A systematic review of randomized controlled trials (RCTs) of exercise interventions using digital activity trackers (E-DAT) in cancer patients.

2018 ◽  
Vol 36 (7_suppl) ◽  
pp. 108-108 ◽  
Author(s):  
Kerry Schaffer ◽  
Narmadha Panneerselvam ◽  
Kah Poh Loh ◽  
Rachel Herrmann ◽  
Ian Kleckner ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cancer Patients ◽  
Inflammatory Markers ◽  
Exercise Adherence ◽  
Activity Level ◽  
Cochrane Library ◽  
Future Research ◽  
Eligibility Criteria ◽  
Exercise Interventions ◽  
Activity Trackers

108 Background: Exercise ameliorates cancer and treatment-related toxicities but adherence to exercise is a barrier. Few studies in the general population suggest that E-DAT may improve exercise adherence. We conducted a systematic review to examine the effects of E-DAT on physical function, health-related quality of life (HRQOL), and serum inflammatory markers during and after cancer treatment. Methods: We used PubMed, Embase, and the Cochrane Library to identify RCTs of E-DAT in cancer patients aged ≥18 years published in English between 1/1/2008 and 7/27/2017. Two authors independently reviewed the titles of articles from the search (n = 160), removed duplicates (n = 49), and reviewed the remaining 111 articles for eligibility and substantive results. We excluded RCTs that used digital activity trackers solely for data collection. Results: Twelve RCTs met eligibility criteria, including 1,450 patients (mean age: 50-70 years) with the following cancers: breast (n = 5 RCTs), colon or breast (n = 2), prostate (n = 1), acute leukemia (n = 1) and various type (n = 3). Duration of E-DAT ranged from 4-24 weeks. Follow-up period was 4-24 weeks with retention of 54-95%. Half of the RCTs had E-DAT with in-person exercise training and the rest had self-directed training. The technology component of E-DAT included pedometers (n = 8); pedometers with smart phone application (n = 1), Wii-Fit (n = 1), or heart rate monitor (n = 1); and a wireless sensor with accelerometer, gyroscope, and magnetometer (n = 1). Adherence to E-DAT was > 70% in 5 of 7 RCTs. Compared to controls (exercise interventions without digital activity trackers or standard of care), E-DAT significantly improved the step count in 60% of 5 RCTs, activity level in 56% of 9 RCTs, and HRQOL in 56% of 9 RCTs (all p < 0.05), with no significant changes of inflammatory markers (i.e. TNF, CRP, c-peptide) in 2 RCTs. No significant correlations were found between duration of E-DAT with adherence (Spearman’s r = 0.16; p = 0.75) or study retention (Spearman’s r = -0.42; p = 0.17). Conclusions: This systematic review shows that E-DAT is feasible to implement in cancer patients. Future research should examine the optimal type, dose and schedule of E-DAT.

scholarly journals Mindfulness based interventions for depression and anxiety in Asian Population: A systematic review

2018 ◽  
Vol 7 (1) ◽  
pp. 10-23
Author(s):  
S. Thapaliya ◽  
K.D. Upadhyaya ◽  
R. Borschmann ◽  
P.P. Kuppili
Keyword(s):  
Systematic Review ◽  
Asian Population ◽  
Anxiety Symptoms ◽  
Cochrane Library ◽  
Future Research ◽  
Control Group ◽  
Depression And Anxiety ◽  
Short Term ◽  
Eligibility Criteria ◽  
Term Efficacy

