global pandemic.Till date, there is no medicine for COVID-19. If the Infection arises in the body then the defence mechanism activated against infection. A recent study suggests that temporarily augmenting the body's immune system in the early stages of COVID-19 can help patient to avoid severe symptoms as it is rightly said prevention is better than cure. Ayurveda approaches to develop physiological reactions to facilitate immunity. Planning of diet is most important to boost immunity.As per many researches to provide supplementary food which contains Zinc, Vitamin C,Vitamin D and immunity boosting foodsuch as citrus natural products, custard apple, apple, papaya is among the Fruits. Vegetables include broccoli, onion, garlic and green leafy vegetables. Nuts, ginger, turmeric, pepper, egg yolk, shellfish, mushroom. The need of the hour is a quick boost to immune system to keep it fit, fighting. One should get the right amount of nutrients from the diet, supplementation regimen to boost immune system.In this review, there are few common supplements and super food studies have been included. It might be a torch bearer as sample menu and their alternatives are given for a normal adult. Needy may change contemplated according to age, sex, body mass index and daily physical activities.

Nutritional Recommendation for COVID-19

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 753-757
Author(s):  
Anagha Gulhane ◽  
Shamli Hiware
Keyword(s):  
Immune System ◽  
Global Health ◽  
Infectious Diseases ◽  
Immune Function ◽  
The Body ◽  
Health Issue ◽  
System Quality ◽  
Life Phase ◽  
Global Health Issue ◽  
Nutritional Recommendation

It is the most unreliable truth that anybody can get infected by the COVID-19, and nobody can escape from the danger of getting tainted by the virus. Yet, the line of hope is that anyone and everyone can boost their resistance, thus avoid the risk of getting affected by the illness. The immunity of humans pulls down as they grow older. If their immune system is robust, them falling sick is feeble. If their resistance is weak, them getting ill is sound. Several factors affect the immune system and its ability, including its nourishment. A two-way connection between nutrition, infection and immunity presents. Changes in one part will affect the others part in our body that's the nature's rule. Well defined immune system quality which is present between each life phase may influence the type, generality and the degree of infections. At the same time, low nutrition to the body will decrease the immune function and expose the body to the danger of getting infected by infectious diseases. Different quantity of micronutrients is required for increasing the immunity power of our body. Generally the vitamins A,C,D,E,B2,B6,B12, iron, zinc and selenium.The deficiencies of micronutrients are acknowledged as a global health issue, and also low nutrition makes it prone to establishes the infections in the body.

Role of Rasayana in Prevention of COVID-19 - A Review

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 716-722
Author(s):  
Sneha Dhakite ◽  
Sadhana Misar Wajpeyi
Keyword(s):  
Immune System ◽  
Respiratory System ◽  
Viral Infections ◽  
Cost Effective ◽  
The Body ◽  
Healthy Life ◽  
Vital Functions ◽  
Healthy Life Style ◽  
And Control

The “Coronavirus disease 19 (COVID-19)” is caused by “Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)”, a newly discovered member of the Coronaviridae family of viruses which is a highly communicable. There is no effective medical treatment till date for Coronavirus disease hence prevention is the best way to keep disease away. Rasayana proved to be highly efficacious and cost effective for the Prevention and Control of viral infections when vaccines and standard therapies are lacking. Rasayana Chikitsa is one of the eight branches of Ashtanga Ayurveda which helps to maintain healthy life style. Rasayana improves immunity and performs many vital functions of human body. Vyadhikshamatva that is immune mechanism of the body is involved in Prevention of the occurrence of a new disease and it also decreases the virulence and progression of an existing disease. In COVID-19 the Respiratory system mainly get affected which is evident from its symptoms like cold, cough and breathlessness. Here the drugs help in enhancing immune system and strengthening functions of Respiratory system can be useful. For this purpose, the Rasayana like Chyavanprasha, Agastya Haritaki, Pippali Rasayana, Guduchi, Yashtimadhu, Haridra, Ashwagandha, Tulsi are used. Rasayana working on Respiratory system are best for Prevention of Coronavirus and boosting immune system. Rasayana Chikitsa can be effective in the Prevention as well as reducing symptoms of COVID-19.

