scholarly journals Serum nesfatin in overweight and obese children

2020 ◽  
Vol 17 (2) ◽  
pp. 200-207
Author(s):  
Vladimir V. Bazarnyi ◽  
Elena V. Anufrieva ◽  
Arina Yu. Maksimova ◽  
Larisa G. Polushina ◽  
Olga P. Kovtun
Keyword(s):  
Overweight And Obesity ◽  
School Age Children ◽  
Enzyme Linked Immunosorbent Assay ◽  
Healthy Children ◽  
Obese Children ◽  
Normal Body ◽  
Body Fat Content ◽  
Normal Body Weight ◽  
Natural Hormones

BACKGROUND: Obesity is one of the most common children diseases. In present time it is being actively studied the natural hormones role in the pathogenesis of obesity. AIMS: To determine the relationship between serum nesfatin level with impaired lipid metabolism in school age children with overweight and obesity. MATERIALS AND METHODS: The study included children with overweight and obesity (case) and healthy children with normal body mass (control) aged 9 to 15 years. All children were determined by concentration in cholesterol blood and its factions, apoA-1, apoB. Enzyme-linked immunosorbent assay (Bio Human Nesfatin Enzyme Immunoassay Kit). RESULTS: Groups of patients with overweight and obesity (n = 53) and healthy children (n = 31) were comparable by age and sex. In obese children, a significant decrease in the level of nesfatin-1 was revealed compared with the group with normal body weight. In cases of children obesity there is a marked decrease in the concentration of nesfatin-1 in serum, especially expressed in the dyslipidemia presence. The nesfatin-1 level are negatively correlated to BMI and body fat content. CONCLUSIONS: The obtained data suggest that along with the known key role of nesfatin in the regulation of eating behavior and appetite, it also affects anthropometric indicators, primarily associated with the accumulation of excess fat mass. Based on the data obtained, nesfatin-1 should be considered as a possible marker for the development of obesity in children.

scholarly journals PREVALENCE AND RISK FACTORS FOR VITAMIN D DEFICIENCY IN OVERWEIGHT AND OBESE ADOLESCENTS IN UKRAINE

2019 ◽  
Vol 4 (2) ◽  
pp. 24-30
Author(s):  
A-M. A. Shulhai ◽  
H. A. Pavlyshyn
Keyword(s):  
Risk Factors ◽  
Vitamin D ◽  
Body Weight ◽  
Vitamin D Deficiency ◽  
Overweight And Obesity ◽  
Vitamin D Status ◽  
Obese Children ◽  
Obese Adolescents ◽  
Normal Body ◽  
Normal Body Weight

Background. Vitamin D affects the function of many organs and systems. Lipid metabolism disorder is established to be one of the risk factors for vitamin D deficiency, and the amount of adipose tissue is crucial. Objective. The aim of the study was to determine the prevalence and risk factors for vitamin D deficiency in overweight and obese adolescents. Methods. 146 children with excessive weight and obesity as well as 63 healthy children with normal body weight were examined. In the study groups, there were no children taking vitamin D. Vitamin D status was evaluated by the level of 25(OH)D in blood serum. Vitamin D deficiency was diagnosed at the level of 25(OH)D between 20 and 29 ng/ml, and significant deficiency – below 20 ng/ml, normal calcidiol content was 30-100 ng/ml. Results. The average level of 25(OH)D in the adolescents with normal body weight was 19.76±4.28 ng/ml, in the adolescents with excessive body weight – 15.24±3.47 ng/ml, and in the obese children – 13.87±2.71 ng/ml. The prevalence of vitamin D deficiency in the overweight adolescents was 70.62%, and in the adolescents with obesity – 77.19%. Conclusions. Vitamin D deficiency is prevalent in the adolescents with overweight and obesity. To prevent the development of hypovitaminosis and vitamin D deficiency, it is necessary to carry out educational activities with adolescents for promotion of healthy lifestyle and healthy food, as well as to develop an optimal program for improving vitamin D status in the obese children.

scholarly journals PLASMA CONCENTRATION OF ENDOTHELIN-1 IN PATIENTS WITH HYPERTENSION ASSOCIATED WITH OBESITY, DEPENDING ON THE LYS198ASN POLYMORPHISM OF THE ENDOTHELIN-1 GENE

