scholarly journals Study of correlation between age with incidence of endometrial cancer and histopathological type

2021 ◽  
Vol 10 (6) ◽  
pp. 2473
Author(s):  
Ganesh Bharaswadkar
Keyword(s):  
Endometrial Cancer ◽  
Endometrial Carcinoma ◽  
Uterine Cancer ◽  
Age Groups ◽  
Common Type ◽  
Age Group ◽  
Elderly Age ◽  
Gynecological Malignancy ◽  
Dismal Prognosis ◽  
Histopathological Type

Endometrial carcinoma is one of the commonest Gynecological malignancy. Endometrioid type is the most common type associated with hyper-estrogenic state and has better prognosis. While non endometrioid type is less common, associated with elderly age and has dismal prognosis. Uterine cancer is most often observed in higher age group with average age at diagnosis of 60 years. It most often occurs in women over 50. 16 cases of endometrial carcinoma were collected from January 2018 until November 2020.The study evaluated the correlation of age with incidence and type of endometrial cancer by categorizing patients into different age groups and then analyzing them. The most affected age group was between 60-70 years and commonest type of endometrial cancer identified was Endometrioid type. 

Assessment of Risk Scoring Model for Prediction of Endometrial Cancer Among Symptomatic Postmenopausal Women (A Prospective Cohort Study)

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Magdy M Abd Elgawaad ◽  
Amr M El Helaly ◽  
Malames M Faisal ◽  
Asmaa F Kasem
Keyword(s):  
Endometrial Cancer ◽  
Family History ◽  
Endometrial Carcinoma ◽  
Endometrial Hyperplasia ◽  
Endometrial Thickness ◽  
Serous Carcinoma ◽  
Scoring Model ◽  
Gynecological Malignancy ◽  
Risk Scoring ◽  
Study Population

Abstract Background Endometrial carcinoma is the most common gynecological malignancy in the developed countries and the third common gynecological malignancy in Egypt after breast and ovarian cancers. Aim of the Work to evaluate this risk scoring model on Egyptian patients and to study the effect of adding other patient characteristics (DM, BMI and relevant family history) on the sensitivity and specificity of RHEA scoring model. Patients and Methods The current study was conducted in Ain Shams University Maternity Hospital in the period between September 2017 and December 2018. A total of 100 women with postmenopausal bleeding and endometrial thickness > 4mm were included in the study. Results Histological examination revealed that benign pathology (n = 65) (73%) was found to be: most common cause was endometrial hyperplasia without atypia (20.3%) followed by chronic endometritis (13.5%), then endometrial polyp (11.3%), cystic atrophy of endometrium (8.9%), proliferative endometrium (8.9%), endometrial hyperplasia with atypia (6.7%) and lastly mucous polyp (3.4%) while malignant histopathology(n = 24)(27%) which is significantly higher than the international rates showed: Endometriod adenocarcinoma (n = 19)(21.3%), papillary serous carcinoma (n = 4)(4.5%) and undifferentiated carcinoma (n = 1)(1.1%). The current study showed that RHEA score performs in our study population with a comparable validity to that reported by its inventors with sensitivity 79.2% (57.8% - 92.9%) vs. 87.5% and specificity 84.6% (73.5% - 92.4%) vs. 80.1% respectively. In results of the current study it was found that the time since onset of menopause rather than age was associated with endometrial cancer with the optimum cut-off for postmenopausal duration was estimated to be 9 years achieving a sensitivity of 87.5% and a specificity of 60.0%, but it needs multivariate analysis on larger and more representative sample size to confirm this association, A statistically significant regression model was including only postmenopausal duration, recurrent bleeding and endometrial thickness. None of age, BMI, family history or hypertension proved a statistically significant predictive effect after adjustment for other predictive variables. Conclusion Taking in consideration the higher prevalence of endometrial carcinoma in the sample of the current study, the wide 95% confidence intervals for the different validity indices for the RHEA scores derived from this study, it seems that RHEA score performs in this study population with a comparable validity to that reported by its inventors.