Pathway of Inflammation due to Asbestiform fiber "Fluoro-edenite" Exposure: an Update

2020 ◽  
Vol 16 ◽  
Author(s):  
Caterina Ledda ◽  
Claudia Lombardo ◽  
Elisabetta A. Tendi ◽  
Maria Hagnas ◽  
Gianluca Paravizzini ◽  
...  
Keyword(s):  
Immune System ◽  
Autoimmune Disease ◽  
Early Response ◽  
The Body ◽  
Volcanic Area ◽  
Asbestos Fibers ◽  
Inflammatory Processes

: Fluoro-edenite (FE) is an asbestos-like amphibole present in the bentonitic lavas extracted from a stone quarry in Biancavilla, a village sited in the Etnean Volcanic Area (Italy). : Thoracic pathologies are the results of excessive inflammatory processes that are the early response of the immune system to inhaled fibers. As demonstrated for asbestos, fibers may trigger immune system cells in an acute and/or chronic manner. This review aims to clarify the pathways of inflammation in workers exposed to FE fibers. : Based on the articles reviewed, it seems that a permanent stimulus created by repeatedly inhaling the FE fibers and their persistence in the body can act as trigger both in promoting inflammatory processes and in immunological induction of autoimmune disease.

scholarly journals Involvement of Probiotics and Postbiotics in the Immune System Modulation

Biologics ◽  
2021 ◽  
Vol 1 (2) ◽  
pp. 89-110
Author(s):  
Neslihan Yeşilyurt ◽  
Birsen Yılmaz ◽  
Duygu Ağagündüz ◽  
Raffaele Capasso
Keyword(s):  
Immune System ◽  
Pharmaceutical Industry ◽  
Intestinal Microbiota ◽  
Health Benefits ◽  
The Body ◽  
Future Research ◽  
Immune Systems ◽  
Advantages And Disadvantages ◽  
Immune System Modulation ◽  
Molecular Patterns

Intestinal microbiota interacts with other systems, especially the immune system, which is responsible for protecting the body by recognizing “stranger” (pathogen associated molecular patterns-PAMPs) and “danger” (damage-associated molecular patterns-DAMPs) molecular motifs. In this manner, it plays an important role in the pathogenesis of various diseases and health. Despite the use of probiotics that modulate the intestinal microbiota in providing health benefits and in the treatment of diseases, there are some possible concerns about the possibility of developing adverse effects, especially in people with suppressed immune systems. Since probiotics provide health benefits with bioactive compounds, studies are carried out on the use of products containing non-living probiotic microorganisms (paraprobiotics) and/or their metabolites (postbiotics) instead of probiotic products. It is even reported that these microbial compounds have more immunomodulatory activities than living microorganisms via some possible mechanism and eliminates some disadvantages of probiotics. Considering the increasing use of functional foods in health and disease, further studies are needed with respect to the benefits and advantages of parabiotic and/or postbiotic use in the food and pharmaceutical industry as well as immune system modulation. Although probiotics have been extensive studied for a long time, it seems that postbiotics are promising tools for future research and applications according to the recent literature. This review aimed to evaluate the interaction of probiotics and postbiotics with the immune systems and also their advantages and disadvantages in the area of food-pharmaceutical industry and immune system modulation.

scholarly journals Inflammation-Related Carcinogenesis: Lessons from Animal Models to Clinical Aspects

Cancers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 921
Author(s):  
Futoshi Okada ◽  
Runa Izutsu ◽  
Keisuke Goto ◽  
Mitsuhiko Osaki
Keyword(s):  
Animal Models ◽  
Tissue Injury ◽  
Economic Status ◽  
Gene Mutations ◽  
Inflammatory Cells ◽  
The Body ◽  
Clinical Aspects ◽  
Promote Cell Proliferation ◽  
Organ Specific ◽  
Altered Gene