Introduction: Mindfulness based interventions (MBIs) have emerged as effective interventions for various psychiatric conditions including depression and anxiety. Asia being home to Buddhist tradition, it will be interesting to explore the trend and efficacy of MBIs in Asian population in Asian settings. The aim of this study is to perform a systematic review of mindfulness based interventions (MBIs) for management of depression and anxiety (disorders or symptoms) in Asian population. Material And Method: Two researchers independently searched for literature published between January 2007 to December 2018 in Medline, Google Scholar, PsychInfo and Cochrane library using the search terms - ‘Mindfulness/Vipassana’ combined with ‘meditation’, ‘intervention’ ‘therapy’, ‘depression', ‘anxiety’ ‘Asia’ etc. Further, publications were also identified from the references recited in the retrieved articles. After screening 185 articles and applying the eligibility criteria, 40 articles were finally selected for the systematic review. Results: Out of 40 selected articles, 33 articles were controlled trials and 7 had a pre-post test design without any control group. Most of the published studies have evaluated MBCT and MBSR for depressive and anxiety symptoms in different settings. Some of the studies have tested traditional Buddhist meditation and modified models. Overall, MBCT and MBSR seem to be efficacious over ‘routine treatment’ or ‘no treatment’ control for reducing depressive and anxiety symptoms at the end of the treatment. Studies which have modified MBIs based on MBCT/MBSR models have also demonstrated their feasibility and short term efficacy in specific populations like medical professionals with evidence for short term efficacy. Conclusion: Overall, there is emerging evidence of MBIs for depression and anxiety across diverse settings in Asia. Future research should address methodological limitations of current research to strengthen the evidence.

scholarly journals Home-based physiotherapy programmes for individuals with neurological diseases: systematic review

2019 ◽  
Vol 32 ◽  
Author(s):  
Paulo Roberto Fonseca Junior ◽  
Paola Pinto Souza ◽  
Kelly Kuguio Maurino dos Reis ◽  
Eduardo Filoni
Keyword(s):  
Systematic Review ◽  
Positive Impact ◽  
Neurological Diseases ◽  
Rehabilitation Program ◽  
Activity Level ◽  
Cochrane Library ◽  
Controlled Clinical Trial ◽  
Eligibility Criteria ◽  
Home Based ◽  
Home Based Intervention

Abstract Introduction: Home-based programmes have received increasing attention in rehabilitation, providing an opportunity to continue aspects of therapy, benefiting the retention of established intervention effects. Objective: To describe the available home-based physiotherapy programmes in neurorehabilitation for people with neurological diseases. Method: MEDLINE, EMBASE, Cochrane Library, OTseeker and PEDro were searched, no restrictions regarding the date of publication or language restrictions for randomized controlled clinical trial. The quality of the selected studies using the PEDro scale and the Cochrane Collaboration’s tool for assessing the risk of bias. Results: Fifteen articles met the eligibility criteria and quality assessment and were selected for the present systematic review. The findings supports the positive impact of home-based intervention, finding evidence in the changes in activity level, improvement in the control and muscle strength, balance and walking in patients with neurological conditions who perform rehabilitation program at home, with a good adherence of participants in total. Conclusion: Models of rehabilitative such as home-based programmes can be an alternative efficient method to deliver rehabilitation, showing to be beneficial in improving different aspects of activities, and participation.

scholarly journals Prison cell spatial density and infectious and communicable diseases: a systematic review

BMJ Open ◽  
2019 ◽  
Vol 9 (7) ◽  
pp. e026806 ◽  
Author(s):  
Paul L Simpson ◽  
Melanie Simpson ◽  
Armita Adily ◽  
Luke Grant ◽  
Tony Butler
Keyword(s):  
Systematic Review ◽  
Communicable Disease ◽  
Correctional Facility ◽  
Communicable Diseases ◽  
The Body ◽  
Cochrane Library ◽  
Spatial Density ◽  
Future Research ◽  
Advisory Panel ◽  
Eligibility Criteria