scholarly journals Outpatient antibiotic prescribing and demographic factors associated with state-level septicemia mortality rates in US adults

2018 ◽  
Author(s):  
Edward Goldstein ◽  
Marc Lipsitch
Keyword(s):  
Age Groups ◽  
Group Living ◽  
Antibiotic Use ◽  
Mortality Rates ◽  
Antibiotic Prescribing ◽  
Age Group ◽  
Poverty Level ◽  
Sepsis Mortality ◽  
Elderly Age ◽  
Average Annual Temperature

AbstractBackgroundRates of septicemia/sepsis mortality and hospitalization in the US have risen significantly during the recent years, and antibiotic use may contribute to those rates through various mechanisms.MethodsWe used multivariable linear regression to relate state-specific rates of outpatient prescribing overall for fluoroquinolones, penicillins, macrolides, and cephalosporins between 2013-2014 to state-specific rates of septicemia mortality (ICD-10 codes A40-41 present as either the underlying or contributing causes of death) in each of the following age groups of adults: (18-49y, 50-64y, 65-74y, 75-84y, 85+y) between 2013-2014, adjusting for median household income, average annual temperature, age-specific percentages of state residents who (i) lived below the poverty level, (ii) were African American, (iii) lacked health insurance (in non-elderly age groups), and random effects associated with the different US Health and Human Services (HHS) regions.ResultsRates of penicillin prescribing were positively associated with septicemia mortality rates in the analyses for persons aged 65-74y, 75-84y and over 85y. Rates of cephalosporin prescribing were positively associated with septicemia mortality rates in the analyses for persons aged 18-49y and 65-74y. Rates of fluoroquinolone prescribing were positively associated with septicemia mortality rates in the analyses for persons aged 18-49y. Percent African Americans in a given age group was positively associated with septicemia mortality rates in the analyses for age groups over 65y, and 18-49y. Percent of residents in a given age group living below the poverty level was positively associated with septicemia mortality rates in the analysis for persons aged 65-74y.ConclusionsOur results suggest that rates of penicillin prescribing are associated with rates of septicemia mortality in older US adults, while rates of cephalosporin prescribing are associated with rates of septicemia mortality in persons aged 18-49y and 65-74y, and rates of fluoroquinolone prescribing are associated with rates of septicemia mortality in persons aged 18-49y. Further studies are needed to better understand the potential effect of antibiotic replacement in the treatment of different syndromes, such as replacement of fluoroquinolones by other antibiotics, possibly penicillins and cephalosporins following the recent US FDA guidelines on restriction of fluoroquinolone use, on the rates of sepsis mortality.

scholarly journals Age-Specific Crisis Awareness Survey for Coronavirus Disease 2019 (COVID-19): How Much Do You Think You Should Pay for Hypothetical Prophylactic Vaccine and Therapeutic Drug for COVID-19?

2020 ◽  
Author(s):  
Takashi Kawahara ◽  
Masahiro Yao ◽  
Hiroji Uemura
Keyword(s):  
Age Groups ◽  
Therapeutic Drug ◽  
Prophylactic Vaccine ◽  
Age Group ◽  
Elderly Age ◽  
Japanese Adults ◽  
Worldwide Phenomenon ◽  
Similar Survey ◽  
The Mean ◽  
The Government

Abstract BACKGROUND: The spread of coronavirus disease 2019 (COVID-19) has been a worldwide phenomenon with 2,063,161 people infected and 136,938 deaths globally as of April 16, 2020. This study conducted a chronological survey of crisis awareness regarding COVID-19 within different age groups.METHODS: An internet-based survey was performed of healthy Japanese adults to investigate the value of a hypothetical prophylactic vaccine and therapeutic drug for COVID-19 in each age group. The survey was conducted on Friday of each week commencing from February 14, 2020 to April 10, 2020. At certain times or events such as when the government released major announcements or when there was a rapid increase in the number of infected individuals, a similar survey was conducted on an additional 1,200 individuals per week.RESULTS: A total of 12 surveys, including weekly surveys spanning over 9 weeks, were conducted, and a total of 19,113 samples from 12,254 individuals were obtained. The mean price for a hypothetical prophylactic vaccine was 2876.3 JPY (26.9 USD) at the first survey and was significantly increased to 3357.4 JPY (31.4 USD) for the most recent survey (p < 0.0001). CONCLUSIONS: Though the percentage of those who will not pay were higher in young age group than in elderly age group, the percentage of those who will pay more than standard costs of influenza vaccine or treatment drugs were same between each aging group.