2021 ◽  
Vol 9 (1) ◽  
pp. 87-94
Author(s):  
Yu.O. Smiianova
Keyword(s):  
Body Weight ◽  
Heart Rhythm ◽  
Pathological Process ◽  
Main Group ◽  
Overweight And Obesity ◽  
Control Group ◽  
Endothelin 1 ◽  
Normal Body ◽  
Heart Rhythm Disorders ◽  
Normal Body Weight

Endothelial dysfunction is considered one of the main mechanisms for the further development of arterial hypertension (AH) and its complications, and endothelin-1 (ЕТ-1) plays one of the key roles in this process. Endothelium is drawn into the pathological process at the earliest stages of AH development. ЕТ-1 is currently considered as a marker and predictor of the stage and consequences of AH, chronic heart failure (CHF), coronary heart disease (CHD), in particularly, acute myocardial infarction (MI), heart rhythm disorders, pulmonary hypertension, atherosclerotic vascular injury, target vascular disorders. One factor that may influence the level of ЕТ-1 is the endothelin-1 gene Lys198Asn polymorphism, which is considered by many researchers as a possible genetic marker of AH. However, the effect of this polymorphism on the level of plasma ЕТ-1 level in patients with AH of varying severity in Ukraine is understudied. The basis of this work were the materials of a complete examination of 160 patients with a verified diagnosis of AH I, stage II of 1, 2, 3 degrees (main group) and 110 apparently healthy persons (control group). Patients of the main group were divided into three subgroups: 1st group ­– 75 patients with normal body weight; 2nd group – 48 overweight patients; 3rd group – 37 patients with alimentary obesity. In obese patients, the waist circumference in women was around 103 (96–115) cm, and in men – 108 (105–116) cm, which indicates an abdominal type of obesity in these patients. As a result of the study, it was found that the level of ЕТ-1 is higher in patients with AH who suffer with overweight and obesity as compared with patients with AH and normal body weight. Also, the peptide level depends on the genotype of patients and is higher in AH patients with the genotype Asn198Asn and Lys198Asn as compared to carriers of the genotype Lys198Lys.

scholarly journals The importance of blood lipids in the association between BMI and blood pressure among Chinese overweight and obese children

2016 ◽  
Vol 116 (1) ◽  
pp. 45-51 ◽  
Author(s):  
Zhi-yong Zou ◽  
Yi-de Yang ◽  
Shuo Wang ◽  
Bin Dong ◽  
Xiao-hui Li ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Lipids ◽  
Ldl Cholesterol ◽  
Plasma Lipid ◽  
Underlying Mechanism ◽  
Overweight And Obesity ◽  
Mediation Effect ◽  
Obese Children ◽  
Beijing China

AbstractWe aimed to examine the contribution of blood lipids to the association between BMI and blood pressure (BP) in children with overweight and obesity. Data were collected in elementary and high schools of Chaoyang District, Beijing, China in 2012. Participants’ weight, height, BP and fasting plasma lipid profile were measured by standard protocols. Mediation analysis was used to examine the mediation role of blood lipids on the relation between BMI and BP, with age included as a covariate. We found that in boys 8·29 % (mediation effect=0·106, P=0·012) of the association between BMI and systolic BP was mediated through TAG. TAG mediated 12·53 % (mediation effect=0·093, P=0·018) and LDL-cholesterol mediated 7·75 % (mediation effect=0·57, P=0·046) of the association between BMI and diastolic BP was mediated by TAG and LDL-cholesterol, respectively. However, blood lipids did not show the mediation effect in girls. Our findings suggested that there was a sex difference in the contribution of blood lipids to the association between BMI and BP. Controlling TAG or LDL-cholesterol may be beneficial for reducing the risk of the BMI-related high BP in overweight boys; however, this outcome is not the case when controlling TAG or LDL-cholesterol in girls. This study may provide clues to explore the underlying mechanism of the association between obesity and hypertension.

scholarly journals Correlates of overweight and obesity among school going children of Himachal Pradesh