ObjectiveTo summarise the extent and quality of evidence on the association between prison cell spatial density (a measure of crowding) and infectious and communicable diseases transmission among prisoners.DesignSystematic review.Data sourcesEmbase, PubMed, Medline, Scopus, Web of Science, PsycINFO, PsycExtra, ProQuest Databases, ProQuest Dissertations and Theses Global, Index to Legal Periodicals, InformitOnline, Cochrane Library, Criminal Justice Abstracts and ICONDA were searched to 31 December 2018.Eligibility criteriaStudies that reported on the association between prison cell spatial density (measured in square feet or square metres of cell floor area per person) and infectious and communicable diseases in juvenile and adult populations incarcerated in a correctional facility.Data extraction and synthesisA review protocol was developed in consultation with an advisory panel. Two reviewers independently extracted data and used the Australian National Health and Medical Research Council’s (NHMRC) checklist to critically appraise individual studies. An assessment of the overall body of the evidence was conducted using the NHMRC’s Evidence Scale and Statement Form.ResultsA total of 5126 articles were initially identified with seven included in the review from Pakistan (2003), Chile (2016), Nigeria (2012, 2013) and the USA (1980s). Infectious and communicable disease outcomes included pneumococcal disease/acute pneumonia,Mycobacterium tuberculosis, latent tuberculosis infection, infectious skin conditions and contagious disease reporting to the prison clinic. Five articles reported statistically significant positive associations but were countered by associations possibly being explained by chance, bias or confounding factors. Heterogeneity prevented meta-analysis.ConclusionOverall, the body of evidence provides some support for an association between prison cell special density and infectious and communicable diseases, but care should be taken in the interpretation and transferability of the findings. Future research and policy responses should adequately consider prospective mediating factors implicated in associations between cell spatial density and health effects.

PHYSICAL ACTIVITY AND ß-AMYLOID BRAIN LEVELS IN HUMANS: A SYSTEMATIC REVIEW

2015 ◽  
pp. 1-8
Author(s):  
P. de Souto Barreto ◽  
B. Vellas ◽  
S. Andrieu ◽  
Y. Rolland
Keyword(s):  
Physical Activity ◽  
Systematic Review ◽  
Cochrane Library ◽  
Future Research ◽  
Eligibility Criteria ◽  
Cross Sectional ◽  
Apoe Ε4 ◽  
Allele Specific ◽  
Study Population ◽  
Β Amyloid

Physical activity (PA) contributes to brain health and plasticity, which suggests that PA would protect against the development of Alzheimer’s disease (AD). However, research on PA and AD biomarkers is very scarce. The objective of the present study was to perform a systematic review of studies that investigated the associations between PA and β-amyloid brain deposition in humans. Electronic searches were performed in PubMed, Cochrane Library, SportDiscus, PEDro, and PsychInfo databases. Articles were eligible if they have assessed both PA and β-amyloid brain deposition in humans. Five articles, published between 2010 and 2013, met eligibility criteria (study population varied across studies from 54 to 515, according with the β-amyloid measure. All five studies assessed both PA and PET-amyloid; among them, two studies also assessed CSF Aβ42 levels). All studies were based on cross-sectional data, from non-demented populations. Among the five included studies, three found significant associations between PA and β-amyloid brain deposition, and the other two did not find any significant association; limited evidence suggests that PA-amyloid plaques associations would be APOE ε4 allele-specific. In sum, no solid conclusions can be drawn on the associations between PA and human β-amyloid brain deposition currently. Future research on this topic should particularly pay attention to the operationalisation of clinically relevant and valid PA variables and should include important confounders in multivariate analysis. More information is needed on the potential interactions between PA and other AD risk factors (e.g., cognitive activities, APOE ε4 status, nutrition, smoking) and their combined effects on AD biomarkers.

scholarly journals Systematic Review on Exercise Training as a Neuroplasticity-Inducing Behavior in Multiple Sclerosis

2020 ◽  
Vol 34 (7) ◽  
pp. 575-588 ◽  
Author(s):  
Brian M. Sandroff ◽  
C. Danielle Jones ◽  
Jessica F. Baird ◽  
Robert W. Motl
Keyword(s):  
Multiple Sclerosis ◽  
Systematic Review ◽  
Exercise Training ◽  
Functional Outcomes ◽  
Future Research ◽  
Eligibility Criteria ◽  
Exercise Interventions ◽  
Functional Changes ◽  
Study Results ◽  
Quasi Experimental

