scholarly journals Antitumor Effects of Cadmium Against Diethylnitrosamine-induced Liver Tumors in Mice

2021 ◽  
Author(s):  
Yu Nie ◽  
Bo Huang ◽  
An-Ling Hu ◽  
Yun-Yan Xu ◽  
Yan Zou ◽  
...  
Keyword(s):  
Drinking Water ◽  
Body Weight ◽  
Weight Gain ◽  
Liver Tumors ◽  
Body Weight Gain ◽  
Tumor Formation ◽  
Tumor Incidence ◽  
Antitumor Effects ◽  
Animal Body ◽  
Body Weights

Abstract Background: Cadmium (Cd) is reported to have antitumor effects against chemical-induced liver tumors. Antitumor effects of Cd are not completely understood, but may be related to metallothionein-deficiency in tumors, which makes tumor vulnerable to necrotic effects of Cd. Methods: Eight-week old male C57BL/6 mice were given injections of diethylnitrosamine (DEN, 90 mg/kg, and 50 mg/kg two weeks later), followed by promotion with CCl4. CdCl2 was administered in the drinking water (500 ppm) from 21-40 weeks after DEN initiation. Body weights were recorded and liver tumor formation was monitored via ultrasound. At the end of experiments, livers were removed, weighed, and the tumor incidence, tumor numbers and tumor size scores were recorded. Liver histology and metallothionein immunostaining were performed. Results: After DEN injection, animal body weight decreased, and slowly recovered afterwards. Cd treatment did not affect animal body weight gain. Ultrasounds detected liver tumors 35 weeks after DEN injection. Animals were necropsied at 40 weeks. Liver/body weight ratios increased in DEN and DEN+Cd groups. Cd treatment decreased tumor incidence (71% vs 17%), tumor numbers (15 vs 2), and tumor scores (22 vs 3). Histopathology showed hepatocyte degeneration in all groups, and immunohistochemistry showed metallothionein-deficiency in liver tumors, while metallothionein stain was intensified in tumor surrounding tissues. RT-qPCR showed increases of alpha-fetoprotein in DEN-treated livers, and increases of metallionein-2 and TNFα in Cd-treated livers. Conclusion: Cd is effective in suppression of DEN-induced liver tumors, and the mechanisms may be related to metallothionein-deficiency in tumors and induction of TNFα to kill tumor cells.

Chronic benzylamine administration in the drinking water improves glucose tolerance, reduces body weight gain and circulating cholesterol in high-fat diet-fed mice

2010 ◽  
Vol 61 (4) ◽  
pp. 355-363 ◽  
Author(s):  
Zsuzsa Iffiú-Soltész ◽  
Estelle Wanecq ◽  
Almudena Lomba ◽  
Maria P. Portillo ◽  
Federica Pellati ◽  
...  
Keyword(s):  
Drinking Water ◽  
Body Weight ◽  
Weight Gain ◽  
Glucose Tolerance ◽  
High Fat Diet ◽  
Body Weight Gain ◽  
High Fat

scholarly journals PENGARUH PEMBERIAN DEKOK DAUN SIRSAK, KUNYIT PUTIH, DAN DAUN KERSEN SERTA KOMBINASINYA DALAM AIR MINUM TERHADAP PERFORMANS DAN KOLESTEROL DARAH AYAM PETELUR JANTAN YANG DIINFEKSI BAKTERI ESCHERICHIA COLI

2018 ◽  
Vol 6 (1) ◽  
pp. 38-55
Author(s):  
Erni Ferawati Kadja ◽  
J F BaleTherik ◽  
Maxs U. E. Sanam
Keyword(s):  
Escherichia Coli ◽  
Drinking Water ◽  
Body Weight ◽  
Weight Gain ◽  
Body Weight Gain ◽  
Blood Cholesterol ◽  
Feed Consumption ◽  
Feed Conversion ◽  
Randomized Design ◽  
Completely Randomized Design