scholarly journals Vaccination Prioritization Strategies for COVID-19 in Korea: A Mathematical Modeling Approach

2021 ◽  
Vol 18 (8) ◽  
pp. 4240
Author(s):  
Yongin Choi ◽  
James Slghee Kim ◽  
Jung Eun Kim ◽  
Heejin Choi ◽  
Chang Hyeong Lee
Keyword(s):  
Age Groups ◽  
Epidemiological Data ◽  
The Elderly ◽  
Age Group ◽  
Elderly Age ◽  
Social Distancing ◽  
Vaccination Strategies ◽  
Effective Age ◽  
Incidence And Mortality ◽  
Age Dependent

Coronavirus disease 2019 (COVID-19) vaccination has recently started worldwide. As the vaccine supply will be limited for a considerable period of time in many countries, it is important to devise the effective vaccination strategies that reduce the number of deaths and incidence of infection. One of the characteristics of COVID-19 is that the symptom, severity, and mortality of the disease differ by age. Thus, when the vaccination supply is limited, age-dependent vaccination priority strategy should be implemented to minimize the incidences and mortalities. In this study, we developed an age-structured model for describing the transmission dynamics of COVID-19, including vaccination. Using the model and actual epidemiological data in Korea, we estimated the infection probability for each age group under different levels of social distancing implemented in Korea and investigated the effective age-dependent vaccination strategies to reduce the confirmed cases and fatalities of COVID-19. We found that, in a lower level of social distancing, vaccination priority for the age groups with the highest transmission rates will reduce the incidence mostly, but, in higher levels of social distancing, prioritizing vaccination for the elderly age group reduces the infection incidences more effectively. To reduce mortalities, vaccination priority for the elderly age group is the best strategy in all scenarios of levels of social distancing. Furthermore, we investigated the effect of vaccine supply and efficacy on the reduction in incidence and mortality.

scholarly journals Assessment of Predictors of Hyperkalemia in Cardiovascular Diseased Patients

2021 ◽  
Vol 11 (2) ◽  
pp. 51-54
Author(s):  
Manasa R ◽  
Aksa Johnson ◽  
Presly Thomas Augustine ◽  
Anjana Tom
Keyword(s):  
Cardiovascular Disease ◽  
Cardiovascular Diseases ◽  
Observational Study ◽  
Tertiary Care ◽  
Age Groups ◽  
Common Type ◽  
Age Group ◽  
Aged Patients ◽  
Cross Sectional ◽  
Increased Risk

Purpose: The objective is to determine the predictors of hyperkalaemia, severity of hyperkalaemia and to access the prevalence of cardiovascular diseases Methodology: A cross sectional observational study was conducted on the predictors of hyperkalaemia in CVD patients, in a tertiary care teaching hospital for a period of 6 months. Results: Among 105 patients, there were 83 males and 22 females, the age group from 41-60 year shows more CVDs and 61-80 years aged patients are more prone to hyperkalaemia and shows more prevalent when compared to other age groups. The major risk factors of hyperkalaemia were Drugs (30.23%), Disease (58.13%), and Drug interactions (11.62%).Among the cardiovascular diseases, Myocardial Infarction (38%) were the most common type of CVD, while in hyperkalaemia Ischemic Heart Disease (48.83%) were more prevalent. The severity of hyperkalaemia is measured as Mild (60.46%), Moderate (37.20%), and Severe (2.32%). Conclusion: The present study was carried out in order to assess the predictors, prevalence and severity of hyperkalaemia in cardiovascular disease patients. Our study concluded that patients with cardiovascular disease can have an increased risk of hyperkalaemia. Keywords:  CVD, Hyperkalaemia, Cross sectional observational study, Predictors, Prevalence, Severity.

