Some aspects of pharmacological support with antidysrhythmic drugs

2021 ◽  
Vol 27 (2) ◽  
pp. 145-152
Author(s):  
Vladimir V. Archipov ◽  
Yuliya R. Bolsunovskaya
Keyword(s):  
Cardiovascular Diseases ◽  
Generic Drugs ◽  
Analytical Data ◽  
Open Data ◽  
The State ◽  
Federal Law ◽  
Social Significance ◽  
Conduction Disorders ◽  
State Register ◽  
High Level

A high level of morbidity and mortality from cardiovascular diseases remains prevalent in the Russian Federation, despite a decreasing trend that emerged in recent years. Rhythm and conduction disorders play an essential role in the thanatogenesis of cardiovascular pathology, which determines the medical and social significance of their pharmacotherapy. This is indicated by the stable demand for antidysrhythmic drugs from both the state and the population. This is evidenced by high levels of public procurements and retail sales of drugs for the treatment of cardiovascular diseases, since patients take this drug group for a long time and often permanently. Our marketing analysis of the antidysrhythmic drugs market used current open data from the State Register of Medicines and the State Register of Maximum Selling Prices and available analytical data. It showed that from 54.5% (metoprolol drugs) to 100% (procainamide drugs) of the market share is occupied by generic drugs made in Russia. The presented analysis confirms the assumption of a significant increase in the share of generic drugs in public procurements. This is associated with the implementation of the drug safety program for vital and essential drugs and the optimization of costs by the state. A priority of the state drug policy in Russia is to monitor the effectiveness and safety throughout its entire life cycle. Moreover, particular importance should be given to the issue of interchangeability, which is regulated by Federal Law No. 1360 dated September 5, 2020, On the Procedure for Determining the Interchangeability of Medicines for Medical Use. The annual increase in the share of generic domestic antidysrhythmic drugs on the market poses the problem of selecting the most efficient and safe approach to pharmacotherapy for practicing specialists. The solution may be to develop and implement open automated information systems for the safety profiles of the original and generic antidysrhythmic drugs.

Bronchodilator and anti-inflammatory therapy of chronic obstructive pulmonary disease from the position of interchangeability

2021 ◽  
Vol 31 (4) ◽  
pp. 518-529
Author(s):  
E. A. Orlova ◽  
I. P. Dorfman ◽  
M. A. Orlov ◽  
A. K. Andreeva ◽  
M. A. Abdullaev
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Generic Drugs ◽  
The State ◽  
Chronic Obstructive ◽  
Anticholinergic Drugs ◽  
Adherence To Treatment ◽  
Obstructive Pulmonary Disease ◽  
State Register ◽  
Anti Inflammatory

The choice of drugs used to treat patients with chronic obstructive pulmonary disease (COPD) (inhaled β-agonists, M-anticholinergic drugs, inhaled corticosteroids (ICS)) in view of their interchangeability is reviewed in this article. This aspect is especially important for clinicians when choosing an effective and safe treatment for COPD and for increasing patient adherence to treatment.The aim of this study was to assess the ratio of the number of reference (original), interchangeable, and generic drugs used in COPD.Methods. In accordance with the Russian clinical guidelines 2018 and GOLD 2019, modern drugs for the treatment of COPD with bronchodilator and anti-inflammatory activity were selected. All trade names of the corresponding drugs for each international non-proprietary name (INN) In the State Register of Medicines website were considered. The information on the availability of reference (original) drugs and the corresponding interchangeable products, as well as their presence in the List of vital and essential drugs was analyzed.Results. A large number of generic prodcuts are registered in the State Register of Medicines, and only a few of them are interchangeable with the corresponding reference (original) drug.Conclusion. The analysis will help widen the doctors’ choice of interchangeable drugs in treatment of COPD with an equivalent effect and safety of reference drugs, as well as to increase the patients’ adherence to treatment.

scholarly journals ВИСОКОАДАПТИВНИЙ СОРТ СОЇ АКВАМАРИН

2018 ◽  
pp. 67-69
Author(s):  
Л. Г. Білявська ◽  
Ю. П. Васецький ◽  
О. В. Пилипенко ◽  
Ю. В. Білявський ◽  
А. О. Діянова
Keyword(s):  
Environmental Factors ◽  
Practical Experience ◽  
The State ◽  
Biological Characteristics ◽  
Stress Factors ◽  
State Register ◽  
High Level ◽  
Soy Production ◽  
Abiotic Environmental Factors