The purpose of this study was to determine the effect of soursop leaf (Annona muricata), saffron white (Curcuma mangga Val.) and cherry leaves (Muntingia calabura L.) and theirs combinations in drinking water on performances and blood cholesterol  of  laying roosters that infected by Escherichia coli. This study was designed using  completely randomized design (CRD) with 11 treatments and 3 replications and each treatment using the 4 roosters. That obtained 33 experimental units. The treatments were the drinking water contain decoction of  soursop leaves (DS), saffron white (KP) and cherry leaves (DK), and combinations were as follows: R0: without decoction of herbs (control), R1: 6% of DS decoction, R2: 6% of KP decoction, R3: 6 % of  DK decoction, R4: 2% of  DS decoction + 4% of KP decoction, R5: 2% of  DS decoction + 4% of DK decoction, R6: 2%  of KP decoction + 4% of DS decoction, R7: 2% of KP decoction  + 4% of DK decoction, R8: 2% of DK decoction + 4% of DS decoction, R9: 2% of  DK decoction + 4% of KP decoction, R10: 2%  of DS decoction + 2% of KP decoction + 2% of DK decoction. Parameters of  performance were: feed consumption, water intake, body weight gain, feed conversion. The result showed that the treatment had no effect on the performances (feed consumption, water consumption, body weight gain, feed conversion).

scholarly journals Aplikasi Teknologi Nanopartikel Perak (AgNPs) dalam Air Minum dan Bentuk Kabut terhadap Kadar Amonia Ekskreta Broiler

2019 ◽  
Vol 17 (2) ◽  
pp. 26-31
Author(s):  
Ones Putra Hulu ◽  
M Sihombing ◽  
R H Saputro ◽  
A Darmawan ◽  
Y Herbani
Keyword(s):  
Drinking Water ◽  
Body Weight ◽  
Weight Gain ◽  
Relative Humidity ◽  
Broiler Chickens ◽  
Body Weight Gain ◽  
Feed Consumption ◽  
Broiler Chicks ◽  
Feed Conversion ◽  
Ammonia Content

The purpose this study was evaluate the utilization of nanoparticles silver (AgNPs) on performance and ammonia concentration in broiler excreta.  This study used a factorial completely randomized design with 3x2 treatments and 4 replicates.  First factor (AgNPs at drinking water) was P1 = 0 ppm, P2 = 2 ppm, and P3 = 3 ppm and the  second factor Q (AgNPs by misty) was Q1 = 0 ppm and Q2 = 4 ppm.  The variables measured were excreta ammonia content, feed consumption, body weight gain, feed conversion ratio, mortality, temperature and relative humidity.  The results  showed that there was no interaction between AgNPs in drinking water and AgNPs in  its mist form on ammonia content.  AgNPs 4 ppm by misty also affected reduce FCR and body weight gain at week 3, also increased FCR at fourth week.  AgNPs in drinking water affected (P < 0.05) amonia content.  AgNPs 2 ppm in drinking water reduce until 11% amonia content.  AgNPs by misty also reduced (P< 0.05) amonia content.  AgNPs 0 ppm and 4 ppm by misty not created comfort temperature and relative humidity for broiler chicks. It is concluded that the addition of silver nanoparticles reduce excreta ammonia levels of broiler chickens.

scholarly journals A study of factors affecting weight gain among tuberculosis patients under DOTS in district Amritsar

2018 ◽  
Vol 5 (11) ◽  
pp. 4804
Author(s):  
Pooja Sadana ◽  
Harpreet Kaur ◽  
Vishal Verma
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Body Weight Gain ◽  
Continuation Phase ◽  
Factors Affecting ◽  
Tuberculosis Patients ◽  
End Of Treatment ◽  
Body Weights ◽  
The Mean ◽  
The Difference

