scholarly journals Assessment of the Adaptation Capacities of the Body Based on the Determination of the Natural Antibodies to the Endogenous Bioregulators

2018 ◽  
Vol 1 (3) ◽  
pp. e00038
Author(s):  
M.A. Myagkova ◽  
S.N. Petrochenko ◽  
A.I. Levashova
Keyword(s):  
Natural Antibodies ◽  
The Body ◽  
Control Group ◽  
Practical Recommendation ◽  
Immunological Parameters ◽  
Immunological Monitoring ◽  
Greco Roman ◽  
Stage 1 ◽  
The Relationship

A comparative analysis of natural antibodies to bioregulators of the excitation and inhibition nervous system (glutamate and GABA) was performed in serum of people with different types of physical activity. Immunological monitoring was done in three stages: on day 1 (stage 1), on day 14 (stage 2) and on day 28 of examination (stage 3). The study included individuals who were intensively engaged in certain kinds of sports (Greco-Roman wrestling, hockey) and volunteers, who normally practiced a set of health physical exercises. A significant increase in the level of natural antibodies to GABA and glutamate was found with an increase in the duration of exercise in the training process compared with the control group. For individuals involved in various sports activities, the relationship between the intensity of the loads and the immunological parameters was established. Practical recommendation for the application of the developed method for an estimation of adaptation possibilities of the organism at changing physical loadings is given.

scholarly journals Relevance of the body mass index in the cognitive status of diabetic patients with different alcohol-drinking patterns

2014 ◽  
Vol 66 (1) ◽  
pp. 347-353
Author(s):  
Serban Lacramioara ◽  
Cristina Toarba ◽  
Simona Hogas ◽  
A. Covic ◽  
A. Ciobica ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Alcohol Consumption ◽  
Alcohol Drinking ◽  
The Body ◽  
Control Group ◽  
Diabetic Patients ◽  
Inverse Association ◽  
Drinking Patterns ◽  
Alcohol Drinking Patterns ◽  
The Relationship

Nowadays the general relevance of alcohol consumption in diabetes is extremely controversial. There are recent reports that alcohol consumption could result in a decreased incidence of diabetes, as well as other studies demonstrating a positive association between alcohol consumption and type 2 diabetes; there are also reports arguing for an inverse association between the two or for no correlation at all. The different results obtained in these studies could be explained by the existence of several confounders that could influence the outcome of the aforementioned studies. In this paper, we studied the possible relevance of BMI as a confounder in the relationship between alcohol consumption in diabetes and cognitive function, by analyzing the correlations between BMI values in diabetic patients with different alcohol drinking patterns and the subdomains from some main psychometric tests, such as MMSE (Mini-Mental State Examination) and MOCA (Montreal Cognitive Assessment). Our results provide evidence for BMI as a possible confounder of the relationship between alcohol consumption in diabetes and cognitive function. We found a significant increase (p<0.0001) in BMI values in patients with diabetes compared to our control group. Most importantly, significant correlations between BMI parameters in alcohol-consuming diabetic patients and most of the subdomains for psychometric testing.

scholarly journals Echocardiographic evaluation of ventricular septal defect haemodynamics

2007 ◽  
Vol 135 (9-10) ◽  
pp. 541-546
Author(s):  
Vesna Miranovic
Keyword(s):  
Ventricular Septal Defect ◽  
Pulmonary Artery ◽  
Body Surface ◽  
Septal Defect ◽  
Left Ventricular ◽  
The Body ◽  
Control Group ◽  
Healthy Children ◽  
And Control ◽  
The Relationship

Introduction Ventricular septal defect (VSD) is an opening in the interventricular septum. 30-50% of patients with congenital heart disease have VSD. Objective The aim of the study was to determine the dependence of the left ventricular diastolic dimension (LVD), left ventricular systolic dimension (LVS), shortening fraction (SF), left atrium (LA), pulmonary artery truncus (TPA) on the body surface and compare their values among experimental, control and a group of healthy children. Values of maximal systolic gradient pressure (Pvsd) of VSD were compared with children from one experimental and control group. Method Children were divided into three groups: experimental (32 children with VSD that were to go to surgery), control (20 children with VSD who did not require surgery) and 40 healthy children. Measurements of LVD, LVS, SF, LA, TPA were performed in accordance to recommendations of the American Echocardiographic Association. The value of Pvsd was calculated from the maximal flow velocity (V) in VSD using the following formula: Pvsd=4xV? (mm Hg). Results For children from the experimental group, the relationship between the body surface and the variability of the LVD was explained with 56.85%, LVS with 66.15%, SF with 4.9%, TPA with 58.92%. For children from the control group, the relationship between the body surface and the variability of LVD was explained with 88.8%, LVS with 72.5%, SF with 0.42%, PA with 58.92%. For healthy children, the relationship between the body surface and the variabilitiy of the LVD was explained with 88.8%, LVS with 88.78%, SF with 5.25% and PA with 84.75%. There was a significant statistical difference between average values of Pvsd in the experimental and control group (p<0.02). Conclusion The presence of the large VSD has an influence on the enlargement of LVD, LVS, SF, TPA. The enlargement of the size of the pulmonary artery depends on the presence of VSD and there is a direct variation in the magnitude of the shunt. There is a relationship and significant dependence of the LVS and LVD on the body surface. There is no statistically significant dependence between SF and body surface.