scholarly journals Study on clinical profile of hyponatremia in patients admitted to the MIMS in Northern Andhra Pradesh, India

2019 ◽  
Vol 7 (6) ◽  
pp. 2055
Author(s):  
Anand Sankar Sastry ◽  
Buridi Praneetha
Keyword(s):  
Common Type ◽  
Chronic Illnesses ◽  
Clinical Profile ◽  
Age Group ◽  
Medical Sciences ◽  
Elderly Age ◽  
Common Cause ◽  
Electrolyte Disorder ◽  
Common Etiology ◽  
Epidemiological Profile

Background: Hyponatremia, most common electrolyte disorder has symptomatology ranging from asymptomatic to being comatose and etiologically from simple G.I. loss to chronic illnesses like CCF, CKD. Very sparse study has been done in this region on clinic-epidemiological profile of hyponatremia. The aims and objective of this study was to find out most common etiology, type, clinical features and outcome in hospitalised hyponatremic patients and to Correlate clinical profile and outcome with etiology, severity and treatment.Methods: The present observational study was conducted in department of medicine, Maharajah’s Institute of medical sciences, for two months. All patients aged ≥15 years having true hyponatremia were included. Detailed history, examination, relevant investigations including serum and urinary Na were done. Patients were classified to euvolemic, hypervolemic and hypovolemic depending on volume status and proper etiologies were determined in each group.Results: Of 50 patients included, mean age was 50.12±8.8 years. Hyponatremia was more common in older age group>40 years (P<0.05%). CNS manifestations were more prevalent in patients with Na<125 Meq. (80%) P< 0.05%. Hypervolemic was most common type (50%) followed by hypovolemic (34%) and euvolemic (16%). CKD was the most common cause overall (24%) and also among hypervolemic type (40%).Conclusions: Hyponatremia was more predominant in elderly age group (P<0.05%). It is more in 40-60 years age group. Hypervolemic type (50%) of hyponatremia is most common type of the hyponatremia and CKD (24%), to be most common cause of the hyponatremia attributed to Uddanam nephropathy in this region.

scholarly journals GYNECOLOGICAL MALIGNANCY IN BPKMCH, BHARATPUR: A RETROSPECTIVE ANALYSIS OF 321 CASES

2003 ◽  
Vol 40 (139) ◽  
pp. 108-111
Author(s):  
Manohar Pradhan ◽  
H P Dhakal ◽  
C B Pun ◽  
S Pradhan ◽  
G Dangal
Keyword(s):  
Ovarian Cancer ◽  
Squamous Cell Carcinoma ◽  
Endometrial Cancer ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Age Group ◽  
Cancer Cervix ◽  
Gynecological Malignancy ◽  
Patients With Cancer ◽  
Carcinoma Of Cervix

Gynecological Malignancy is the leading cancer in female not only in Nepal butworldwide. A retrospective study of histopathological specimens was conducted inBPKMCH Bharatpur from July 1999 to January 2001, duration of 19 months. Total321 cases of Gynecological Malignancy were diagnosed in Department of Pathologyof BPKMCH. Out of which 272(84.73%) cases of cancer of cervix; 17 cases (5.29%)of cancer of vulva; 14 cases (4.36%) of ovarian cancer, 12 cases (3.73%) of cancer ofvagina and 6 cases (1.86%) of endometrial cancer were detected. Cancer of cervixwas most common in 40-49 years age group followed by 50-59 years age group. Meanage of the patients with cancer of cervix was 50 years and 10 months; minimum of 29years and maximum of 76 years. Out of 272 cases of cancer of cervix, 266 (97.79%)were squamous cell carcinoma and rest 6 (2.20%) were adenocarcinoma. Commonesthistology in vulva and vagina was squamous cell carcinoma, whereas adenocarcinomawas commonest in endometrium and ovary. The higher incidence of gynecologicalmalignancies particularly carcinoma of cervix was observed in BPKMCH.Key Words: Cancer, Cervix, Vagina, Vulva, Ovary.

scholarly journals Endometrial Carcinoma staging Issues Laparotomy versus Laparoscopic Approach which is More Feasible and Safer?