Показано цінність білкової культури сої, універсальність її використання, генетичний потенціал, вимоги споживача та переробника. Розглядаються шляхи та перспективи формування сортових ресурсів сої в Україні. До державного Реєстру сортів рослин, придатних для поширення в Україні, занесено значну кількість різноманітних сортів сої. Відмічається зростання частки скоростиглих сортів. Відповідно до сучасних вимог, сорт сої повинен бути високоврожайним, адаптивним, із високим генетичним потенціалом та мати відповідний рівень захисту рослин від біотичних та абіотичних факторів середовища. Базуючись на довготривалому практичному досвіді в селекції сої, у полтавському селекцентрі створено сорти з підвищеним базовим потенціалом. Серед них особливу цінність має сорт Аквамарин, занесений до Державного реєстру сортів рослин, придатних для поширення в Україні в 2013 році. Представлено окремі вимоги до елементів агротехніки. The value of protein culture of soy, the universality of its use is shown. The ways of increasing soy production in Ukraine are considered. To the State Register of plant varieties, suitable for distribution, a significant number of various soybean varieties are listed in Ukraine, most of which have a narrow ecological-geographical adaptation. In modern conditions, the soybean must be highly productive, adaptive, with a high level of resistance to biotic and abiotic environmental factors. Based on long-term practical experience in soybean selection, the hybridization of sources of adaptability to stress factors of the environment resulted in a variety with a higher base potential. Aquamarine variety, entered in the State Register of plant varieties, is suitable for distribution in Ukraine. The morphological and biological characteristics of the variety are given.

scholarly journals Correlation of reference and generic fluconazole-based drugs

2020 ◽  
pp. 98-104
Author(s):  
A. S. Dukhanin
Keyword(s):  
Generic Drugs ◽  
Medical Community ◽  
Quantitative Composition ◽  
Therapeutic Equivalence ◽  
Efficacy And Safety ◽  
Federal Law ◽  
Reference Drug ◽  
State Register ◽  
The Law ◽  
Preclinical And Clinical Studies

The article describes the basic rules for the selection of a systemic antifungal drug from the fluconazole-based preparations available on the Russian pharmaceutical market. Questions of interchangeability of generic and original drugs, research of equivalence (pharmaceutical, pharmacokinetic), possible methodological difficulties of its estimation are discussed. Data on comparative analysis of original and generic fluconazole drugs are presented. The algorithm of rational choice of a drug on an example of fluconazole is formulated, property of a drug to suppress selectively activity of fungi of genus Candida, not showing hepatotoxic drugs, and also questions of correlation between reference and generic drugs on the basis of fluconazole is considered. The Federal Law “On Amendments to the Federal Law “On Circulation of Medicines“ No. 429-FZ (adopted on December 22, 2014 and entered into force on July 1, 2015) regarding the establishment of the procedure for determining the interchangeability of drugs, states: “Information on the interchangeability of drugs shall be included in the State Register of Medicines from January 1, 2018“. The law discloses the notion of interchangeable drugs, which “means a drug with proven therapeutic equivalence or bioequivalence regarding reference drugs, having equivalent qualitative formula and quantitative composition of active substances, formula and method of administration“. However, some definitions used so far in the law have been changed. Thus, instead of the term “original medicine“ the term “reference drug“ is used from July 1, 2015, which is defined as a medicine first registered in the Russian Federation, the quality, efficacy and safety of which has been proved based on the results of preclinical and clinical studies, and which is used to assess the bioequivalence or therapeutic equivalence, quality, efficacy and safety of generic or bioanalogue medicine. However, this article still uses the terms “original“ and “generic“ drugs, which are familiar to our medical community.

scholarly journals Subtropical and flower crops breeding at the Subtropical Scientific Centre

2021 ◽  
Vol 25 (4) ◽  
pp. 420-432
Author(s):  
A. V. Ryndin ◽  
R. V. Kulyan ◽  
N. A. Slepchenko
Keyword(s):  
Storage Period ◽  
Scientific Work ◽  
Tea Plant ◽  
The State ◽  
Biological Traits ◽  
Cut Flowers ◽  
State Register ◽  
Growing Conditions ◽  
High Level ◽  
New Cultivars