scholarly journals Serum biomarkers and clinical characteristics of patients with Hodgkin lymphoma

2018 ◽  
Vol 75 (9) ◽  
pp. 911-917
Author(s):  
Olivera Simonovic ◽  
Milena Todorovic ◽  
Biljana Mihaljevic ◽  
Tatjana Stoimenov-Jevtovic ◽  
Ivan Petkovic ◽  
...  
Keyword(s):  
Progressive Disease ◽  
Clinical Status ◽  
Scoring Systems ◽  
Control Group ◽  
Newly Diagnosed ◽  
Risk Patients ◽  
Tumor Environment ◽  
Prognostic Scoring Systems ◽  
The Relationship

Background/Aim. In classical Hodgkin?s lymphoma (cHL) the existing prognostic scoring systems do not include markers that adequately reflect the interaction of malignant Hodgkin and Reed-Sternberg (HRS) cells and tumor environment. The aim of this study was to determine the relationship between serum Galectin-1 (Gal-1) and soluble CD163 (sCD163) and the clinical status of patients with cHL, with special emphasis on the presence of relapse, progression, or resistance to the therapy applied. Methods. The research included 79 patients of whom 63 were patients with cHL, and the control group of 16 healthy volunteers. The study group of 63 patients with cHL included a subgroup of newly diagnosed patients without therapy, newly diagnosed patients with therapy, patients with relapse and progression of the disease and primary refractory patients during 2014 and 2015. Results. Analysis of the levels of sCD163 and Gal-1 within a group of patients suffering from cHL showed that the values of both molecules were higher in relapsed patients and the subgroup with progressive disease comparing to the subgroup of newly diagnosed patients without therapy or patients with therapy onset. Conclusion. Determination of Gal-1 and sCD163 levels is simple and reliable analysis that can contribute to the identification of high-risk patients with cHL and deserves inclusion in current prognostic scoring systems.

scholarly journals THE USE OF BIOSTIMULANT FOR INCREASING THE BODY WEIGHT GAIN OF CHICKENS

2020 ◽  
Vol 17 (35) ◽  
pp. 800-812
Author(s):  
Ilgiz DOLININ ◽  
George BAZEKIN ◽  
Evgeny SKOVORODIN ◽  
Almaz SHARIPOV ◽  
Ivan CHUDOV
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Broiler Chickens ◽  
Body Weight Gain ◽  
Live Weight ◽  
The Body ◽  
New Drugs ◽  
Natural Resistance ◽  
Control Group ◽  
Immunological Parameters

Poultry farming holds a special place in ensuring the products that the consumers demand, it provides the population with essential food products,such as eggs and meat,that contain vital micro and macronutrients, proteins, lipids, and vitamins. Therefore, the issues of rational, economically feasible feeding of meat poultry, namely broiler chickens, are an urgent task. It is also essential to find effective methods of their application in order to correct the natural resistance and immune and biological reactivity of birds. The purpose of this research is to study the effect of the biological stimulant-Nucleostim on the growth and development of chickens, hematological, and immunological parameters of the blood of birds.This Biostimulant is a purified bovine spleen extract containing at least 1 mg / ml of low molecular weight peptides (nucleotides and nucleosides) formed as a result of autolysis, using dry whey and diatomite as fillers. Onthe application ofNucleostim, the gain in live weight of chickens was increased by 9.7%. At the end of the experiment, the livability of the chicks of the experimental group treated with Nucleostimcame up to 88%, compared with the 72% of the control group. The use of biostimulant had a stimulating effect on the liver of chickens confirmed by the research results presented in the article, as well as contributed to the development of the thymus in the setting of general dystrophy. Thus, it improved chicklivability and increased body weight gain. The biological stimulant-Nucleostim as an adaptogenic, anabolic, and immunostimulatory agent is promising for finding new drugs that improve the health and productivity of poultry.

