scholarly journals A Case-Control Study On Dietary Nutrition and Dietary Habits of Kazakh Esophageal Cancer Patients in Xinjiang

2022 ◽  
Author(s):  
Dong YIN ◽  
Yu YIN ◽  
Siyao LI ◽  
Yanchao DENG ◽  
Xufeng LI ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Vitamin B12 ◽  
Low Income ◽  
Dietary Habits ◽  
Serum Vitamin ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Dietary Nutrients ◽  
Fresh Vegetables ◽  
Nutrients Intake

Abstract Objective To explore the causes of esophageal cancer (ESCC) and provide a theoretical basis for prevention and treatment of ESCC by analyzing dietary nutrients intake and other blood indicators of Kazakh patients with ESCC.Methods 198 ESCC cases and 200 controls were recruited in Xinjiang. The food frequency questionnaire was used to investigate the dietary nutrients intake. After collecting blood samples, the automated chemiluminescence immunoassay analyzer was applied to measure serum FA level and serum vitamin B12 level. The enzyme-linked immunosorbent assay was used to observe the serum DNMT1 level.Results The cholesterol intake of ESCC group was higher than that of the control group while the intakes of protein, thiamin, riboflavin, FA, vitamin A, B6, C and E were lower than the control group. Levels of serum FA and serum vitamin B12 in ESCC group were lower, while the serum DNMT1 level was higher.Conclusion Lacking fresh vegetables, low educational level, low income, alcoholism, eating solid and dry food and smoked meat, dieting irregularly, low serum FA level, high serum DNMT1 level were risky factors of ESCC for Kazakhs. The occurrence of ESCC reduced with the increase of serum FA but increased when serum DNMT1 increased.

scholarly journals Serum Homocysteine, Vitamin B12, Folic Acid Levels and Methylenetetrahydrofolate Reductase (MTHFR) Gene Polymorphism in Vitiligo

2012 ◽  
Vol 33 (2) ◽  
pp. 85-89 ◽  
Author(s):  
Ali Yasar ◽  
Kamer Gunduz ◽  
Ece Onur ◽  
Mehmet Calkan
Keyword(s):  
Folic Acid ◽  
Gene Polymorphism ◽  
Vitamin B12 ◽  
Significant Relationship ◽  
Gene Polymorphisms ◽  
Serum Vitamin ◽  
Mthfr Gene ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Mthfr Gene Polymorphism

The aim of this study was to determine serum vitamin B12, folic acid and homocysteine (Hcy) levels as well as MTHFR (C677, A1298C) gene polymorphisms in patients with vitiligo, and to compare the results with healthy controls. Forty patients with vitiligo and 40 age and sex matched healthy subjects were studied. Serum vitamin B12 and folate levels were determined by enzyme-linked immunosorbent assay. Plasma Hcy levels and MTHFR polymorphisms were determined by chemiluminescence and real time PCR methods, respectively. Mean serum vitamin B12 and Hcy levels were not significantly different while folic acid levels were significantly lower in the control group. There was no significant relationship between disease activity and vitamin B12, folic acid and homocystein levels. No significant difference in C677T gene polymorphism was detected. Heterozygote A1298C gene polymorphism in the patient group was statistically higher than the control group. There was no significant relationship between MTHFR gene polymorphisms and vitamin B12, folic acid and homocysteine levels. In conclusion, vitamin B12, folate and Hcy levels are not altered in vitiligo and MTHFR gene mutations (C677T and A1298C) do not seem to create susceptibility for vitiligo.

scholarly journals Nutrition Knowledge and Dietary Intake in Pregnancy in Rural Malawi: Comparing Supplementary Nutrition Education and -Counseling With Routine Antenatal Care

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 145-145
Author(s):  
Lillian Katenga-Kaunda ◽  
Penjani Rhoda Kamudoni ◽  
Gerd Holmboe-Ottesen ◽  
Heidi Fjeld ◽  
Ibrahimu Mdala ◽  
...  
Keyword(s):  
Nutrition Education ◽  
Low Income ◽  
Dietary Habits ◽  
Dietary Diversity ◽  
Intervention Group ◽  
Study Groups ◽  
Nutrition Knowledge ◽  
Randomised Control Trial ◽  
Control Group ◽  
End Point

