scholarly journals Respiratory, Hepatic, Renal and Hematological Disorders Among Adolescent Females Environmentally Exposed To Pesticides, Menoufia Governorate, Egypt

2021 ◽  
Author(s):  
Gaafar Mohamed Abdel-Rasoul ◽  
Eman Abdel-Azeem Salem ◽  
Olfat Mohamed Hendy ◽  
Diane S Rohlman ◽  
Asmaa Abdel-Rehim Abdel-Latif ◽  
...  
Keyword(s):  
Serum Creatinine ◽  
Total Protein ◽  
Ache Activity ◽  
Adolescent Females ◽  
Exposed Group ◽  
Control Group ◽  
Pesticide Application ◽  
Hematological Disorders ◽  
G Ratio ◽  
Group Post

Abstract Adolescent females are often environmentally exposed to pesticides by living near agricultural fields, by using pesticides at home, or by having contact with contaminated clothes and pesticide application work tools. This study assessed respiratory, hepatic, renal and hematological health disorders that might arise due to environmental exposure to pesticides among adolescent females. A cross-sectional study was conducted with 100 adolescent females environmentally exposed to pesticides who had one or more of their family members working as seasonal pesticides' applicators and 50 non- exposed (control) adolescent females from Menoufia governorate, Egypt. The studied period of pesticide application season of cotton crop was from May 1st to the end of September 2017. Participants completed a self-administered questionnaire about pesticide exposure and respiratory, hepatic, renal and hematological disorders. In addition, serum acetyl cholinesterase (AChE), spirometry, complete blood count, liver and kidney functions' tests were measured pre and post pesticide application season. The control adolescent females had a higher AChE activity, a lower prevalence of respiratory symptoms and higher means of spirometric measurements than the exposed group. During the pre and postseason, the exposed group presented a prevalence of (6%, 24%) for cough, (4%, 11%) for rhinitis, and (6%, 26%) for dyspnea during the pre and postseason; respectively. In addition, there was a decrease in means of spirometric measurements (FEV1%, FEV1/FVC%, FEF 25-75% and PEF%) in post season compared to preseason among the exposed group. Also, there were significant associations between (AChE) activity and both the prevalence of respiratory manifestations and spirometric measurements among the exposed females. On the other hand, there were significantly increased red blood corpuscles (RBCs) and lymphocytes counts, and a significantly lower mean hemoglobin level among the exposed group (post season) than each of their pre-season values and the control group (P<0.05). AChE level, total protein, albumin and albumin/globulin (A/G) ratio levels were significantly lower, while SGPT, SGOT, and globulin, blood urea and serum creatinine mean levels were significantly higher among the exposed group (post season) than either of their pre-season or the control group (P<0.05). There was a positive correlation between AChE level and all studied CBC parameters for the exposed group reaching a significant level with basophils (P<0.05). Also, there was a negative correlation between AChE level and each of SGPT, SGOT, ALP, globulin, blood urea and serum creatinine for the exposed group reaching a significant level with each of SGPT and SGOT (P<0.05). At the same time, a non-significant positive correlation was found between AChE level and each of total protein, albumin and A/G ratio (P>0.05). So, environmental exposure to organophosphorus pesticides has a detrimental impact on respiratory, hepatic, renal and hematological systems of adolescent females living in rural districts at Menoufia governorate. Educational and training intervention programs on pesticide handling and safety precautions are recommended for protecting both pesticides' workers and their family members who might be exposed.

scholarly journals Influence of exposure to pesticides on liver enzymes and cholinesterase levels in male agriculture workers

2014 ◽  
Vol 16 (5) ◽  
pp. 1006-1015 ◽  
Keyword(s):  
Liver Enzymes ◽  
Economic Status ◽  
Exposed Group ◽  
Direct Bilirubin ◽  
Control Group ◽  
Pesticide Application ◽  
Positive Correlation ◽  
Agricultural Work ◽  
Exposed Workers ◽  
Liver Functions