Background: Wasting is a common feature in tuberculosis and treatment is aimed at achieving weight gain in pulmonary tuberculosis patients. The aims and objectives of the study were to study the extent of body weight gain during treatment and to identify the effect of different factors on weight gain among TB patients.Methods: The study was conducted on a total of 326 patients residing in the area of PHC Verka and registered with District Tuberculosis Centre, Amritsar. Weight change was assessed by taking the difference of weight at initial diagnosis and after completion of continuation phase therapy.Results: A total of 228 patients participated in the study. The mean (±SD) body weights (in kg) for the patients were 44.92±12.7 at diagnosis and 48.79±12.9 at the end of treatment. The mean (±SD) weight gain was 3.86±4.55 kgs at the end of treatment. The gain in weight at the end of treatment was associated with supervision of treatment and outcome of the TB patient.Conclusions: The findings showed that there is an association between gain in weight with supervision of treatment and outcome of the TB patient.

Evaluation of Exogenous Laccase Enzyme Treated Finger Millet Straw on Body Weight Gain, DM Intake and Nutrient Digestibility in Heifers

2021 ◽  
Author(s):  
Vidya Pradeep Kumar ◽  
Ramya G. Rao ◽  
A. Dhali ◽  
Vandana Thammiaha ◽  
Manpal Sridhar
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Finger Millet ◽  
Body Weight Gain ◽  
Test Group ◽  
Nutrient Digestibility ◽  
Control Group ◽  
Widespread Application ◽  
Body Weights ◽  
Effect Of Feeding

Background: Fungal laccases have widespread application in a number of biotechnological processes including the biodegradation of lignin. Their low yield in the native state limits their practical use in the deconstruction of lignocellulosic biomass for feeding ruminants. Enzymes in bulk quantities are required to treat biomass which has got greater product consistency and less lot to lot variations. The present study was an attempt to evaluate the effect of feeding finger millet straw treated with exogenous laccases in heifers.Methods: The effect of feeding exogenous laccases obtained from immobilized Schizophyllum commune (MTCC 11893) on body weight gain, dry matter intake and nutrient digestibility in heifers was evaluated in three groups of heifers (4-each) with body weights ranging between 275 ± 47.12 to 276.75 ± 64.48kg. The control group received ad lib. finger millet straw treated with only production media (GI). Test group 1 (GII) received ad lib. straw treated with laccase rich media in a 3:5 (w/v) ratio, while test group 2 (GIII) received ad lib. straw treated in a 4:5 (w/v) ratio. Result: After 14- days of feeding, gain in body weights for GI, GII and GIII were 277.9 ± 68.47; 277.50 ± 46.43 and 278.85 ± 37.22 respectively with an overall increase of 1.15, 4.25 and 3.60 kgs. No significant variation (P greater than 0.05) was observed with regard to DMD (%) between the groups which was 46 ± 5.8 for the control animals and 41±13.0 and 41± 3.4 in G2 and G3 groups. Though significant variations were observed digestibility studies proved inconclusive. Though preliminary results indicate that applying lignin degrading enzymes as feed supplements could enhance digestibility of crop residues in ruminants.

scholarly journals Effect of lead acetate alone and in combination with whole milk (Star ship®) on body growth and liver functions in an experimentally induced lead toxicity in rat

2016 ◽  
Vol 2 (2) ◽  
pp. 183-189 ◽  
Author(s):  
Mohammad Usman Gani ◽  
Md Saiful Islam Siddiqui ◽  
Md Harun Or Rashid ◽  
Kamrul Islam ◽  
Sharifunnessa Moonmoon ◽  
...  
Keyword(s):  
Drinking Water ◽  
Body Weight ◽  
Weight Gain ◽  
Lead Acetate ◽  
Body Weight Gain ◽  
Body Growth ◽  
The Body ◽  
Whole Milk ◽  
Liver Functions ◽  
Group B