Abstract Objectives To describe and compare changes in nutrition knowledge, perception and dietary habits between the intervention and control group and to evaluate the effects of nutrition knowledge on dietary diversification among the two study groups. Methods This study was a two armed randomised control trial. We recruited 257 women (gestational week 9–12) of which 195 (76%) were available for analyses: intervention 92; Control 103) the women were assessed at inclusion (baseine) and two weeks before the expected date of delivery (study end-point) for differences in nutrition knowledge, perception (using a structured questionnaire) and dietary habits (assessing dietary diversity score). We performed descriptive analyses to assess these differences between the two study groups. Three-level linear multilevel regression models with random intercept and random effect of time on participant at level 1 and village level 2 were used to expore the association between nutrition knowledge and dietary habits Results Our results show that both nutrition knowledge and dietary diversity improved in both study groups, but the improvement were significantly higher in the intervention group at study-end point. Increase in nutrition knowledge was associated with improved dietary diversity only among women in the intervention group. Moreover, women in the intervention group improved their nutrition perception and behaviour. Conclusions Our results provide evidence that poor nutrition knowledge is a barrier to consumption of healthy diet during pregnancy, thus supporting the relevance for augmenting nutrition education offered at ANC with supplementary and community-based nutrition interventions. We thus suggest that efforts should be made to strengthen the education component of ANC services as these are decentralized and locally accessible in Malawi and other low-income countries Funding Sources This project was funded by the University of Oslo, The Global Health and Vaccination Program (GLOBVAC) of the research council of Norway and by the Throne Holst foundation.

scholarly journals Changes in Fitness of Rural Primary School Students from Southwest China after Two-Year’s Nutrition Intervention

Nutrients ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 3544
Author(s):  
Ran Zhao ◽  
Qian Gan ◽  
Zhuolun Hu ◽  
Peipei Xu ◽  
Li Li ◽  
...  
Keyword(s):  
Vitamin D ◽  
Primary School ◽  
Repeated Measures ◽  
Southwest China ◽  
Serum Vitamin ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Primary School Students ◽  
School Students ◽  
Vitamin D Levels

Children in China’s poor rural areas often have insufficient protein and micronutrient intake. There is little research about the effect of milk and egg supplementation published on these children. A prospective randomized controlled trial was applied to evaluate the effect of milk and egg supplementation on the growth and fitness of poor rural primary school students in southwest China whose physical development was below national averages. A total of 955 healthy students aged 6–13 years old were recruited. The intervention group (538) received 200 g milk and 50 g braised egg at each school day, while the control group (417) kept their normal diet and received no extra supplementation. Serum vitamin D levels were measured by an enzyme-linked immunosorbent assay. A mixed linear model with repeated measures was performed to analyze the efficacy of the supplementation. Statistically significant interactions between groups and time were seen in weight in boys, but not in girls. Significant improvement in vitamin D levels, the broad jump, and the 8 × 50 m shuttle run were observed in both genders. Therefore, the supplementation of egg and milk for two years might have a positive effect on growth and physical fitness and decreasing vitamin D deficiency in poor rural Chinese children.

Weight-Loss Resilience Among Low-Income Postpartum Women: Association With Health Habits

2019 ◽  
Vol 41 (12) ◽  
pp. 1709-1723 ◽  
Author(s):  
Lorraine O. Walker ◽  
Sookja Kang ◽  
Bobbie S. Sterling
Keyword(s):  
Physical Activity ◽  
Social Support ◽  
Weight Loss ◽  
Perceived Stress ◽  
Low Income ◽  
Group Intervention ◽  
Dietary Habits ◽  
Control Group ◽  
Postpartum Women ◽  
Health Habits

Using a weight resilience framework, health habits of diet and physical activity, social support, and perceived stress were compared in women who lost weight (resilient) and those who did not lose or gained weight (nonresilient) during a weight-loss intervention. Participants were low-income postpartum women participating in a 13-week randomized treatment-control group intervention, with 20 of 50 classified as resilient in losing weight. Measures included the Postpartum Support Scale, the Perceived Stress Scale, and health habit items from the Self Care Inventory. Weight-loss resilient women showed significantly more frequent healthful dietary habits, such as eating a nutritious breakfast, and less frequent unhealthy habits, such as substituting junk food for meals, and less perceived stress than their nonresilient counterparts at both the midpoint and end of the study. Weight-loss resilient women also showed significantly more frequent physical activity habits at the end of the study. No social support differences were found.