scholarly journals Peculiarities of Evaluation of Biological Effects of the Influence of Electromagnetic Radiation in Conditions of Reduced Temperature (Experiment)

2021 ◽  
Vol 6 (2) ◽  
pp. 227-235
Author(s):  
O. Litovchenko ◽  
◽  
I. Perova ◽  
Keyword(s):  
Electromagnetic Radiation ◽  
Negative Impact ◽  
Biological Effects ◽  
The Body ◽  
Combined Effect ◽  
Male Rats ◽  
Control Group ◽  
Prevention Measures ◽  
Immunological Parameters ◽  
Reduced Temperature

In modern conditions there is a high need to improve methods for establishing the nature of the combined influence of factors using modern approaches for further development of prevention measures against the negative impact of factors on the body. The purpose of the study was to investigate the combined effect of electromagnetic radiation and low temperatures with subsequent determination of the level of contribution of each factor in the formation of biological effects within the experiment by mathematical analysis of data using the method of artificial intelligence. Materials and methods. The subchronic experiment (30 days) was performed on male rats. The animals were divided into groups: combined exposure to electromagnetic radiation (70 kHz, 600 V/m) and reduced temperature (40C), isolated exposure to reduced temperature, isolated exposure to electromagnetic radiation and a control group. The establishment of biological effects was performed at stages 5, 15 and 30 days of the experiment. Changes in the body were assessed by physiological, biochemical and immunological parameters of the blood (30 indicators). Data processing was performed using computational intelligence methods (Neuro-fuzzy system). Results and discussion. The combined effect of the factors was manifested by the following biological effects: intensification of peroxidation processes with simultaneous moderate suppression of antioxidant protection, intensification of lipid metabolism was characterized by dyslipoproteinemia, manifesting in: increase in triglycerides, cholesterol and its fractions. Changes of the immune system were decrease in the ability of neutrophils to phagocytosis at different stages of the experiment, imbalance of the activation of the system of reducing the concentration of C4 at the background of increased intensity of IgM and IgG synthesis. The method of determining the intensity of the factors, developed on the basis of factor and cluster analysis, allowed to determine that during the experiment the ratios between the factors changed, but the greatest contribution was made by reduced temperature by both biochemical parameters (63%) and immunological (53%) at the same time, the level of electromagnetic radiation contribution was 37% and 47%, respectively. Thus, the reduced temperature was the leading factor in the combined effect, which added 60% to the overall biological effect throughout the study, against the effect of electromagnetic radiation for which the level of contribution was only 40%. By means of the factor analysis informative indicators, making it possible to establish the characteristics of biological effects, and therefore leading indicators in formation of biological effects were the increase in concentration of DC with simultaneous decrease in concentration of SH-groups, increase in VLDL and suppression of oxygen-dependent metabolism of neutrophil-test. Conclusion. Thus, the tested mathematical approach allowed to determine the leading role of each of the studied factors under the conditions of their combined influence in different systems, which allows to predict probable appropriate reactions of the whole organism and gives a reasonable approach to the development of preventive measures

scholarly journals BODY IMMUNOLOGICAL REACTIVITY IN OPIOMANIA

2021 ◽  
Vol 23 (4) ◽  
pp. 781-784
Author(s):  
K. K. Kulmukanova ◽  
A. U. Baiduissenova ◽  
E. A. Akhmediyarova ◽  
A. A. Yktiyarov ◽  
G. A. Bekniyazova ◽  
...  
Keyword(s):  
Relative Number ◽  
Neurological Status ◽  
The Body ◽  
Control Group ◽  
Immunological Reactivity ◽  
Immunological Parameters ◽  
Group I ◽  
Opioid Drugs ◽  
Therapeutic Measures ◽  
Opium Addiction

Due to the general trend of changes in reactivity in many exogenous and endogenous diseases, more and more attention is currently being paid to changes in immunological reactivity in drug addiction. The expediency of assessing the state of immune mechanisms in opioid addiction is determined by the need to predict their course and outcome. The aim of the study was to study the immunological reactivity of the body in patients with opium addiction in a stage of abstinence. For this purpose, clinical and immunological studies were conducted in 80 patients who use opioid drugs. The duration of the disease ranged from 0.5-19 years. Of these, the disease duration is up to 3 years – 28 patients (group I), and over 3 years – 52 patients (group II). The number of subjects in the control group was n = 50. Authors carried out the assessment of the mental, narcological, somatic, and neurological status. In addition, they have studied the general clinical, biochemical and immunological parameters As a result of this study, it was found, that patients of group I had more pronounced T-lymphocytopenia. A persistent increase in the value of serum IgM was revealed both in the dynamics of abstinence and depending on the duration of the disease, which may indicate a strain on the humoral link of immunity in opium addiction. In addition, as the duration of chronic narcotization increases, there is a tendency to increase the relative number of B-lymphocytes. Thus, at the patients with opium addiction in a state of abstinence develop T-lymphocytopenia. Moreover, with an increase in the duration of the disease, an increase in the level of IgM by 2-2.6 times. The revealed changes in the immunological reactivity of the organism suggest the need to include immunocorrective therapy in the complex of therapeutic measures for opium addiction. 