This paper presents the results on the breeding work carried out by the Subtropical Scientific Centre of the Russian Academy of Sciences. Currently, the Centre’s breeders are doing a lot of work aimed at breeding new fine yielding cultivars of subtropical and flower crops that will be resistant to growing conditions; they include kaki persimmon, feijoa, mandarin, freesia, crown anemone, pelargonium and chrysanthemum. The sources of high-level priority traits in flower crops that are valuable for further breeding in order to improve decorative (colour, flower shape, inflorescence), economic and biological traits (flowering period, a large number of flowers in the inflorescence, storage period of cut flowers, disease resistance, high reproduction coefficient) were recorded. The aim of the research is to improve the subtropical and flower crops assortment. The objects of the research were 989 hybrid forms: 136 citrus crops, 56 persimmon, 36 feijoa, 38 tea plant, 11 pear, 24 hazel, 108 freesia, 398 crown anemone, 120 pelargonium and 62 chrysanthemum hybrids. New cultivars with a complex of valuable traits have been created as a result of the scientific work. Over the past five years, FRC SSC of RAS has created 50 new cultivars: 26 pelargonium, 15 anemone, 5 freesia, 2 chrysanthemum, 1 persimmon and 1 apple and submitted them to the State Cultivar Commission. The “State Register of Selection Achievements Authorized for Use for Production Purposes” has included 63 cultivars developed by FRC SSC RAS, including 26 pelargonium, 13 anemone, 9 chrysanthemum, 7 freesia, 4 hazel, 3 feijoa and 1 tea plant cultivars. 46 patents for breeding achievements have been obtained.

ALFALFA VARIETIES ZONED IN THE CENTRAL CHERNOZEM ZONE OF THE RUSSIAN FEDERATION

2020 ◽  
Author(s):  
Galina Stepanova
Keyword(s):  
Medicago Sativa ◽  
Dry Matter ◽  
Maximum Yield ◽  
The State ◽  
Average Yield ◽  
State Register ◽  
Independent Evaluation ◽  
Medicago Sativa L ◽  
Alfalfa Varieties ◽  
Central Chernozem

The article describes the main morphological and biological features of alfalfa varieties included in the State register of breeding achievements approved for use in the Central Chernozem zone of Russia. A total of 32 alfalfa varieties are included in the State register. This is 9 varieties of blue alfalfa (Medicago sativa L. subsp. Sativa) of domestic selection and 8 foreign, 11 varieties of variable alfalfa (Medicago sativa L. nothosubsp. varia (Martyn) Arcang.) domestic selection and 1 variety of foreign and 3 varieties of yellow alfalfa (Medicago sativa L. subsp. falcata (L.) Arcang.). It shows the average and maximum yield of varieties determined in the process of state variety testing, as well as independent evaluation in research institutions in the region. Varieties of blue alfalfa of domestic selection Kevsala, Elena, Satellite, Vavilovskaya Yubileynaya were the most productive. The average yield of dry matter of these varieties reaches 8.4–9.2 t/ha, the maximum — 15.3–17.7 t/ha. Alfalfa varieties Timbale and Galaxy were the most productive among foreign varieties: the average yield of dry matter was 8.1 and 8.3 t/ha, the maximum – 15.5 and 17.2 t/ha. Varieties of alfalfa variable Vitalina and Vela provided an average yield of dry matter of 7.6 and 9.0 t/ha, the maximum yield reached 15.4 and 18.1 t/ha.

The issue of radioactive contamination in context of ecosystem services development

2016 ◽  
Vol 3 (3) ◽  
pp. 48-53 ◽  
Author(s):  
G. Chobotko ◽  
L. Raychuk ◽  
I. McDonald
Keyword(s):  
Ecosystem Services ◽  
The State ◽  
Natural Ecosystems ◽  
Type Region ◽  
State Register ◽  
Agrarian Policy ◽  
Literary Sources ◽  
Radiation Contamination ◽  
Logical Research

The aim of the article was to defi ne the role of the radioactive environment contamination in the formation of ecosystem services strategy. Methods. Monographic, systemic and structural, factor analysis, abstract and logical research methods have been used. The data from the State Statistics Service of Ukraine, the Ministry of Agrarian Policy and Food of Ukraine, the Ministry of Ecology and Natural Resources of Ukraine, materials of scientifi c researches, international materials and reports and other literary sources on the issues investigated have been used as an information base. Results. Retrospective analysis of sources and state of radioactive eco- systems contamination was conducted and the priority steps in developing the concept of ecosystem services in conditions of radiation contamination were found. Conclusions. The current socio-ecological paradigm of the transition from environmental use to environmental management should be refl ected in the relevant envi- ronmental management mechanisms. Currently, when assessing the state of ecosystem services in Ukraine and worldwide one must take into account the changes in food demand of residents of radioactively contaminated areas, the exploitation of radioactively safe ecosystems growth, their overload and degradation. All of this re- quires an inventory of ecosystem services by type, region, consumers, etc. and the formation of a state register of ecosystem services with a clear assignment of area of responsibility for appropriate natural ecosystems. This will help to make the economic evaluation of different ecosystem services and mechanisms of charges for ecosystem services.