scholarly journals 25-Hydroxy Vitamin D Detection Using Different Analytic Methods in Patients with Migraine

2019 ◽  
Vol 8 (6) ◽  
pp. 895 ◽  
Author(s):  
Luca Gallelli ◽  
Andzelika Michniewicz ◽  
Erika Cione ◽  
Aida Squillace ◽  
Manuela Colosimo ◽  
...  
Keyword(s):  
Liquid Chromatography ◽  
Vitamin D3 ◽  
Healthy Subjects ◽  
High Performance ◽  
Serum Vitamin ◽  
Reference Method ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Mean Values ◽  
Analytic Methods

Objectives: The aim of this study was to evaluate the performance of different analytic methods, such as liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS), high-performance liquid chromatography-ultraviolet (HPLC-UV), enzyme-linked immunosorbent assay (EIA), and chemiluminescence immunoassays (CLIA), in order to highlight whether or not there is relative superiority amongst the assays. We analyzed two groups of subjects suffering from headache and two groups of healthy subjects. Design and Methods: We performed a prospective, single-blind single-center control-group study on 220 subjects with migraine. Subjects of both sexes >10 years old and with 12 months’ history of migraine were eligible for the study. As a control group, 120 healthy subjects were chosen by their family physician. Results: LC-MS/MS evaluation documented that in all enrolled subjects (migraine and control groups), the serum vitamin D3 levels were lower with respect to the normal range (30–100 ng/mL), with a mean value of 15.4 ng/mL, without difference between sex. The mean values measured using HPLC-UV, EIA, and CLIA tests such as Liaison® and Architect® did not show significant differences compared to the values obtained using LC-MS/MS. Conclusions: In conclusion, the population generally has low values of the vitamin D3 hormone, and the suggested range should probably be revised. HPLC-UV and CLIA were found to have appropriate analytical values compared to the reference method (LC-MS/MS), so it is possible to suggest their routine use to optimize care.

scholarly journals Vitamin B 12: the hidden ingredient of stroke

2020 ◽  
Vol 8 (2) ◽  
pp. 644
Author(s):  
Mehul Prajapati ◽  
Labani M. Ghosh
Keyword(s):  
Risk Factors ◽  
Vitamin B12 ◽  
Serum Vitamin ◽  
Serum Levels ◽  
Control Group ◽  
Case Group ◽  
Cerebral Stroke ◽  
Chi Square ◽  
Median Serum ◽  
Increased Risk

Background: Study aimed to evaluate the relationship between vitamin B12 and acute cerebral stroke in this study.Methods: Blood samples drawn within 24 hours after the stroke from hospitalized patients (n=100) and from 100 control cases matched for age, sex and other modifiable risk factors of stroke were analyzed. With a competitive, ECLIA, serum levels of vitamin B12 were measured. The quantitative data of the groups was compared using Analysis of Varience and Tukeys HSD post hoc test for comparison. Chi-square tests were used.Results: Median serum vitamin B12 levels were significantly lower in the patients than in the control subjects, 188.71 and 256.25 pg/ml respectively (p=0.0001). This difference was independent from other risk factors. The mean age in case group was 62.49 (SD: 12.45 years) and 56.62 (SD: 13.05 years) in control group with p=0.001. Therefore, prevalence of stroke is more between 6th and 7th decade of life. Mean serum vitamin B12 levels were lower in males (201.8pg/ml) than the females (268.pg/ml) in the case group.Conclusions: Low vitamin B12 is associated with an increased risk of stroke, and its relationship is independent from the other known modifiable stroke risk factors.

scholarly journals Association between the Level of Serum Vitamin B12 and Venous Thromboembolism in African American Population

Blood ◽  
2019 ◽  
Vol 134 (Supplement_1) ◽  
pp. 4957-4957
Author(s):  
Ratesh Khillan ◽  
Nyein Htway Yu ◽  
Haoxu Ouyang ◽  
Mohan Preet
Keyword(s):  
Cohort Study ◽  
Venous Thromboembolism ◽  
Elderly Patients ◽  
Vitamin B12 ◽  
Cancer Patients ◽  
Orthopedic Surgery ◽  
Serum Vitamin ◽  
Serum Levels ◽  
Control Group ◽  
Chi Square