Background. Exercise training is associated with functional improvements in persons with multiple sclerosis (MS), perhaps based on neuroplasticity. However, inferences regarding neuroplasticity require observations of exercise-related changes in the central nervous system that explain functional adaptations. This systematic review critically evaluated studies on exercise training, neuroimaging outcomes, and functional outcomes in MS based on consistency with a well-established conceptual model for characterizing exercise training as a possible neuroplasticity-inducing behavior in this population. Methods. We performed targeted and comprehensive searches of multiple databases for papers involving exercise training interventions on functional and neuroimaging outcomes in persons with MS. Acceptable study designs included randomized controlled trials, single-group pre/post designs, and quasi-experimental designs. Four independent reviewers extracted relevant data from each eligible paper on characteristics of participants, exercise interventions, neuroimaging outcomes, functional outcomes, pattern of study results, and potential risks of bias. Results. The literature search returned only 10 papers (involving 8 original interventions) that met eligibility criteria wherein inferences regarding neuroplasticity could be drawn, based on inclusion of neuroimaging and functional endpoints. Within those 10 papers, there is mixed evidence for exercise training as a neuroplasticity-inducing behavior in persons with MS. Conclusions. Such a paucity of evidence supporting exercise-induced neuroplasticity in MS is likely a product of a very small number of papers that do not sufficiently examine hypothesized mechanisms of action. Future research might consider examining specific neural changes that might result from exercise prescriptions that are specifically designed to induce certain functional changes among persons with MS.

scholarly journals Effects of Exercise Interventions on Immune Function in Children and Adolescents With Cancer and HSCT Recipients - A Systematic Review

2021 ◽  
Vol 12 ◽  
Author(s):  
Ronja Beller ◽  
Sabrina Bianca Bennstein ◽  
Miriam Götte
Keyword(s):  
Systematic Review ◽  
Immune System ◽  
Children And Adolescents ◽  
Cancer Patients ◽  
Pediatric Cancer ◽  
Immune Cell ◽  
Systemic Review ◽  
Cochrane Library ◽  
Exercise Interventions ◽  
Pediatric Cancer Patients

BackgroundPediatric cancer patients are at high risk for life-threatening infections, therapy associated complications and cancer-related side effects. Exercise is a promising tool to support the immune system and reduce inflammation. The primary objective of this systematic review was to evaluate the effects of exercise interventions in pediatric cancer patients and survivors on the immune system.MethodsFor this systematic review (PROSPERO ID: CRD42021194282) we searched four databases (MEDLINE, Cochrane Library, ClinicalTrials.gov, SPORTDiscus) in June 2021. Studies with pediatric patients with oncological disease were included as main criterion. Two authors independently performed data extraction, risk of bias assessment, descriptive analysis and a direction ratio was calculated for all immune cell parameters.FindingsOf the 1448 detected articles, eight studies with overall n = 400 children and adolescents with cancer and n = 17 healthy children as controls aged 4-19 years met the inclusion criteria. Three randomized, four non-randomized controlled trials and one case series were analyzed descriptively. The exercise interventions had no negative adverse effects on the immune system. Statistically significant results indicated enhanced cytotoxicity through exercise, while changes in immune cell numbers did not differ significantly. Interventions further reduced days of in-hospitalization and reduced the risk of infections. Several beneficial direction ratios in immune parameters were identified favoring the intervention group.InterpretationExercise interventions for pediatric cancer patients and survivors had no negative but promising beneficial effects on the immune system, especially regarding cytotoxicity, but data is very limited. Further research should be conducted on the immunological effects of different training modalities and intensities, during various treatment phases, and for different pediatric cancer types. The direction ratio parameters given here may provide useful guidance for future clinical trials.Systemic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021194282, Prospero ID: CRD42021194282.

scholarly journals A Systematic Review of the Safety, Feasibility and Benefits of Exercise for Patients with Advanced Cancer