<div> <p>human health and the environment. The study aimed to explore the effects of exposure to pesticides on the liver functions and acetycholinesterase levels in serum (AChES) and red blood cells (AChER) of 100 male participating in agricultural work ranging in age between 20 and 60 year with mean age 37.11&plusmn;9.3. One hundred males matched for age and socio economic status were recruited as a control group to compare levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), bilriubin, alkaline phosphatase (ALP), total protein, AChES and AChER. The results indicate that AST, ALT and ALP were significantly (<em>P</em>&lt;0.05) increased in pesticide-exposed workers compared with control. There was also a highly significantly (<em>P</em>&lt;0.01) decrease in AChER among male agriculture workers compared with controls. At 10 - 50 times of pesticides applications there was a significantly (<em>P&lt;</em>0.05) decrease in AChER and increase in AST, ALT and ALP activity among exposed group. However, there was a negative correlation between AST, ALT, direct bilirubin, and AChES and age among control group and a positive correlation between ALT and AST and age among exposed group. According to the number of pesticide application, there was a positive correlation between AST, ALP, total and direct bilirubin and number of pesticide application. Agricultural villages in Egypt require more attention to decrease the percentage of literacy among the farmers and raise their health awareness.&nbsp;</p> </div> <p>&nbsp;</p>

scholarly journals Nephroprotective Effect of Herbal Extract Eurycoma longifolia on Paracetamol-Induced Nephrotoxicity in Rats

2019 ◽  
Vol 2019 ◽  
pp. 1-6 ◽  
Author(s):  
Sasikala M. Chinnappan ◽  
Annie George ◽  
Praveen Thaggikuppe ◽  
YogendraKumar Choudhary ◽  
Vandana K. Choudhary ◽  
...  
Keyword(s):  
Serum Creatinine ◽  
Creatinine Clearance ◽  
Total Protein ◽  
Herbal Extract ◽  
Control Group ◽  
Serum Total Protein ◽  
Treatment Groups ◽  
Eurycoma Longifolia ◽  
Induced Changes ◽  
Dose Dependent

Paracetamol (PCM) is a well-known drug widely used for its analgesic and antipyretic properties. PCM is generally considered as safe but overdose of PCM can cause nephrotoxicity. Traditionally, herbs have been used for the treatment of drug or toxin-induced renal disorders and numerous medicinal plants were tested for nephroprotection effect in PCM-induced nephrotoxicity model. The aim of the present study was to evaluate the protective effect of the herbal extract Eurycoma longifolia (EL) against PCM-induced nephrotoxicity rat model. Forty Wistar rats were randomly divided into five groups of eight rats each: control (vehicle 10 ml/kg), PCM alone (200 mg/kg PCM), EL 100 (EL 100 mg/kg+200 mg/kg PCM), EL 200 (EL 200 mg/kg+200 mg/kg PCM), and EL 400 (EL 400 mg/kg+200 mg/kg PCM). All animals from control group received vehicle daily and animals from groups PCM alone, EL 100, EL 200, and EL 400 received repeated dose of PCM and the assigned treatment of EL daily for a period of 14 days. On the 15th day, serum creatinine, blood urea nitrogen, protein, and albumin were measured in blood and creatinine clearance was measured in urine collected over 24 hours. Kidney sections of all experimental groups underwent histopathological analysis. There was a significant (p<0.05) increase in serum creatinine and blood urea levels in the PCM alone group compared to the treatment groups due to nephrotoxicity. In the treatment groups, there was a dose-dependent protection against PCM-induced changes observed in serum total protein, albumin, urea, and creatinine. Significant (p<0.05) drop was seen in serum creatinine and blood urea content in EL 200 and EL 400 groups. Creatinine clearance significantly increased for EL 200 (p<0.01) and EL 400 (p < 0.001) groups. Serum total protein and serum albumin content were significantly increased (p<0.05) in EL 200 and EL 400 groups compared to PCM alone group. Histopathological examination (H&E staining) of the rat kidneys revealed severe degeneration in the PCM alone group, while there was evidence of significant dose-dependent protection in the treatment groups against PCM-induced changes. The serum and urine biochemical results and histopathology analysis of the kidney indicate the nephroprotective potential of EL extract against PCM-induced nephrotoxicity.

scholarly journals EVALUATION FOR NEPHROPROTECTIVE ACTIVITY OF ETHANOLIC EXTRACT OF ALLIUM CEPA LINN. IN GENTAMICIN-INDUCED NEPHROTOXICITY IN RATS

