scholarly journals Effect of Acute Exposure of Cigarette Smoke on Endometrium Thickness and Number of Ovarian Follicles in Rats

2021 ◽  
Vol 2 (1) ◽  
pp. 1-8
Author(s):  
Izdihar Ramadhanty Abiyasa Putri ◽  
R Haryanto Aswin ◽  
Tri Hartini Yuliawati
Keyword(s):  
Cigarette Smoke ◽  
Negative Impact ◽  
Endometrial Thickness ◽  
Ovarian Follicles ◽  
Reproductive Organ ◽  
Vaginal Swab ◽  
Female Rats ◽  
Acute Exposure ◽  
Before And After ◽  
Histological Slide

Background: Cigarrete smoke has been ascociated with many health-related problems especially in long time use. One of many health problems that are affected is the reproductive system that give negative impact in fertility. However, there are limited studies about this in acute exposure of cigarette smoke. Objective: The aim of this study is to investigate the effect of acute exposure of cigarette smoke on endometrial thickness and number of ovarian follicles in rats. Methods: Thirty adult female rats were randomly divided into 3 groups: P0, P1 and P2. The P1 and P2 groups were exposed to cigarette smoke for 15 days with dose of 2 and 4 cigarettes daily, respectively. Vaginal swab was done twice, before and after the last treatment, to determine the proestrus phase of the animals. Histological slide of uterus and ovarium using Haematoxylin Eosin staining were observed under light microscop. Number of ovarian follicles were measured, and the thickness of endometrium was meassured using CellSens software version 2.3 (Olympus Life Science). Statistical analysis of data was performed using MANOVA in SPSS software version 23 for Windows.   Results: There were no significant differences in both endometrial thickness and number of ovarian follicles between 3 groups (p>0.05). However, we found that there were a downward trend of some variables (endometrial thickness, number of primary follicles, de Graff follicles, and corpus luteum) from P0 to P2. Conclusion: We concluded that acute exposure of cigarette smoke not yet influenced the female reproductive organ, based on histological appearance of endemotrium and ovarium.

scholarly journals Effects of Red Bit Extract (Beta vulgaris L.) on VEGF, and Endometrial Thickness in Mice (Rattus norvegicus) Exposed to Cigarette Smoke

2018 ◽  
pp. 133-140
Author(s):  
Zulfa Hanum Dahlan ◽  
Dewita Dewita
Keyword(s):  
Cigarette Smoke ◽  
Low Income ◽  
Endometrial Thickness ◽  
Ethanol Extract ◽  
The Body ◽  
Female Rats ◽  
Food Sources ◽  
Control Group ◽  
P Value ◽  
Red Beet

Exposure to cigarette smoke often occurs among people, especially low-income countries. Frequent exposure to cigarette smoke can cause an increase in ROS in the body resulting in increased oxidative stress. As a result of ROS increases the antioxidants in the body decreases, therefore it takes antioxidants from the outside contained in food sources, one red bit. Red bits contain betalain compounds that are high in antioxidants that function to neutralize ROS in the body. This study aims to determine the effect of red beet ethanol extract with various doses to increase the expression of VEGF, and thickness in endometrium of mice exposed to cigarette smoke. The research design is True Experiments with Post Control Only Control Group Design design. The study used 25 female rats divided into 5 groups: negative control group, positive control, treatment I, II and III. The dose of bit extract used was PI (125 mg/kgBW/day), PII (250 mg/kgBW/day), PIII (500 mg/kgBW/day). The data were analyzed using One Way Anova with p-value VEGF (p = 0.000), and p-value of thickness endometrium (p = 0.000). The results showed that administration of red beet ethanol extract at doses of 500 mg/kgBW/day increased the expression of VEGF, and endometrial thickness of mice exposed to cigarette smoke.   Keywords:  Exposure to cigarette smoke, VEGF Expression, Endometrial Thickness, Red Beet.

scholarly journals Effect of Red Fruit Oil on Ovarian Follicles Development in Rat Exposed to Cigarette Smoke