Cancers ◽  
2021 ◽  
Vol 13 (17) ◽  
pp. 4478
Author(s):  
Nico De Lazzari ◽  
Timo Niels ◽  
Mitra Tewes ◽  
Miriam Götte
Keyword(s):  
Systematic Review ◽  
Adverse Events ◽  
Cancer Patients ◽  
Advanced Cancer ◽  
Exercise Intervention ◽  
Cochrane Library ◽  
Controlled Trials ◽  
Advanced Cancer Patients ◽  
Exercise Interventions ◽  
Positive Effects

Exercise therapy is a common supportive strategy in curative cancer treatment with strong evidence regarding its positive effects on, for example, cancer-related fatigue, health- related quality of life, and physical function. In the field of advanced cancer patients, knowledge about exercise as a useful supportive strategy is missing. The aim of this systematic review was to evaluate the feasibility and safety of exercise interventions as well as its effects on lowering the symptom burden. We included randomized controlled trials and nonrandomized controlled trials with advanced cancer patients receiving any type of exercise intervention. After an extensive literature search (in accordance to PRIMSA guidelines) in PubMed, Cochrane Library, and SPORTDiscus, 14 studies including 940 participants with different cancer entities were eligible. The results indicated the safety of exercise. In total, 493 participants received exercise interventions, with nine adverse events and no severe adverse events. The median recruitment rate was 68.33%, and adherence to exercise intervention was 86%. Further research with a high-quality and larger sample size is needed to clarify the potential of exercise with advanced cancer patients. Different advanced cancer entities have distinguished symptoms, and future research should construct entities-specific trial populations to figure out the best supportive exercise interventions.

Chasing the Anchor: A Systematic Review and Meta-analysis of Perceptual Anchoring Deficits in Developmental Dyslexia

2020 ◽  
Author(s):  
Kurt D Shulver ◽  
Nicholas A Badcock
Keyword(s):  
Systematic Review ◽  
Reading Ability ◽  
English Language ◽  
Prediction Interval ◽  
Meta Analysis ◽  
Visual Assessment ◽  
Individual Performance ◽  
Future Research ◽  
Significant Heterogeneity ◽  
Eligibility Criteria

We report the results of a systematic review and meta-analysis investigating the relationship between perceptual anchoring and dyslexia. Our goal was to assess the direction and degree of effect between perceptual anchoring and reading ability in typical and atypical (dyslexic) readers. We performed a literature search of experiments explicitly assessing perceptual anchoring and reading ability using PsycInfo (Ovid, 1860 to 2020), MEDLINE (Ovid, 1860 to 2019), EMBASE (Ovid, 1883 to 2019), and PubMed for all available years up to June (2020). Our eligibility criteria consisted of English-language articles and, at minimum, one experimental group identified as dyslexic - either by reading assessment at the time, or by previous diagnosis. We assessed for risk of bias using an adapted version of the Newcastle-Ottawa scale. Six studies were included in this review, but only five (n = 280 participants) were included in the meta-analysis (we were unable to access the necessary data for one study).The overall effect was negative, large and statistically significant; g = -0.87, 95% CI [-1.47, 0.27]: a negative effect size indicating less perceptual anchoring in dyslexic versus non-dyslexic groups. Visual assessment of funnel plot and Egger’s test suggest minimal bias but with significant heterogeneity; Q (4) = 9.70, PI (prediction interval) [-2.32, -0.58]. The primary limitation of the current review is the small number of included studies. We discuss methodological limitations, such as limited power, and how future research may redress these concerns. The variability of effect sizes appears consistent with the inherent variability within subtypes of dyslexia. This level of dispersion seems indicative of the how we define cut-off thresholds between typical reading and dyslexia populations, but also the methodological tools we use to investigate individual performance.

scholarly journals Biomarkers predictive of treatment response in psoriasis and psoriatic arthritis: a systematic review