Embodied Inner Human Being

2014 ◽  
Vol 21 (1-2) ◽  
pp. 20-57
Author(s):  
Annette Weissenrieder ◽  
Gregor Etzelmüller
Keyword(s):  
Deep Understanding ◽  
The Body ◽  
Human Being ◽  
Ancient Medicine ◽  
The Core ◽  
Greco Roman ◽  
Medicine And Philosophy ◽  
Philosophical Texts ◽  
Definition Of ◽  
The Relationship

In this paper we take issue with George H. van Kooten’s recent argument that Paul’s concept of inner human being has a background in ancient philosophical treatises as a metaphor of the soul. We argue that its Greco-Roman physiological meaning was decisive in its adoption by Paul and that the split between ancient medicine and philosophy was not essential in antiquity. Ancient medical-philosophical texts did not focus on the core or center of a person but rather sought a deep understanding of his or her inner aspects. These texts sought to understand how it is that we can discover bodily information about this inner person and to what degree the relationship between the inner and outer person can be interpreted. At the same time, however, we are discussing Walter Burkert’s evolutionary understanding of Pauline’s concept of the inner and outer human being. Paul’s definition of the inner human being corresponds to recent anthropological concepts of embodiment insofar as the visible outer human being has an inside which, according to Paul, is not detached from the body, but must be grasped from a physical perspective.

The indirect determination of energy retention in farm animals: I. The development of method

1956 ◽  
Vol 48 (2) ◽  
pp. 194-209 ◽  
Author(s):  
K. L. Blaxter ◽  
J. A. F. Rook
Keyword(s):  
Water Content ◽  
Allantoic Fluid ◽  
The Body ◽  
Farm Animals ◽  
High Concentration ◽  
Adult Cattle ◽  
Indirect Determination ◽  
Energy Retention ◽  
The Relationship

1. Methods of estimating water retention in the body of cattle are discussed, and it is shown that methods based on determinations of the initial and final body-water content are of low accuracy and are not suitable for the indirect estimation of fat balance over a period of 24 days.2. Analyses of tissues from young and adult cattle showed that with the exception of serum, brain, skin and bone, water content of the tissues may be predicted from the following equation:Water(g./100g.) = 0·292 Na(mg./100g.) + 0·147 K(mg./100g.).This equation shows that 1 m.equiv. of the Na of tissues is associated with more water than is 1 m.equiv. of the K.3. No differences between cattle aged from less than 1 week to more than 5 years were observed in the relationship between water and Na and K content.4. The equation applied also to the contents of the digestive tract, other than those of the abomasum which gave low results, ascribed to the presence of a high concentration of H+ ions.5. Analyses of whole foetuses for Na, K and H2O showed that their water content could be predicted accurately. The same was true of amniotic fluid, but the water content of allantoic fluid was underestimated by 50%.6. It was shown that despite the anomalous behaviour of brain, serum, skin and bone, accurate predictions of the water content of the animal could be made from simultaneous determinations of Na and K retentions, providing a correction was made for the storage of bound Na in bone.7. Data are presented which indicate that the equations apply equally well to the tissues of the sheep.

scholarly journals Phagocytic and metabolic activity of neutrophils of rats in the early stages of post-embryonic development under the influence of biologically active substances of the salt extract of Hirudo verbana

2016 ◽  
Vol 7 (2) ◽  
pp. 96-100 ◽  
Author(s):  
R. F. Aminov ◽  
A. K. Frolov
Keyword(s):  
Metabolic Activity ◽  
The Body ◽  
Biologically Active ◽  
Control Group ◽  
Standard Diet ◽  
Immunological Parameters ◽  
Ether Anesthesia ◽  
Saline Extract ◽  
Nbt Test ◽  
Salt Extract