2018 ◽  
Vol 10 (2) ◽  
pp. 402-408
Author(s):  
Isrotun Ngesti Utami ◽  
Enny Yusuf Yuniwarti ◽  
Tyas Rini Saraswati
Keyword(s):  
Cigarette Smoke ◽  
Unsaturated Fatty Acids ◽  
Beta Carotene ◽  
Ovarian Follicles ◽  
Positive Control ◽  
Negative Control ◽  
Alpha Tocopherol ◽  
Female Rats ◽  
Ovarian Weight ◽  
Fruit Oil

Red fruit oil (Pandanus conoideus Lam) contains active substances in the form of alpha-tocopherol, beta-carotene and unsaturated fatty acids that can potentially be antioxidants. This study aims to examine the effect of red fruit oil (Pandanus conoideus) on the development of ovarian follicles of rat exposed to cigarette smoke, (in increasing the number of primary follicles, secondary follicles, tertiary follicles and ovarian weight). This study used Completely Randomized Design with 20 female rats (3 months old) divided into 4 treatment groups: P0 (Positive control), P1 (negative control of exposure to cigarette smoke for 8 days), P2 (exposure to cigarette smoke for 8 days + 0.1 ml red fruit oil) and P3 (exposure of cigarette smoke for 8 days + 0.2 ml red fruit oil) with 5 time repetition and 28 days red fruit treatment for the research parameters were the number of primary follicles, secondary follicles, tertiary follicles and ovarian weight. The data obtained were analyzed using one-way ANOVA with 95% confidence level (P < 0.05). The results showed that the administration of red fruit oil at doses of 0.1 ml and 0.2 ml was not significantly affecting (P > 0.05) the number of primary follicles, secondary follicles, tertiary follicles and ovarian weight, so it can be conclusion that the administration of red fruit oil at a dose of 0.1 ml and 0.2 ml cannot increase the number of primary follicles, secondary follicles, tertiary follicles and ovarian weight in rat exposed to cigarette smoke.

Migration Patterns and Labor Market Outcomes

2018 ◽  
Author(s):  
Anda David ◽  
Mohamed Ali Marouani
Keyword(s):  
Labor Market ◽  
Negative Impact ◽  
Labor Market Outcomes ◽  
Wealth Index ◽  
Transition Matrices ◽  
Market Outcomes ◽  
Migration Patterns ◽  
Depth Analysis ◽  
Before And After ◽  
Spatial Composition

This chapter focuses on the external effects of emigration on non-migrants, and particularly on the interactions with labor market outcomes in Tunisia before and after the revolution. Using the new Tunisia Labor Market Panel Survey (TLMPS), we conduct an in-depth analysis of the structure and dynamics of migration, including the profile of migrants and their origin households, mainly in terms of skills and spatial composition. We investigate transition matrices, employment status, income for current migrants and returnees, and the evolution of remittances. Our analysis confirms the role of emigration as a safety valve for the Tunisian labor market. Moreover, origin households of migrants have a significantly higher wealth index. Our analysis also tends to confirm the effects of remittances on labor supply of non-migrants, which can have a negative impact on Tunisia’s unemployment rate when a crisis in destination countries affects the remittance rate negatively.

scholarly journals Kidney Injury Caused by Preeclamptic Pregnancy Recovers Postpartum in a Transgenic Rat Model

2021 ◽  
Vol 22 (7) ◽  
pp. 3762
Author(s):  
Sarah M. Kedziora ◽  
Kristin Kräker ◽  
Lajos Markó ◽  
Julia Binder ◽  
Meryam Sugulle ◽  
...  
Keyword(s):  
Rat Model ◽  
Renal Damage ◽  
Kidney Injury ◽  
Tissue Growth ◽  
Female Rats ◽  
Male Rats ◽  
Renal Diseases ◽  
Transgenic Rat ◽  
Increased Risk ◽  
Before And After

