Overweight in Boys With ADHD Is Related to Candidate Genes and Not to Deficits in Cognitive Functions

2016 ◽  
Vol 22 (12) ◽  
pp. 1158-1172 ◽  
Author(s):  
Tomasz Hanć ◽  
Monika Dmitrzak-Węglarz ◽  
Aneta Borkowska ◽  
Tomasz Wolańczyk ◽  
Natalia Pytlińska ◽  
...  
Keyword(s):  
Executive Functions ◽  
Candidate Genes ◽  
Cognitive Functions ◽  
Neuropsychological Tests ◽  
Task Force ◽  
Neuropsychological Test ◽  
Test Results ◽  
International Obesity Task Force ◽  
Relationship Of ◽  
The Relationship

Objective: The aim of the study was to assess the relationship of overweight, the polymorphisms of selected candidate genes, and deficits in the executive functions among children with ADHD. Method: We examined 109 boys with ADHD aged between 7 and 17 years. The study indicated variants of 14 polymorphisms in eight candidate genes. We applied seven neuropsychological tests to evaluate the executive functions. Overweight was diagnosed on the basis of the guidelines of the International Obesity Task Force. Results: Analyses revealed significant association between DRD4 rs1800955, SNAP25 rs363039 and rs363043, 5HTR2A rs17288723, and overweight in boys with ADHD. There were no significant differences in the level of neuropsychological test results between patients with overweight and without overweight. Conclusion: Overweight in boys with ADHD is associated with polymorphisms in three candidate genes: DRD4, SNAP25, and 5HTR2A, but not through conditioning deficits in cognitive functions.

Chronic Akinetic Mutism After Mesencephalic-Diencephalic Infarction: Remediated with Dopaminergic Medications

2001 ◽  
Vol 15 (2) ◽  
pp. 151-156 ◽  
Author(s):  
Michael P. Alexander
Keyword(s):  
Executive Functions ◽  
Key Words ◽  
Ventral Tegmental Area ◽  
Cognitive Functions ◽  
Neuropsychological Tests ◽  
Functional Independence Measure ◽  
Functional Independence ◽  
Akinetic Mutism ◽  
Rapid Improvement ◽  
The Relationship

Objective: Akinetic mutism (AKM) is an uncommon disorder with a complex neuropathology. There is no generally accepted treatment, and it is not known if late treatments are effective. The relationship between AKM and abulia is uncertain. Methods: The effects of dopaminergic treatment of a patient with chronic AKM after discrete bilateral infarctions of the mesencephalic ventral tegmental area and the lat eral hypothalamus were studied with motor measures, the Functional Independence Measure (FIM), and neuropsychological tests. Results: Treatment with a combination of carbidopa/levodopa and pergolide produced prompt amelioration of AKM with dra matic and rapid improvement in FIM. An apathetic, amotivational state persisted de spite resolution of akinesia and normal frontal executive functions. Conclusions: AKM may respond to dopaminergic treatment even after months of severe akinesia. The mechanism of abulia is more complex than simply a partial dopaminergic deficiency state and may persist even when AKM is treated and frontal cognitive functions are normal. Key Words: Akinetic mutism—Dopamine—Abulia.

Problematic Internet Use digunakan Ketika Kesepian pada Remaja

2020 ◽  
Vol 14 (1) ◽  
pp. 45-60
Author(s):  
Yashinta Yashinta ◽  
Dwi Hurriyati
Keyword(s):  
Internet Use ◽  
Hypothesis Test ◽  
Problematic Internet Use ◽  
Coefficient Of Determination ◽  
Test Results ◽  
Research Subjects ◽  
Significance Level ◽  
Relationship Of ◽  
The Relationship ◽  
Effective Contribution