Inflammation-related carcinogenesis has long been known as one of the carcinogenesis patterns in humans. Common carcinogenic factors are inflammation caused by infection with pathogens or the uptake of foreign substances from the environment into the body. Inflammation-related carcinogenesis as a cause for cancer-related death worldwide accounts for approximately 20%, and the incidence varies widely by continent, country, and even region of the country and can be affected by economic status or development. Many novel approaches are currently available concerning the development of animal models to elucidate inflammation-related carcinogenesis. By learning from the oldest to the latest animal models for each organ, we sought to uncover the essential common causes of inflammation-related carcinogenesis. This review confirmed that a common etiology of organ-specific animal models that mimic human inflammation-related carcinogenesis is prolonged exudation of inflammatory cells. Genotoxicity or epigenetic modifications by inflammatory cells resulted in gene mutations or altered gene expression, respectively. Inflammatory cytokines/growth factors released from inflammatory cells promote cell proliferation and repair tissue injury, and inflammation serves as a “carcinogenic niche”, because these fundamental biological events are common to all types of carcinogenesis, not just inflammation-related carcinogenesis. Since clinical strategies are needed to prevent carcinogenesis, we propose the therapeutic apheresis of inflammatory cells as a means of eliminating fundamental cause of inflammation-related carcinogenesis.

scholarly journals Epigenetic Regulation of Cannabinoid-Mediated Attenuation of Inflammation and Its Impact on the Use of Cannabinoids to Treat Autoimmune Diseases

2021 ◽  
Vol 22 (14) ◽  
pp. 7302
Author(s):  
Bryan Latrell Holloman ◽  
Mitzi Nagarkatti ◽  
Prakash Nagarkatti
Keyword(s):  
Autoimmune Diseases ◽  
Chronic Inflammation ◽  
Cannabinoid Receptors ◽  
T Regulatory Cells ◽  
Neurological Diseases ◽  
Suppressor Cells ◽  
The Body ◽  
New Class ◽  
Wide Range ◽  
Clinical Disorders

Chronic inflammation is considered to be a silent killer because it is the underlying cause of a wide range of clinical disorders, from cardiovascular to neurological diseases, and from cancer to obesity. In addition, there are over 80 different types of debilitating autoimmune diseases for which there are no cure. Currently, the drugs that are available to suppress chronic inflammation are either ineffective or overtly suppress the inflammation, thereby causing increased susceptibility to infections and cancer. Thus, the development of a new class of drugs that can suppress chronic inflammation is imperative. Cannabinoids are a group of compounds produced in the body (endocannabinoids) or found in cannabis (phytocannabinoids) that act through cannabinoid receptors and various other receptors expressed widely in the brain and immune system. In the last decade, cannabinoids have been well established experimentally to mediate anti-inflammatory properties. Research has shown that they suppress inflammation through multiple pathways, including apoptosis and inducing immunosuppressive T regulatory cells (Tregs) and myeloid-derived suppressor cells (MDSCs). Interestingly, cannabinoids also mediate epigenetic alterations in genes that regulate inflammation. In the current review, we highlight how the epigenetic modulations caused by cannabinoids lead to the suppression of inflammation and help identify novel pathways that can be used to target autoimmune diseases.

Serum immunoglobulins in patients with chronic tonsillitis

1984 ◽  
Vol 98 (12) ◽  
pp. 1213-1216 ◽  
Author(s):  
Harbans Lal ◽  
O. P. Sachdeva ◽  
H. R. Mehta
Keyword(s):  
Immune System ◽  
Mean Value ◽  
The Body ◽  
Antigenic Stimulation ◽  
Chronic Tonsillitis ◽  
Serum Immunoglobulin ◽  
Control Group ◽  
Humoral Immune ◽  
Humoral Immune System ◽  
The Mean

AbstractSerum immunoglobulin (IgG, IgA and IgM) levels were determined in patients with chronic tonsillitis before and one month after tonsillectomy. The preoperative levels of serum IgG, IgA and IgM were significantly higher when compared with the controls. The increase may be due to repeated antigenic stimulation. The post-operative levels for the three immunoglobulins were decreased; however, a significant reduction was observed for IgG only where the mean value was comparable with the control group. The data confirm that tonsillectomy does not disturb the humoral immune system of the body.

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