2020 ◽  
Vol 5 (05) ◽  
pp. 146-150
Author(s):  
Minakshi Chimanchod ◽  
Vijay Chaudhary ◽  
Abhimanyu Kumar
Keyword(s):  
Body Mass Index ◽  
Children And Adolescents ◽  
Body Mass ◽  
Life Style ◽  
Food Habits ◽  
Overweight And Obesity ◽  
School Age Children ◽  
School Age ◽  
Adult Obesity ◽  
Obese Children

Overweight and obesity are important determinants of health leading to adverse metabolic changes and increase the risk of non-communicable diseases. Following the increase in adult obesity, the proportion of overweight and obese children and adolescents has also been increasing. Erroneous life style and food habits are mainly responsible for rising graph of obesity. Hence, the present study was undertaken to study the magnitude of overweight/obesity and its correlates among school-age children ranging from 5-15 years, on the basis of 85th and 95th percentile of body mass index (BMI). Result showed the prevalence of overweight and obesity as 10.33% and 3.33%, respectively. Among number of other correlates related with life style, Kapha predominant Prakriti evolved as an important predictor of obesity. Data of this study clearly delineates that obesity is an increasing malady in rural and semi urban populations also on the pattern of metro cities.

scholarly journals TRAUMATIC DISEASE PECULIARITIES COURSE, ITS DIAGNOSTICS AND TREATMENT AT POLYTRAUMA IN SUFFER OBESE PATIENTS

2019 ◽  
Vol 43 (4) ◽  
pp. 47-53
Author(s):  
S.D. Khimich ◽  
O. M. Chemerys
Keyword(s):  
Body Mass Index ◽  
Body Weight ◽  
Body Mass ◽  
Overweight And Obesity ◽  
The Body ◽  
Obese Patients ◽  
Prognostic Features ◽  
Normal Body ◽  
Significant Difference ◽  
Normal Body Weight

Abstract Introduction. It’s known that the issue of polytrauma is one of the most urgent problems of surgery, and among injured patients a special approach is required for patients with overweight and obesity of varying degrees. Purpose of the study. To study prognostic features of traumatic disease course and to improve the results of diagnostics and surgical treatment of patients with polytrauma suffer obesity. Materials and methods. Clinical material was made up of 106 patients with combined body trauma, which were divided into three groups according to body mass index. Results. The results of the research showed a significant difference in the course of traumatic disease in patients with normal body weight and obesity. In particular, in the process of diagnostics of blunt chest and abdominal trauma the frequency of application of interventional methods of diagnostics was directly proportional to the increase of body mass index. The course of traumatic disease in the obese patients had a number of characteristic features that formed the basis for the development of diagnostics and differential program of treatment. Conclusions. The results of the research showed that the course of traumatic disease in combined injury obese patients is directly proportional to the body mass index and has certain features that differentiate them from patients with normal body weight. Keywords: polytrauma, obesity, traumatic disease, diagnostics, treatment.

scholarly journals Cardiopulmonary Capacity in Overweight and Obese Children and Adolescents: A Cross-Sectional Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Agata Grzyb ◽  
Małgorzata Domagalska-Szopa ◽  
Andrzej Siwiec ◽  
Ilona Kwiecień-Czerwieniec ◽  
Andrzej Szopa
Keyword(s):  
Body Weight ◽  
Children And Adolescents ◽  
Cardiopulmonary Exercise Testing ◽  
High Body Mass Index ◽  
Normal Weight ◽  
Control Group ◽  
Overweight Children ◽  
Obese Children ◽  
Normal Body ◽  
Normal Body Weight

Background: One of the objective methods of assessing the level of cardiopulmonary capacity in overweight and obese children and adolescents is cardiopulmonary exercise testing (CPET).Aims: The purpose of present study is an evaluation of aerobic capacity in high body mass index (BMI) children and adolescents by comparing them with a normal weight control group by CPET.Methods and Procedures: The subjects were recruited from participants of the Program of Treatment for Overweight and Obese Children organized by a local pediatric rehabilitation center in Poland. Based on BMI for age and gender, two validation groups were selected: (1) a group of overweight children (n = 49) and (2) a group of obese children (n = 48). The study included also 53 normal weight participants as a reference group (REF). The study consisted of two parts: anthropometric measurements and CPET. The Godfrey protocol for CPET was applied.Outcomes and Results: In this study, obese children and adolescents showed similar absolute VO2peak values in liters per minute (1.64 L/min) compared to overweight children (1.48 L/min), but significantly higher than children with normal body weight (1.39 L/min). The obese children and adolescents presented lower VO2peak in relation to body weight (25.44 ml/kg/min) compared to their peers with normal body weight (36.5 ml/kg/min), and overweight children (29.18 ml/kg/min).Conclusion and Implications: The main finding of our study was recognition of significant differences between cardiopulmonary capacity parameters in obese children in comparison not only to normal weight peers, but to overweight, too.