2019 ◽  
Vol 4 (2) ◽  
Keyword(s):  
Endometrial Cancer ◽  
Endometrial Carcinoma ◽  
Uterine Cancer ◽  
Surgical Staging ◽  
Peritoneal Cytology ◽  
Tumor Type ◽  
Statistical Significant Difference ◽  
Conversion Rates ◽  
Hospitalization Period ◽  
Significant Difference

Background: Surgical staging of endometrial cancer is considered one of the main pathways for managing those categories of cases. Uterine cancers are considered a challenging surgical scenario in many situations due to anatomical changes in tissue planes and metastatic disease besides the presence of obesity in many cases requiring management. Aim: To compare laparoscopy versus laparotomy for complete uterine cancer surgical staging. Methodology: Cases having clinical stage I to IIA endometrial carcinoma have been randomly allocated to laparoscopy or open laparotomy including hysterectomy, salpingo - oophorectomy, pelvic cytology, pelvic and para-aortic lymphadenectomy. The chief research study outcomes were the 6-week morbidity, mortality issues, hospitalization period and conversion rates from laparoscopy to laparotomy. Results: There was no statistical significant difference as regards the Surgical stage, tumor type, types and numbers of nodes of the studied research groups in which there was no statistical significant difference as regards surgical staging, tumor type observed, peritoneal cytology, type of nodes, no nodes, Para aortic nodes only, pelvic nodes only, both pelvic and para - aortic nodes, any pelvic node, no. of nodes median (IQR) values = 0.996, 0.998, 0.929, 0.607, 0.928, 0.669, 0.541, 0.562, 0.680, 0.934 consecutively. Conclusions and recommendations: The current research elucidates the privilege of laparoscopic surgical staging for early stage endometrial cancer, however future research studies are required to be performed in multi centric fashion and to put in consideration variability’s in BMI, coexisting medical morbidities e.g. DM, hypertension besides the racial and ethnic differences

scholarly journals DISTRIBUTION OF DR-TB BY SEX, AGE GROUPS, OCCUPATION, PROVINCE, DIVISION, DISTRICT, TYPE OF DISEASE, TYPE OF DRUG RESISTANCE, TREATMENT REGIMEN AND OUTCOME OF TREATMENT IN DR-TB POPULATION IN D.I.KHAN DIVISION, PAKISTAN

2020 ◽  
Vol 18 (3) ◽  
pp. 116-131
Author(s):  
Zeeshan Saleem ◽  
Imran Ullah ◽  
Muhammad Sarim Bin Farooq Awan ◽  
Jamal Tauqir ◽  
Faisal Younis ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Treatment Outcome ◽  
Success Rate ◽  
Treatment Regimen ◽  
Treatment Success ◽  
Age Groups ◽  
Common Type ◽  
Disease Type ◽  
Age Group ◽  
Pulmonary Tb