2017 ◽  
Vol 10 (3) ◽  
pp. 356
Author(s):  
Madhan Mohan Elsani ◽  
Krishna Mohan Chinnala ◽  
Prathyusha Achanta ◽  
Vijaya Laxmi Vangala
Keyword(s):  
Body Weight ◽  
Serum Creatinine ◽  
Protective Effect ◽  
Allium Cepa ◽  
Total Protein ◽  
Ethanolic Extract ◽  
The Body ◽  
Control Group ◽  
Standard Group ◽  
Nephroprotective Activity

ABSTRACTObjective: Kidney diseases are a major problem of worldwide proportions, and renal damage is very common since kidney has the capacity to excretetoxic substances. This study aimed to evaluate the protective effect of the ethanolic extract of Allium cepa Linn. (EEAC) plant leaves against gentamicininducednephrotoxicity in rats.Methods: Nephroprotective activity was estimated by inducing gentamicin (100 mg/kg) to all the groups of animals; acute kidney dysfunction is anevidenced by significant elevation of serum creatinine, total protein and decreased body weight with multiple histological damages.Results: Treatment with the A. cepa Linn. has shown significant (p<0.01 and p<0.001) dose-dependent improvement in the body weight at the doseof 200 and 400 mg/kg and also shown significant improvement by protecting the kidney from the oxidative stress. It is also identified that treatmentwith A. cepa significantly lowered the level of serum creatinine, total protein when compared with the toxic group.Conclusion: Nephroprotective activity of EEAC treatment was found compared with the standard group (Vitamin E – 250 mg/kg) and control groupagainst the toxic control group animals in parameters including serum creatinine, total protein, kidney weights, and body weights. The histopathologicalstudies were also evinced the protective effect of EEAC.Keywords: Nephroprotective activity, Gentamicin, Nephrotoxicity, Allium cepa Linn.

scholarly journals Changes in oxidative markers, endogenous antioxidants and activity of the enzyme acetylcholinesterase in farmers exposed to agricultural pesticides - a pilot study

2014 ◽  
Vol 44 (7) ◽  
pp. 1186-1193 ◽  
Author(s):  
Camila Murussi ◽  
Roberta Cattaneo Horn ◽  
Adriana Santi ◽  
Barbara Estevão Clasen ◽  
Gabriel Reis ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Total Protein ◽  
Ache Activity ◽  
Agricultural Practices ◽  
Protein Carbonyl ◽  
Cellular Damage ◽  
Control Group ◽  
Rural Workers ◽  
Oxidative Markers ◽  
Significant Difference

Agricultural practices are directly related to the use of pesticides, which indiscriminately and without due care may contribute to the occurrence of numerous intoxications. Several studies have demonstrated the relationship of certain pesticides and the occurrence of oxidative stress and therefore, in recent years have developed methods of analysis of several biomarkers of cellular damage that can be measured and quantified. In this context, the objective of this study was to evaluate the possible changes in biochemical markers: glutamic aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine, urea, total protein, and oxidative markers such as lipid peroxidation, damage to proteins and the activity of the enzymes acetylcholinesterase (AChE) and catalase (CAT) in farmers exposed to different pesticides for at least five years from Ibirubá - RS city. With the exception of AST and ALT, the results showed a significant difference between the mean total protein, urea and creatinine in the control group, showing that no changes in liver or kidney function of rural workers. In the oxidative parameters, there was a decrease in AChE activity and CAT in the control group; there were an increase in protein carbonyl and a decreased on TBARS compared to control group. Therefore, the results demonstrated a change in oxidative status of rural workers compared with the control group, mainly by possible inhibition of AChE activity and the occurrence of oxidative stress without showing changes in biochemical parameters.

The effect of fucoidan on the changes of some biochemical parameters and protein electrophoresis in hepatotoxicity induced by carbontetrachloride in rats

2017 ◽  
Author(s):  
Nesrullah Aysin ◽  
Handan Mert ◽  
Nihat Mert ◽  
Kivanc Irak
Keyword(s):  
Serum Protein ◽  
Total Protein ◽  
Brown Algae ◽  
Biochemical Parameters ◽  
Protein Electrophoresis ◽  
Protein Fractions ◽  
Control Group ◽  
Pharmacological Properties ◽  
Blood Samples ◽  
G Ratio