scholarly journals COMPOSITIONAL COMPOSITION OF THE BODY IN OBESE CHILDREN AND ADOLESCENTS

2019 ◽  
Vol 6 (1) ◽  
pp. 51-57 ◽  
Author(s):  
O. A. Gerasimchik ◽  
Ya. V. Girsh
Keyword(s):  
Weight Loss ◽  
Body Weight ◽  
Fat Mass ◽  
Dynamic Control ◽  
Overweight And Obesity ◽  
The Body ◽  
Excess Body Weight ◽  
Sequential Effects ◽  
Normal Body ◽  
Normal Body Weight

Background. The steady growth of obesity in the children’s age group determines the need for integrated modern approaches to diagnosis and therapy.Objective. To determine the body composition of adolescents with different body mass for the quantitative analysis of the internal environment of the organism using the method bioimpendancemetria.Design and methods. To determine the composition of the body, 121 adolescents aged 10–17 years were examined, the average age was 13.9 years (± 2.1). Evaluation of anthropometric data and determination of BMI at the 1st stage of the study allowed to identify 3 groups of patients: group 1 — adolescents with normal body weight, 40 people (33 %), group 2 — overweight, 48 people (40 %) and group 3 — obese, 33 adolescents (27 %). At stage 2nd, the analysis of the body structure using computer impedance, which allows to determine the composition of the body in a percentage.Results. When assessing the structure of the body, in group with normal body weight, the content of adipose tissue corresponds to the normal value. In adolescents overweight and obesity in 100 % of cases there was an increased content of fat mass. In the group of adolescents with normal body weight, the percentage deviation of AKM is 16–17 %, in the group with excess body weight 12–40 %. Insufficient as well as excessive percentage of AKM causes hunger. The higher AKM in full adolescents, the more difficult the process of weight loss. During the evaluation of the main metabolism it was found that in the group of obese patients the indicators exceeded those in the groups with normal and overweight.Conclusion. The use of bioimpedance analysis allows to create an optimal set of sequential effects aimed at correcting the fat mass, water composition and muscle mass of the patient, which determines a more directed and effective weight loss and the possibility of dynamic control.

scholarly journals Association of environmental factors with overweight and obesity in preschool and primary school children

2021 ◽  
Vol 36 (3) ◽  
pp. 148-153
Author(s):  
E. V. Shrayner ◽  
N. V. Kokh ◽  
G. I. Lifshits
Keyword(s):  
Risk Factors ◽  
Body Weight ◽  
School Children ◽  
Physical Inactivity ◽  
Sleep Time ◽  
Overweight And Obesity ◽  
Primary School Children ◽  
Obese Children ◽  
Normal Body Weight ◽  
Excessive Consumption