Preeclampsia (PE) is characterized by the onset of hypertension (≥140/90 mmHg) and presence of proteinuria (>300 mg/L/24 h urine) or other maternal organ dysfunctions. During human PE, renal injuries have been observed. Some studies suggest that women with PE diagnosis have an increased risk to develop renal diseases later in life. However, in human studies PE as a single cause of this development cannot be investigated. Here, we aimed to investigate the effect of PE on postpartum renal damage in an established transgenic PE rat model. Female rats harboring the human-angiotensinogen gene develop a preeclamptic phenotype after mating with male rats harboring the human-renin gene, but are normotensive before and after pregnancy. During pregnancy PE rats developed mild tubular and glomerular changes assessed by histologic analysis, increased gene expression of renal damage markers such as kidney injury marker 1 and connective-tissue growth factor, and albuminuria compared to female wild-type rats (WT). However, four weeks postpartum, most PE-related renal pathologies were absent, including albuminuria and elevated biomarker expression. Only mild enlargement of the glomerular tuft could be detected. Overall, the glomerular and tubular function were affected during pregnancy in the transgenic PE rat. However, almost all these pathologies observed during PE recovered postpartum.

Impact of Dividend Tax Change on the Payout Policy of Indian Companies

2019 ◽  
Vol 20 (5) ◽  
pp. 1282-1291
Author(s):  
Sanjay Dhamija ◽  
Ravinder Kumar Arora
Keyword(s):  
Negative Impact ◽  
Payout Policy ◽  
Tax Law ◽  
Dividend Payout ◽  
Inside Ownership ◽  
Regulatory Changes ◽  
Before And After ◽  
The Government ◽  
The Impact ◽  
Dividend Tax

The article examines the impact of regulatory changes in the tax on dividends on the payout policy of Indian companies. The tax law was recently amended to levy tax on dividends received by large shareholders. As the promoters group is the largest shareholder, this is expected to have a negative impact on the payout policy of companies. Furthermore, companies with larger promoter holdings have a higher motivation to reduce their payout. The study covers 370 companies present in the BSE 500 Index and compares the dividend payout of the companies before and after the introduction of tax levy. The study finds that the newly introduced tax indeed caused a shift in the dividend policy of companies, particularly those companies which have high levels of inside ownership. The findings have significant implications for companies, investors and the government.

Spouse Caregivers' Perceptions of Influence of Dementia on Marriage

2002 ◽  
Vol 14 (1) ◽  
pp. 47-58 ◽  
Author(s):  
Ulla Eloniemi-Sulkava ◽  
Irma-Leena Notkola ◽  
Kaija Hämäläinen ◽  
Terhi Rahkonen ◽  
Petteri Viramo ◽  
...  
Keyword(s):  
Behavioral Change ◽  
Intervention Study ◽  
Negative Impact ◽  
Behavioral Changes ◽  
Telephone Interviews ◽  
Before And After ◽  
Spouse Caregivers ◽  
Dementing Illness ◽  
Male Patients ◽  
Patients Experience

Objectives: To investigate what kind of changes spouse caregivers of demented patients experience after the onset of dementia (a) in the general atmosphere, happiness, and relations of marriage and (b) in the sexual side of marriage. Design: Semistructured telephone interviews of spouse caregivers of demented patients. Setting: Community-living demented patients and their spouse caregivers in eastern Finland. Participants: The spouse caregivers of 42 demented patients recruited from a previous intervention study. Measures: The questionnaire covered different areas of marriage from the time before and after the onset of dementia. Results: A statistically significant decline had occured in extent of happiness (p = .012), in equal relations (p = .001), and in patients' expressions of sexual needs (p < .001) when compared the time before and after dementia. Twenty-five (60%) of the caregivers reported that the demented patient had shown at least one negative sexual behavioral change during the course of dementia. Seven male patients (24%) had shown the behavioral symptom of constantly expressing need for making love. One in 10 caregivers had experienced positive sexual behavioral changes. In one third of the patients, the expressions of tenderness towards the caregiver had increased. Dementia did not affect significantly the general atmosphere of the marriage. Out of those still in home care, at 3 years from the onset of dementia, 19 couples (46%) continued to practice intercourse, at 5 years the number was 15 couples (41%), and at 7 years it had declined to 7 couples (28%). Conclusions: Dementing illness has a major negative impact on many dimensions of marriage. However, there are also positive changes and preserved aspects of marriage. Dementia seems to have a surprisingly little impact on whether the couple continues to have intercourse when compared with the general aging population.