Background: Drug-resistant tuberculosis (DR-TB) is the major cause of mortality worldwide. Our objectives were to determine the distribution of DR-TB by sex, age groups, occupation, province, division, district, type of disease, type of drug resistance, treatment regimen and outcome of treatment in DR-TB population in D.I.Khan Division, Pakistan.Materials Methods: This cross-sectional study was conducted in Department of Community Medicine, Gomal Medical College, D.I.Khan, Pakistan. A sample of 286 DR-TB patients was selected consecutively from population at risk. Sex, age groups, occupation, province, division and district were demographic while type of disease, type of drug resistance, treatment regimen and outcome of treatment were research variables. All variables being nominal were described by count, percentage cumulative percentage with 95% confidence interval for proportion. Distribution of DR-TB patients by all the ten variables were substantiated by chi-square goodness-of-fit test.Results: Out of 286 DR-TB patients, 123 (43%) were men and 163 (57%) women. DR-TB cases were most prevalent in age group 15-44 years 172 (60.14%), housewife 140 (48.95%), Khyber Pakhtunkhwa 175 (61.19%), D.I.Khan Division 178 (62.24%) and district 121 (42.31%). Most common type of disease, drug resistance and treatment regimen was pulmonary TB 282 (98.60%), MDR 273 (95.45%) and longer treatment (n=273 MDR-TB) 246 (90.11%) respectively. Treatment success rate was 161 (56.29%). The observed prevalence by occupation, province, division, district and type of disease in our sample was similar to expected prevalence in population (p.05 for all), while it was different from population by sex, age groups, type of drug resistance, regimen and treatment outcome (p.05 for all).Conclusion: The prevalence of DR-TB was higher in women, age group 15-44 years, housewife, Khyber Pakhtunkhwa and D.I.Khan Division and District. Most common type of disease, drug resistance and treatment regimen was pulmonary TB, MDR and longer treatment respectively. Treatment success rate was 56.29%. The observed prevalence by occupation, province, division, district and type of disease in sample was similar to population, while it was different by sex, age groups, type of drug resistance, regimen and treatment outcome.

Trends of endometrial cancer incidence from 2000 to 2015 in the United States.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. 5591-5591
Author(s):  
V V Pavan Kedar Mukthinuthalapati ◽  
Muhammad Zain Farooq ◽  
Shweta Gupta
Keyword(s):  
Endometrial Cancer ◽  
Age Groups ◽  
Cancer Registries ◽  
The United States ◽  
Population Based ◽  
P Value ◽  
Age Group ◽  
Histologic Subtype ◽  
The Us ◽  
Histologic Subtypes

5591 Background: Recent studies have shown that obesity related cancers are increasing in incidence in the US as the rates of obesity rise and some cancers, like colorectal cancer, are occurring in younger age groups. We studied trends in incidence of endometrial cancer (EC), one of the obesity related cancers, in a population wide analysis. Methods: We analyzed data from all cases of EC between 2000 and 2015 from 18 US cancer registries using the National Cancer Institute’s Surveillance, Epidemiology and End Results Program. SEER*Stat was used to query the database for annual percent changes (APC), incidence ratios and percent change in incidence across different age groups, years of diagnosis, histologic subtypes, grade and race. We also studied the reported rates and trends of obesity in the US. Results: APC of age-adjusted EC incidence between 2000 and 2015 was +0.9% (95% confidence interval (CI) 1.1-0.6, p value<0.05). Incidence of EC rose from 17.8 per 100,000 to 19.7 per 100,000 during the same duration. APC for EC incidence for age groups 20-39 and >40 were +3.2% (p-value <0.05) and +0.8% (p value <0.05), respectively. For the age-group 20-39, endometrioid EC was the only histologic subtype that rose in incidence, with an APC of +5.5% and absolute percentage change of 156%. The APC of EC in 20-39 age group was more for whites (3.5%, p-value<0.05) and Asians (2.2%, p-value<0.05) than blacks (1.8, p-value <0.05). CDC reported an increase in obesity rates in adults from 30.5% in 2000 to 37.7% in 2014. Table shows trends of EC incidence in age groups 20-39 and >40 years across various histologic subtypes. (Abbreviations: S significant, NS not significant, NC non-calculable). Conclusions: Endometrial cancer, especially of endometrioid histology, is increasing in incidence and is occurring more often in the younger population. The concomitant rise in obesity rates during the same period point towards a possible causality of the increased in incidence of EC. Population based strategies are needed to decrease the trends in obesity so as to decrease the risk of endometrial cancer in younger women. [Table: see text]

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