Aim. The aim of work was to study the existing environmental risk factors for overweight and obesity in preschool and primary school children living in Novosibirsk.Material and Methods. The study included 56 patients who visited a pediatrician or endocrinologist in Clinic of New Medical Technology Center, Institute of Chemical Biology and Fundamental Medicine. We used the individual food preference questionnaire developed based on the most common foods affecting body weight gain according to data of World Health Organization (WHO). Physical inactivity was assessment using a questionnaire developed based on the materials the International Physical Activity Prevalence Study. Children were divided into groups according consumption of carbohydrates: group 1 comprised children with excess consumption of carbohydrates; children of group 2 consumed normal amount of carbohydrates. The examined children included 21 children with normal body weight (10 boys and 11 girls with the average age of 7.19 ± 0.56 years); 35 children were overweight/obese (15 boys and 20 girls with the average age of 7.37 ± 0.35 years). A group of children with sleep time less than eight hours was assigned depending on sleep duration assessment.Results and discussion. The study included 56 children including 21 patients with normal body weight (37.5%), seven overweight children (12.5%), and 28 obese children (50%). The following significant differences were found between groups of obese and control children: physical inactivity was detected in 71.4% out of 35 obese children and in 23.8% of children in control group (p < 0.005, χ2 = 10.12). Sleep duration less than eight hours was observed in 34.3% of obese children and in 4.7% of healthy children (p < 0.01). Excessive consumption of carbohydrates was observed in 65.7% of obese children and in 19% of children with normal weight (p < 0.001). Intake of complex carbohydrates was approximately the same in both groups.Conclusion. We identified the following risk factors for overweight and obesity in our study: (1) factors contributing to obesity were physical inactivity, excessive consumption of carbohydrates, and impaired sleep-wakefulness pattern due to decrease in sleep time at night less than eight hours; (2) consumption of recommended amounts of fresh fruits and berries was protective against overweight and obesity.

scholarly journals Role of Hyperinsulinemia and Glucose Intolerance in the Pathogenesis of Nonalcoholic Fatty Liver in Patients with Normal Body Weight

1998 ◽  
Vol 13 (1) ◽  
pp. 10-14 ◽  
Author(s):  
Joon Hyoek Lee ◽  
Poong Lyul Rhee ◽  
Jong Kyun Lee ◽  
Kyu Taek Lee ◽  
Jae Jun Kim ◽  
...  
Keyword(s):  
Body Weight ◽  
Fatty Liver ◽  
Glucose Intolerance ◽  
Nonalcoholic Fatty Liver ◽  
Normal Body ◽  
Normal Body Weight

scholarly journals PECULIARITY PERSONALITY OF ADOLESTENTS WITH ESSENTIAL ARTERIAL HYPERTENSION AND OVERWEIGHT/OBESITY

2019 ◽  
Vol 15 (1-2) ◽  
pp. 69-73
Author(s):  
O.M. Misiura ◽  
M.V. Khaitovych
Keyword(s):  
Body Weight ◽  
Essential Hypertension ◽  
Children And Adolescents ◽  
Overweight And Obesity ◽  
Personality Characteristics ◽  
Emotional Instability ◽  
Psychological Study ◽  
Normal Body ◽  
Normal Body Weight ◽  
Comparative Group

Relevance. Recent changes in lifestyle and diet have led to a significant increase of overweight and obesity among children and adolescents. According to the results of our previous studies, it was found that among adolescents with overweight/obesity, essential hypertension is 1,5-7,5 times more common than among peers. It is known that children and adolescents with obesity are inherent in emotional instability and impulsivity. Objective of this work was to study the personality characteristics of adolescents with essential hypertension and overweight/obesity. Materials and methods. In the Kiev Children's Clinical Hospital No. 6, a comprehensive clinical and psychological study of 67 adolescents (18 girls, 49 boys) aged 12-17 years (average of 14,40±1,63 years) was carried out, who were hospitalized for essential hypertension. Overweight was found in 7 girls and 21 boys, obesity - in 2 girls and 8 boys. The remaining patients (9 girls and 20 boys) had normal body weight (comparative group). We evaluated the level of anxiety, alexithymia, depression, the type of attitude to the disease, and also determined the personality characteristics of the patients. Results. Adolescents with essential hypertension and overweight/obesity on average differed significantly higher pulse daily blood pressure (61,98±8,13 mmHg versus 57,02±6,70; P<0,005), lower values of anxiety scales (5,11±4,77 points versus 9,62±7,72 points; P<0,01), hypochondria (5,70±5,20 points versus 9,00±5,20 points; P<0,05), neurasthenia (7,19±7,49 points versus 11,14±7,90 points; P<0,05) and egocentrism (5,70±4,44 points versus 8,57±5,08 points; P<0,05) related to TOBOL test. According to the personality test R.-B. Kettell in adolescents with overweight/obesity was on average higher level Q2 scale (6,72±2,14 points versus 4,91±2,63 points; P<0,05). Conclusion. Adolescents with essential hypertension and overweight, obesity, in contrast to patients with normal body weight, are less neurotic by the disease, but they are characterized by non-conformity.

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