This study aims to determine the relationship of loneliness with problematic internet use on boarding students on Silaberanti street in Siantan jaya Opposite Ulu 1 Palembang city. Research subjects numbered 220 people using random sampling methods. Data was collected using a 60 item problematic internet use scale and a 60 item loneliness. Realibility is generated on scale of problematic internet use of 0,955 and loneliness of 0,946.Hypothesis testing uses product moment correlation analysis techniques. Hypothesis test results showed a positive relationshif between loneliness with problematic internet use on boarding students on Silaberanti street in Siantan jaya Opposite Ulu 1 Palembang city r= 0,684 with a significance level of 0,000 (p<0,01). Loneliness in this study made an effective contribution of 46,8% to problematic internet use which can be seen from the coefficient of determination (r²) that is equel to 0,468.

scholarly journals Study of the Interaction between Executive Function and Adaptive Behavior at School in Girls with Fragile X Syndrome

Genes ◽  
2021 ◽  
Vol 12 (8) ◽  
pp. 1108
Author(s):  
Lorena Joga-Elvira ◽  
Jennifer Martinez-Olmo ◽  
María-Luisa Joga ◽  
Carlos Jacas ◽  
Ana Roche-Martínez ◽  
...  
Keyword(s):  
Executive Function ◽  
Executive Functions ◽  
Fragile X Syndrome ◽  
Adaptive Behavior ◽  
Neuropsychological Tests ◽  
Rating Scale ◽  
Fragile X ◽  
School Setting ◽  
Control Group ◽  
The Relationship

The aim of this research is to analyze the relationship between executive functions and adaptive behavior in girls with Fragile X syndrome (FXS) in the school setting. This study is part of a larger investigation conducted at the Hospital Parc Tauli in Sabadell. The sample consists of a total of 40 girls (26 with FXS and 14 control) aged 7–16 years, who were administered different neuropsychological tests (WISC-V, NEPSY-II, WCST, TOL) and questionnaires answered by teachers (ABAS-II, BRIEF 2, ADHD Rating Scale). The results show that there is a greater interaction between some areas of executive function (cognitive flexibility, auditory attention, and visual abstraction capacity) and certain areas of adaptive behavior (conceptual, practical, social, and total domains) in the FXS group than in the control group. These results suggest that an alteration in the executive functions was affecting the daily functioning of the girls with FXS to a greater extent.

scholarly journals Derivation and Performance of Standardized Enhanced Liver Fibrosis (ELF) Test Thresholds for the Detection and Prognosis of Liver Fibrosis

2019 ◽  
Vol 3 (5) ◽  
pp. 815-826 ◽  
Author(s):  
James Day ◽  
Preya Patel ◽  
Julie Parkes ◽  
William Rosenberg
Keyword(s):  
Liver Fibrosis ◽  
Delphi Panel ◽  
Test Results ◽  
Hazard Ratios ◽  
Test Thresholds ◽  
And Performance ◽  
Using Data ◽  
Relationship Of ◽  
The Relationship ◽  
Selection Of

Abstract Introduction Noninvasive tests are increasingly used to assess liver fibrosis and determine prognosis but suggested test thresholds vary. We describe the selection of standardized thresholds for the Enhanced Liver Fibrosis (ELF) test for the detection of liver fibrosis and for prognostication in chronic liver disease. Methods A Delphi method was used to identify thresholds for the ELF test to predict histological liver fibrosis stages, including cirrhosis, using data derived from 921 patients in the EUROGOLF cohort. These thresholds were then used to determine the prognostic performance of ELF in a subset of 457 patients followed for a mean of 5 years. Results The Delphi panel selected sensitivity of 85% for the detection of fibrosis and &gt;95% specificity for cirrhosis. The corresponding thresholds were 7.7, 9.8, and 11.3. Eighty-five percent of patients with mild or worse fibrosis had an ELF score ≥7.7. The sensitivity for cirrhosis of ELF ≥9.8 was 76%. ELF ≥11.3 was 97% specific for cirrhosis. ELF scores show a near-linear relationship with Ishak fibrosis stages. Relative to the &lt;7.7 group, the hazard ratios for a liver-related outcome at 5 years were 21.00 (95% CI, 2.68–164.65) and 71.04 (95% CI, 9.4–536.7) in the 9.8 to &lt;11.3 and ≥11.3 subgroups, respectively. Conclusion The selection of standard thresholds for detection and prognosis of liver fibrosis is described and their performance reported. These thresholds should prove useful in both interpreting and explaining test results and when considering the relationship of ELF score to Ishak stage in the context of monitoring.