The Effect of lead acetate alone and in combination with whole milk on body weight gain and some biochemical parameters were carried out on a total of 15 (15 days old) male weaning Long- Evans strain rats. The rats were randomly divided into three equal groups, each consisting of five rats. Rats of group A were kept as control (without giving any treatment), group B received lead acetate alone @ 6mg/ml drinking water and group C received lead acetate @ 6mg/ml plus whole milk (Star ship®) 150 mg/ml drinking water. The result showed that body weight gain of control group per week per rat was found to increase but in treated group B, the body weight gain was found to decrease most significantly (P< 0.01) on day 56 while in group C, body weight was reduced significantly (P< 0.05) on day 56. The reducing body weight gain was less in group C than group B. A most significantly (P< 0.01) increased SGOT and SGPT values were observed in Group B but in group C, those count increased significantly (P< 0.05) on day 56 of experiment. From the study it was concluded that treatment with lead acetate at low doses has adverse effects on body growth and liver functions in experimental animals.Asian J. Med. Biol. Res. June 2016, 2(2): 183-189

scholarly journals The Effect of Isoleucine Supplementation on Body Weight Gain and Blood Glucose Response in Lean and Obese Mice

Nutrients ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2446
Author(s):  
Rebecca O’Rielly ◽  
Hui Li ◽  
See Meng Lim ◽  
Roger Yazbeck ◽  
Stamatiki Kritas ◽  
...  
Keyword(s):  
Drinking Water ◽  
Body Weight ◽  
Weight Gain ◽  
Gastric Emptying ◽  
Glucose Tolerance ◽  
Body Weight Gain ◽  
Oral Glucose ◽  
Obese Mice ◽  
Glucose Response ◽  
The Impact

Chronic isoleucine supplementation prevents diet-induced weight gain in rodents. Acute-isoleucine administration improves glucose tolerance in rodents and reduces postprandial glucose levels in humans. However, the effect of chronic-isoleucine supplementation on body weight and glucose tolerance in obesity is unknown. This study aimed to investigate the impact of chronic isoleucine on body weight gain and glucose tolerance in lean and high-fat-diet (HFD) induced-obese mice. Male C57BL/6-mice, fed a standard-laboratory-diet (SLD) or HFD for 12 weeks, were randomly allocated to: (1) Control: Drinking water; (2) Acute: Drinking water with a gavage of isoleucine (300 mg/kg) prior to the oral-glucose-tolerance-test (OGTT) or gastric-emptying-breath-test (GEBT); (3) Chronic: Drinking water with 1.5% isoleucine, for a further six weeks. At 16 weeks, an OGTT and GEBT was performed and at 17 weeks metabolic monitoring. In SLD- and HFD-mice, there was no difference in body weight, fat mass, and plasma lipid profiles between isoleucine treatment groups. Acute-isoleucine did not improve glucose tolerance in SLD- or HFD-mice. Chronic-isoleucine impaired glucose tolerance in SLD-mice. There was no difference in gastric emptying between any groups. Chronic-isoleucine did not alter energy intake, energy expenditure, or respiratory quotient in SLD- or HFD-mice. In conclusion, chronic isoleucine supplementation may not be an effective treatment for obesity or glucose intolerance.

Short-Term Toxicity (1 and 10 Days) of Cadmium Chloride in Male and Female Rats: Gavage and Drinking Water

1989 ◽  
Vol 8 (2) ◽  
pp. 377-404 ◽  
Author(s):  
Joseph F. Borzelleca ◽  
Elizabeth C. Clarke ◽  
L. W. Condie
Keyword(s):  
Drinking Water ◽  
Body Weight ◽  
Weight Gain ◽  
Body Weight Gain ◽  
Female Rats ◽  
Testicular Atrophy ◽  
Dependent Manner ◽  
Male And Female ◽  
Males And Females ◽  
Dose Dependent