Background Multiple risk factors have been linked to venous thromboembolism (VTE). It is well established that elevated level of homocysteine correlated with increased risk of VTE. Some studies showed that vitamin B12 deficiency may be the cause for homocysteinemia. Therefore, it is recommended by some groups that vitamin B12 should be supplemented in the patient with high homocysteine to prevent VTE. However, more recent study has shown that there is correlation between the high serum Vitamin B12 level and risk of VTE in cancer patients.[1] provoked VTE after orthopedic surgery was also shown to be associated with elevated vitamin B12 serum levels in elderly patients. The role of vitamin B12 in VTE patients is not fully understood. Our study is to see whether there is correlation between serum Vitamin B12 level and risk of VTE in general population. Methods 177 Patients admitted to Kingsbrook Jewish Medical Center between January 1st, 2015 to December 31st, 2018 with the diagnosis of VTE were identified. 95 cases had measured serum Vitamin B12 results within 3 months. 97 patients without any history of VTE who were seen in the hematology clinic during the same period time were used as control in this study. Demographic information and Vitamin B12 level were collected. T test and chi-square were used for statistical analysis. Results VTE patients had a median age of 70, which is significantly higher than the median age of 57 in the control group. The mean level of vitamin B12 in control group was 620 pg/mL, which was lower than the average vitamin B12 level (770 pg/mL, p=0.0344) in the VTE group. When we divided the patients into 3 groups based on Vitamin B12 level: Low B12 (<250 pg/mL), Moderate B12 (250-800 pg/mL) and High B12 (>800 pg/mL). We observed 41% of VTE patients have B12 level more than 800 pg/mL while only 20% of control patients have high B12 level (chi-square, p=0.006). Discussion Our study showed that vitamin B12 level is significantly elevated in patients diagnosed with VTE and more than 40% of those patients actually have vitamin b12 level more than 800 pg/mL. It is known that elevated vitamin B12 level is associated with inflammation and increased mortality.[2] An association between elevated B12 levels and cancer has been reported in several studies [3]. It is unclear elevated vitamin B12 levels predict undiagnosed cancer which is a known risk factor for VTE or vitamin B12 directly contribute hypercoagulation. Nevertheless, we should be cautious when supplementing vitamin B12 and the dosage may need to be titrated closely. More clinical studies are definitely warranted. References 1. Arendt JFH, el al. Elevated plasma vitamin B12 levels and risk of venous thromboembolism among cancer patients: A population-based cohort study. PubMed ID: 26724465 2. Grossfeld A1, et al. Symptomatic venous thromboembolism in elderly patients following major orthopedic surgery of the lower limb is associated with elevated vitamin B12 serum levels. PubMed ID:23000313 3. Johan F.H. Arendt, Henrik T. Sørensen, Laura J. Horsfall and Irene Petersen. Elevated Vitamin B12 Levels and Cancer Risk in UK Primary Care: A THIN Database Cohort Study. EPI-17-1136 Published April 2019 Disclosures No relevant conflicts of interest to declare.

Prevalence of Levodopa-Induced Peripheral Neuropathy in Patients with Parkinson’s Disease and Vitamin B12 Deficiency

2021 ◽  
Vol 10 ◽  
pp. 1837
Author(s):  
Mohammad Yazdchi Marandi ◽  
Hormoz Ayromlou ◽  
Safa Najmi ◽  
Seyyed-Reza Sadat-Ebrahimi ◽  
Zakaria Pezeshki ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Peripheral Neuropathy ◽  
Vitamin B12 ◽  
Serum Vitamin ◽  
Vitamin B12 Deficiency ◽  
Term Treatment ◽  
Control Group ◽  
Long Term Treatment ◽  
B12 Deficiency