Gonadal hormones organize and modulate the circadian system of the rat

1981 ◽  
Vol 241 (1) ◽  
pp. R62-R66 ◽  
Author(s):  
H. E. Albers
Keyword(s):  
Testosterone Propionate ◽  
Wheel Running ◽  
Activity Rhythm ◽  
Gonadal Hormones ◽  
Circadian System ◽  
Female Rats ◽  
Constant Darkness ◽  
Before And After ◽  
Free Running ◽  
Free Running Period

The circadian wheel-running rhythms of gonadectomized adult male, female, and perinatally androgenized female rats, maintained in constant darkness, were examined before and after implantation of Silastic capsules containing cholesterol (C) or estradiol-17 beta (E). The free-running period of the activity rhythm (tau) before capsule implantation tended to be shorter in animals exposed to perinatal androgen. Administration of C did not reliably alter tau in any group. E significantly shortened tau in 100% of females injected with oil on day 3 of life. In females, injected with 3.5 micrograms testosterone propionate on day 3, and males, E shortened or lengthened tau, with the direction and magnitude of this change in tau inversely related to the length of the individual's pretreatment tau. These data indicate that the presence of perinatal androgen does not eliminate the sensitivity of the circadian system of the rat to estrogen, since estrogen alters tau in a manner that depends on its pretreatment length.

Dissimilar Anxiety-like Behavior in Prepubertal and Young Adult Female Rats on Acute Exposure to Aluminium

2021 ◽  
Vol 22 ◽  
Author(s):  
Trina Sengupta ◽  
Sutirtha Ghosh ◽  
Archana Gaur T. ◽  
Prasunpriya Nayak
Keyword(s):  
Body Weight ◽  
Young Adult ◽  
Adult Female ◽  
Developmental Stages ◽  
Elevated Plus Maze ◽  
Age Groups ◽  
Female Rats ◽  
Acute Exposure ◽  
Adult Rats ◽  
Plus Maze

Background: Puberty is a developmental transition in which an estrogenic surge occurs, mediating the release of xenoestrogens, like aluminium. Aluminium’s effect on anxiety in rodents at the different developmental stages is inconsistent. Aims: This study aimed at investigating the effect of the metalloestrogenic property of aluminium on anxiety-like behavioral changes in prepubertal and young adult female rats. Objective: Considering this aim, our objective was to evaluate the anxiety-like behavior by the elevated plus maze in prepubertal and young adult female rats with or without acute exposure to aluminium. Methods: To address this property of aluminium, 5mg/Kg body weight (Al-5) and 10 mg/Kg body weight (Al-10) of aluminium was administered intraperitoneally to female rats at two developmental stages, prepubertal (PP; n = 8 for each dose) and young adult (YA; n = 6 for each dose) for two weeks. Post-treatment, three days behavioral assessment of the rats was done employing elevated plus maze. Results: Reduced escape latency was seen in Al-5, Al-10 pre-pubertal rats, and Al-5 young-adult rats on day 3. A significant reduction in open arm time was seen in the Al-5 young-adult rats. Aluminium treatment in the pre-pubertal rats reduced their head dipping and grooming. Reduced sniffing, head dipping, and stretch-attended posture in the treated young-adult female rats showed that they had impaired risk-taking tendency. Conclusion: Differential effect on the anxiety-like behavior in the pre-pubertal and young-adult female rats might be due to the metalloestrogenic property of aluminium, acting differently on the two age groups.