Fucoidan is a sulfate polysaccharide extracted from brown algae. Fucoidan has various pharmacological properties, such as anti-tumor, anti-mutagenic, anti-inflammatory, antiviral, antioxidant, anti-fibrogenic activity and anti-complementary activities Objective: This study was aimed to explore the effect of fucoidan on biochemical parameters (ALT, AST, GGT, total protein, albumin, globulin) and protein fractions in hepatotoxicity induced by CCl4 in rats. Materials and Methods: The rats used in the study were randomly divided into four groups of 8 rats each: Control group, fucoidan group, fucoidan+CCl4 group and CCl4 group. After 24 hours from the process of an eight-day experiment, blood samples were taken. The analysis of ALT, AST, GGT activities and total protein, albumin, globulin levels were done by an autoanalyser and serum protein fractions (albumin, á1- globulin, á2-globulin â- globulin, ã- globulin and A/G ratio) were electrophoretically determined. Results: In the group of fucoidan+CCl4, it was determined that the levels of AST (p>0.001), GGT (p>0.001), total protein (p>0.01), globulin (p>0.01), â-globulin % (p>0.01), ã-globulin % (p>0.001) statistically decreased compared to CCl4 group. Conclusion: It can be said that fucoidan has the property of hepatoprotectant by looking to some biochemical parameters and changes in protein fractions that examined in hepatotoxicity induced by CCl4.

Effect of opioid peptides on liver function after patial hepatectomy

2018 ◽  
pp. 67-71
Author(s):  
А.В. Солин ◽  
А.Ю. Ляшев ◽  
Ю.Д. Ляшев
Keyword(s):  
Lactate Dehydrogenase ◽  
Liver Failure ◽  
Partial Hepatectomy ◽  
Opioid Receptors ◽  
Total Protein ◽  
Pronounced Effect ◽  
Male Rats ◽  
Control Group ◽  
Peptide Molecule ◽  
Selective Agonists

Цель исследования - сравнительный анализ влияния селективных агонистов отдельных классов опиоидных рецепторов на белковосинтетическую функцию печени, развитие цитолитического и холестатического синдромов у крыс, подвергшихся частичной гепатэктомии. Методика. Работа выполнена на 152 крысах-самцах Вистар массой 200-250 г. Частичную гепатэктомию выполняли по методу, описанному Higgins G.M. и Anderson R.M. с удалением 70% ткани печени. В плазме крови определяли концентрации общего белка, альбуминов, общего билирубина, активность аланинтрансаминазы (АЛТ), аспартаттрансаминазы (АСТ), лактатдегидрогеназы (ЛДГ) традиционными методами. Опиоиды: DAGO в дозе 6,3 мкг/кг, DSLET в дозе 10,0 мкг/кг, динорфин А (1-13) в дозе 20,1 мкг/кг, вводили внутрибрюшинно ежедневно 1 раз в сутки в течение 5 сут. эксперимента в объеме 0,2 мл. Контрольным животным аналогично вводили физраствор. Результаты. Удаление 70% ткани печени у крыс-самцов Вистар сопровождается развитием печеночной недостаточности, проявляющейся гипербилирубинемией, гипоальбуминемией, гипопротеинемией, повышением активности трансаминаз и лактатдегидрогеназы. Применение селективных агонистов опиоидных рецепторов у крыс, которым моделировали частичную гепатэктомию, оказывало гепатопротективное действие и снижало выраженность проявлений печеночной недостаточности, начиная с 3-х сут. после резекции. Активность трансаминаз, лактатдегидрогеназы и концентрация общего билирубина у животных, которым вводили опиоиды, были существенно ниже, чем в контрольной группе. Содержание общего белка и альбуминов было статистически значимо выше в группах, которые получали исследованные пептиды, по сравнению с контрольной группой на 7-е сут. после частичной гепатэктомии. Наиболее выраженное действие проявлял селективный агонист опиоидных мю-рецепторов DAGO. По нашему мнению, такое влияние пептидов объясняется присущими им антиоксидантным и антигипоксическим эффектами, что снижает повреждающее действие оперативного вмешательства на печень. Более выраженное влияние DAGO связано, по-видимому, с особенностями распределения опиоидных рецепторов или устойчивостью пептида к действию эндопептидаз благодаря модификациям в молекуле пептида. Заключение. Применение опиоидов стимулирует восстановление функциональной активности печени после частичной гепатэктомии. Наибольший эффект отмечается при введении мю-агониста DAGO. Aim. The aim of the study was to compare effects of selective agonists of opioid receptors from different classes on the protein-synthesizing function of liver and development of cytolytic and cholestatic syndromes in rats after partial hepatectomy. Methods. The study was conducted on 152 Wistar male rats weighing 200-250 g. The animals were subjected to partial hepatectomy according to the Higgins and Anderson method. Concentrations of total protein, albumin, total bilirubin, and activities of alanine aminotransferase, aspartate aminotransferase, and lactate dehydrogenase were measured in plasma using standard methods. The opioids, DAGO (6.3 mg/kg), DSLET (10.0 mg/kg), and dynorphin A (1-13) (20.1 mg/kg), were injected in 0.2 ml of saline daily for 5 days. Control animals were injected with 0.2 ml of saline for 5 days. Results. Resection of 70% of liver tissue resulted in development of liver failure as evidenced by hyperbilirubinemia, hypoalbuminemia, hypoproteinemia, and increased transaminase and lactate dehydrogenase activities. Selective agonists of opioid receptors administered to the rats after partial hepatectomy exerted a hepatoprotective effect and alleviated the signs of liver failure beginning from the 3 day after resection. Transaminase and lactate dehydrogenase activities were significantly lower in opioid-treated rats than in the control group. Levels of total protein and albumins were significantly higher in the groups injected with the study peptides compared to the control group on the 7 day after partial hepatectomy. The selective agonist of opioid m-receptors, DAGO, exerted the most pronounced effect. Apparently, the similar effects of peptides were due to their antioxidant and anti-hypoxic action, which alleviated the detrimental effect of liver surgery. The more pronounced effect of DAGO apparently resulted from peculiarities of opioid receptors distribution or peptide resistance to endopeptidase action due to modifications of the peptide molecule. Conclusion. Administration of opioids stimulated restoration of liver functional activity after partial hepatectomy. Injections of the m-agonist, DAGO, produced the most pronounced effect.