Male and female Sprague-Dawley-derived rats received CdCl2 by gavage at doses of 25, 51, 107, and 225 mg CdCl2 per kg body weight per day for 1 or 10 consecutive days or in drinking solutions at concentrations of 13–323 mg CdCl2 per liter for 10 consecutive days. There were appropriate controls. In the 1 day study in males only, an apparent treatment-related but not statistically significant decrease in body weight was reported; spleen weights and ratios were significantly lower and lung weights and ratios were significantly higher (in the highest dose only). Dose-dependent mortality was observed in the 10 day gavage study. Body weight gain was depressed in a dose-dependent manner in both males and females. Weights and/or ratios of brain, liver, spleen, lungs, thymus, kidneys, and testes of treated males were depressed in a dose-dependent manner. In females, weights and/or ratios of liver, spleen, thymus, and kidneys were depressed in a dose-dependent manner. Focal necrotic changes in renal tubular epithelium and tubular degeneration were reported in males and females. Testicular and hepatic histopathologic changes (testicular atrophy and necrosis and hepatic necrosis) were also reported in males. In the drinking water study, males demonstrated dose-dependent decreases in body weight gain and weight and/or ratios of liver, spleen, thymus, and kidneys. There were no significant compound-related effects in females, although liver weights and ratios were lower. There were no compound-related histopathologic effects.

DIALLEL CROSSES OF REPLICATE SELECTED LINES OF RATS

1975 ◽  
Vol 55 (4) ◽  
pp. 479-486 ◽  
Author(s):  
J. J. RUTLEDGE ◽  
A. B. CHAPMAN
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Combining Ability ◽  
Body Weight Gain ◽  
Selected Lines ◽  
Gene Effects ◽  
Body Weights ◽  
Marginal Means ◽  
Additive Gene ◽  
Good Agreement

A 6 × 6 diallel experiment was conducted with two control lines (Ri), two lines (Ui) selected for increased and two lines (Di) selected for decreased 3- to 9-wk body weight gain. Traits studied were 2-, 3-, 6- and 9-wk body weights and 3- to 9-wk body weight gain. For all traits, marginal means for dams or sires ranked in the order U > R > D. There was good agreement between replicate dam lines and between replicate sire lines for general combining ability. There was no clear evidence of any specific combining ability (non-additive gene effects) from crosses of lines within or between selection treatments.

scholarly journals Effect of Folic Acid by injection and supplementary on growth and puberty of Karadi male lambs

2021 ◽  
pp. 37-45
Author(s):  
Ismael Othman Karim
Keyword(s):  
Body Weight ◽  
Folic Acid ◽  
Weight Gain ◽  
Body Weight Gain ◽  
Live Weight ◽  
Total Body Weight ◽  
Seminiferous Tubules ◽  
Average Weight ◽  
Testosterone Concentration ◽  
Animal Body

The present study is carried out to study the effect of Folic Acid (FA) by injection and supplementary on animal body weight gain, Testes volume before slaughtering, Testes volume after slaughtering, Testosterone concentration in blood, and FA concentration in blood. Twenty-five (25) Karadi male lambs five months aged and the average weight was 24.54 ±1.92 kg were used in this experiment. The animals weighed after three months of treatment to get animal increased live weight, The testes measured after one, two, and three months of treatment to calculate testes volume, testosterone, and FA concentration level in the blood were taken after one, two, and three months of treatment. The present study demonstrated that animal body weight, animal body weight gain, and total body weight gain significantly not increased (p>0.05). Testicular length, and testicular circumference not increased (p>0.05) after 1st, 2nd, and 3rd months after treatment, and after slaughtering. However, testicular high increased (p<0.05) after each month of treatment and slaughtering. Testosterone concentration in the blood significantly not different (p>0.05) reported between treatments after the 1st, 2nd, and 3rd months of treatment. FA concentration in the blood significantly increased (p<0.05) when used 3 and 6 mg FA by injection compared to control after 1st and 2nd months of treatment. However, blood FA concentration increased (p<0.05) when used FA 6mg/ml as an injection after the 2nd month of treatment compared to control. While using FA by supplementation and injection significantly (p>0.05) on the diameter and circumference of seminiferous tubules, germ cells thickness, and lumen diameters.

Sign in / Sign up

Export Citation Format

Share Document