O3-induced inflammation in prepregnant, pregnant, and lactating rats correlates with O3 dose estimated by18O

1999 ◽  
Vol 276 (2) ◽  
pp. L332-L340 ◽  
Author(s):  
Albert F. Gunnison ◽  
Gary E. Hatch
Keyword(s):  
Ascorbic Acid ◽  
Acid Concentration ◽  
Inflammatory Responses ◽  
Virgin Female ◽  
Chemical Species ◽  
Female Rats ◽  
Acute Exposure ◽  
Physiological Status ◽  
Ascorbic Acid Concentration ◽  
Lower Lung

Previous studies have shown that rats late in pregnancy and throughout lactation are more susceptible to ozone (O3)-induced pulmonary inflammation than are prepregnant (virgin) or postlactating rats. The major aim of the present study was to determine whether these differences in response intensity could be accounted for by the O3 dose to the lower region of the lung. The relative O3 dose to the lower lung of groups of pregnant, lactating, and virgin female rats was estimated by measuring the incorporation of the18O isotope into low-speed (cells) and high-speed (surfactant) pellets of bronchoalveolar lavage fluid immediately after acute exposure to 0.5–1.1 parts/million18O3. The polymorphonuclear leukocyte (PMN) and protein inflammatory responses were established 20 h after acute exposure of identical physiological groups to 0.5–1.1 parts/million16O3(common isotope). A single regression of PMN inflammation data against surfactant 18O concentration for all physiological groups gave a linear relationship, indicating direct proportionality of PMN inflammation with this estimate of relative dose to the lower lung regardless of physiological status. This implies that the chemical species that react with surfactant molecules, i.e., O3 or its metabolites, are the same as or proportional to those chemical species responsible for initiating PMN inflammation. Additional experiments showed that lung tissue ascorbic acid concentration was significantly lower in pregnant and lactating rats than in virgin female rats. Although a causative relationship cannot be assumed, the deficit in tissue ascorbic acid concentration in pregnant and lactating rats compared with virgin female rats is consistent with their greater responsiveness and higher relative surfactant O3 dose.

The Effect of Passive Smoking on Mucociliary Clearance and Inferior Concha Reactivity

2020 ◽  
pp. 194589242096761
Author(s):  
Osman Kılıç ◽  
Aslı Şahin Yılmaz ◽  
Çağatay Oysu
Keyword(s):  
Cigarette Smoke ◽  
Passive Smoking ◽  
Mucociliary Clearance ◽  
Inferior Turbinate ◽  
Control Group ◽  
Nasal Decongestants ◽  
Significant Difference ◽  
Mucosal Response ◽  
Before And After ◽  
And Control

Introduction The aim of this study is to investigate the effect of cigarette smoke on turbinate reactivity and mucociliary clearance (MCC) in passive smokers. Methods 60 adult patients (30 passive smokers and 30 healthy subjects as the control group) were recruited for this study. Following a questionnaire on passive smoke exposure, MCC measurement using the saccharin test was carried out to all participants. The baseline and after decongestant acoustic rhinometry values (MCA1, MCA2, VOL1, VOL2) were measured and the percentage changes between the two test values (ie; response to nasal decongestants = concha reactivity) were recorded. Results All 60 patients, including 37 women (61.7%) and 23 men (38.3%) were between 18–57 years of age . MCC’s average measurements were 11.13 minutes in the passive smokers group, 7.87 minutes in the control group, which was statistically significantly different (p < 0.05). There was a statistically significant difference between the passive smokers and control group for acoustic rhinometric measurement of the ratio of MCA2 and VOL2 values before and after decongestant application (p < 0.05). Discussion Passive smoking can damage the nasal mucosa at least as active smoking. The number of studies on this subject is limited. There are no studies in the literature showing the effect of cigarette smoke on the inferior turbinate mucosal response. In our study, the inferior turbinate decongestant capacity was found to be significantly decreased in the passive smokers compared to the control group. Conclusion As a result of cigarette exposure, the erectile function of the lower turbines may be impaired. The task of the ENT physicians is to warn the passive smokers in this regard.

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