Erythrocyte and reticulocyte parameters during biological monitoring of lead exposure to the body

2020 ◽  
Vol 60 (11) ◽  
pp. 873-876
Author(s):  
Anastasiya G. Khotuleva ◽  
Mariya S. Kozyreva
Keyword(s):  
Biological Monitoring ◽  
Hematological Parameters ◽  
Lead Level ◽  
Statistical Processing ◽  
Absorption Spectrometry ◽  
The Body ◽  
Control Group ◽  
Processing Plant ◽  
Hematological Disorders ◽  
Globin Synthesis

Introduction. The most susceptible to lead is the hematopoietic system of hematopoietic organs due to lead inhibition of heme and globin synthesis and cytotoxic effect on the membrane of Mature red blood cells. The aim of study was to evaluate the informative value of the study of erythrocyte and reticulocyte parameters determined on modern hematological analyzers in patients working in contact with lead during medical and biological monitoring. Materials and methods. 45 employees of the lead battery processing plant and 30 persons of control group were examined. The level of lead in the blood was determined by atomic absorption spectrometry, δ-ALA in the urine-by the reaction of pyrol formation with acetylacetone in terms of gram of creatinine, the study of hematological parameters was performed on a Sysmex HT-2000i analyzer. Statistical processing of the results was performed using the program STATISTICA 10.0. Results. Significant changes in erythrocytic (RDW) and reticulocytic (RET, IRF, LFR, MFR, HFR, RET-He) parameters, erythropoietin in workers in contact with lead compared to the control group, changes in MCV, MCH, RDW, RET indicators in the group working in dynamics after 2 years were revealed. Associations of hematological parameters with biomarkers of exposure and effect (lead level in blood and ALA in urine) were revealed. Conclusions. Assessment of erythrocyte (MCV, MCH, RDW) and reticulocyte parameters (RET% and their distribution by maturity) in dynamics during periodic medical examinations of workers in contact with lead allows us to detect the development of hematological disorders at early stages.