Селекция и семеноводство картофеля в Камчатском крае

2018 ◽  
Author(s):  
N.I. Ryakhovskaya ◽  
T.P. Sherstyukova ◽  
M.L. Gamolina
Keyword(s):  
Russian Federation ◽  
Potato Yield ◽  
The State ◽  
Limiting Factors ◽  
State Register ◽  
Region Selection ◽  
New Varieties ◽  
The Russian Federation ◽  
Selection Of

Рассмотрены агроклиматические условия Камчатского края и лимитирующие факторы, сдерживающие рост урожайности картофеля. Приведены характеристики новых сортов картофеля селекции Камчатского НИИСХ созданных в соответствии с приоритетными для региона направлениями селекции, включенных в Государственный реестр селекционных достижений РФ и охраняемых патентами.Agroclimatic conditions of the Kamchatka Krai and limiting factors that restrain the growth of potato yield are considered. The characteristics of new varieties of potatoes of the selection of the Kamchatsky RIA are created in accordance with the priority for the region selection areas included in the State Register of Selection Achievements of the Russian Federation and protected by patents.

THE IMAGE OF AN ACTIVE WOMAN IN THE SPIRITUAL HERITAGE OF EASTERN THINKERS

2020 ◽  
Vol 7 (3) ◽  
pp. 97-105
Author(s):  
Feruza Davronova ◽  
Keyword(s):  
The State ◽  
Political Activity ◽  
Spiritual Values ◽  
Social Significance ◽  
Active Woman ◽  
State And Society ◽  
The Family

The purpose of this article is to study the image of socio-political activity of women, their role and importance in the life of the state and society.In this, we referred to the unique books of orientalists and studied their opinions and views on this topic. The article considers the socio-political activity of women, their role in the state and society, the role of the mother in the family and raising a child, oriental culture, national and spiritual values, traditions and social significance of women

Breeding study of sea buckthorn (Hippophae rhamnoides L.) in the Institute of Horticulture, NAAS оf Ukraine

2020 ◽  
pp. 37-49
Author(s):  
V.V. Moskalets ◽  
◽  
T.Z. Moskalets ◽  
I.V. Grynyk ◽  
O.A. Shevchuk ◽  
...  
Keyword(s):  
Genetic Markers ◽  
Cell Biology ◽  
Molecular Genetic ◽  
The State ◽  
Sea Buckthorn ◽  
National Academy Of Sciences ◽  
Scientific Cooperation ◽  
State Register ◽  
Academy Of Sciences

The authors present the results of the sea buckthorn breeding at the Institute of Horticulture (NAAS). The stages of the work have been analyzed – from studying and selecting the initial material in the conditions of the Polissya, Polissya-Lisosteppe and Lisosteppe ecotopes (2012-2016) to the successful targeted introduction to the Northern part of the Lisosteppe (2017-2019) and new forms have been characterized according to the traits valuable for economy and molec-ular genetic markers. The new forms of the researched crop taking into consideration the high indices of their productiv-ity,adaptivity to the unfavourable abiotic and biotic environmental factors and consumption quality of fruits for pro-cessing and making functionary products were entered officially into Genetic Fund of the Plants of Ukraine as con-firmed by the certificates of copyright and developed genetic passports. The list of these genotypes includes 1-15-1 (Nos-ivchanka, UA3700073), 1-15-8S (Mitsna, UA3700079), make form 1-15-6Ch (Aboryhen 6/11, UA3700080), 1-15-9 Ka-rotynna, UA3700082), 1-15-3 (Pamiatka, UA3700076), 1-15-8V (Soniachne siayvo, UA3700075), 1-15-11 (Lymonna, UA3700072), 2-15-73 (Morkviana, UA3700077), 1-15-5 (Adaptyvna, UA3700078), 1-15-8B (Osoblyva, UA3700083), 1-15-6 (Apelsynova, UA3700084) and forms 6A/11 (UA3700081), 1-15-5a (Sribnolysta 5a, UA3700074). The possibility of using 5 DNA markers to characterize genotypes of sea buckthorn bymeans of the molecular genetic markers was tested and evaluated in the framework of the scientific cooperation with the Institute of Cell Biology and Genetic Engineering of the National Academy of Sciences of Ukraine. It should be noted that the most polymorphic markers were HrMS025 and HrMS026. However, the marker HrMS014 was monomorphic, but appeared in all the samples, so it can be used as a reference. The best forms of sea buckthorn Adaptyvna (certificate №190899) and Osoblyva (certificate №190900) were included into the State Register of Plant Varieties Suitable for dissemination in Ukraine, and the cultivars of the univer-sal use Nadiina (applications №18299010), Oliana (applications №18299009) and Morkviana (applications № 20299001) and cv pollinator Obrii (applications №18299008) undergo the State strain test. The attention is concentrat-ed on the promising directions of the new sea buckthorn genotypes for the prior breeding and genetic investigations at the Institute of Horticulture (NAAS) and its network.

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