scholarly journals PENGARUH SUMBER DAYA MANUSIA TERHADAP PROFESIONALISME PRAJURIT PANGKALAN TNI AL DI PANTAI BARAT

2020 ◽  
Vol 8 (1) ◽  
Author(s):  
Bambang Supriyono ◽  
Prio Budi Leksono ◽  
Devi Erlita
Keyword(s):  
Human Resource ◽  
West Coast ◽  
Task Force ◽  
Command And Control ◽  
Weapon System ◽  
And Control ◽  
Relationship Of ◽  
The Relationship ◽  
Naval Base ◽  
Operating Units

<strong><em>Naval base as one of the integral components of the SSAT is the spearhead of power in carrying out support for the tasks of the operating units both in peacetime and during war. In carrying out its duties the Navy has an Integrated Fleet Weapon System (SSAT) which is the integration of strength of the capabilities of the KRI, Aircraft, Marines and Naval base components. To find out the professional level of the soldier, it is necessary to hold a Test of Combat Naval Base Task Force in order to realize, maintain and improve the skills of both individuals and groups, which in turn will increase the establishment of Operational Command and Control, Operational Procedures and the establishment of mastery of appropriate techniques and tactics. With the implementation of the test, it is expected to know about Naval Base Combat Readiness, a condition where the base can carry out its main tasks. Combat Duty Rehearsal is an exercise carried out by KRI or base to maintain the ability and professionalism of soldiers both programmed and programmed. This study aims to determine whether the relationship of human resource readiness influences the professional abilities of the Naval Base on west coast.</em></strong>

scholarly journals HUBUNGAN ACCESS BLOCK DENGAN PERBURUKAN KONDISI PASIEN DI INSTALASI GAWAT DARURAT RSUD ULIN BANJARMASIN

2020 ◽  
Vol 11 (1) ◽  
pp. 110-119
Author(s):  
Julianto Julianto ◽  
Izma Daud ◽  
Sari Milyati
Keyword(s):  
Research Method ◽  
Sampling Technique ◽  
P Value ◽  
Test Results ◽  
Hospital Emergency ◽  
Cross Sectional ◽  
Analytical Design ◽  
A Value ◽  
Relationship Of ◽  
The Relationship

Abstrak  Latar Belakang :Access block adalah situasi dimana pasien yang mengalami lama rawat di IGD 6 karena kurangnya akses ke ruang rawat inap dan kepadatan jumlah pasien yang tidak terkendali, dampaknya ditemukan bahwa semakin lama access block  semakin tinggi pula perburukan pasien dalam 24 jam.Tujuan : ini bertujuan untuk mengetahui hubungan access block dengan perburukan kondisi pasien di Instalasi Gawat Darurat RSUD Ulin Banjarmasin.Metode :Penelitian menggunakan desain analitik dengan pendekatan cross sectional. Jumlah sampel yang diambil berjumlah 40 orang dengan teknik pengambilan accidental sampling. Analisis data melalui uji spearman rank.Hasil : Hasil uji dipapatkan nilai p hitung 0,000 (0,05) ada hubungan antara access block dengan perburukan kondisi pasien di instalasi gawat darurat RSUD Ulin Banjarmasi.Simpulan: Berdasarka hasil penelitian Ada hubungan antara access block dengan perburukan kondisi pasien di Instalasi Gawat Darurat RSUD Ulin Banjarmasin dengan nilai P= 0,000 nilai α = 0,05 dengan nilai koefisien korelasi 0,588 Kata kunci: Access Block, Perburukan Pasien. Abstract Background :Access block is a situation where patients who experience length of stay in the ED 6 due to lack of access to the inpatient room and uncontrolled density of patients, it is found that the longer the access block the higher the deterioration of patients in 24 hours.Purpose: This study aims to determine the relationship of access block with deteriorating condition of patients in Emergency Installation Ulin Hospital Banjarmasin.Method : The research method uses an analytical design with a cross sectional approach. The number of samples taken is 40 people using the accidental sampling technique. Data analysis through spearman rank test.Result: The test results obtained p value calculated 0,000 (0.05) there is a relationship between the access block and deterioration of the patient's condition at the Ulin Banjarmasin Hospital emergency department.Conclusion: Based on the results of the study, there is a relationship between the access block and the worsening of the patient's condition at the Emergency Department of RSUD Ulin Banjarmasin with a value of P = 0.000 value α = 0.05 with a correlation coefficient value of 0.588. Keywords: Access Block, Patient worsening 