Background: Parkinson’s disease (PD) is one of the widespread neurodegenerative diseases. Recently, a few studies have suggested that treatment with levodopa and vitamin B12 deficiency may have some role in developing peripheral neuropathy (PN) among PD patients. Hence, the aim of this study was to evaluate PN in patients suffering from PD under long-term treatment with levodopa and also vitamin B12 deficiency in these patients. Materials and Methods: Thirty PD patients who received levodopa for at least two years, 30 levodopa-naïve PD patients, and 30 age-matched controls individuals were included. The participants were subjected to electrodiagnostic tests and the level of vitamin B12 was measured. The prevalence of neuropathy was determined according to electrodiagnostic criteria and compared among the three groups. Results: Overall, 23.3% of cases in levodopa receivers, 3.3% in the levodopa-naïve group, and 3.3% in control group had PN (odds ratio=8.8, 95% confidence interval=1.7-45.6). Levodopa group had significantly lower serum vitamin B12 than the other two groups (P=0.006). Vitamin B12 insufficiency was detected in 36.6% of patients in the levodopa group, which was significantly higher than other groups (23.3% in the levodopa-naïve and 6.6% in the control groups, P=0.02). A significantly negative correlation was noticed between the duration of levodopa exposure and serum level of vitamin B12 (r=-0.31, P=0.016). Conclusion: Our study demonstrated a significantly higher prevalence of vitamin B12 insufficiency and PN in PD patients under treatment with levodopa. Also, our results advocate the role of levodopa in PN development through the vitamin B12 derangement. [GMJ.2021;10:e1837]

scholarly journals Study on Serum Vitamin B12 And Folic Acid in Patients of Ischaemic Stroke

1970 ◽  
Vol 19 (2) ◽  
pp. 115-117
Author(s):  
K Kirtania ◽  
S Ahmed ◽  
N Sultana ◽  
MZ Hossain ◽  
MM Rahman
Keyword(s):  
Folic Acid ◽  
Vitamin B12 ◽  
Ischaemic Stroke ◽  
Large Population ◽  
Serum Vitamin ◽  
Developed Countries ◽  
Control Group ◽  
Case Group ◽  
Key Words Ischaemic Stroke ◽  
The Mean

Context: Stroke is the third commonest cause of death in developed countries and is responsible for the physical disability of a large population. Of two types, ischaemic stroke covers 85% and haemorrhagic stroke is only 15%. Methods: A case control study was designed to see the association of serum vitamin B12 and folic acid level with ischemic stroke. The study was done from January to December 2009 in the Department of Biochemistry, Dhaka Medical College, Dhaka. A total of 60 subjects were selected as study population. Among them 30 were diagnosed case of ischaemic stroke and 30 were age and sex matched healthy control. Results: The mean vitamin B12 and folic acid levels in case group were 231.02±10.81 pg/ml and 2.29±0.54 ng/ml respectively. For control group, the mean vitamin B12 and folic acid levels were 278.72±15.88 pg/ml and 7.24±2.19 ng/ml respectively. Conclusion: The study suggests that low levels of serum vitamin B12 and folic acid are associated with ischaemic stroke. Key words: Ischaemic stroke; vitamin B12; folic acid. DOI: 10.3329/jdmc.v19i2.7080J Dhaka Med Coll. 2010; 19(2) : 115-117

scholarly journals Serum vitamin B12 and folic acid status in Autism spectrum disorder children

2020 ◽  
Vol 14 (2) ◽  
pp. 43-47
Author(s):  
Syeda Nusrat Mahruba ◽  
Shelina Begum ◽  
Shorifa Shahjadi ◽  
Sharmin Afroz ◽  
Umme Raihan Siddiqi ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Folic Acid ◽  
Vitamin B12 ◽  
Neurodevelopmental Disorder ◽  
Serum Vitamin ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Control Group ◽  
P Value ◽  
Healthy Children

Background: Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder. The etiology of ASD involves gene-environmental interaction. Vitamin B12 and folic acid have important roles as methyl donor in many biosynthetic pathways, protein synthesis and formation of myelin sheath throughout the central nervous system. Therefore, deficiency of vitamin B12 and folic acid may act as environmental risk factor for ASD. Objective: To evaluate serum vitamin B12 and folic acid levels in ASD children. Methods: This cross-sectional study was conducted in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka, from 2018 to 2019. Total 100 children 3-10 years of age were enrolled for this study.Among them fifty (50) diagnosed children with ASD were included in the study group. Fifty (50) healthy children constituted the control group. ASD children were selected from the Parent’s Forum for autistic children. No children were included receiving any vitamin supplementation or had acute illness. For this study, serum level of vitamin B12 and folic acid were measured by automated analyzer.For statistical analysis unpaired “t” test and chi square test were done. Result: The mean values of vitamin B12 and folic acid were significantly lower in ASD children than those of control group (p value <0.05). In addition 4% ASD children had vitamin B12 deficiency. Conclusion: Low serum vitamin B12 and folic acid was associated with ASD. J Bangladesh Soc Physiol. 2019, December; 14(2): 43-47

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