Haemato-Biochemical Alterations After Epidural Administration of Dexmedetomidine Alone and in Combination with Bupivacaine in Buffalo Calves

2017 ◽  
Vol 12 (3) ◽  
Author(s):  
A. Jaiswal ◽  
S. S. Pandey ◽  
A. S. Parihar ◽  
N. Rajput ◽  
R. Jain
Keyword(s):  
Alkaline Phosphatase ◽  
Blood Glucose ◽  
Serum Creatinine ◽  
Total Protein ◽  
Epidural Injection ◽  
Epidural Administration ◽  
Healthy Male ◽  
Buffalo Calves ◽  
Biochemical Alterations ◽  
Biochemical Examination

The study was conducted on 12 healthy male buffalo calves weighing between 50 to 60 Kg to evaluate haemato-biochemical alterations after epidural injection of dexmedetomidine alone and in combination with bupivacaine. Haematological examination showed nonsignificant alterations. Biochemical examination showed significant increase in blood glucose, blood urea nitrogen and serum creatinine while there was nonsignificant alterations in total protein and alkaline phosphatase. All haemato-biochemical changes were transient and compensatory.

Alteration in the oxidative status of Drosophila melanogaster Meigen (Diptera: Drosophilidae) fed with a diet containing Centaurea depressa M. Bieb. (Asteraceae)

2020 ◽  
Vol 70 (2) ◽  
pp. 227-237
Author(s):  
Eda Güneş
Keyword(s):  
Oxidative Stress ◽  
Superoxide Dismutase ◽  
Antioxidant Enzymes ◽  
Total Protein ◽  
Protein Carbonyl ◽  
Control Group ◽  
Carbonyl Content ◽  
Protein Carbonyl Content ◽  
Freeze Dried ◽  
Dried Extract

Abstract The aim of the this study was to evaluate the effects of fresh, dried and freeze-dried Centaurea depressa M. Bieb. (Asteraceae) on the oxidant and antioxidant status of the model organism D. melanogaster Meigen (Diptera: Drosophilidae) experimentally. The study was carried out from 2016 to 2019, and plant leaf extracts (0-50 mg/l) were added to insect standard artificial diets. The total protein, protein carbonyl content and glutathione-S-transferase, superoxide dismutase and catalase activities were quantified at the insect’s third larval stage. Our data showed that protein carbonyl content varied from 2.70 nmol/mg protein in the control group to 59.11 nmol/mg protein in the group fed with fresh leaf extract signifying induction of oxidative stress. All extracts increased the levels of all antioxidant enzymes and decreased the amounts of total protein. Meanwhile, the group fed with the freeze-dried extract showed no significant difference in the levels of total protein and protein carbonyl content except at the 50 mg/l concentration of the extract. Moreover, this group had superoxide dismutase and catalase activities 4 to 5 times higher than in the control group. In conclusion, induction of oxidative stress indicates that the fresh form of C. depressa leaves may have potential as a natural pesticide, whereas induction of endogenous antioxidant enzymes by the freeze-dried extract suggest its potential as an antioxidant.

Effects of Short-Term Mission Trips on Recipients’ Self-Esteem and Readiness for Self-Directed Learning

2021 ◽  
pp. 009164712110115
Author(s):  
Charissa H. W. Wong ◽  
Li Neng Lee ◽  
Alberto Pérez Pereiro
Keyword(s):  
Self Esteem ◽  
Control Group ◽  
Short Term ◽  
Self Directed Learning ◽  
Positive Effects ◽  
Post Test ◽  
Quasi Experimental ◽  
Directed Learning ◽  
Group Post ◽  
Mission Trips

Short-term Christian overseas volunteer trips, also known as short-term mission trips (STMs), have become increasingly prevalent (Howell & Dorr, 2007). However, research on these programs has been limited. This quasi-experimental study adds to the literature by quantitatively measuring the effects of an STM from Singapore to Thailand. STM recipients’ ( n = 44) self-esteem and readiness for self-directed learning (RSDL) were compared across timepoints – pre-test, post-test, follow-up – and with a control group ( n = 50). It was hypothesized that recipients would experience an increase in self-esteem and RSDL such that their scores would be higher than the control group post-STM. Results provide partial support for the hypotheses; while improvements among recipients were either not significant (for self-esteem) or not long-lasting (for RSDL), recipients had higher scores than the control group post-STM. This suggests that STMs have some, albeit limited, positive effects. Recommendations for promoting greater and longer-lasting effects are offered.

Sign in / Sign up

Export Citation Format

Share Document