A Study on Dynamic Properties of Cement-Stabilized Soils

2011 ◽  
Vol 243-249 ◽  
pp. 2050-2054 ◽  
Author(s):  
Pei Hsun Tsai ◽  
Sheng Huoo Ni
Keyword(s):  
Shear Modulus ◽  
Dynamic Properties ◽  
Damping Ratio ◽  
Confining Pressure ◽  
Test Results ◽  
Resonant Column Test ◽  
Stabilized Soil ◽  
Shearing Strain ◽  
Relationship Of ◽  
The Relationship

In this paper the dynamic property (shear modulus and damping ratio) of cement-stabilized soil is studied with using the resonant column test. The amount of cement admixed, the magnitude of confining pressure, and shearing strain amplitude are the parameters considered. Test results show that the maximum shear modulus of cement-stabilized soil increases with increasing confining pressure, the minimum damping ratio decreases with increasing confining pressure. The shear modulus of cement-stabilized soil decreases with increasing shearing strain while the damping ratio increases with increasing shearing strain. In the paper the relationship of shear modulus versus shearing strain is fitted into the Ramberg-Osgood equations using regression analysis.

Neuropsychological function in bulimia with comorbid borderline personality disorder and depression

2006 ◽  
Vol 18 (3-4) ◽  
pp. 162-167 ◽  
Author(s):  
Cecilia M. Bourke ◽  
Richard J. Porter ◽  
Patrick Sullivan ◽  
Cynthia M. Bulik ◽  
Frances A. Carter ◽  
...  
Keyword(s):  
Executive Function ◽  
Borderline Personality Disorder ◽  
Personality Disorder ◽  
Neuropsychological Tests ◽  
Neuropsychological Test ◽  
Borderline Personality ◽  
Neuropsychological Function ◽  
Test Results ◽  
Trail Making ◽  
The Impact

Background:In bulimia nervosa (BN), borderline personality disorder (BPD) and major depression (MDD) are frequently comorbid conditions. Executive function has been found to be impaired in BPD and MDD, but the impact of comorbidity on neuropsychological function has rarely been investigated.Objective:To investigate neuropsychological function in BN with a focus on comorbid BPD and MDD.Methods:One hundred forty-four medication-free female patients entering a study of psychological treatments for BN performed a brief battery of neuropsychological tests. Comorbid MDD and BPD were systematically identified using standard interviews. Neuropsychological test results were compared.Results:Forty-one subjects had comorbid BPD and 35 had comorbid MDD, while 15 had both. There was no effect of comorbid MDD, but there was a significant effect of BPD and a significant interaction between the diagnosis of MDD and BPD on executive tasks (trail making and Stroop). Thus, compared with subjects without BPD, subjects with BPD performed significantly worse on tests of executive function, while the group with both comorbidities performed even worse.Conclusions:There appears to be an additive effect of BPD and MDD resulting in impaired executive neuropsychological function. Future studies on either disorder and on BN should examine and account for the effect of comorbidity.

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