The nitroblue tetrazolium test reflects the degree of activation of oxygen-dependent mechanisms of bactericidal activity of phagocytotic cells, so the increase in nbt-test and phagocytic indices shows increased activation in the bacterial process and enhanced protection with the help of the absorption ability of the cells in the body. We examined females of nonlinear rats after feeding of their offspring, which 2 weeks before and 2 weeks after mating were injected intraperitoneally with antigens of saline extract of medical leeches (4 injections) and the offspring at days 1, 15, 30, 45, 60. The dosage of salt extract antigens was carried out by determining the protein concentrations using the Lowry protein assay. The animals were immobilized using an immobilizing device. The animals were distributed into three groups: the first research and experimental group of animals was subject to the influence of medical leech salt extract antigens to the amount of 0.5 ml (at the rate of 3 µg/g of animal weight); the second group of intact animals was not subject to intervention, the third control group of animals was administered intraperitoneally saline 0.5 ml of 9% saline solution. We studied females after feeding offspring and offspring at 1, 15, 30, 60 days. The animals were kept in vivarium conditions in individual cages on a standard diet. In the experiment we used 60 females of non-linear rats and 300 of their offspring. All animals were decapitated under ether anesthesia. After that, we took blood, made a solution with crystal heparin and examined the laboratory parameters: total number of leukocytes and leukocyte formula. Evaluation of nonspecific resistance of the organism was investigated using tests which characterize the activity of neutrophils (nbt-test, phagocytosis indices). The results of our studies revealed a positive effect of antigens of saline extract of medical leeches on the absorptive and metabolic activity of neutrophils in the females and their offspring in all study periods compared with the control, an increased number of leukocytes, due to the change of the process of differentiation and deposition of cells in immunogenic organs on proliferation. Changes in immunological parameters indicate the immunostimulatory effect of AG ML on leukopoiesis and on the functional activity of neutrophils – the first line of defense against entry into the body of a variety of bacteria, fungi and protozoa. 

scholarly journals Influence of the supplement «Press-Acid» on protein-mineral metabolism and resistance of piglets

2018 ◽  
Vol 20 (83) ◽  
pp. 320-324 ◽  
Author(s):  
N.V. Chеrniy ◽  
E.V. Matsenko ◽  
Yu.A. Shchepetilnikov ◽  
Yu. V. Maslak ◽  
O.S. Machula ◽  
...  
Keyword(s):  
Blood Serum ◽  
Mineral Metabolism ◽  
The Body ◽  
Control Group ◽  
Immunological Parameters ◽  
Oxidative Reaction ◽  
Experimental Animals ◽  
Growth Energy ◽  
First Time ◽  
Experimental Group

The aim of this study was to determine the effect of supplement «Press-Acid» on some parameters of mineral and protein metabolism and resistance of piglets. The study was done in condition «Meta» on two groups of piglets of the F-1 (BWхL) genotype. There were determined indexes of bacterial and lysocim activity of blood serum, calcium and phosphorus in piglets at the age of 21–30–45–75 days. Effect of supplement on the growth rate, morbidity and safety of pigs were revealed. We used hygienic, zootechnical, hematological, biochemical, immunological and statistical methods of analysis. The influence of «Press-Acid», which consist of formic, lactic, citric and fumaric acids, was established for the first time. The concentration of calcium in blood serum of experimental group of piglets were lower than in animals of control group. The level of phosphorus increased in blood serum of experimental animals on 11.83% (30 day), on 3.74% (45%), on 17.65% (75 day) respectively. Concentration of hemoglobin and the amount of erythrocytes increased on 11.8% and on 1.82% (30 day) in animals that feed the supplement. There were established the increase of viability of the pigs with gastro-intestinal diseases which were given the supplement in comparison with that, who did not feed it. Severity of diseases was determined using the Melenberg coefficient which did not higher than 1.2–2.4 score, it was lower on 6,0–9,3 unit than in control group. Using the supplement allowed to increase the intensity of growth of piglets by 3.7% (45 day) and 9.4% (75 day) respectively. Concentration of total protein, albumines and globulins increased on 8.66%, 9.90%, 7.3% respectively. The activity of alaninaminotransphaerasae in the blood serum of experimental animals were lower on 3.45% than in control piglets. Lysocym and bacterial activity of blood serum were higher in experimental group of piglets. Feeding piglets with addition supplement Press Acid promotes higher grow rates in experimental animals, that can be explained increases of oxidative-reducing processes in them organism. Feeding piglets with acidifier «Press-Acid», «Nifulin», zinc oxide, probiotics «Lactisan Complex» promotes growth energy, increase of morphological, biochemical and immunological parameters which indicates a higher level of oxidative reaction in the body. A low coefficient of Melenberg is recorded in the piglets at the age of 1 day. Safety was within 92.1–97.0%. That indicates a more successful elimination of complexes of protein, mineral substances, humoral protection in blood of experimental group of animals.

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