2021 ◽  
Vol 13 ◽  
pp. 1759720X2110140
Author(s):  
Conor Magee ◽  
Hannah Jethwa ◽  
Oliver M. FitzGerald ◽  
Deepak R. Jadon
Keyword(s):  
Systematic Review ◽  
Psoriatic Arthritis ◽  
Treatment Response ◽  
Unmet Need ◽  
Response To Treatment ◽  
Cochrane Library ◽  
Original Research ◽  
Eligibility Criteria ◽  
Psoriatic Disease ◽  
Subsequent Response

Aims: The ability to predict response to treatment remains a key unmet need in psoriatic disease. We conducted a systematic review of studies relating to biomarkers associated with response to treatment in either psoriasis vulgaris (PsV) or psoriatic arthritis (PsA). Methods: A search was conducted in PubMed, Embase and the Cochrane library from their inception to 2 September 2020, and conference proceedings from four major rheumatology conferences. Original research articles studying pre-treatment biomarker levels associated with subsequent response to pharmacologic treatment in either PsV or PsA were included. Results: A total of 765 articles were retrieved and after review, 44 articles (22 relating to PsV and 22 to PsA) met the systematic review’s eligibility criteria. One study examined the response to methotrexate, one the response to tofacitinib and all the other studies to biologic disease-modifying antirheumatic drugs (DMARDs). Whilst several studies examined the HLA-C*06 allele in PsV, the results were conflicting. Interleukin (IL)-12 serum levels and polymorphisms in the IL-12B gene show promise as biomarkers of treatment response in PsV. Most, but not all, studies found that higher baseline levels of C-reactive protein (CRP) were associated with a better clinical response to treatment in patients with PsA. Conclusion: Several studies have identified biomarkers associated with subsequent response to treatment in psoriatic disease. However, due to the different types of biomarkers, treatments and outcome measures used, firm conclusions cannot be drawn. Further validation is needed before any of these biomarkers translate to clinical practice.

scholarly journals Hypnotherapy for Procedural Pain and Distress in Children: A scoping Review Protocol

Pain Medicine ◽  
2021 ◽  
Author(s):  
Daly Geagea ◽  
Zephanie Tyack ◽  
Roy Kimble ◽  
Lars Eriksson ◽  
Vince Polito ◽  
...  
Keyword(s):  
Scoping Review ◽  
Grey Literature ◽  
Cochrane Library ◽  
Procedural Pain ◽  
Future Research ◽  
Theoretical Frameworks ◽  
Eligibility Criteria ◽  
Pharmacological Agents ◽  
Review Protocol ◽  
Meta Analyses

Abstract Objective Inadequately treated pain and distress elicited by medical procedures can put children at higher risks of acute and chronic biopsychosocial sequelae. Children can benefit from hypnotherapy, a psychological tailored intervention, as an adjunct to pharmacological agents to address the multiple components of pain and distress. Despite providing evidence on the effectiveness and potential superiority of hypnotherapy to other psychological interventions, research on hypnotherapy for paediatric procedural pain and distress has been predominantly limited to oncology and needle procedures. Plus, there is a lack of reporting of intervention manuals, factors influencing hypnotic responding, pain unpleasantness outcomes, theoretical frameworks, adverse events, as well as barriers and facilitators to the feasibility of delivering the intervention and study procedures. The proposed review aims to map the range and nature of the evidence on hypnotherapy for procedural pain and distress in children to identify gaps in literature and areas requiring further investigation. Methods This review will follow the Arksey and O'Malley (2005) methodology and incorporate additional scoping review recommendations by The Joanna Briggs Institute and Preferred Reporting Items for Systematic reviews and Meta-Analyses. Relevant studies will be identified through searching published literature databases (PubMed, Cochrane Library, PsycINFO, Embase, CINAHL, Scopus and Web of Science) and grey literature in addition to hand-searching of reference lists and key journals. Two authors will independently screen titles and abstracts of search results followed by full-texts review against eligibility criteria. Conclusion Findings are anticipated to guide future research and inform the development of tailored hypnotic interventions in children.

Sign in / Sign up

Export Citation Format

Share Document